2025
Assessing frailty screening tools for predicting morbidity for suboccipital decompression in adults with Chiari malformation type I.
Serrato P, Hansen J, Ghanekar S, Mitre L, DiLuna M, Elsamadicy A. Assessing frailty screening tools for predicting morbidity for suboccipital decompression in adults with Chiari malformation type I. Journal Of Neurosurgery Spine 2025, 1-11. PMID: 40712174, DOI: 10.3171/2025.4.spine2597.Peer-Reviewed Original ResearchMFI-5 scoreChiari malformation type ILength of stayRAI-revAdverse eventsSuboccipital decompressionMFI-5Nonroutine dischargeHospital lengthAmerican College of Surgeons National Surgical Quality Improvement Program databaseSurgeons National Surgical Quality Improvement Program databaseMultivariate analysisNational Surgical Quality Improvement Program databaseComprehensive assessment toolAmerican CollegeModified 5-item frailty indexQuality Improvement Program databaseHospital length of stayRetrospective cohort studyRisk Analysis IndexType IPatient ageCM-IProgram databaseCohort studyRisk Factors for and Prediction of Early Thromboembolic Disease Following Adult Spinal Deformity Surgery
Gallagher D, Bondar K, Hirase T, Harris J, Vemu S, Louie P, Varthi A, Lambert B, Saifi C. Risk Factors for and Prediction of Early Thromboembolic Disease Following Adult Spinal Deformity Surgery. Journal Of Bone And Joint Surgery 2025, 107: 1219-1226. PMID: 40273208, PMCID: PMC12118619, DOI: 10.2106/jbjs.23.01391.Peer-Reviewed Original ResearchConceptsDeep vein thrombosisChronic corticosteroid useAdult spinal deformityPulmonary embolismCorticosteroid useVTE riskRisk factorsCurrent Procedural TerminologyASA classAmerican College of Surgeons National Surgical Quality Improvement Program databaseFactors associated with deep vein thrombosisSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseRisk factors associated with deep vein thrombosisAmerican Society of Anesthesiologists (ASA) classAdult spinal deformity surgeryQuality Improvement Program databaseRisk of deep vein thrombosisRate of deep vein thrombosisPostoperative deep vein thrombosisDescription of levels of evidenceSpinal deformity surgeryAssociated with VTE riskPostoperative VTE riskPreoperative risk assessmentSingle-Pedicled, Supercharged, or Bi-Pedicled? A Multi-Institutional Outcome Comparison of Pedicled TRAM Flap for Autologous Breast Reconstruction
Knoedler S, Matar D, Schaschinger T, Boroumand S, Tsolakidis S, Könneker S, Orgill D, Panayi A, Kim B. Single-Pedicled, Supercharged, or Bi-Pedicled? A Multi-Institutional Outcome Comparison of Pedicled TRAM Flap for Autologous Breast Reconstruction. Clinical Breast Cancer 2025, 25: e857-e867. PMID: 40319006, DOI: 10.1016/j.clbc.2025.03.022.Peer-Reviewed Original ResearchRisk of medical complicationsHigher ASA classTRAM flapMedical complicationsSingle-pedicleASA classBreast reconstructionHigher BMIPedicled TRAM flap breast reconstructionAmerican College of Surgeons National Surgical Quality Improvement Program databaseSurgeons National Surgical Quality Improvement Program databaseIncreased likelihood of reoperationNational Surgical Quality Improvement Program databaseHigher risk of medical complicationsQuality Improvement Program databaseTRAM flap breast reconstructionTRAM flap reconstructionFlap breast reconstructionPedicled TRAM flapAutologous breast reconstructionLikelihood of reoperationBi-pedicledComparison of outcomesFlap reconstructionSurgical complicationsThe Use of Acellular Dermal Matrix May Not Increase 30-Day Complications in Direct-to-Implant Breast Reconstruction: A Multi-institutional Analysis of 10,177 Cases.
Knoedler S, Klimitz F, Friedrich S, Schemet L, Broer P, Cherubino M, Könneker S, Kim B, Pomahac B, Kauke-Navarro M. The Use of Acellular Dermal Matrix May Not Increase 30-Day Complications in Direct-to-Implant Breast Reconstruction: A Multi-institutional Analysis of 10,177 Cases. Annals Of Plastic Surgery 2025 PMID: 39874559, DOI: 10.1097/sap.0000000000004234.Peer-Reviewed Original ResearchDirect-to-implant breast reconstructionDirect-to-implantAcellular dermal matrixBreast reconstructionPropensity score matchingHigher risk of short-term complicationsMedical complicationsAmerican College of Surgeons National Surgical Quality Improvement Program databaseSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseIncreased 30-day complicationsMultivariate analysisRisk of short-term complicationsQuality Improvement Program databaseThirty-day postoperative complicationsSurgical complication rateIncorporation of acellular dermal matrixScore matchingMulti-institutional analysisMulti-institutional databaseShort-term complicationsComplication ratePostoperative complicationsWound dehiscenceNo significant difference
2024
Protein as a preoperative predictor – Impact of hypoalbuminemia on 30-day outcomes of breast reduction surgery
Knoedler S, Klimitz F, Diatta F, Perozzo F, Sofo G, Alfertshofer M, Cherubino M, Mayer H, Panayi A, Kim B, Pomahac B, Kauke-Navarro M. Protein as a preoperative predictor – Impact of hypoalbuminemia on 30-day outcomes of breast reduction surgery. Journal Of Plastic Reconstructive & Aesthetic Surgery 2024, 100: 144-152. PMID: 39615141, DOI: 10.1016/j.bjps.2024.11.011.Peer-Reviewed Original ResearchBreast reduction surgeryImpact of hypoalbuminemiaReduction surgeryBody mass indexPostoperative complicationsSurgical outcomesMass indexAmerican College of Surgeons National Surgical Quality Improvement Program databaseSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseAssociated with adverse surgical outcomesPredictor of postoperative complicationsIncreased risk of complicationsQuality Improvement Program databasePreoperative nutritional assessmentSuperficial incisional infectionNormal albumin levelsBiomarkers of malnutritionHigher Body Mass IndexAdverse surgical outcomesRisk of complicationsImprove surgical outcomesChronic obstructive pulmonary diseaseMultivariate logistic regressionObstructive pulmonary diseaseImpact of preoperative nutritional status on morbidity and mortality in elderly patients undergoing subdural hematoma evacuation: the role of the Geriatric Nutritional Risk Index.
Serrato P, Craft S, Sayeed S, Hengartner A, Belkasim S, Sadeghzadeh S, DiLuna M, Elsamadicy A. Impact of preoperative nutritional status on morbidity and mortality in elderly patients undergoing subdural hematoma evacuation: the role of the Geriatric Nutritional Risk Index. Journal Of Neurosurgery 2024, 142: 1035-1045. PMID: 39546774, DOI: 10.3171/2024.7.jns24875.Peer-Reviewed Original ResearchGeriatric Nutritional Risk IndexLength of hospital stayPreoperative nutritional statusSubdural hematoma evacuationAssociated with increased oddsNutritional Risk IndexProportion of patientsHematoma evacuationAdverse eventsShort-term outcomesMalnourished statusNutritional statusNonroutine dischargeElderly patientsImpact of preoperative nutritional statusAmerican College of Surgeons National Surgical Quality Improvement Program databaseSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseQuality Improvement Program databaseMultivariate logistic regression analysisExtended length of hospital staySevere adverse eventsRetrospective cohort studyPostoperative adverse eventsMinor adverse eventsRisk factors and outcomes after surgery for malignant neoplasm of the parotid gland: An ACS-NSQIP study
Knoedler L, Knoedler S, Hoch C, Safi A, Wollenberg B, Alfertshofer M, Pomahac B, Kauke-Navarro M, Clune J. Risk factors and outcomes after surgery for malignant neoplasm of the parotid gland: An ACS-NSQIP study. Journal Of Plastic Reconstructive & Aesthetic Surgery 2024, 101: 264-274. PMID: 39448324, DOI: 10.1016/j.bjps.2024.09.067.Peer-Reviewed Original ResearchBlood urea nitrogenRisk factorsRenal failureParotid glandMalignant neoplasmsAmerican College of Surgeons National Surgical Quality Improvement Program databaseSurgeons National Surgical Quality Improvement Program databaseAssociated with higher creatinineNational Surgical Quality Improvement Program databaseMicrosurgical proceduresPre-operative risk factorsQuality Improvement Program databaseRisk of postoperative adverse eventsBlood urea nitrogen levelsHigher ASA classPostoperative adverse eventsOccurrence of complicationsPost-surgical outcomesTumor resectionComplication rateFlap surgeryPostoperative outcomesACS-NSQIPASA classHigher creatinineSurgical Outcomes and Utilization of Laparoscopic Versus Robotic Techniques for Elective Colectomy in Asian American and Native Hawaiian-Pacific Islanders (AAPI) Diagnosed With Colon Cancer
Ahuja V, Murthy S, Leeds I, Paredes L, Su D, Tsutsumi A, Perkal M, King J. Surgical Outcomes and Utilization of Laparoscopic Versus Robotic Techniques for Elective Colectomy in Asian American and Native Hawaiian-Pacific Islanders (AAPI) Diagnosed With Colon Cancer. Journal Of Surgical Research 2024, 302: 40-46. PMID: 39083904, DOI: 10.1016/j.jss.2024.07.007.Peer-Reviewed Original ResearchLaparoscopic colectomyRobotic colectomyAAPI patientsColorectal cancerLength of stayClinical outcomesNative Hawaiian Pacific IslanderAmerican College of Surgeons National Surgical Quality Improvement Program databaseSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseOperative timeQuality Improvement Program databaseMultivariate logistic regression analysisMean operative timeColorectal cancer resectionOutcomes of LCMinimally invasive approachMultivariate logistic regressionStandard of careLogistic regression analysisElective RCElective LCAnastomotic leakElective colectomySurgical outcomesSurgical Management of Breast Capsular Contracture—A Multi-institutional Data Analysis of Risk Factors for Early Complications
Knoedler S, Knoedler L, Boroumand S, Alfertshofer M, Diatta F, Sofo G, Huelsboemer L, Hansen F, Könneker S, Kim B, Perozzo F, Ayyala H, Allam O, Pomahac B, Kauke-Navarro M. Surgical Management of Breast Capsular Contracture—A Multi-institutional Data Analysis of Risk Factors for Early Complications. Aesthetic Plastic Surgery 2024, 49: 516-527. PMID: 38926252, DOI: 10.1007/s00266-024-04203-x.Peer-Reviewed Original ResearchRisk factorsPostoperative complicationsCC surgeryInpatient settingMedical complicationsAmerican College of Surgeons National Surgical Quality Improvement Program databaseRisk factors of postoperative complicationsSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseImplant-based breast surgeryMultivariate analysisPreoperative diagnosis of hypertensionFactors of postoperative complicationsQuality Improvement Program databaseLevel of Evidence IIIThis journalEvidence-Based Medicine ratingsAnalysis of risk factorsDay complication ratesDays follow-upEvidence IIIThis journalLevel of evidenceSurgical adverse eventsDiagnosis of hypertensionMulti-institutional dataTreatment of CCAssociation of Malnutrition with Surgical and Hospital Outcomes after Spine Surgery for Spinal Metastases: A National Surgical Quality Improvement Program Study of 1613 Patients
Elsamadicy A, Havlik J, Reeves B, Sherman J, Craft S, Serrato P, Sayeed S, Koo A, Khalid S, Lo S, Shin J, Mendel E, Sciubba D. Association of Malnutrition with Surgical and Hospital Outcomes after Spine Surgery for Spinal Metastases: A National Surgical Quality Improvement Program Study of 1613 Patients. Journal Of Clinical Medicine 2024, 13: 1542. PMID: 38541767, PMCID: PMC10971134, DOI: 10.3390/jcm13061542.Peer-Reviewed Original ResearchNon-routine dischargeLength of stayImpact of malnutritionSpinal metastasesAdverse eventsMalnourished patientsNourished patientsSurgeons National Surgical Quality Improvement Program databaseSurgical treatment of spinal metastasesNational Surgical Quality Improvement Program databaseTreatment of spinal metastasesNational Surgical Quality Improvement Program studyQuality Improvement Program databaseRisk of postoperative complicationsMultivariate logistic regression analysisMetastatic spinal diseaseHospital length of stayProlonged length of stayAssociation of malnutritionRetrospective cohort studyPostoperative adverse eventsHealthcare resource utilizationAssessed patient demographicsExtradural spinal metastasisBaseline comorbidity burdenNational trends and outcomes of total proctocolectomy and completion proctectomy ileal pouch−anal anastomosis procedures for ulcerative colitis
Chen S, Radomski S, Stem M, Done J, Caturegli G, Atallah C, Efron J, Safar B. National trends and outcomes of total proctocolectomy and completion proctectomy ileal pouch−anal anastomosis procedures for ulcerative colitis. Colorectal Disease 2024, 26: 497-507. PMID: 38302723, DOI: 10.1111/codi.16891.Peer-Reviewed Original ResearchConceptsAssociated with increased oddsTPC-IPAASteroid/immunosuppressive therapyUlcerative colitisTotal proctocolectomySurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseFactors associated with 30-dayIleal pouch-anal anastomosis procedureOutcomes of ulcerative colitisQuality Improvement Program databaseIleal pouch-anal anastomosisAdult UC patientsAnastomotic leak ratePouch-anal anastomosisLonger hospital lengthMultivariate logistic regressionIncreased morbidity riskDelayed surgeryObese patientsCompletion proctectomyUC patientsProgram databaseHospital lengthUnadjusted analysis
2023
Racial disparities in surgical outcomes after mastectomy in 223 000 female breast cancer patients: a retrospective cohort study
Knoedler S, Kauke-Navarro M, Knoedler L, Friedrich S, Matar D, Diatta F, Mookerjee V, Ayyala H, Wu M, Kim B, Machens H, Pomahac B, Orgill D, Broer P, Panayi A. Racial disparities in surgical outcomes after mastectomy in 223 000 female breast cancer patients: a retrospective cohort study. International Journal Of Surgery 2023, 110: 684-699. PMID: 38052017, PMCID: PMC10871660, DOI: 10.1097/js9.0000000000000909.Peer-Reviewed Original ResearchAmerican Indian/Alaska Native womenBreast cancer patientsAlaska Native womenSurgical complicationsRadical mastectomyPartial mastectomyCancer patientsSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseQuality Improvement Program databaseFemale breast cancer patientsNon-home dischargeRetrospective cohort studyImprovement Program databaseLikelihood of readmissionBreast cancer mortalityBreast cancer surgeryAfrican American patientsAmerican Indians/Alaska NativesBlack/African AmericanNative Hawaiian/Pacific IslanderComplication occurrencePerioperative complicationsPerioperative outcomesAdverse eventsAn ACS-NSQIP Data Analysis of 30-Day Outcomes Following Surgery for Bell’s Palsy
Knoedler S, Knoedler L, Hoch C, Kauke-Navarro M, Kehrer A, Friedman L, Prantl L, Machens H, Orgill D, Panayi A. An ACS-NSQIP Data Analysis of 30-Day Outcomes Following Surgery for Bell’s Palsy. Journal Of Craniofacial Surgery 2023, 35: 23-28. PMID: 37695075, PMCID: PMC10841222, DOI: 10.1097/scs.0000000000009739.Peer-Reviewed Original ResearchBell's palsyHospital stayPostoperative outcomesSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseFuture large-scale prospective studiesDiagnosis of BPQuality Improvement Program databaseLarge-scale prospective studiesImprovement Program databasePoor postoperative outcomesRoutine laboratory valuesOutcome of surgeryMulti-institutional analysisBlood urea nitrogenMulti-institutional databaseMajority of proceduresMulti-institutional studyQuality of careCommon comorbiditiesFrequent complicationPerioperative protocolComplication rateMedical complicationsPreoperative evaluationIncidence and Risk Factors of Postoperative Complications After Rhinoplasty: A Multi-Institutional ACS-NSQIP Analysis
Knoedler S, Knoedler L, Wu M, Haug V, Broer P, Kauke-Navarro M, Hundeshagen G, Prantl L, Orgill D, Panayi A. Incidence and Risk Factors of Postoperative Complications After Rhinoplasty: A Multi-Institutional ACS-NSQIP Analysis. Journal Of Craniofacial Surgery 2023, 34: 1722-1726. PMID: 37487058, DOI: 10.1097/scs.0000000000009553.Peer-Reviewed Original ResearchConceptsLow serum albuminSurgical adverse eventsAdverse eventsRisk factorsPostoperative outcomesASA scoreComplication rateMale sexSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseQuality Improvement Program databasePreoperative nutritional optimizationSuperficial incisional infectionAverage patient ageHigher ASA scoreImprovement Program databasePreoperative laboratory valuesACS-NSQIP AnalysisMulti-institutional analysisSingle-institution reportsIncisional infectionPostoperative complicationsPreoperative albuminComplication occurrenceMost patientsThe surgical patient of yesterday, today, and tomorrow—a time-trend analysis based on a cohort of 8.7 million surgical patients
Knoedler S, Matar D, Friedrich S, Knoedler L, Haug V, Hundeshagen G, Kauke-Navarro M, Kneser U, Pomahac B, Orgill D, Panayi A. The surgical patient of yesterday, today, and tomorrow—a time-trend analysis based on a cohort of 8.7 million surgical patients. International Journal Of Surgery 2023, 109: 2631-2640. PMID: 37788019, PMCID: PMC10498871, DOI: 10.1097/js9.0000000000000511.Peer-Reviewed Original ResearchConceptsSurgical patientsMedian ageMedian BMISurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseQuality Improvement Program databaseACS-NSQIP databaseImprovement Program databaseObesity class IProportion of patientsCohort of patientsPrevalence of diabetesType 2 diabetesGlobal healthcare deliveryFuture surgical careField of surgeryTime trend analysisPatient ageSurgical cohortDiabetes prevalenceProgram databaseSurgical careAmerican CollegeGeneral populationPatientsImpact of nonmalignant ascites on outcomes of open inguinal hernia repair in the USA
Kerekes D, Sznol J, Khan S, Becher R. Impact of nonmalignant ascites on outcomes of open inguinal hernia repair in the USA. Hernia 2023, 27: 1497-1506. PMID: 37029887, DOI: 10.1007/s10029-023-02790-3.Peer-Reviewed Original ResearchConceptsOpen inguinal herniorrhaphyOdds of mortalityInguinal hernia repairSerious complicationsInguinal herniorrhaphyNonelective repairElective repairAscites patientsHernia repairSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseQuality Improvement Program databaseOpen inguinal hernia repairImpact of ascitesNational US databasePrimary end pointImprovement Program databaseRetrospective cohort studyChallenging clinical dilemmaPreoperative ascitesCohort studyComposite outcomeNonelective surgeryPoor outcomeSurgical outcomesEarly Outcomes and Risk Factors in Orthognathic Surgery for Mandibular and Maxillary Hypo- and Hyperplasia: A 13-Year Analysis of a Multi-Institutional Database
Knoedler S, Baecher H, Hoch C, Obed D, Matar D, Rendenbach C, Kim B, Harhaus L, Kauke-Navarro M, Hundeshagen G, Knoedler L, Orgill D, Panayi A. Early Outcomes and Risk Factors in Orthognathic Surgery for Mandibular and Maxillary Hypo- and Hyperplasia: A 13-Year Analysis of a Multi-Institutional Database. Journal Of Clinical Medicine 2023, 12: 1444. PMID: 36835979, PMCID: PMC9965345, DOI: 10.3390/jcm12041444.Peer-Reviewed Original ResearchMulti-institutional databaseRisk factorsOrthognathic surgeryJaw surgeryAdverse eventsSurgical complicationsSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseQuality Improvement Program databaseSingle-institutional reportSuperficial incisional infectionPostoperative adverse eventsACS-NSQIP databaseImprovement Program databaseCommon surgical complicationPositive safety profileHigh complication rateSingle surgeon's experienceSingle-jaw surgeryNovel risk factorsDouble-jaw surgeryEqual gender distributionWarrants further investigationIncisional infectionPostoperative complications
2022
30-Day Postoperative Outcomes in Adults with Obstructive Sleep Apnea Undergoing Upper Airway Surgery
Knoedler S, Knoedler L, Baecher H, Kauke-Navarro M, Obed D, Hoch C, Diehm Y, Vosler P, Harréus U, Kneser U, Panayi A. 30-Day Postoperative Outcomes in Adults with Obstructive Sleep Apnea Undergoing Upper Airway Surgery. Journal Of Clinical Medicine 2022, 11: 7371. PMID: 36555986, PMCID: PMC9783895, DOI: 10.3390/jcm11247371.Peer-Reviewed Original ResearchObstructive sleep apneaOSA surgeryPostoperative outcomesMedical complicationsSleep apneaSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseMulti-institutional national databaseQuality Improvement Program databaseUpper airway surgeryTotal complication rateHistory of diabetesImprovement Program databasePositive safety profileAlkaline phosphatasePostoperative complicationsComplication ratePostoperative periodAirway surgeryFrequent comorbiditiesMale sexSafety profileUpper airwaySurgery outcomesChronic disordersPerioperative Outcomes and Risk Profile of 4730 Cosmetic Breast Surgery Cases in Academic Institutions: An ACS-NSQIP Analysis
Knoedler S, Kauke-Navarro M, Haug V, Broer P, Pomahac B, Knoedler L, Panayi A. Perioperative Outcomes and Risk Profile of 4730 Cosmetic Breast Surgery Cases in Academic Institutions: An ACS-NSQIP Analysis. Aesthetic Surgery Journal 2022, 43: 433-451. PMID: 36472232, DOI: 10.1093/asj/sjac320.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseCosmetic breast surgeryObstructive pulmonary diseaseRisk factorsSurgical complicationsPulmonary diseaseSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseMulti-institutional national databaseMultiple proceduresQuality Improvement Program databaseImprovement Program databaseIndependent risk factorCongestive heart failurePositive safety profileObesity class 1ACS-NSQIP AnalysisAnesthesiology scoreBreast surgery casesPerioperative outcomesPerioperative protocolPostoperative outcomesClinical patternHeart failureFemale patientsThe modified 5-item frailty index is a predictor of perioperative risk in breast reconstruction: An analysis of 40,415 cases
Panayi AC, Foroutanjazi S, Parikh N, Haug V, Kauke-Navarro M, Diehm YF, Pomahac B. The modified 5-item frailty index is a predictor of perioperative risk in breast reconstruction: An analysis of 40,415 cases. Journal Of Plastic Reconstructive & Aesthetic Surgery 2022, 75: 2941-2954. PMID: 35599223, DOI: 10.1016/j.bjps.2022.04.035.Peer-Reviewed Original ResearchConceptsImplant-based reconstructionBreast reconstructionMFI-5Unplanned readmissionPostoperative outcomesSurgical complicationsMedical complicationsMFI scoreRisk predictorsSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseQuality Improvement Program databaseBreast reconstruction patientsFrailty index-5Powerful risk predictorImprovement Program databasePreoperative risk stratificationStrong risk predictorAutologous breast reconstructionAdverse surgical outcomesType of reconstructionHigh rateFrail patientsHospital stayPerioperative risk
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