2025
Emergence and dynamics of delusions and hallucinations across stages in early psychosis
Mourgues-Codern C, Benrimoh D, Gandhi J, Farina E, Vin R, Zamorano T, Parekh D, Malla A, Joober R, Lepage M, Iyer S, Addington J, Bearden C, Cadenhead K, Cornblatt B, Keshavan M, Stone W, Mathalon D, Perkins D, Walker E, Cannon T, Woods S, Shah J, Powers A. Emergence and dynamics of delusions and hallucinations across stages in early psychosis. Biological Psychiatry 2025 PMID: 40020853, DOI: 10.1016/j.biopsych.2025.02.891.Peer-Reviewed Original ResearchFirst-episode psychosis patientsSymptom patternsNorth American Prodrome Longitudinal StudyPositive symptoms of psychosisSymptoms of psychosisCHR-P samplesEarly intervention programsPositive symptomsDelusional ideationPsychosis patientsEarly psychosisCHR-PNeural mechanismsDelusionsHallucination onsetHallucinationsPsychosisBaseline assessmentLongitudinal studyIntervention programsSymptomsTime courseParticipantsIdeationOnset
2024
Adolescents with first-episode psychosis and clinical high risk in the Province of Ferrara: an audit on the implementation of a specialised early intervention program
Magnabosco V, Ferrara M, Domenicano I, Cruciata M, Sarela A, Emanuelli F, Grassi L. Adolescents with first-episode psychosis and clinical high risk in the Province of Ferrara: an audit on the implementation of a specialised early intervention program. International Journal Of Psychiatry In Clinical Practice 2024, 28: 224-234. PMID: 39810320, DOI: 10.1080/13651501.2024.2446777.Peer-Reviewed Original ResearchConceptsClinical high riskFirst-episode psychosisGeneral practitionersSpecialised mental health careStandardised assessmentMental health careQuality improvement initiativesAdolescent mental healthAdult psychiatric servicesHigh riskCAMH careCAMH servicesEarly intervention programsHealth careSub-optimal adherenceImprovement initiativesMental healthPsychiatric hospitalisationPsychiatric servicesPharmacological prescriptionsDrug prescribingIntervention programsDescriptive statisticsPsychiatric differential diagnosisPsychiatric unit
2023
Using dimensionality-reduction techniques to understand the organization of psychotic symptoms in persistent psychotic illness and first episode psychosis
Fleming L, Lemonde A, Benrimoh D, Gold J, Taylor J, Malla A, Joober R, Iyer S, Lepage M, Shah J, Corlett P. Using dimensionality-reduction techniques to understand the organization of psychotic symptoms in persistent psychotic illness and first episode psychosis. Scientific Reports 2023, 13: 4841. PMID: 36964175, PMCID: PMC10039017, DOI: 10.1038/s41598-023-31909-w.Peer-Reviewed Original ResearchConceptsHallucinations/delusionsFirst-episode psychosisFirst-episode psychosis participantsEarly intervention programsPathophysiological mechanismsUnderlying pathophysiologyEpisode psychosisPsychotic illnessPsychotic symptomsPsychotic disordersSchizoaffective disorderAuditory hallucinationsPositive symptomsHallucination severityNegative symptomsSymptomsDisorganization symptomsIntervention programsHallucinationsIllnessPsychosis participantsPsychosisDelusionsDisordersParticipants
2022
Inattention symptoms in early pregnancy predict parenting skills and infant maltreatment during the first year of life
de Oliveira J, Fatori D, Shephard E, Xavier M, Matijasevich A, Ferraro A, Rohde L, Chiesa A, Miguel E, Polanczyk G. Inattention symptoms in early pregnancy predict parenting skills and infant maltreatment during the first year of life. Brazilian Journal Of Psychiatry 2022, 44: 388-400. PMID: 35751597, PMCID: PMC9375657, DOI: 10.47626/1516-4446-2021-2045.Peer-Reviewed Original ResearchConceptsMaternal attention-deficit/hyperactivity disorderAttention-deficit/hyperactivity disorderHyperactivity/impulsivity symptomsInattention symptomsImpulsivity symptomsAdolescent mothersHyperactivity disorderMaternal inattentionInfant maltreatmentEarly intervention programsParenting skillsPoor home environmentInfant developmentIntervention programsInattentionChild maltreatmentMaternal competenceMaltreatmentSkillsHome visit programHome environmentFirst yearInfant's lifeMultilevel linear regression modelsEarly pregnancy
2021
Factors Contributing to Early Intervention Evaluation
Chan G, Gaither JR, Leventhal JM, Leary CB, Fenick AM. Factors Contributing to Early Intervention Evaluation. Academic Pediatrics 2021, 22: 227-232. PMID: 33746044, DOI: 10.1016/j.acap.2021.03.010.Peer-Reviewed Original ResearchConceptsTime of referralInner-city pediatric primary care clinicPediatric primary care clinicMultivariable logistic regression modelEarly intervention evaluationChronic medical illnessPrimary care clinicsYears of ageLogistic regression modelsEarly intervention programsNon-English speaking familiesCare clinicsMedical illnessEI referralReferral characteristicsMedical historyInitial referralMedical recordsFirst referralPediatric careReferral systemAverage ageEI evaluationReferralAdditional months
2018
Need for evidence-based early intervention programmes: a public health perspective
Guloksuz S, van Os J. Need for evidence-based early intervention programmes: a public health perspective. BMJ Mental Health 2018, 21: 128. PMID: 30282627, PMCID: PMC10270415, DOI: 10.1136/ebmental-2018-300030.Peer-Reviewed Original ResearchConceptsClinical high riskUltra-high riskPsychotic symptomsEarly intervention programsSpecific effective treatmentBroader prevention strategiesIntervention programsPositive psychotic symptomsPublic health impactPublic health perspectivePrognostic accuracyHelp-seeking populationEffective treatmentHigh riskPsychosis benefitPrevention strategiesRisk enrichmentPredictive valueTherapeutic interventionsMeta-analytical evidenceSymptomsHealth perspectiveEarly psychopathologyHealth impactsAssessment toolThe early care environment and DNA methylome variation in childhood
Garg E, Chen L, Nguyen TTT, Pokhvisneva I, Chen LM, Unternaehrer E, MacIsaac JL, McEwen LM, Mah SM, Gaudreau H, Levitan R, Moss E, Sokolowski MB, Kennedy JL, Steiner MS, Meaney MJ, Holbrook JD, Silveira PP, Karnani N, Kobor MS, O'Donnell KJ. The early care environment and DNA methylome variation in childhood. Development And Psychopathology 2018, 30: 891-903. PMID: 30068421, DOI: 10.1017/s0954579418000627.Peer-Reviewed Original ResearchConceptsGenome-wide DNA methylationDNA methylationGenetic variationGenetic dataEarly care environmentsMethylome variationInfant attachment styleInfant attachmentEpigenetic modificationsAttachment styleBuccal epithelial samplesMethylationMolecular signaturesPrenatal adversityGenetic contributionInfant developmentChild genetic variationInfant cognitive developmentDisorganized attachment styleLater mental health problemsNegative effectsEarly intervention programsChild mental healthMental health problemsCognitive developmentDNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up
O’Donnell K, Chen L, MacIsaac JL, McEwen LM, Nguyen T, Beckmann K, Zhu Y, Chen LM, Brooks-Gunn J, Goldman D, Grigorenko EL, Leckman JF, Diorio J, Karnani N, Olds DL, Holbrook JD, Kobor MS, Meaney MJ. DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up. Translational Psychiatry 2018, 8: 15. PMID: 29317599, PMCID: PMC5802588, DOI: 10.1038/s41398-017-0063-9.Peer-Reviewed Original ResearchConceptsNurse-Family PartnershipIntervention programsProspective longitudinal studyYears of ageMajor psychiatric disordersAge 27 yearsChild maltreatmentPsychosocial intervention programEarly intervention programsLifestyle factorsIntervention groupBlood samplesPsychiatric disordersAdult offspringDiagnostic InterviewChildhood adversityNFP programInterindividual variationLongitudinal studyComponent scoresSustained impactAbuse/neglectDNA methylationFamily partnershipsDNA methylome
2010
Early Intervention Options for Acute Low Back Pain Patients: A Randomized Clinical Trial with One-Year Follow-Up Outcomes
Whitfill T, Haggard R, Bierner S, Pransky G, Hassett R, Gatchel R. Early Intervention Options for Acute Low Back Pain Patients: A Randomized Clinical Trial with One-Year Follow-Up Outcomes. Journal Of Occupational Rehabilitation 2010, 20: 256-263. PMID: 20369277, DOI: 10.1007/s10926-010-9238-4.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, PsychologicalAdolescentAdultAgedAlgorithmsBehavior TherapyDisability EvaluationFemaleFollow-Up StudiesHumansLow Back PainMaleMiddle AgedOutcome and Process Assessment, Health CarePersons with DisabilitiesPhysical Therapy ModalitiesRiskSocioeconomic FactorsTime FactorsTreatment OutcomeWork Capacity EvaluationYoung AdultConceptsChronic low back pain disabilityStandard careEarly interventionAcute low back pain patientsEarly intervention treatment programLow back pain disabilityLow back pain patientsPsychosocial functioningBack pain patientsBack pain disabilityCompletion of treatmentOne-year followMore symptom improvementEarly intervention treatmentSignificant differencesEarly intervention optionsEarly intervention programsALBP patientsPain patientsPain disabilitySymptom improvementClinical trialsWT groupHigh riskUp Outcomes
1996
Alcohol Use and T‐Lymphocyte Subsets among Injection Drug Users with HIV‐1 Infection: A Prospective Analysis
Crum R, Galai N, Cohn S, Celentano D, Vlahov D. Alcohol Use and T‐Lymphocyte Subsets among Injection Drug Users with HIV‐1 Infection: A Prospective Analysis. Alcohol Clinical And Experimental Research 1996, 20: 364-371. PMID: 8730231, DOI: 10.1111/j.1530-0277.1996.tb01654.x.Peer-Reviewed Original ResearchConceptsInjection drug usersCohort of IDUsT lymphocyte subsetsDrinks/weekHIV seroconversionAlcohol useYears postseroconversionDrug usersAlcohol categoriesHIV-positive injection drug usersCD8 absolute countsHIV-1 seroconvertersProgression of immunodeficiencyLevels of CD4Intravenous drug useT lymphocyte subpopulationsFirst prospective studyHIV-1 infectionTime of seroconversionSignificant differencesEarly intervention programsHIV infectionHIV progressionOutpatient clinicProspective study
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