2025
Neighborhood social fragmentation in relation to impaired mismatch negativity among youth at clinical high risk for psychosis and healthy comparisons
Ku B, Hamilton H, Yuan Q, Parker D, Roach B, Bachman P, Belger A, Carrión R, Duncan E, Johannesen J, Light G, Niznikiewicz M, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Perkins D, Stone W, Woods S, Walker E, Mathalon D. Neighborhood social fragmentation in relation to impaired mismatch negativity among youth at clinical high risk for psychosis and healthy comparisons. Neuropsychopharmacology 2025, 1-9. PMID: 40175526, DOI: 10.1038/s41386-025-02093-4.Peer-Reviewed Original ResearchNeighbourhood social fragmentationClinical high riskCHR-PMismatch negativitySocial fragmentationHealthy comparisonDouble-deviant MMNHigh riskCHR-P groupImpaired mismatch negativityMismatch negativity impairmentsSchizophrenia-like behaviorsMMN-like responsesAuditory oddball paradigmParental history of psychosisHigh-risk individualsHistory of psychosisNorth American Prodrome Longitudinal Study Phase 2Pitch-deviantsMMN amplitudeStudy phase 2Animal studiesParental historyOddball paradigmNeighborhood povertyThe role of childhood social fragmentation and perceived discrimination on maladaptive core schemas later in life among young adults at clinical high risk for psychosis and healthy comparisons
Diomino A, Yuan Q, Cadenhead K, Addington J, Bearden C, Cannon T, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S, Ku B. The role of childhood social fragmentation and perceived discrimination on maladaptive core schemas later in life among young adults at clinical high risk for psychosis and healthy comparisons. Schizophrenia Research 2025, 279: 71-78. PMID: 40174486, PMCID: PMC12035737, DOI: 10.1016/j.schres.2025.03.023.Peer-Reviewed Original ResearchConceptsClinical high riskCore schemasHealthy comparisonNeighbourhood social fragmentationNorth American Prodrome Longitudinal Study 2Perceived DiscriminationSocial fragmentationIn adulthoodNegative-self schemaPoor social functioningCross-sectional studyLongitudinal Study 2High riskU.S. Census dataNegative-selfStudy 2Design interventionsSchema formationSocial functioningPsychosisBaseline dataYoung adultsCensus dataAdulthoodChildhoodRelations of temporoparietal connectivity with neighborhood social fragmentation in youth at clinical high-risk for psychosis
Aberizk K, Sefik E, Yuan Q, Cao H, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Woods S, Walker E, Ku B. Relations of temporoparietal connectivity with neighborhood social fragmentation in youth at clinical high-risk for psychosis. Schizophrenia Research 2025, 277: 151-158. PMID: 40068446, PMCID: PMC11970632, DOI: 10.1016/j.schres.2025.02.012.Peer-Reviewed Original ResearchConceptsClinical high riskCHR-PCHR-P.Functional connectivityNorth American Prodrome Longitudinal StudyPatterns of brain connectivitySchizophrenia spectrum conditionsSocial engagementAutobiographical memory recallTemporoparietal brain regionsSuperior temporal poleBrain functional correlatesHippocampal functional connectivityTemporoparietal brain areasNeighbourhood social fragmentationArea-level characteristicsTemporal lobe abnormalitiesSocial fragmentationHealthy comparisonPsychotic disordersNeurobiological mechanismsHigh riskTemporal poleMemory recallBrain areas
2024
Social Engagement Moderates Relations Between Hippocampal-Temporoparietal Junction Connectivity and Neighborhood Social Fragmentation in Youth at Clinical High Risk for Psychosis
Aberizk K, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Tsuang M, Woods S, Walker E, Ku B. Social Engagement Moderates Relations Between Hippocampal-Temporoparietal Junction Connectivity and Neighborhood Social Fragmentation in Youth at Clinical High Risk for Psychosis. Biological Psychiatry 2024, 95: s37-s38. DOI: 10.1016/j.biopsych.2024.02.095.Peer-Reviewed Original Research
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