2025
Risk of Atherosclerotic Cardiovascular Disease After Chronic Obstructive Pulmonary Disease Hospitalization among Primary and Secondary Prevention Older Adults
Mosher C, Osazuwa‐Peters O, Nanna M, MacIntyre N, Que L, Palmer S, Jones W, O'Brien E. Risk of Atherosclerotic Cardiovascular Disease After Chronic Obstructive Pulmonary Disease Hospitalization among Primary and Secondary Prevention Older Adults. Journal Of The American Heart Association 2025, 14: e035010. PMID: 39791395, PMCID: PMC12054414, DOI: 10.1161/jaha.124.035010.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary disease hospitalizationsChronic obstructive pulmonary diseaseAtherosclerotic cardiovascular diseaseSecondary prevention cohortPrevention cohortASCVD hospitalizationRisk of atherosclerotic cardiovascular diseaseHazard ratioHospital outcomesHigh riskRisk factorsCardiovascular disease eventsCardiovascular diseasePrimary prevention cohortIdentified multiple risk factorsRisk of cardiovascular disease eventsMultiple risk factorsPulmonary disease hospitalizationsObstructive pulmonary diseaseOlder adultsHigh-risk patient cohortASCVD eventsDisease eventsHigh-risk patientsMeta-analyses
2024
Lipid‐Lowering Therapy Use When Indicated and Subsequent Ischemic Stroke Severity
Gordon-Kundu B, Peyravi R, Garg A, Baker A, Salas S, Levien M, Faridi K, de Havenon A, Krumholz H, Sheth K, Forman R, Sharma R. Lipid‐Lowering Therapy Use When Indicated and Subsequent Ischemic Stroke Severity. Journal Of The American Heart Association 2024, 14: e033365. PMID: 39699007, PMCID: PMC12054410, DOI: 10.1161/jaha.123.033365.Peer-Reviewed Original ResearchConceptsPrescribed lipid-lowering therapyNational Institutes of Health Stroke Scale scoreAcute ischemic strokeLipid-Lowering TherapyStroke Scale scoreStroke severityGuidelines-Stroke registryAtherosclerotic cardiovascular disease eventsCardiovascular disease eventsScale scoreGuideline-recommended criteriaSevere stroke symptomsStudy assessed usePropensity score subclassificationLipid-lowering therapy useNational InstituteLogistic regression modelsCholesterol management guidelinesPoststroke disabilityElevated low-density lipoprotein cholesterolInstitutional GetSmall vessel diseaseTime of acute ischemic strokeLarge-artery atherosclerosisLow-density lipoprotein cholesterolPathways From Socioeconomic Factors to Major Cardiovascular Events Among Postmenopausal Veteran and Nonveteran Women: Findings From the Women's Health Initiative.
Beydoun H, Beydoun M, Kinney R, Liu S, Yu R, Allison M, Wallace R, Xiao Q, Liu L, Gradidge P, Jung S, Tindle H, Follis S, Brunner R, Tsai J. Pathways From Socioeconomic Factors to Major Cardiovascular Events Among Postmenopausal Veteran and Nonveteran Women: Findings From the Women's Health Initiative. Journal Of The American Heart Association 2024, 13: e037253. PMID: 39673348, PMCID: PMC11935538, DOI: 10.1161/jaha.124.037253.Peer-Reviewed Original ResearchConceptsSelf-rated healthCardiovascular disease eventsCardiometabolic risk factorsNeighborhood socioeconomic statusBody mass indexSocioeconomic statusMass indexCardiovascular diseaseRisk factorsIndicators of socioeconomic statusEffect of socioeconomic statusHousehold incomeSocioeconomic status characteristicsWomen's Health InitiativeGeneralized structural equation modelHealth characteristicsHealth initiativesPostmenopausal womenLower educationProvider accessVeteran statusMarital statusNonveteran counterpartsSocioeconomic factorsBiopsychosocial mechanismsRisk of Atherosclerotic Cardiovascular Disease Hospitalizations after Chronic Obstructive Pulmonary Disease Hospitalization among Older Adults.
Mosher C, Osazuwa-Peters O, Nanna M, MacIntyre N, Que L, Jones W, Palmer S, O'Brien E. Risk of Atherosclerotic Cardiovascular Disease Hospitalizations after Chronic Obstructive Pulmonary Disease Hospitalization among Older Adults. Annals Of The American Thoracic Society 2024, 21: 1516-1523. PMID: 39018486, PMCID: PMC11568506, DOI: 10.1513/annalsats.202401-017oc.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary disease hospitalizationsChronic obstructive pulmonary diseaseAtherosclerotic cardiovascular diseaseASCVD hospitalizationHospital outcomesMedicare beneficiariesCardiovascular diseaseHospitalization severityCardiovascular disease hospitalizationCardiovascular disease eventsRisk of cardiovascular diseaseAssociated with higher riskCox proportional hazards modelsPopulation of chronic obstructive pulmonary diseasePulmonary disease hospitalizationsHazard ratio estimatesRisk of atherosclerotic cardiovascular diseaseProportional hazards modelHospital 1 yearRetrospective cohort studyObstructive pulmonary diseaseOlder adultsClaims dataHospitalization riskHigh-risk subgroupsThe Association Between Rheumatic Disease Therapies and Cardiovascular Outcomes in People with HIV—A Retrospective Cohort Study
Titanji B, Nagatomi S, Gallini J, Cui X, Hanberg J, Hsieh E, Marconi V. The Association Between Rheumatic Disease Therapies and Cardiovascular Outcomes in People with HIV—A Retrospective Cohort Study. Journal Of Clinical Medicine 2024, 13: 6209. PMID: 39458159, PMCID: PMC11508247, DOI: 10.3390/jcm13206209.Peer-Reviewed Original ResearchRisk of CVD eventsElectronic health recordsCardiovascular disease eventsCVD eventsRetrospective cohort studyCardiovascular diseaseCohort studyIncidence of CVD eventsIncreased risk of CVD eventsRheumatic diseasesCardiovascular disease outcomesCardiovascular disease riskRisk of cardiovascular diseaseHealth recordsAssociated with increased CVD eventsGeneral populationPrimary outcomeDisease therapyAtlanta VAMCIncreased riskHIV infectionExacerbated inflammationCardiovascular outcomesPatient populationHIVLipoprotein(a) and Coronary Plaque in Asymptomatic Individuals: The Miami Heart Study at Baptist Health South Florida
Mszar R, Cainzos-Achirica M, Valero-Elizondo J, Lahan S, Al-Kindi S, Quispe R, Ali S, Arias L, Saxena A, Shah S, Cury R, Budoff M, Blaha M, Shapiro M, Sharma G, Santos R, Blankstein R, Feldman T, Fialkow J, Nasir K. Lipoprotein(a) and Coronary Plaque in Asymptomatic Individuals: The Miami Heart Study at Baptist Health South Florida. Circulation Cardiovascular Imaging 2024, 17: e016152. PMID: 39012945, DOI: 10.1161/circimaging.123.016152.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAsymptomatic DiseasesBiomarkersComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCoronary VesselsFemaleFloridaHumansLipoprotein(a)MaleMiddle AgedPlaque, AtheroscleroticPredictive Value of TestsPrevalenceProspective StudiesRisk AssessmentRisk FactorsUp-RegulationVascular CalcificationConceptsCoronary artery calcium scoreCoronary Computed Tomography AngiographyHigh-risk plaque featuresHigh-risk featuresArtery calcium scoreElevated Lp(aCoronary plaquesCalcium scorePlaque featuresHigh-risk coronary plaque featuresPresence of coronary plaqueRisk of atherosclerotic cardiovascular disease eventsClinical atherosclerotic cardiovascular diseaseLipid-Lowering TherapyCoronary plaque characteristicsAtherosclerotic cardiovascular disease eventsContemporary US cohortBaptist Health South FloridaCoronary plaque featuresAtherosclerotic cardiovascular diseaseAssessment of coronary atherosclerosisCardiovascular disease eventsNoninvasive gold standardAsymptomatic adultsIncreased riskTranslational Research of the Acute Effects of Negative Emotions on Vascular Endothelial Health: Findings From a Randomized Controlled Study
Shimbo D, Cohen M, McGoldrick M, Ensari I, Diaz K, Fu J, Duran A, Zhao S, Suls J, Burg M, Chaplin W. Translational Research of the Acute Effects of Negative Emotions on Vascular Endothelial Health: Findings From a Randomized Controlled Study. Journal Of The American Heart Association 2024, 13: e032698. PMID: 38690710, PMCID: PMC11179860, DOI: 10.1161/jaha.123.032698.Peer-Reviewed Original ResearchConceptsEndothelial cell-derived microparticlesEndothelium-dependent vasodilationCell-derived microparticlesEndothelial progenitor cellsGroup x time interactionEndothelial cell healthCirculating bone marrow-derived endothelial progenitor cellsIncreased risk of cardiovascular disease eventsIndex scoreEndothelial healthProgenitor cellsImpaired endothelium-dependent vasodilationRisk of cardiovascular disease eventsAcute effectsTime interactionBone marrow-derived endothelial progenitor cellsMarrow-derived endothelial progenitor cellsRecall taskStatistically significant group x time interactionsSignificant group x time interactionRandomized Controlled StudyCardiovascular disease eventsVascular endothelial healthRandomized controlled experimental studyNegative emotionsEffect of Stress-Related Neural Pathways on the Cardiovascular Benefit of Physical Activity
Zureigat H, Osborne M, Abohashem S, Mezue K, Gharios C, Grewal S, Cardeiro A, Naddaf N, Civieri G, Abbasi T, Radfar A, Aldosoky W, Seligowski A, Wasfy M, Guseh J, Churchill T, Rosovsky R, Fayad Z, Rosenzweig A, Baggish A, Pitman R, Choi K, Smoller J, Shin L, Tawakol A. Effect of Stress-Related Neural Pathways on the Cardiovascular Benefit of Physical Activity. Journal Of The American College Of Cardiology 2024, 83: 1543-1553. PMID: 38631773, PMCID: PMC11164527, DOI: 10.1016/j.jacc.2024.02.029.Peer-Reviewed Original ResearchConceptsCardiovascular disease eventsPhysical activityCardiovascular diseaseCVD riskBenefits of physical activityMass General Brigham BiobankElectronic health recordsIncident CVD eventsReduce CVD riskDecrease CVDCardiovascular disease riskPA surveyGreater PANeural activityPA benefitsHealth recordsPotential cardiovascular diseaseCVD eventsPreexisting depressionGuideline recommendationsStress-related activationCardiovascular disease benefitMultivariate modelDepressionNeural effectsAssociation of Periodic Limb Movements and Obstructive Sleep Apnea With Risk of Cardiovascular Disease and Mortality
Zinchuk A, Srivali N, Qin L, Jeon S, Ibrahim A, Sands S, Koo B, Yaggi H. Association of Periodic Limb Movements and Obstructive Sleep Apnea With Risk of Cardiovascular Disease and Mortality. Journal Of The American Heart Association 2024, 13: e031630. PMID: 38240208, PMCID: PMC11056155, DOI: 10.1161/jaha.123.031630.Peer-Reviewed Original ResearchConceptsPeriodic limb movement indexApnea-hypopnea indexObstructive sleep apneaPeriodic limb movementsSleep apneaIncident cardiovascular diseasePrimary outcomeCardiovascular diseaseAssociation of apnea-hypopnea indexIncreased risk of primary outcomeIncreased riskRisk factorsRisk of primary outcomeAssociated with primary outcomeMedian Follow-UpBaseline risk of mortalityCox proportional hazards regressionRisk of cardiovascular diseaseLimb movement indexCharlson Comorbidity IndexFramingham risk scoreProportional hazards regressionRisk of mortalityCardiovascular disease eventsFollow-up
2023
The sleep justice study - a prospective cohort study assessing sleep as a cardiometabolic risk factor after incarceration: a protocol paper
Elumn J, Saeed G, Aminawung J, Horton N, Lin H, Yaggi H, Wang E. The sleep justice study - a prospective cohort study assessing sleep as a cardiometabolic risk factor after incarceration: a protocol paper. BMC Public Health 2023, 23: 2107. PMID: 37884957, PMCID: PMC10605958, DOI: 10.1186/s12889-023-16985-x.Peer-Reviewed Original ResearchConceptsCVD risk factor controlPittsburgh Sleep Quality IndexRisk factor controlRisk factorsSleep healthCardiovascular healthCarceral facilitiesEpidemiology of CVDCardiometabolic risk factorsCardiovascular risk factorsCardiovascular disease eventsOngoing prospective cohortProspective cohort studySleep Quality IndexPopulation-specific risk factorsHistory of incarcerationRest-activity patternsObjective measuresSTOP-BangCardiovascular outcomesCardiovascular riskCohort studyProspective cohortCVD epidemiologyFactor controlCardiovascular-Kidney-Metabolic Health: A Presidential Advisory From the American Heart Association
Ndumele C, Rangaswami J, Chow S, Neeland I, Tuttle K, Khan S, Coresh J, Mathew R, Baker-Smith C, Carnethon M, Despres J, Ho J, Joseph J, Kernan W, Khera A, Kosiborod M, Lekavich C, Lewis E, Lo K, Ozkan B, Palaniappan L, Patel S, Pencina M, Powell-Wiley T, Sperling L, Virani S, Wright J, Singh R, Elkind M, Association O. Cardiovascular-Kidney-Metabolic Health: A Presidential Advisory From the American Heart Association. Circulation 2023, 148: 1606-1635. PMID: 37807924, DOI: 10.1161/cir.0000000000001184.Peer-Reviewed Original ResearchConceptsMetabolic risk factorsMetabolic healthMetabolic syndromeRisk factorsPresidential AdvisorySocial determinantsCardiovascular disease eventsChronic kidney diseaseAdverse social determinantsAmerican Heart AssociationSignificant clinical impactMetabolic stagingSubspecialty guidelinesCardiovascular mortalityCardioprotective effectsKidney functionKidney diseaseTherapeutic optionsHeart AssociationInterdisciplinary careCardiovascular diseaseClinical impactHigh prevalenceCare fragmentationCare modelCannabis use disorder and adverse cardiovascular outcomes: A population‐based retrospective cohort analysis of adults from Alberta, Canada
Bahji A, Hathaway J, Adams D, Crockford D, Edelman E, Stein M, Patten S. Cannabis use disorder and adverse cardiovascular outcomes: A population‐based retrospective cohort analysis of adults from Alberta, Canada. Addiction 2023, 119: 137-148. PMID: 37766508, PMCID: PMC12282584, DOI: 10.1111/add.16337.Peer-Reviewed Original ResearchConceptsCVD eventsRisk ratioIncident CVDPopulation-based retrospective cohort analysisPopulation-based retrospective cohort studyAdverse cardiovascular disease (CVD) eventsAdverse cardiovascular disease outcomesAdverse CVD eventsGreater risk ratioIncident CVD eventsRetrospective cohort studyAdverse cardiovascular outcomesCardiovascular disease eventsRetrospective cohort analysisCardiovascular disease outcomesMental health comorbiditiesTime of presentationAdministrative health databasesHealth service usePrescription medication useCannabis use disorderMantel-Haenszel techniqueHealth care servicesPoisson regression modelsYear of birth
2022
The combined effect of air and transportation noise pollution on atherosclerotic inflammation and risk of cardiovascular disease events
Osborne M, Abohashem S, Naddaf N, Abbasi T, Zureigat H, Mezue K, Ghoneem A, Dar T, Cardeiro A, Mehta N, Rajagopalan S, Fayad Z, Tawakol A. The combined effect of air and transportation noise pollution on atherosclerotic inflammation and risk of cardiovascular disease events. Journal Of Nuclear Cardiology 2022, 30: 665-679. PMID: 35915324, PMCID: PMC9889575, DOI: 10.1007/s12350-022-03003-7.Peer-Reviewed Original ResearchConceptsAir pollutionNoise exposureAverage air pollutionMajor adverse cardiovascular eventsTransportation noise exposureCardiovascular disease eventsPollutionRisk of cardiovascular disease eventsHigher exposuresDisease eventsIndividual residentsMajor adverse cardiovascular events riskActive cancerCardiovascular diseaseNoise pollutionAssociated with major adverse cardiovascular eventsAdverse cardiovascular eventsExposureF-FDG PET/CT imagingCardiovascular eventsRiskEffect of airAirArterial inflammationYears
2021
Long-Term Prognostic Implications and Role of Further Testing in Adults Aged ≤55 Years With a Coronary Calcium Score of Zero (from the Multi-Ethnic Study of Atherosclerosis)
Cainzos-Achirica M, Acquah I, Dardari Z, Mszar R, Greenland P, Blankstein R, Bittencourt M, Rajagopalan S, Al-Kindi S, Polak J, Blumenthal R, Blaha M, Nasir K. Long-Term Prognostic Implications and Role of Further Testing in Adults Aged ≤55 Years With a Coronary Calcium Score of Zero (from the Multi-Ethnic Study of Atherosclerosis). The American Journal Of Cardiology 2021, 161: 26-35. PMID: 34794615, PMCID: PMC8607758, DOI: 10.1016/j.amjcard.2021.08.067.Peer-Reviewed Original ResearchConceptsAortic valve calciumCoronary artery calciumCoronary calcium scoreLong-term prognosisCardiovascular diseaseICA-IMTCoronary calcium score of zeroCalcium score of zeroHigh-sensitivity C-reactive protein levelsLong-term prognostic significanceC-reactive protein levelsMedian Follow-UpMulti-Ethnic StudyMitral annular calciumEvent ratesPremature family historyThoracic aortic calciumScore of zeroCardiovascular disease eventsAnkle-brachial indexValve calciumAnnular calciumPrognostic significancePrognostic implicationsAortic calciumDeterminants and Outcomes Associated With Urinary Calcium Excretion in Chronic Kidney Disease
Liu J, Tio M, Verma A, Schmidt I, Ilori T, Knauf F, Mc Causland F, Waikar S. Determinants and Outcomes Associated With Urinary Calcium Excretion in Chronic Kidney Disease. The Journal Of Clinical Endocrinology & Metabolism 2021, 107: e281-e292. PMID: 34390334, PMCID: PMC8684460, DOI: 10.1210/clinem/dgab574.Peer-Reviewed Original ResearchConceptsUrinary calcium excretionChronic kidney diseaseEnd-stage kidney diseaseCalcium excretionKidney diseaseChronic Renal Insufficiency Cohort (CRIC) StudyIncident end-stage kidney diseaseLevel of CKDSelf-identified black raceAtherosclerotic cardiovascular disease eventsSerum parathyroid hormoneCardiovascular disease eventsAdverse clinical eventsAdverse clinical outcomesStage kidney diseaseBaseline eGFRCKD progressionUrinary sodiumCause mortalityCohort studyLoop diureticsThiazide diureticsClinical outcomesParathyroid hormoneVascular calcificationPrognostic Utility of Risk Enhancers and Coronary Artery Calcium Score Recommended in the 2018 ACC/AHA Multisociety Cholesterol Treatment Guidelines Over the Pooled Cohort Equation: Insights From 3 Large Prospective Cohorts
Akintoye E, Afonso L, Jayanna M, Bao W, Briasoulis A, Robinson J. Prognostic Utility of Risk Enhancers and Coronary Artery Calcium Score Recommended in the 2018 ACC/AHA Multisociety Cholesterol Treatment Guidelines Over the Pooled Cohort Equation: Insights From 3 Large Prospective Cohorts. Journal Of The American Heart Association 2021, 10: e019589. PMID: 34092110, PMCID: PMC8477885, DOI: 10.1161/jaha.120.019589.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmerican Heart AssociationBiomarkersCardiovascular DiseasesCholesterolClinical Decision-MakingCoronary Artery DiseaseDecision Support TechniquesDyslipidemiasFemaleHeart Disease Risk FactorsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIncidenceMaleMiddle AgedPractice Guidelines as TopicPredictive Value of TestsPrimary PreventionPrognosisRisk AssessmentTime FactorsUnited StatesVascular CalcificationConceptsPooled Cohort EquationsCoronary artery calcium scoreCholesterol treatment guidelinesArtery calcium scoreAtherosclerotic cardiovascular diseaseCohort EquationsRisk enhancersCalcium scoreTreatment guidelinesCardiovascular diseaseAmerican Heart Association/American CollegeAtherosclerotic cardiovascular disease eventsBackground Limited dataIntermediate-risk participantsIntermediate-risk patientsCardiovascular disease eventsLarge prospective cohortIncremental valueNet reclassification indexStatin therapyCAC testingProspective cohortPrognostic utilityC-statisticReclassification indexCardiotoxic safety communications after FDA approval of novel cancer therapies.
Bonsu J, Kola-Kehinde O, Kim L, Ruz P, Lustberg M, Brammer J, Addison D. Cardiotoxic safety communications after FDA approval of novel cancer therapies. Journal Of Clinical Oncology 2021, 39: e18629-e18629. DOI: 10.1200/jco.2021.39.15_suppl.e18629.Peer-Reviewed Original ResearchBlack box warningNovel anticancer therapiesHeart failureNovel cancer therapiesThromboembolic diseaseBox warningCancer therapyCardiovascular disease eventsAnticancer therapyMultivariable logistic regressionSudden cardiac deathApproval statusNew safety informationPriority review statusUncontrolled hypertensionCVD eventsCardiac deathCoronary diseaseCVD deathDrug withdrawalElectrocardiographic changesMyocardial infarctionDrug classesLabel warningsMultivariable modelThe incremental value of angiographic features for predicting recurrent cardiovascular events: Insights from the Duke Databank for Cardiovascular Disease
Nanna MG, Peterson ED, Chiswell K, Overton RA, Nelson AJ, Kong DF, Navar AM. The incremental value of angiographic features for predicting recurrent cardiovascular events: Insights from the Duke Databank for Cardiovascular Disease. Atherosclerosis 2021, 321: 1-7. PMID: 33582446, PMCID: PMC8221430, DOI: 10.1016/j.atherosclerosis.2021.02.004.Peer-Reviewed Original ResearchConceptsSecondary risk predictionAngiographic featuresCardiovascular diseaseCardiovascular eventsClinical characteristicsDuke DatabankMultivariable modelIncremental valueRisk predictionAtherosclerotic cardiovascular disease eventsSignificant coronary artery diseaseBaseline clinical factorsDuke CAD indexRecurrent cardiovascular eventsCardiovascular disease eventsSame health systemCoronary artery diseasePrimary care physiciansCardiac catheterization patientsCoronary angiographic featuresRecurrent eventsRisk prediction modelAngiographic variablesInitial revascularizationAngiographic predictors
2020
Community‐Acquired Pneumonia and Risk of Cardiovascular Events in People Living With HIV
Zifodya JS, Duncan MS, So‐Armah K, Attia EF, Akgün KM, Rodriguez‐Barradas M, Marconi VC, Budoff MJ, Bedimo RJ, Alcorn CW, Hoo G, Butt AA, Kim JW, Sico JJ, Tindle HA, Huang L, Tate JP, Justice AC, Freiberg MS, Crothers K. Community‐Acquired Pneumonia and Risk of Cardiovascular Events in People Living With HIV. Journal Of The American Heart Association 2020, 9: e017645. PMID: 33222591, PMCID: PMC7763776, DOI: 10.1161/jaha.120.017645.Peer-Reviewed Original ResearchConceptsCommunity-acquired pneumoniaCVD risk factorsCVD eventsRisk factorsCAP severityHIV infectionHIV statusSevere community-acquired pneumoniaVeterans Aging Cohort StudyIncident CVD eventsCardiovascular disease eventsMultivariable-adjusted modelsAging Cohort StudyCox regression analysisDate of admissionMultivariable-adjusted analysesHigher mortality riskBackground HospitalizationCAP hospitalizationsHIV-uninfectedCardiovascular eventsIncident CVDCohort studyCVD riskUS veteransUnderuse of statins for secondary prevention of atherosclerotic cardiovascular disease events among ambulatory surgical patients
Schonberger RB, Vallurupalli V, Matlin H, Blitz D, Nwozuzu A, Barron B, Zhang Y, Dai F, Jacoby D, Nasir K, Bardia A. Underuse of statins for secondary prevention of atherosclerotic cardiovascular disease events among ambulatory surgical patients. Preventive Medicine Reports 2020, 18: 101085. PMID: 32368435, PMCID: PMC7190748, DOI: 10.1016/j.pmedr.2020.101085.Peer-Reviewed Original ResearchAmbulatory surgical patientsCardiovascular disease eventsAtherosclerotic cardiovascular diseaseSurgical patientsSecondary preventionCardiovascular diseaseDisease eventsHigh-intensity statin doseLong-term cardiovascular morbidityAtherosclerotic cardiovascular disease eventsMultivariable logistic regression analysisNon-surgical populationUnderuse of statinsTertiary care hospitalRetrospective observational studySubset of patientsPatients age 40High-risk groupLogistic regression analysisAmbulatory surgical centerReferral periodStatin doseStatin underuseCardiovascular morbidityStatin therapy
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