2025
The Implications of Oxygen-Dependent Chronic Obstructive Pulmonary Disease on Sac Growth and Mortality Following Endovascular Aneurysm Repair
Bellamkonda K, Suckow B, Columbo J, Upchurch G, Jacobs B, Ochoa Chaar C, Scully R, Goodney P, Scali S, Stone D. The Implications of Oxygen-Dependent Chronic Obstructive Pulmonary Disease on Sac Growth and Mortality Following Endovascular Aneurysm Repair. Annals Of Vascular Surgery 2025, 115: 98-106. PMID: 40081526, PMCID: PMC12047741, DOI: 10.1016/j.avsg.2025.02.019.Peer-Reviewed Original ResearchChronic obstructive pulmonary diseaseEndovascular AAA repairObstructive pulmonary diseaseSac growthImpact of chronic obstructive pulmonary diseaseOxygen-dependent chronic obstructive pulmonary diseaseEffect of COPD severityCox proportional hazards regressionElective endovascular AAA repairAAA-related mortalityPulmonary diseaseChronic obstructive pulmonary disease severityChronic obstructive pulmonary disease patientsLimited life expectancyIncreased reintervention rateAbdominal aortic aneurysm (AAAEndovascular aneurysm repairElevated mortality ratesPredictors of mortalityPrimary exposureHazards regressionInclusion criteriaIncreased reinterventionsLogistic regressionPost-EVAR
2024
Racial Differences in 1-Year Mortality after Hospitalization for Chronic Obstructive Pulmonary Disease in the United States.
Jain S, Priya A, Pekow P, Spitzer K, Walkey A, Opara I, Krumholz H, Lindenauer P. Racial Differences in 1-Year Mortality after Hospitalization for Chronic Obstructive Pulmonary Disease in the United States. Annals Of The American Thoracic Society 2024, 21: 585-594. PMID: 37943953, PMCID: PMC10995557, DOI: 10.1513/annalsats.202304-359oc.Peer-Reviewed Original ResearchChronic obstructive pulmonary diseaseChronic obstructive pulmonary disease hospitalizationsObstructive pulmonary diseaseMedicare beneficiariesWhite racePulmonary diseaseChronic obstructive pulmonary disease exacerbationsChronic obstructive pulmonary disease patientsObstructive pulmonary disease exacerbationsObstructive pulmonary disease patientsHospital-level clusteringPulmonary disease exacerbationsRetrospective cohort studyPulmonary disease patientsCox regression modelIndividual socioeconomic statusDisease exacerbationPulmonary rehabilitationCohort studyDischarge dispositionOverall mortalityIllness severityHospitalized populationCare factorsDisease patients
2023
The serotype-specific prevalence of pneumococci in hospitalized pneumonia patients with COPD: a prospective, multi-center, cohort study
Kim J, Jung J, Kang M, Kim D, Choi H, Cho Y, Jang S, Lee C, Oh Y, Park J. The serotype-specific prevalence of pneumococci in hospitalized pneumonia patients with COPD: a prospective, multi-center, cohort study. The Korean Journal Of Internal Medicine 2023, 38: 714-724. PMID: 37586811, PMCID: PMC10493435, DOI: 10.3904/kjim.2023.152.Peer-Reviewed Original ResearchConceptsCommunity-acquired pneumoniaSerotype-specific prevalencePneumococcal pneumoniaCohort studyS. pneumoniaeChronic obstructive pulmonary disease patientsPneumococcal polysaccharide vaccine 23Obstructive pulmonary disease patientsPCV-13 vaccinationUrine antigen detectionPulmonary disease patientsCommon pneumococcal serotypesPost-vaccination eraPneumococcal vaccinationSerotype 22FCOPD patientsInfluenza vaccinationPCV-13Clinical characteristicsVaccination statusOverall incidencePneumonia patientsPPV-23Pneumococcal serotypesVaccination rates
2022
Phenotypic and endotypic features of COPD associated with lung cancer development.
Lee K, Cohn D, Liu Z, Ai L, Paek H, Jin L, Raja K, Li M, Zhang X, Jun T, Higashi M, Oh W, Calay E, Savic R, Ghosh K, Kasarskis A, Mullaney T, Pan Q, Schadt E, Wang X. Phenotypic and endotypic features of COPD associated with lung cancer development. Journal Of Clinical Oncology 2022, 40: e13563-e13563. DOI: 10.1200/jco.2022.40.16_suppl.e13563.Peer-Reviewed Original ResearchElectronic health recordsChronic obstructive pulmonary disease patientsChronic obstructive pulmonary diseaseLung cancer onsetLung cancer developmentConcurrent asthmaHazard ratioRisk of lung cancerRisk of lung cancer developmentChronic obstructive pulmonary disease cohortManual chart reviewElectronic medical recordsSevere exacerbation historyCancer onsetCohort of COPD patientsPotential risk factorsHealth recordsFeatures of chronic obstructive pulmonary diseaseObstructive pulmonary diseaseDevelopment of lung cancerSmoking statusCox regression modelsLow eosinophil countAssociated with lung cancer developmentLung cancerCharacterization of pulmonary vascular remodeling and MicroRNA-126-targets in COPD-pulmonary hypertension
Goel K, Egersdorf N, Gill A, Cao D, Collum S, Jyothula S, Huang H, Sauler M, Lee P, Majka S, Karmouty-Quintana H, Petrache I. Characterization of pulmonary vascular remodeling and MicroRNA-126-targets in COPD-pulmonary hypertension. Respiratory Research 2022, 23: 349. PMID: 36522710, PMCID: PMC9756782, DOI: 10.1186/s12931-022-02267-4.Peer-Reviewed Original ResearchConceptsSmall pulmonary arteriesChronic cigarette smokingPulmonary vascular remodelingPulmonary hypertensionPulmonary arteryLung microvasculatureVascular remodelingEndothelial cellsCOPD-PHMiR126 expressionChronic obstructive pulmonary disease patientsObstructive pulmonary disease patientsCOPD pulmonary hypertensionPulmonary artery sizePulmonary artery remodelingPulmonary disease patientsPulmonary vascular bedPulmonary arterial wallEndothelial cell marker CD31Microvascular endothelial cellsEndothelial cell markersVessel endothelial cellsNon-COPD lungsLarge vessel endothelial cellsArtery remodeling
2018
Is Transcatheter Aortic Valve Replacement Better Than Surgical Aortic Valve Replacement in Patients With Chronic Obstructive Pulmonary Disease? A Nationwide Inpatient Sample Analysis
Ando T, Adegbala O, Akintoye E, Ashraf S, Pahuja M, Briasoulis A, Takagi H, Grines C, Afonso L, Schreiber T. Is Transcatheter Aortic Valve Replacement Better Than Surgical Aortic Valve Replacement in Patients With Chronic Obstructive Pulmonary Disease? A Nationwide Inpatient Sample Analysis. Journal Of The American Heart Association 2018, 7: e008408. PMID: 29606641, PMCID: PMC5907603, DOI: 10.1161/jaha.117.008408.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAortic Valve StenosisCost SavingsCost-Benefit AnalysisDatabases, FactualFemaleHealth StatusHeart Valve Prosthesis ImplantationHospital CostsHospital MortalityHumansInpatientsLength of StayMaleMiddle AgedPostoperative ComplicationsPulmonary Disease, Chronic ObstructiveRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeUnited StatesConceptsTranscatheter aortic valve replacementAortic valve replacementValve replacementCOPD patientsChronic obstructive pulmonary disease patientsAortic valve replacement resultsNationwide Inpatient Sample AnalysisSurgical aortic valve replacementObstructive pulmonary disease patientsChronic obstructive pulmonary diseaseNationwide Inpatient Sample databaseRespiratory-related complicationsAcute kidney injuryAcute respiratory failurePropensity-matched cohortPulmonary disease patientsNoninvasive mechanical ventilationObstructive pulmonary diseaseAcute myocardial infarctionRespiratory related complicationsHospital mortalitySAVR patientsHospital stayKidney injuryRespiratory failureAzithromycin Pharmacodynamics against Persistent Haemophilus influenzae in Chronic Obstructive Pulmonary Disease
Tsuji BT, Fisher J, Boadi-Yeboah R, Holden PN, Sethi S, Pettigrew MM, Murphy TF. Azithromycin Pharmacodynamics against Persistent Haemophilus influenzae in Chronic Obstructive Pulmonary Disease. Antimicrobial Agents And Chemotherapy 2018, 62: 10.1128/aac.01995-17. PMID: 29180527, PMCID: PMC5786777, DOI: 10.1128/aac.01995-17.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary disease patientsObstructive pulmonary disease patientsChronic obstructive pulmonary diseaseHollow-fiber infection modelStrains of NTHiPulmonary disease patientsObstructive pulmonary diseasePulmonary diseaseConcentration-dependent activityDisease patientsPharmacodynamic profilePharmacodynamic responseSame patientHaemophilus influenzaeInfection modelPatientsAzithromycinPersistent strainsDaysAirwayNTHiPharmacodynamicsInfluenzaeDiseaseHaemophilus
2015
Bronchial hyperresponsiveness
Borak J, Lefkowitz RY. Bronchial hyperresponsiveness. Occupational Medicine 2015, 66: 95-105. PMID: 26590957, DOI: 10.1093/occmed/kqv158.Peer-Reviewed Original ResearchConceptsBronchial hyperresponsivenessBronchoprovocation testingChronic obstructive pulmonary disease patientsVariety of stimuliAssessment of BHRPrevalence of BHRObstructive pulmonary disease patientsPulmonary disease patientsDiagnosis of asthmaStudy of smokersGreat clinical valueBHR testingAirway diseaseLung diseaseDisease patientsClinical valueGeneral populationPathological mechanismsAsthmaHand searchSystematic reviewClinical patientsPatientsWorking populationHyperresponsiveness
2009
C-reactive protein velocity following antibiotics in patients with chronic obstructive pulmonary disease exacerbation and community acquired pneumonia
Justo D, Lachmi S, Saar N, Joffe E, Atzmony L, Mashav N, Henis O, Sade B, Chundadze T, Steinvil A, Paran Y. C-reactive protein velocity following antibiotics in patients with chronic obstructive pulmonary disease exacerbation and community acquired pneumonia. European Journal Of Internal Medicine 2009, 20: 518-521. PMID: 19712857, DOI: 10.1016/j.ejim.2009.03.008.Peer-Reviewed Original ResearchConceptsCAP patientsChronic obstructive pulmonary disease exacerbationsCommunity acquired pneumoniaChronic obstructive pulmonary diseaseInitiation of antibacterial treatmentChronic obstructive pulmonary disease exacerbation patientsCRP levelsExacerbation patientsC-reactive protein velocityAntibacterial treatmentTreated with cephalosporinsChronic obstructive pulmonary disease patientsDays of hospitalizationChest X-rayInternal medicine departmentObstructive pulmonary diseaseProductive coughAntibiotic administrationDisease exacerbationStudy groupPulmonary diseaseCRPPatientsExacerbationMedicine department
2005
In Search of an Understanding: Pulmonary Hypertension in Chronic Obstructive Pulmonary Disease
Trow T. In Search of an Understanding: Pulmonary Hypertension in Chronic Obstructive Pulmonary Disease. Clinical Pulmonary Medicine 2005, 12: 326-327. DOI: 10.1097/01.cpm.0000182641.77430.c4.Peer-Reviewed Original Research
2004
COPD: Big Trouble in the Small Airways
Trow T. COPD: Big Trouble in the Small Airways. Clinical Pulmonary Medicine 2004, 11: 386-387. DOI: 10.1097/01.cpm.0000145623.18955.50.Peer-Reviewed Original ResearchChronic obstructive pulmonary disease patientsLymphoid follicle formationInflammatory cell infiltrationObstructive pulmonary disease patientsChronic obstructive pulmonary diseaseSmall airway obstructionPulmonary disease patientsObstructive pulmonary diseaseCell infiltrationFollicle formationDisease progressionPulmonary diseaseSmall airwaysDisease patients
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