2025
B-cell immune repertoire sequencing in tobacco cigarette smoking, vaping, and chronic obstructive pulmonary disease in the COPDGene cohort
Moll M, Xu Z, Boueiz A, Ryu M, Silverman E, Cho M, Hersh C, Sauler M, Polverino F, Kinney G, Curtis J, Crotty-Alexander L, Vollmers C, Castaldi P. B-cell immune repertoire sequencing in tobacco cigarette smoking, vaping, and chronic obstructive pulmonary disease in the COPDGene cohort. Frontiers In Immunology 2025, 16: 1508786. PMID: 40386772, PMCID: PMC12082042, DOI: 10.3389/fimmu.2025.1508786.Peer-Reviewed Original ResearchConceptsB cell activationB cell functionB cellsCigarette smokingClonal expansionClass switchingB cell clonal expansionImpaired B-cell functionIncreased B cell activationImpact of e-cigarette useSecretory IgA productionB cell receptor sequencesTobacco cigarette smokingChronic obstructive pulmonary diseaseE-cigarette useImmune repertoire sequencingIncreased infection riskObstructive pulmonary diseaseBCR-seqResponse to infectionBlood RNA samplesAssessed multivariable associationsBenjamini-Hochberg methodDual usersMultiple alterations
2013
Mosaic Copy Number Variation in Human Neurons
McConnell MJ, Lindberg MR, Brennand KJ, Piper JC, Voet T, Cowing-Zitron C, Shumilina S, Lasken RS, Vermeesch JR, Hall IM, Gage FH. Mosaic Copy Number Variation in Human Neurons. Science 2013, 342: 632-637. PMID: 24179226, PMCID: PMC3975283, DOI: 10.1126/science.1243472.Peer-Reviewed Original ResearchConceptsCopy number variationsHiPSC-derived neuronsSingle-cell genomic approachesNumber variationsDNA copy number variationsSingle-cell sequencingHuman neuronsLarge copy number variationsStem cell linesNeural progenitor cellsNovo copy-number variationsPluripotent stem cell lineAneuploid neuronsGenomic approachesDe novo copy-number variationsSubchromosomal copy number variationsAberrant genomesFrontal cortex neuronsLarge deletionsProgenitor cellsCell linesSubset of neuronsEuploid neuronsDeletionMultiple alterations
2012
Semaphorins in cancer: Biological mechanisms and therapeutic approaches
Rehman M, Tamagnone L. Semaphorins in cancer: Biological mechanisms and therapeutic approaches. Seminars In Cell And Developmental Biology 2012, 24: 179-189. PMID: 23099250, DOI: 10.1016/j.semcdb.2012.10.005.Peer-Reviewed Original ResearchConceptsResponsive cell typesHallmarks of cancerMultiple experimental approachesEpigenetic changesSemaphorin signalsPhysiological processesCell migrationPivotal signalsCell typesReceptor complexCell proliferationSemaphorinsCancer cellsDifferent semaphorinsBiological mechanismsHuman tumorsTumor progressionMultiple alterationsTumor angiogenesisPathwayExperimental approachFamily membersTumor microenvironmentImportant roleCells
1995
Differential expression of ORCC and CFTR induced by low temperature in CF airway epithelial cells
Egan M, Schwiebert E, Guggino W. Differential expression of ORCC and CFTR induced by low temperature in CF airway epithelial cells. American Journal Of Physiology 1995, 268: c243-c251. PMID: 7530908, DOI: 10.1152/ajpcell.1995.268.1.c243.Peer-Reviewed Original ResearchConceptsCl- channel activityAirway epithelial cellsEpithelial cellsCFTR Cl- channel activityProtein kinase ANonepithelial cell typesMutant proteinsKinase ACF airway epithelial cellsIon channel expressionDifferential expressionIncubation temperatureCell typesCF airway epitheliaChannel expressionRegulator mutationsCFTRMultiple alterationsMutationsCells
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply