2025
Sequential decreases in basolateral amygdala response to threat predict failure to recover from PTSD
Roeckner A, Lin E, Hinrichs R, Harnett N, Lebois L, van Rooij S, Ely T, Jovanovic T, Murty V, Bruce S, House S, Beaudoin F, An X, Neylan T, Clifford G, Linnstaedt S, Germine L, Rauch S, Haran J, Storrow A, Lewandowski C, Musey P, Hendry P, Sheikh S, Jones C, Punches B, Swor R, Hudak L, Pascual J, Seamon M, Datner E, Pearson C, Peak D, Merchant R, Domeier R, Rathlev N, O’Neil B, Sergot P, Sanchez L, Joormann J, Sheridan J, Harte S, Koenen K, Kessler R, McLean S, Ressler K, Stevens J. Sequential decreases in basolateral amygdala response to threat predict failure to recover from PTSD. Neuropsychopharmacology 2025, 1-10. PMID: 40319171, DOI: 10.1038/s41386-025-02115-1.Peer-Reviewed Original ResearchBasolateral amygdalaResponses to threatMonths post-traumaPTSD severityTraumatic eventsFunctional connectivityPost-traumaAmygdala responses to threatAssociated with PTSD severityBLA functionIncreased PTSD severityReactivity to threatDorsal attention networkGeneralizability of findingsAmygdala hyperreactivityThreat cuesThreat processingNeurobiological correlatesFear memoryStress disorderAttention networkMultisite studyAmygdalaSample of ED patientsReplicate samplesSample ascertainment and clinical outcome measures in the Accelerating Medicines Partnership® Schizophrenia Program
Addington J, Liu L, Braun A, Auther A, Calkins M, Cornblatt B, Corcoran C, Fusar-Poli P, Kerr M, Mourgues-Codern C, Nunez A, Oliver D, Strauss G, Walsh B, Alameda L, Arango C, Breitborde N, Broome M, Cadenhead K, Carrion R, Chen E, Choi J, Coleman M, Conus P, Diaz-Caneja C, Dwyer D, Ellman L, Faghankhani M, Gaspar P, Gerber C, Glenthøj L, Horton L, Hui C, Jacobs G, Kambeitz J, Kambeitz-Ilankovic L, Keshavan M, Kim S, Koutsouleris N, Kwon J, Langbein K, Lewandowski K, Mamah D, Marcy P, Mathalon D, Mittal V, Nordentoft M, Pearlson G, Penzel N, Perez J, Perkins D, Powers A, Rogers J, Sabb F, Schiffman J, Shah J, Silverstein S, Smesny S, Stone W, Thompson A, Thompson J, Upthegrove R, Verma S, Wang J, Wastler H, Wickham A, Rossum I, Wolf D, Bouix S, Pasternak O, Kahn R, Bearden C, Kane J, McGorry P, Buccilli K, Nelson B, Shenton M, Woods S, Yung A. Sample ascertainment and clinical outcome measures in the Accelerating Medicines Partnership® Schizophrenia Program. Schizophrenia 2025, 11: 54. PMID: 40180953, PMCID: PMC11968923, DOI: 10.1038/s41537-025-00556-7.Peer-Reviewed Original ResearchMultisite studyClinical measuresAssessment protocolTraining of clinical staffSchizophrenia ProgramClinical ratingsClinical ascertainmentExpert clinical inputClinical assessment protocolResearch NetworkNative languageClinical outcome measuresReporting of clinical dataClinical staffSample ascertainmentClinical trainingAscertainment criteriaOutcome measuresAscertainmentClinical assessmentMeasurement teamObservational studyClinical inputCoordinating CenterSchizophreniaThe Impact of Applicant Sex on Pulmonary and Critical Care Medicine Fellowship Letters of Recommendation: A Multisite Study
Byrd K, Spiegel M, Kilb E, Vranas K, Schweiger L, Lee K, Schroeder J, Vita A, Agarwal G, Choudhuri I, Arora I, Sarma N, Jain S, Akgün K, Heath J, Viglianti E. The Impact of Applicant Sex on Pulmonary and Critical Care Medicine Fellowship Letters of Recommendation: A Multisite Study. ATS Scholar 2025, 6: 65-73. PMID: 39909018, PMCID: PMC11984647, DOI: 10.34197/ats-scholar.2024-0074oc.Peer-Reviewed Original Research
2023
Clinical Penetrance of the Transthyretin V122I Variant in Older Black Patients With Heart Failure: The SCAN‐MP (Screening for Cardiac Amyloidosis With Nuclear Imaging in Minority Populations) Study
Madhani A, Sabogal N, Massillon D, Paul L, Rodriguez C, Fine D, Helmke S, Winburn M, Kurian D, Raiszadeh F, Teruya S, Cohn E, Einstein A, Miller E, Connors L, Maurer M, Ruberg F. Clinical Penetrance of the Transthyretin V122I Variant in Older Black Patients With Heart Failure: The SCAN‐MP (Screening for Cardiac Amyloidosis With Nuclear Imaging in Minority Populations) Study. Journal Of The American Heart Association 2023, 12: e028973. PMID: 37486082, PMCID: PMC10492994, DOI: 10.1161/jaha.122.028973.Peer-Reviewed Original ResearchConceptsATTR-CMHeart failurePrealbumin concentrationsLeft ventricular wall thicknessPhenotypic penetranceHereditary ATTR-CMOlder black patientsAdvanced heart failureV122I variantVentricular wall thicknessProspective multisite studyYears of ageBlack individualsPyrophosphate imagingEchocardiographic parametersUnderdiagnosed causeBlack patientsSelf-identified Black individualsHF controlsClinical penetrancePrevalenceHispanic individualsMultisite studyBlack participantsPatients
2019
Examining effects of unit price on preference for reduced nicotine content cigarettes and smoking rate
Davis D, DeSarno M, Bergeria C, Streck J, Tidey J, Sigmon S, Heil S, Gaalema D, Stitzer M, Higgins S. Examining effects of unit price on preference for reduced nicotine content cigarettes and smoking rate. Preventive Medicine 2019, 128: 105823. PMID: 31470023, PMCID: PMC6879848, DOI: 10.1016/j.ypmed.2019.105823.Peer-Reviewed Original ResearchConceptsNicotine content cigarettesReduced nicotine content cigarettesContent cigarettesSmoking ratesVulnerable populationsLower smoking ratesNormal nicotine content cigarettesNicotine contentCigarette preferenceSmoking reductionDaily smokersDoseMultisite studyCondition 2CigarettesCondition 1Tobacco regulationPresent studyBinomial testSmokersSmokingPopulationNicotine
2018
The Influence of Housing Status on the HIV Continuum of Care: Results From a Multisite Study of Patient Navigation Models to Build a Medical Home for People Living With HIV Experiencing Homelessness
Rajabiun S, Tryon J, Feaster M, Pan A, McKeithan L, Fortu K, Cabral HJ, Borne D, Altice FL. The Influence of Housing Status on the HIV Continuum of Care: Results From a Multisite Study of Patient Navigation Models to Build a Medical Home for People Living With HIV Experiencing Homelessness. American Journal Of Public Health 2018, 108: s539-s545. PMID: 32941777, PMCID: PMC6290582, DOI: 10.2105/ajph.2018.304736.Peer-Reviewed Original ResearchPatient navigation modelViral suppressionHIV outcomesHousing statusCo-occurring substance useAntiretroviral therapy prescriptionHigh rateAntiretroviral therapyChart reviewHIV continuumPatient navigatorsTherapy prescriptionMedical homePsychiatric disordersSubstance useMultisite studyHIVStable housingOutcomesCareMonthsHousing stabilityInterventionStatusNetwork of servicesBroad Coping Repertoire Mediates the Effect of the Combined Behavioral Intervention on Alcohol Outcomes in the COMBINE Study: An Application of Latent Class Mediation.
Witkiewitz K, Roos CR, Tofighi D, Van Horn ML. Broad Coping Repertoire Mediates the Effect of the Combined Behavioral Intervention on Alcohol Outcomes in the COMBINE Study: An Application of Latent Class Mediation. Journal Of Studies On Alcohol And Drugs 2018, 79: 199-207. PMID: 29553346, PMCID: PMC6019776, DOI: 10.15288/jsad.2018.79.199.Peer-Reviewed Original ResearchConceptsAlcohol use disorderMedication managementBehavioral interventionsDrinking outcomesOutcomes 12 monthsCombined Behavioral InterventionCombined PharmacotherapiesUse disordersAUD treatmentCoping repertoireCOMBINE StudySecondary analysisSignificant mediatorAlcohol Dependence (COMBINE) StudyBehavioral treatmentIntervention efficacyBroad coping repertoireMultisite studyInterventionGreater likelihoodOutcomesTreatmentMediatorsAlcohol outcomesBehavior change
2016
Multisite reliability of MR-based functional connectivity
Noble S, Scheinost D, Finn ES, Shen X, Papademetris X, McEwen SC, Bearden CE, Addington J, Goodyear B, Cadenhead KS, Mirzakhanian H, Cornblatt BA, Olvet DM, Mathalon DH, McGlashan TH, Perkins DO, Belger A, Seidman LJ, Thermenos H, Tsuang MT, van Erp TGM, Walker EF, Hamann S, Woods SW, Cannon TD, Constable RT. Multisite reliability of MR-based functional connectivity. NeuroImage 2016, 146: 959-970. PMID: 27746386, PMCID: PMC5322153, DOI: 10.1016/j.neuroimage.2016.10.020.Peer-Reviewed Original ResearchConceptsNorth American Prodrome Longitudinal StudyRight motor cortexIntrinsic connectivity distributionPosterior cingulate cortexFunctional connectivity studiesFunctional connectivity measurementsMultisite studyVoxel-wise connectivityConnectivity studiesConnectivity measuresSeed-based connectivityConnectivity analysisMotor cortexHealthy cohortCingulate cortexScan durationSingle-subject levelFcMRI dataFunctional connectivityConnectivity measurementsClinical populationsLittle dataLongitudinal studyMultisite reliabilityScanner manufacturersCompensatory Hyperconnectivity in Developing Brains of Young Children With Type 1 Diabetes
Saggar M, Tsalikian E, Mauras N, Mazaika P, White NH, Weinzimer S, Buckingham B, Hershey T, Reiss AL. Compensatory Hyperconnectivity in Developing Brains of Young Children With Type 1 Diabetes. Diabetes 2016, 66: 754-762. PMID: 27702833, PMCID: PMC5319714, DOI: 10.2337/db16-0414.Peer-Reviewed Original ResearchConceptsControl subjectsIntrinsic connectivityAge-matched control subjectsYoung childrenBrain intrinsic connectivityResting-state functional MRI dataType 1 diabetesSeed-based analysisCognitive functioningBlood glucoseSustained dysregulationOverall group differencesLarge multisite studyT1DYounger ageFunctional MRI dataCognitive deficitsType 1Cognitive functionObserved positive associationDiabetesMultisite studyCompensatory roleGroup differencesBrain
2015
Overdose Education and Naloxone Rescue Kits for Family Members of Individuals who Use Opioids: Characteristics, Motivations, and Naloxone Use
Bagley SM, Peterson J, Cheng DM, Jose C, Quinn E, O'Connor P, Walley AY. Overdose Education and Naloxone Rescue Kits for Family Members of Individuals who Use Opioids: Characteristics, Motivations, and Naloxone Use. Substance Abuse 2015, 36: 149-154. PMID: 25564892, PMCID: PMC4809347, DOI: 10.1080/08897077.2014.989352.Peer-Reviewed Original ResearchConceptsNaloxone rescue kitsOverdose educationRescue kitsOverdose rescueSupport groupsFamily membersOverdose prevention trainingCommunity support groupsFamilies of peopleOpioid usersOpioidsOverdose epidemicNaloxone useSelf-administered surveyKit useNaloxonePrevention trainingOverdoseMultisite studyFurther studiesReliability of an fMRI paradigm for emotional processing in a multisite longitudinal study
Gee DG, McEwen SC, Forsyth JK, Haut KM, Bearden CE, Addington J, Goodyear B, Cadenhead KS, Mirzakhanian H, Cornblatt BA, Olvet D, Mathalon DH, McGlashan TH, Perkins DO, Belger A, Seidman LJ, Thermenos H, Tsuang MT, van Erp TG, Walker EF, Hamann S, Woods SW, Constable T, Cannon TD. Reliability of an fMRI paradigm for emotional processing in a multisite longitudinal study. Human Brain Mapping 2015, 36: 2558-2579. PMID: 25821147, PMCID: PMC4478164, DOI: 10.1002/hbm.22791.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imaging (fMRI) taskBlood oxygen level-dependent (BOLD) signalFusiform gyrusRobust activationEmotion processing areasAnterior cingulate cortexLevel-dependent signalBrain-related changesMean activationExcellent reliabilityPatient groupRare conditionInferior frontal gyrusHealthy volunteersGeneral populationEmotion processing taskHealthy individualsCingulate cortexMultisite longitudinal studyConsecutive daysFrontal gyrusAmygdalaBrain activationMultisite studyMixed effects models
2014
Fyn kinase inhibition as a novel therapy for Alzheimer’s disease
Nygaard HB, van Dyck CH, Strittmatter SM. Fyn kinase inhibition as a novel therapy for Alzheimer’s disease. Alzheimer's Research & Therapy 2014, 6: 8. PMID: 24495408, PMCID: PMC3978417, DOI: 10.1186/alzrt238.Peer-Reviewed Original ResearchAlzheimer's diseasePathogenesis of ADTreatment of ADPhase Ib studyLate-stage clinical testingUnique therapeutic targetMajor pathologic hallmarkDevastating neurodegenerative disorderPathologic hallmarkNovel therapiesIb studyTherapeutic strategiesTherapeutic targetSmall molecule inhibitorsClinical testingTyrosine kinase FynCellular prion proteinNeurodegenerative disordersDiseaseAβ oligomersCell surface bindingMultisite studyHigh potencyMolecule inhibitorsTherapy
2012
CONCEPTUALIZING SOCIAL INTEGRATION AMONG FORMERLY HOMELESS ADULTS WITH SEVERE MENTAL ILLNESS
Tsai J, Rosenheck R. CONCEPTUALIZING SOCIAL INTEGRATION AMONG FORMERLY HOMELESS ADULTS WITH SEVERE MENTAL ILLNESS. Journal Of Community Psychology 2012, 40: 456-467. DOI: 10.1002/jcop.20527.Peer-Reviewed Original Research
2011
Adherence to HIV Treatment and Care Among Previously Homeless Jail Detainees
Chen NE, Meyer JP, Avery AK, Draine J, Flanigan TP, Lincoln T, Spaulding AC, Springer SA, Altice FL. Adherence to HIV Treatment and Care Among Previously Homeless Jail Detainees. AIDS And Behavior 2011, 17: 2654-2666. PMID: 22065234, PMCID: PMC3325326, DOI: 10.1007/s10461-011-0080-2.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalysis of VarianceAnti-HIV AgentsCross-Sectional StudiesFemaleHealth Services AccessibilityHealth Services Needs and DemandHealthcare DisparitiesHIV InfectionsHumansIll-Housed PersonsInsurance CoverageInsurance, HealthMaleMedication AdherenceMental DisordersNeeds AssessmentPrisonersSubstance Abuse, IntravenousUnited StatesVulnerable Populations
2010
HIV/AIDS, comorbidity, and alcohol: can we make a difference?
Justice A, Sullivan L, Fiellin D. HIV/AIDS, comorbidity, and alcohol: can we make a difference? Alcohol Research 2010, 33: 258-66. PMID: 23584067, PMCID: PMC3711181.BooksConceptsVeterans Aging Cohort StudyHIV infectionLong-term HIV infectionAlcohol useAging Cohort StudyHIV/AIDSAssociated comorbidityCohort studyHIV outcomesMedical managementIntervention trialsAlcohol consumptionHealth outcomesAlcohol treatmentMultisite studyComorbiditiesHIVInfectionOutcomesTreatmentAIDSDiseaseTrialsImportant role
2009
Functional connectivity differences in first episode and chronic schizophrenia patients during an auditory sensorimotor task revealed by independent component analysis of a large multisite study
Juárez M, White T, Pearlson G, Bustillo J, Lauriello J, Ho B, Bockholt H, Clark V, Gollub R, Magnotta V, Machado G, Calhoun V. Functional connectivity differences in first episode and chronic schizophrenia patients during an auditory sensorimotor task revealed by independent component analysis of a large multisite study. NeuroImage 2009, 47: s158. DOI: 10.1016/s1053-8119(09)71664-7.Peer-Reviewed Original ResearchA comparison of neurocognitive functioning in children previously randomized to dexamethasone or prednisone in the treatment of childhood acute lymphoblastic leukemia
Kadan-Lottick NS, Brouwers P, Breiger D, Kaleita T, Dziura J, Liu H, Chen L, Nicoletti M, Stork L, Bostrom B, Neglia JP. A comparison of neurocognitive functioning in children previously randomized to dexamethasone or prednisone in the treatment of childhood acute lymphoblastic leukemia. Blood 2009, 114: 1746-1752. PMID: 19546477, PMCID: PMC2738566, DOI: 10.1182/blood-2008-12-186502.Peer-Reviewed Original ResearchConceptsAcute lymphoblastic leukemiaChildhood acute lymphoblastic leukemiaDexamethasone groupLymphoblastic leukemiaNeurocognitive functioningHigher event-free survival rateEvent-free survival rateCentral nervous system penetrationLong-term cognitive functioningPsychotropic drug usePrevious clinical trialsWorse neurocognitive functioningCorticosteroid RandomizationNeurocognitive toxicityPrednisone groupNeurologic complicationsClinical trialsSignificant overall differenceSurvival rateDrug useYounger ageWorse functioningOlder ageDiagnosisMultisite studyPopulation admixture modulates risk for alcohol dependence
Zuo L, Luo X, Listman JB, Kranzler HR, Wang S, Anton RF, Blumberg HP, Stein MB, Pearlson GD, Covault J, Charney DS, van Kammen DP, Price LH, Lappalainen J, Cramer J, Krystal JH, Gelernter J. Population admixture modulates risk for alcohol dependence. Human Genetics 2009, 125: 605-613. PMID: 19306106, PMCID: PMC2777998, DOI: 10.1007/s00439-009-0647-4.Peer-Reviewed Original Research
2007
Development of a parent training program for children with pervasive developmental disorders
Johnson C, Handen B, Butter E, Wagner A, Mulick J, Sukhodolsky D, Williams S, Swiezy N, Arnold L, Aman M, Scahill L, Stigler K, McDougle C, Vitiello B, Smith T. Development of a parent training program for children with pervasive developmental disorders. Behavioral Interventions 2007, 22: 201-221. DOI: 10.1002/bin.237.Peer-Reviewed Original ResearchPervasive developmental disorderApplied behavior analysisBehavioral parent training programParent training programSingle-subject design methodologyAdaptive functioningChild functioningPsychosocial interventionsTreatment fidelityBehavioral interventionsTraining procedureDevelopmental disordersPT programImportant next stepTraining programPediatric psychopharmacologyFunctioningLarge sampleMultisite studyParentsBehavior analysisInterventionMeaningful outcomesChildrenPharmacological treatment
2000
Attention-Deficit/Hyperactivity Disorder Overview Historical Perspective, Current Controversies, and Future Directions
Stubbe D. Attention-Deficit/Hyperactivity Disorder Overview Historical Perspective, Current Controversies, and Future Directions. Child And Adolescent Psychiatric Clinics Of North America 2000, 9: 469-479. PMID: 10944651, DOI: 10.1016/s1056-4993(18)30101-9.Peer-Reviewed Original Research
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