2025
Characterizing the Social Epigenome in Mexican Patients with Early-Onset Psychosis
Ruiz-Ramos D, Martínez-Magaña J, Juárez-Rojop I, Nolasco-Rosales G, Sosa-Hernández F, Cruz-Castillo J, Cavazos J, Callejas A, Zavaleta-Ramírez P, Zorrilla-Dosal J, Lanzagorta N, Nicolini H, Montalvo-Ortiz J, Glahn D, Genis-Mendoza A. Characterizing the Social Epigenome in Mexican Patients with Early-Onset Psychosis. Genes 2025, 16: 591. PMID: 40428414, PMCID: PMC12111507, DOI: 10.3390/genes16050591.Peer-Reviewed Original ResearchConceptsEarly-onset psychosisRisk scoreEpigenetic ageEpigenome-wide association studiesAssociation studiesYears of educationShort life expectancyMexican patientsPsychiatric admissionsAssociation of DNA methylationSocial epigenomicsYears of schoolingAccelerated Epigenetic AgingLife expectancyAssociated with panic disorderEnvironmental exposuresEarly-onsetGlobal functioningClinical characteristicsClinical manifestationsDNA methylationAgeEpigenetic mechanismsPsychosisManifestation of psychosisThe problem of missing data for learning health systems focused on first-episode psychosis
Robinson D, Schooler N, John M, Cahill J, Gonzalez C, Marcy P, Adams C, Distasio M, Gerber C, Hackett B, Nunez M, Srihari V, Kane J. The problem of missing data for learning health systems focused on first-episode psychosis. Schizophrenia Research 2025, 279: 79-86. PMID: 40174487, PMCID: PMC12051462, DOI: 10.1016/j.schres.2025.03.021.Peer-Reviewed Original ResearchConceptsFirst-episode psychosisCoordinated Specialty CarePrematurely terminated treatmentLearning health systemGlobal functioningCharacteristics of individualsLong-actingPatient-reported outcomesSocial scaleExploratory analysisPsychosisProcess of recoveryHealth systemCSC treatmentParticipantsUnstable housingRates of missing dataClinic patientsSpecialty careImprove careUS clinicsScaleLong durationCommercial insuranceResearch prioritiesThe impact of Duration of Untreated Psychosis on functioning and quality of life over one year of Coordinated Specialty Care (CSC)
Hazan H, Tayfur S, Zhou B, Li F, Gibbs-Dean T, Karmani S, Kline E, Ferrara M, Corbera S, Riley S, Sykes L, Tek C, Keshavan M, Srihari V. The impact of Duration of Untreated Psychosis on functioning and quality of life over one year of Coordinated Specialty Care (CSC). PLOS ONE 2025, 20: e0312740. PMID: 39928579, PMCID: PMC11809850, DOI: 10.1371/journal.pone.0312740.Peer-Reviewed Original ResearchConceptsCoordinated Specialty CareQuality of lifeDuration of untreated psychosisDUP groupWorld Health OrganizationYear of coordinated specialty careGeneralized linear modelConfidence intervalsBinary outcomesGlobal functioningDuration of untreated psychosis groupSymptom severityUntreated psychosisSpecialty careCSC programsImpact of duration of untreated psychosisFunctional gainsModel repeated measuresMixed model repeated measuresOdds ratioNo significant differenceLogit link functionStatus improvementContinuous outcomesSocial functioning
2024
The Exposome Paradigm: Applications in Psychopathology and Psychopharmacology
Fusar-Poli L, Guloksuz S. The Exposome Paradigm: Applications in Psychopathology and Psychopharmacology. 2024, 337-349. DOI: 10.1007/978-3-031-61992-2_20.Peer-Reviewed Original ResearchES-SCZNonclinical populationsMental disordersResponse to psychopharmacologic treatmentCourse of mental disordersSchizophrenia spectrum disordersPsychopharmacological treatmentClinical psychiatrySpectrum disorderGlobal functioningDevelopmental trajectoriesExposome scoreGeneral populationSchizophreniaEnvironmental risk factorsPsychopathologyPsychopharmacologyDisordersExposome paradigmPsychiatryPhysical outcomesParadigmEnvironmental exposuresPotential utilityClinical characterizationEnhancing Early Diagnosis of Bipolar Disorder in Adolescents Through Multimodal Neuroimaging
Wu J, Lin K, Lu W, Zou W, Li X, Tan Y, Yang J, Zheng D, Liu X, Lam B, Xu G, Wang K, McIntyre R, Wang F, So K, Wang J. Enhancing Early Diagnosis of Bipolar Disorder in Adolescents Through Multimodal Neuroimaging. Biological Psychiatry 2024, 97: 313-322. PMID: 39069165, DOI: 10.1016/j.biopsych.2024.07.018.Peer-Reviewed Original ResearchAt-Risk AdolescentsBipolar disorderBehavioral assessmentBD patientsDiagnosis of bipolar disorderEarly diagnosis of bipolar disordersSevere neuropsychiatric conditionMultimodal MRIAt-riskBehavioral attributesEnhancing early diagnosisSubthreshold symptomsClinical InterviewPsychiatric symptomsNeuropsychiatric conditionsStructural equation modelingMultimodal neuroimagingGlobal functioningBrain healthBD diagnosisBD DiagnosticsAdvanced imaging techniquesSubgroup distinctionsAdolescentsRetrospective cohortRace/ethnicity and socioeconomic status as predictors of outcome following family therapy in youth at clinical high risk for psychosis
Ruiz‐Yu B, Le T, Weintraub M, Zinberg J, Addington J, O'Brien M, Walsh B, Friedman‐Yakoobian M, Auther A, Cornblatt, Domingues I, Cannon T, Miklowitz D, Bearden C. Race/ethnicity and socioeconomic status as predictors of outcome following family therapy in youth at clinical high risk for psychosis. Early Intervention In Psychiatry 2024, 18: 981-990. PMID: 38676463, PMCID: PMC11512687, DOI: 10.1111/eip.13541.Peer-Reviewed Original ResearchClinical high riskNegative symptomsFamily therapyRandomized trial of family-focused therapyGlobal functioningEffect of race/ethnicityNHW participantsTrial of family therapyFamily-focused therapyParental educationAssociated with greater improvementSociodemographic factorsSocioeconomic statusPositive symptomsPsychosocial treatmentsPsychosocial functioningHigher parental educationFollow-up measurementsHigh riskInfluence of race/ethnicityGreater improvementRandomized trialsTreatment outcomesPsychosisPredictors of outcomeMIR137 polygenic risk for schizophrenia and ephrin-regulated pathway: Role in lateral ventricles and corpus callosum volume
Blokland G, Maleki N, Jovicich J, Mesholam-Gately R, DeLisi L, Turner J, Shenton M, Voineskos A, Kahn R, Roffman J, Holt D, Ehrlich S, Kikinis Z, Dazzan P, Murray R, Lee J, Sim K, Lam M, de Zwarte S, Walton E, Kelly S, Picchioni M, Bramon E, Makris N, David A, Mondelli V, Reinders A, Oykhman E, Morris D, Gill M, Corvin A, Cahn W, Ho N, Liu J, Gollub R, Manoach D, Calhoun V, Sponheim S, Buka S, Cherkerzian S, Thermenos H, Dickie E, Ciufolini S, Marques T, Crossley N, Purcell S, Smoller J, van Haren N, Toulopoulou T, Donohoe G, Goldstein J, Keshavan M, Petryshen T, del Re E. MIR137 polygenic risk for schizophrenia and ephrin-regulated pathway: Role in lateral ventricles and corpus callosum volume. International Journal Of Clinical And Health Psychology 2024, 24: 100458. PMID: 38623146, PMCID: PMC11017057, DOI: 10.1016/j.ijchp.2024.100458.Peer-Reviewed Original ResearchIncreased LV volumesLV ratioLateral ventricleLV volumesCorpus callosumEphrin pathwaysSZ probandsHallmarks of schizophreniaEnlarged lateral ventriclesSNP-based heritability estimatesGlobal Assessment of FunctioningBrain MRI scansGlobal functioningCorpus callosum volumeAssessment of functioningClinical dataCC abnormalitiesMicroRNA MIR137MRI scansCC volumeGlobal assessmentMid-anteriorInverse correlationSchizophreniaMIR137Differential expression of haptoglobin in individuals at clinical high risk of psychosis and its association with global functioning and clinical symptoms
Healy C, Byrne J, Raj Suasi S, Föcking M, Mongan D, Kodosaki E, Heurich M, Cagney G, Wynne K, Bearden C, Woods S, Cornblatt B, Mathalon D, Stone W, Cannon T, Addington J, Cadenhead K, Perkins D, Jeffries C, Cotter D. Differential expression of haptoglobin in individuals at clinical high risk of psychosis and its association with global functioning and clinical symptoms. Brain Behavior And Immunity 2024, 117: 175-180. PMID: 38219978, DOI: 10.1016/j.bbi.2023.12.018.Peer-Reviewed Original ResearchGlobal Assessment of Functioning ScaleNorth American Prodrome Longitudinal StudyClinical high riskPoor functionScale of Psychosis-risk SymptomsPsychosis-risk symptomsAssociated with poorer functioningFirst-episode psychosisTransition to psychosisGreater symptom severityFollow-upIndividuals at-riskClinical symptomsPsychotic disordersHigh riskSymptom severityPsychosocial functioningGlobal functioningPsychosisSubscale scoresFDR correctionAcute phase inflammatory responseLongitudinal studyGlobal assessmentFunctional scales
2023
Sampling from different populations: Sociodemographic, clinical, and functional differences between samples of first episode psychosis individuals and clinical high-risk individuals who progressed to psychosis
Hagler M, Ferrara M, Yoviene Sykes L, Li F, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Perkins D, Mathalon D, Seidman L, Tsuang M, Walker E, Powers A, Allen A, Srihari V, Woods S. Sampling from different populations: Sociodemographic, clinical, and functional differences between samples of first episode psychosis individuals and clinical high-risk individuals who progressed to psychosis. Schizophrenia Research 2023, 255: 239-245. PMID: 37028205, PMCID: PMC10207144, DOI: 10.1016/j.schres.2023.03.047.Peer-Reviewed Original ResearchConceptsFirst-episode psychosis servicesClinical high riskClinical high-risk individualsEarly detectionFirst-episode psychosis individualsRecent psychiatric hospitalizationCourse of illnessHigh-risk individualsAttenuated positive symptomsCHR researchGeographic catchmentSyndromal psychosisPsychosis individualsPsychiatric hospitalizationEarly intervention effortsHigh riskPsychosis servicesPositive symptomsGlobal functioningClinical resourcesProtective factorsDifferent populationsFE participantsGeneralizability of findingsFES program
2021
Depression Predicts Global Functional Outcomes in Individuals at Clinical High Risk for Psychosis
Deng W, Addington J, Bearden CE, Cadenhead KS, Cornblatt BA, Mathalon DH, McGlashan TH, Perkins DO, Seidman LJ, Tsuang MT, Woods SW, Walker EF, Joormann J, Cannon T. Depression Predicts Global Functional Outcomes in Individuals at Clinical High Risk for Psychosis. Psychiatric Research And Clinical Practice 2021, 3: 163-171. PMID: 36101655, PMCID: PMC9175802, DOI: 10.1176/appi.prcp.20210023.Peer-Reviewed Original ResearchGlobal functional outcomeFunctional outcomeCHR-P populationDepressive symptomsCHR individualsBetter global functional outcomeCo-occurring depressive symptomsCo-morbid depressionPoor functional outcomeBaseline depressive symptomsDepressive symptom scoresLongitudinal study cohortClinical high riskProdromal symptom severityFunctional recoveryStudy cohortSymptom scoresPoor outcomeFavorable courseFunctional improvementHigh riskAffective symptomsDegree of recoverySymptomsGlobal functioning
2020
Altered brain function and clinical features in patients with first-episode, drug naïve major depressive disorder: A resting-state fMRI study
Liang S, Xue K, Wang W, Yu W, Ma X, Luo S, Zhang J, Sun X, Luo X, Liu F, Zhang Y. Altered brain function and clinical features in patients with first-episode, drug naïve major depressive disorder: A resting-state fMRI study. Psychiatry Research Neuroimaging 2020, 303: 111134. PMID: 32652482, DOI: 10.1016/j.pscychresns.2020.111134.Peer-Reviewed Original ResearchConceptsMajor depressive disorderDrug-naïve major depressive disorderAltered brain functionFunctioning Assessment Short TestMATRICS Consensus Cognitive BatteryMDD patientsDepressive disorderDefault mode networkBrain functionClinical featuresFunctional impairmentHealthy subjectsLow-frequency fluctuation (ALFF) valuesDrug-naïve MDD patientsResting-state fMRI studyAssessment Short TestTotal FAST scoresALFF valuesNeurocognitive impairmentPatientsConsensus Cognitive BatteryLingual gyrusOccupational functioningFAST scoreGlobal functioningTest of the stress process model of family caregivers of people living with schizophrenia in China
Yu Y, Liu ZW, Li TX, Li YL, Xiao SY, Tebes JK. Test of the stress process model of family caregivers of people living with schizophrenia in China. Social Science & Medicine 2020, 259: 113113. PMID: 32646627, DOI: 10.1016/j.socscimed.2020.113113.Peer-Reviewed Original ResearchConceptsFamily caregiversStress process modelDepressive symptomsCaregiver burdenSpouse caregiversGlobal functioningPrimary family caregiversPearlin's stress process modelGlobal functioning scoresCommunity-based servicesParent depressive symptomsCaregiver depressionFamily functioningFunctioning scoresCaregivers' feelingsCommunity-based systemCaregiversSymptomsEmotional distressBurdenSchizophreniaStress processPresent studyMediatorsFirst studyS115. EVALUATION OF THE CLINICAL UTILITY OF SYMPTOM DIMENSIONS ON LONG-TERM CLINICAL AND FUNCTIONAL OUTCOMES IN FIRST EPISODE PSYCHOSIS
Bor E, Quattrone D, Rodriguez V, Alameda L, Guloksuz S, Murray R. S115. EVALUATION OF THE CLINICAL UTILITY OF SYMPTOM DIMENSIONS ON LONG-TERM CLINICAL AND FUNCTIONAL OUTCOMES IN FIRST EPISODE PSYCHOSIS. Schizophrenia Bulletin 2020, 46: s78-s78. PMCID: PMC7234345, DOI: 10.1093/schbul/sbaa031.181.Peer-Reviewed Original ResearchLength of hospitalisationCase-control studyClinical outcomesFunctional outcomeClinical utilityDepressive symptomsSymptom dimensionsPositive symptomsNegative symptomsGlobal functioningFirst-episode psychosis patientsMulticentre case-control studyBaseline positive symptomsLong-Term ClinicalRisk of hospitalisationEpisode psychosis patientsPoor clinical outcomeFirst-episode psychosisCurrent clinical utilityPotential clinical utilitySymptom-based approachFurther outcome researchHospital admissionBetter prognosisProspective study
2018
Course, outcome and diagnosis stability of early-onset schizophrenia in Yunnan Province, China-a three years follow-up study
Kang C, Zhou H, Yang J, Yang R, Sun N, Wang S, Yang C, Han D, Srihari VH. Course, outcome and diagnosis stability of early-onset schizophrenia in Yunnan Province, China-a three years follow-up study. Psychiatry Research 2018, 271: 144-149. PMID: 30472510, DOI: 10.1016/j.psychres.2018.11.013.Peer-Reviewed Original ResearchConceptsEarly-onset schizophreniaICD-10 diagnosisDiagnostic stabilityMini International Neuropsychiatric InterviewFirst Affiliated HospitalInternational Neuropsychiatric InterviewKunming Medical UniversityHigh diagnostic stabilityDepartment of PsychiatryPoor outcomeAffiliated HospitalNeuropsychiatric InterviewInternational ClassificationBetter outcomesModerate outcomeMedical UniversityGlobal functioningICD-10Psychosocial outcomesPatientsSchizophreniaDiagnosis stabilityDiagnosisOutcomesHospital
2012
Socioeconomic-status and mental health in a personality disorder sample: the importance of neighborhood factors.
Walsh Z, Shea MT, Yen S, Ansell EB, Grilo CM, McGlashan TH, Stout RL, Bender DS, Skodol AE, Sanislow CA, Morey LC, Gunderson JG. Socioeconomic-status and mental health in a personality disorder sample: the importance of neighborhood factors. Journal Of Personality Disorders 2012, 27: 820-31. PMID: 22984860, PMCID: PMC4628287, DOI: 10.1521/pedi_2012_26_061.Peer-Reviewed Original ResearchConceptsPD symptomsCross-sectional studyCollaborative Longitudinal Personality Disorders StudySocial adjustmentPersonality Disorders StudyPD individualsMore PD symptomsDiagnostic groupsGlobal functioningDisorder diagnostic groupsSymptomsPsychosocial functioningMental healthPersonality disorder samplesDisorders StudyPositive associationTwo-year periodObsessive-CompulsiveDisorder sampleNeighborhood factorsPersonality pathologyRiskAssociationFunctioningLow levelsTourette syndrome in youth with and without obsessive compulsive disorder and attention deficit hyperactivity disorder
Lebowitz ER, Motlagh MG, Katsovich L, King RA, Lombroso PJ, Grantz H, Lin H, Bentley MJ, Gilbert DL, Singer HS, Coffey BJ, the Tourette Syndrome Study Group, Kurlan RM, Leckman JF. Tourette syndrome in youth with and without obsessive compulsive disorder and attention deficit hyperactivity disorder. European Child & Adolescent Psychiatry 2012, 21: 451-457. PMID: 22543961, PMCID: PMC3722559, DOI: 10.1007/s00787-012-0278-5.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderComorbid tic disordersObsessive-compulsive disorderSeverity of ticsChronic tic disorderTic disordersPsychosocial stressDeficit hyperactivity disorderGlobal functioningComorbid diagnosesHyperactivity disorderMore severe ticsComorbid attention deficit hyperactivity disorderDiagnosis of OCDComorbid obsessive-compulsive disorderAdditional comorbid diagnosesSymptoms of anxietyHigh psychosocial stressMore internalizing disordersGreater psychosocial stressSevere ticsOppositional defiant disorderSevere subtypeTic severityTourette syndrome
2009
Chronic Dieting Among Extremely Obese Bariatric Surgery Candidates
Roehrig M, Masheb RM, White MA, Rothschild BS, Burke-Martindale CH, Grilo CM. Chronic Dieting Among Extremely Obese Bariatric Surgery Candidates. Obesity Surgery 2009, 19: 1116-1123. PMID: 19495894, PMCID: PMC3671950, DOI: 10.1007/s11695-009-9865-z.Peer-Reviewed Original ResearchConceptsBody mass indexBariatric surgery candidatesObese bariatric surgery candidatesSurgery candidatesBariatric candidatesPre-operative body mass indexChronic dietersHealth-related qualityWeight loss attemptsBinge-eating statusWeight-related correlatesGreater weight gainMass indexPatient groupWeight cyclingMethodsThe current studyMore episodesClinical significanceWeight historySignificant elevationSelf-report assessmentsDepressive symptomsChronic dietingGlobal functioningWeight gain
2007
Psychosocial impairment and treatment utilization by patients with borderline personality disorder, other personality disorders, mood and anxiety disorders, and a healthy comparison group
Ansell EB, Sanislow CA, McGlashan TH, Grilo CM. Psychosocial impairment and treatment utilization by patients with borderline personality disorder, other personality disorders, mood and anxiety disorders, and a healthy comparison group. Comprehensive Psychiatry 2007, 48: 329-336. PMID: 17560953, DOI: 10.1016/j.comppsych.2007.02.001.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdultAnxiety DisordersBorderline Personality DisorderCross-Sectional StudiesFemaleHealth StatusHumansInterpersonal RelationsMaleMental Health ServicesMiddle AgedMood DisordersPatient Acceptance of Health CarePersonality DisordersPsychiatric Status Rating ScalesPsychotherapySocial AdjustmentStress, PsychologicalConceptsBorderline personality disorderTreatment utilizationHealthy comparison groupPersonality disorderAnxiety disordersBPD groupPsychosocial functioningComparison groupCurrent psychiatric diagnosisMental disorder diagnosesPublic health impactSemistructured research interviewDoctoral-level cliniciansPsychologic distressFunctional impairmentPsychosocial impairmentModerate impairmentBPD diagnosisPsychiatric diagnosisMAD groupGlobal functioningDisorder diagnosisSevere deficitsStatistical ManualDisorders
2005
Measuring Change in OCD: Sensitivity of the Obsessive-Compulsive Inventory-Revised
Abramowitz J, Tolin D, Diefenbach G. Measuring Change in OCD: Sensitivity of the Obsessive-Compulsive Inventory-Revised. Journal Of Psychopathology And Behavioral Assessment 2005, 27: 317-324. DOI: 10.1007/s10862-005-2411-y.Peer-Reviewed Original ResearchObsessive-Compulsive InventoryYale-Brown Obsessive Compulsive ScaleMeasures of OCDCognitive behavioral therapySelf-report measuresObsessive-compulsive disorder severityObsessive Compulsive ScaleResponse preventionOCD symptomsNaturalistic outcome studyOCD patientsDisorder severityGlobal functioningCompulsive ScaleOCDRelated symptomsSymptom InterviewOCIInventoryOutcome studiesTreatment effectsAnxietyMeasuresRevisedFunctioning
2004
Continuity and Intensity of Care Among Women Receiving Outpatient Care for PTSD
Greenberg GA, Fontana A, Rosenheck RA. Continuity and Intensity of Care Among Women Receiving Outpatient Care for PTSD. Psychiatric Quarterly 2004, 75: 165-181. PMID: 15168838, DOI: 10.1023/b:psaq.0000019757.85605.fd.Peer-Reviewed Original ResearchConceptsContinuity of careCare measuresMonths of treatmentIntensity of careEntry patientsPTSD measurementClinical benefitPoor outcomeOutpatient careOutpatient treatmentTreatment outcomesOutcome measuresHealth outcomesFemale veteransSignificant associationGlobal functioningCOC measuresAddictive disordersCareInconsistent evidenceMonthsTreatment qualityProgram entryGreater declinePatients
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