2025
Multi-center randomized superiority clinical trial in the early phase of mechanically ventilated patients to preserve diaphragm thickness using non-invasive magnetic phrenic nerve stimulation: STIMIT ACTIVATOR 1 pivotal trial
Schreiber A, Subirà C, Sklar M, Santos M, Ko M, Panelli A, Schaller S, Theodore D, Rowley D, Watson D, Bonde P, Baedorf Kassis E, Talmor D, Ranieri M, Goligher E, Slutsky A, Brochard L. Multi-center randomized superiority clinical trial in the early phase of mechanically ventilated patients to preserve diaphragm thickness using non-invasive magnetic phrenic nerve stimulation: STIMIT ACTIVATOR 1 pivotal trial. Trials 2025, 26: 202. PMID: 40500715, PMCID: PMC12153206, DOI: 10.1186/s13063-025-08838-2.Peer-Reviewed Original ResearchConceptsVentilator-induced diaphragmatic dysfunctionPhrenic nerve stimulationMechanically Ventilated PatientsIntensive care unitNerve stimulationMechanical ventilationClinical trialsProcedure-related adverse eventsMagnetic phrenic nerve stimulationProlonged ventilatory dependencySevere chronic pulmonary diseaseRandomized multi-center studyDiaphragm thicknessMuscle thicknessMaximal inspiratory pressureMulti-center randomized clinical trialChronic pulmonary diseaseRandomized clinical trialsMeasure diaphragm thicknessMulti-center studyRandomized superiority clinical trialInvasive electrical stimulationVentilatory dependenceDiaphragmatic dysfunctionSuperiority clinical trial
2024
Multidisciplinary Lessons from Palliative Extubations at Home
Breyre A, Grammatico M, Policastro A, Ingram C, Prsic E, Sussman L, Couturier K. Multidisciplinary Lessons from Palliative Extubations at Home. Prehospital Emergency Care 2024, ahead-of-print: 1-4. PMID: 39475704, DOI: 10.1080/10903127.2024.2420198.Peer-Reviewed Original ResearchProtective mechanical ventilation in critically ill patients after surgery
Zorrilla-Vaca A, Arevalo J, Grant M. Protective mechanical ventilation in critically ill patients after surgery. Current Opinion In Critical Care 2024, 30: 679-683. PMID: 39503212, DOI: 10.1097/mcc.0000000000001215.Peer-Reviewed Original ResearchIntensive care unitVentilator-induced lung injuryLung protective strategyCritically ill patientsMechanical ventilationCare unitLung injurySurgical patientsFast-track extubation protocolOpen-lung ventilation strategyIll patientsRisk of ventilator-induced lung injuryHigh-flow nasal cannulaHigh-risk surgical patientsOpen lung ventilationOperating roomNoninvasive ventilation supportProtective mechanical ventilationPositive-end expiratory pressureAcute lung injuryMechanically Ventilated PatientsStandard of careThoracic surgeryNasal cannulaRetrospective studyShift-Level Team Familiarity Is Associated with Improved Outcomes in Mechanically Ventilated Adults.
Costa D, Yakusheva O, Khadr L, Ratliff H, Lee K, Sjoding M, Jimenez J, Marriott D. Shift-Level Team Familiarity Is Associated with Improved Outcomes in Mechanically Ventilated Adults. American Journal Of Respiratory And Critical Care Medicine 2024, 210: 311-317. PMID: 38358858, PMCID: PMC12032956, DOI: 10.1164/rccm.202310-1971oc.Peer-Reviewed Original ResearchConceptsInterprofessional teamSpontaneous breathing trialTeam familiarityElectronic health record dataHealth record dataAcademic medical centerAssociated with lower mortalityLower mortalityMechanical ventilationTeam valuesMethods:</b>Shorter duration of mechanical ventilationDuration of mechanical ventilationWorkforce needsShorter MV durationFamiliar dataUnadjusted mortalityAssociated with improved outcomesDuration of MVAverage durationRecord dataMechanically Ventilated PatientsPatient outcomesMechanically ventilated adultsMedical CenterAssociation of Early Dexmedetomidine Utilization With Clinical Outcomes After Moderate-Severe Traumatic Brain Injury: A Retrospective Cohort Study
Liu S, Kelly-Hedrick M, Komisarow J, Hatfield J, Ohnuma T, Treggiari M, Colton K, Arulraja E, Vavilala M, Laskowitz D, Mathew J, Hernandez A, James M, Raghunathan K, Krishnamoorthy V. Association of Early Dexmedetomidine Utilization With Clinical Outcomes After Moderate-Severe Traumatic Brain Injury: A Retrospective Cohort Study. Anesthesia & Analgesia 2024, 139: 366-374. PMID: 38335145, PMCID: PMC11250935, DOI: 10.1213/ane.0000000000006869.Peer-Reviewed Original ResearchLength of stayTraumatic brain injuryImprove patient outcomesModerate-severe TBIRetrospective cohort studyMechanical ventilationMechanically Ventilated PatientsDexmedetomidine exposureDay of admissionCohort studyHospital mortalityOdds of hospital mortalityPatient outcomesAssociated with reduced oddsCohort of critically ill adult patientsPrimary outcome of hospital mortalityReduce length of stayHospital costsAssociated with oddsOutcome of hospital mortalityCritically ill adult patientsDay of ICU admissionHospital length of stayIll adult patientsPublic health problemUse of Early Ketamine Sedation and Association With Clinical and Cost Outcomes Among Mechanically Ventilated Patients With COVID-19: A Retrospective Cohort Study
Royce-Nagel G, Jarzebowski M, Wongsripuemtet P, Krishnamoorthy V, Fuller M, Ohnuma T, Treggiari M, Yaport M, Cobert J, Garrigan E, Bartz R, Raghunathan K. Use of Early Ketamine Sedation and Association With Clinical and Cost Outcomes Among Mechanically Ventilated Patients With COVID-19: A Retrospective Cohort Study. Critical Care Explorations 2024, 6: e1105. PMID: 38904975, PMCID: PMC11196078, DOI: 10.1097/cce.0000000000001105.Peer-Reviewed Original ResearchConceptsRenal replacement therapyLength of stayHospital length of stayHigher hospital mortalityKetamine infusionTotal hospital costsHospital mortalityVasopressor daysKetamine useVentilator daysSample of U.S. hospitalsRenal replacement therapy useAssociated with higher hospital mortalityDays of mechanical ventilationAssociated with in-hospital mortalityHospital costsManagement of critically ill patientsExtracorporeal membrane oxygenationPropensity Score Matching AnalysisRetrospective cohort studyPremier Healthcare DatabaseDays of hospitalizationDays of intubationMechanically Ventilated PatientsCritically ill patientsLongitudinal multicompartment characterization of host-microbiota interactions in patients with acute respiratory failure
Kitsios G, Sayed K, Fitch A, Yang H, Britton N, Shah F, Bain W, Evankovich J, Qin S, Wang X, Li K, Patel A, Zhang Y, Radder J, Dela Cruz C, Okin D, Huang C, Van Tyne D, Benos P, Methé B, Lai P, Morris A, McVerry B. Longitudinal multicompartment characterization of host-microbiota interactions in patients with acute respiratory failure. Nature Communications 2024, 15: 4708. PMID: 38830853, PMCID: PMC11148165, DOI: 10.1038/s41467-024-48819-8.Peer-Reviewed Original ResearchConceptsAcute respiratory failureRespiratory failureCohort of COVID-19 patientsLung microbiotaMechanically Ventilated PatientsChronic obstructive pulmonary diseaseIllumina amplicon sequencingDNA sequencing technologiesHost-microbiota interactionsObstructive pulmonary diseaseCOVID-19 patientsAssociated with specific patternsAntibiotic exposureClinical factorsNanopore metagenomicsPredicting SurvivalPrecision medicine interventionsPrognostic biomarkerSequencing technologiesAmplicon sequencingPulmonary diseaseGut microbiotaCritical illnessMicrobial diversityHuman microbiome
2023
Symptom Assessment for Mechanically Ventilated Patients: Principles and Priorities: An Official American Thoracic Society Workshop Report
Guttormson J, Khan B, Brodsky M, Chlan L, Curley M, Gélinas C, Happ M, Herridge M, Hess D, Hetland B, Hopkins R, Hosey M, Hosie A, Lodolo A, McAndrew N, Mehta S, Misak C, Pisani M, van den Boogaard M, Wang S. Symptom Assessment for Mechanically Ventilated Patients: Principles and Priorities: An Official American Thoracic Society Workshop Report. Annals Of The American Thoracic Society 2023, 20: 491-498. PMID: 37000144, PMCID: PMC10112406, DOI: 10.1513/annalsats.202301-023st.Peer-Reviewed Original ResearchConceptsSymptom assessmentCritical care pharmacistsPatient-centered assessmentClinical practice developmentPractice guideline recommendationsRoutine assessmentAssessment of adult patientsMechanically Ventilated PatientsSymptom managementCare pharmacistsPatient experienceRespiratory therapistsPatient distressNonvocal patientsCritical careGuideline recommendationsIntensive care unit patientsMultiple symptomsSpeech-language pathologistsWorkshop participantsPractice developmentClinical practiceWorkgroup consensusUnit patientsSymptoms
2022
Nitric oxide versus epoprostenol for refractory hypoxemia in Covid-19
Poonam P, Koscik R, Nguyen T, Rikhi S, Lin H. Nitric oxide versus epoprostenol for refractory hypoxemia in Covid-19. PLOS ONE 2022, 17: e0270646. PMID: 35759496, PMCID: PMC9236233, DOI: 10.1371/journal.pone.0270646.Peer-Reviewed Original ResearchConceptsInhaled Nitric OxideInhaled epoprostenolVentilator free daysMechanically Ventilated PatientsP/F ratioRefractory hypoxemiaInitiation of pulmonary vasodilator therapyCohort of mechanically ventilated patientsInhaled nitric oxide groupDuration of mechanical ventilationDays to extubationPulmonary vasodilator therapySeverity of ARDSNitric oxideIn-Hospital MortalityDays of treatmentFree daysPulmonary vasodilationVasodilator therapyNo significant differenceProspective studyCOVID-19 infectionMechanical ventilationDay 1Primary outcomeOutcomes in Temporary ICUs Versus Conventional ICUs: An Observational Cohort of Mechanically Ventilated Patients With COVID-19–Induced Acute Respiratory Distress Syndrome
Jimenez J, Olivas-Martinez A, Rios-Olais F, Ayala-Aguillón F, Gil-López F, Leal-Villarreal M, Rodríguez-Crespo J, Jasso-Molina J, Enamorado-Cerna L, Dardón-Fierro F, Martínez-Guerra B, Román-Montes C, Alvarado-Avila P, Juárez-Meneses N, Morales-Paredes L, Chávez-Suárez A, Gutierrez-Espinoza I, Najera-Ortíz M, Martínez-Becerril M, Gonzalez-Lara M, Ponce de León-Garduño A, Baltazar-Torres J, Rivero-Sigarroa E, Dominguez-Cherit G, Hyzy R, Kershenobich D, Sifuentes-Osornio J. Outcomes in Temporary ICUs Versus Conventional ICUs: An Observational Cohort of Mechanically Ventilated Patients With COVID-19–Induced Acute Respiratory Distress Syndrome. Critical Care Explorations 2022, 4: e0668. PMID: 35372841, PMCID: PMC8963854, DOI: 10.1097/cce.0000000000000668.Peer-Reviewed Original ResearchMechanically Ventilated PatientsIndependent risk factor associated with mortalityRisk factors associated with mortalityAcute respiratory distress syndromeFactors associated with mortalityRespiratory distress syndromeVentilator-free daysICU-free daysManagement of mechanically ventilated patientsIn-Hospital MortalityDistress syndromeHospital lengthObservational cohortCohort of mechanically ventilated patientsCOVID-19-induced acute respiratory distress syndromeLung-protective ventilationHospital length of stayNoninvasive mechanical ventilationObservational cohort studySevere COVID-19Length of stayThirty-dayAdult patientsMechanical ventilationProne positionRapid expansion and extinction of antibiotic resistance mutations during treatment of acute bacterial respiratory infections
Chung H, Merakou C, Schaefers M, Flett K, Martini S, Lu R, Blumenthal J, Webster S, Cross A, Al Ahmar R, Halpin E, Anderson M, Moore N, Snesrud E, Yu H, Goldberg J, O’Toole G, McGann P, Stam J, Hinkle M, McAdam A, Kishony R, Priebe G. Rapid expansion and extinction of antibiotic resistance mutations during treatment of acute bacterial respiratory infections. Nature Communications 2022, 13: 1231. PMID: 35264582, PMCID: PMC8907320, DOI: 10.1038/s41467-022-28188-w.Peer-Reviewed Original ResearchConceptsAntibiotic resistance mutationsResistance mutationsLong-read sequencingEvolution of antibiotic resistanceSputum samplesRespiratory infectionsCulture-based methodsLow-frequency resistance mutationsColonization bottlenecksEarly stages of infectionDays of therapyAcute bacterial infectionBacterial respiratory infectionsMechanically Ventilated PatientsGenomic surveillanceResistance phenotypeStages of infectionAntibiotic resistanceIn vivo frequencyAntibiotic therapyAntibiotic changeMutationsAntibiotic switchTherapy choiceIndividual patients
2020
Tracheostomy for Coronavirus Disease 2019 Patients: Maintaining the Standard of Care
Bassily-Marcus A, Leibner E, Kohli-Seth R. Tracheostomy for Coronavirus Disease 2019 Patients: Maintaining the Standard of Care. Critical Care Explorations 2020, 2: e0190. PMID: 32903998, PMCID: PMC7447361, DOI: 10.1097/cce.0000000000000190.Peer-Reviewed Original ResearchStandard of careTiming of tracheostomyMechanical ventilationProlonged ventilatory supportProlonged mechanical ventilationMechanically Ventilated PatientsDays follow-upLack of symptomsNegative antibody testProspective observational cohortCoronavirus diseaseTracheostomy teamViral clearanceVentilatory supportMedian timeDelayed tracheostomyBronchoscopic guidanceFollow-upAcademic medical centerObservational cohortTracheostomyPatientsPerforming tracheostomyMedical CenterPost-intubation
2004
Confusion Over Delirium: Does It Predict Death in the Intensive Care Unit?
Ferreira G, Trow T. Confusion Over Delirium: Does It Predict Death in the Intensive Care Unit? Clinical Pulmonary Medicine 2004, 11: 387-389. DOI: 10.1097/01.cpm.0000145624.57154.7e.Peer-Reviewed Original ResearchIntensive care unitCare unitPredictors of mortalityRisk factorsDeliriumLonger hospitalMechanically Ventilated PatientsVentilating the Obese Patient With Acute Lung Injury: Should the Strategy Be Different Than That Adopted for the Patient of Normal Weight?
Anderson J, Trow T. Ventilating the Obese Patient With Acute Lung Injury: Should the Strategy Be Different Than That Adopted for the Patient of Normal Weight? Clinical Pulmonary Medicine 2004, 11: 262-264. DOI: 10.1097/01.cpm.0000133057.87989.c3.Peer-Reviewed Original ResearchAcute lung injuryLung injuryObese patientsLow tidal volume strategyPatients of normal weightNormal body mass indexTidal volume strategyExcess body weightMechanically Ventilated PatientsBody mass indexAssociated with outcomeNormal weightMass indexVolume strategyPatientsBody weightInjuryOutcomesObesityAcute
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