2023
A Case of West Nile Encephalitis: Neuroimaging Findings and Clinico-Radiological Mismatch
Mikhaiel J, Mckenzie A, Saab L, Zubair A. A Case of West Nile Encephalitis: Neuroimaging Findings and Clinico-Radiological Mismatch. Cureus 2023, 15: e49727. PMID: 38161903, PMCID: PMC10757579, DOI: 10.7759/cureus.49727.Peer-Reviewed Original ResearchWest Nile neuroinvasive diseaseMagnetic resonance imagingWest Nile encephalitisNeuroinvasive diseaseCerebrospinal fluidNeurologic sequelaeArthropod-borne RNA virusRepeat magnetic resonance imagingLong-term neurologic sequelaeWhite matter signal changesAnti-seizure medicationsDiagnosis of sequelaeMonths of headacheFavorable clinical outcomeWhite matter signal hyperintensitiesAcute flaccid paralysisWhite matter changesNine-month followLimited clinical symptomsT2-weighted magnetic resonance imagesSignal intensity abnormalitiesSevere neurological diseaseGeneralized weaknessLymphocytic pleocytosisFurther seizuresAge-related, multivariate associations between white matter microstructure and behavioral performance in three executive function domains
Anderson J, Calhoun V, Pearlson G, Hawkins K, Stevens M. Age-related, multivariate associations between white matter microstructure and behavioral performance in three executive function domains. Developmental Cognitive Neuroscience 2023, 64: 101318. PMID: 37875033, PMCID: PMC10618425, DOI: 10.1016/j.dcn.2023.101318.Peer-Reviewed Original ResearchConceptsExecutive function domainsResponse inhibitionWhite matter microstructureLower response inhibitionStructure-cognition relationshipsEF abilitiesBehavioral performanceCognitive imbalanceNeurocognitive testsFunction domainTest performanceYoung adulthoodFractional anisotropyBrain changesAge 12Young adultsSS performanceWhite matter FA valuesGreater relianceWhite matter changesWhite matter microstructural differencesSubjects ages 12White matter skeletonIndependent componentsMultivariate associationsCognitive, imaging, and psychiatric changes associated with chronic toluene use: case report and literature review
Jupina M, Weleff J, Harp J, Anand A. Cognitive, imaging, and psychiatric changes associated with chronic toluene use: case report and literature review. Journal Of Addictive Diseases 2023, 42: 556-566. PMID: 37503800, DOI: 10.1080/10550887.2023.2229735.Peer-Reviewed Original ResearchInhalant use disorderUse disorderToluene misuseEvidence-based treatmentsFlat affectVisuospatial functionNeurocognitive deficitsComplex cognitionPsychiatric consequencesPsychiatric deficitsPsychiatric effectsWhite matter changesEffects of tolueneMisuse inhalantsImpact adolescentsDeficitsMatter changesDisordersCognitionInhaler misuseLoss of gray-white matter differentiationDiffuse white matter changesGray-white matter differentiationMisuseCorpus callosum thinning
2021
Transgenic rat models for cerebral amyloid angiopathy type‐1 and ‐2 and related vascular cognitive impairment and dementia (VCID)
Van Nostrand W, Xu F, Lee H, Robinson J, Benveniste H. Transgenic rat models for cerebral amyloid angiopathy type‐1 and ‐2 and related vascular cognitive impairment and dementia (VCID). Alzheimer's & Dementia 2021, 17 DOI: 10.1002/alz.051368.Peer-Reviewed Original ResearchCerebral amyloid angiopathyType 2 ratsWhite matter lossType 1 ratsMonths of ageCAA type 1Vascular cognitive impairmentTransgenic rat modelMagnetic resonance imagingType 1CAA pathologyCerebral microbleedsPathological featuresRat modelTypes of CAAType 2Cognitive impairmentCerebral small vessel diseaseHistological analysisNovel transgenic rat modelSmall vessel diseaseWhite matter changesReliable preclinical modelsCognitive changesParticular pathological featuresWhite matter changes in psychosis risk relate to development and are not impacted by the transition to psychosis
Di Biase MA, Cetin-Karayumak S, Lyall AE, Zalesky A, Cho KIK, Zhang F, Kubicki M, Rathi Y, Lyons MG, Bouix S, Billah T, Anticevic A, Schleifer C, Adkinson BD, Ji JL, Tamayo Z, Addington J, Bearden CE, Cornblatt BA, Keshavan MS, Mathalon DH, McGlashan TH, Perkins DO, Cadenhead KS, Tsuang MT, Woods SW, Stone WS, Shenton ME, Cannon TD, Pasternak O. White matter changes in psychosis risk relate to development and are not impacted by the transition to psychosis. Molecular Psychiatry 2021, 26: 6833-6844. PMID: 34024906, PMCID: PMC8611104, DOI: 10.1038/s41380-021-01128-8.Peer-Reviewed Original ResearchConceptsClinical high riskWhite matter changesWhite matter microstructureHigh riskMatter changesCHR individualsAge-related white matter changesNorth American Prodrome Longitudinal StudyEmergence of psychosisWhite matter abnormalitiesYears of ageImpact of ageIllness onsetExtracellular free waterHealthy controlsLongitudinal cohortCHR subjectsMagnetic resonance imaging dataProspective analysisRegional fatLinear mixed effects modelsHigh fatPsychosisFractional anisotropyBaseline measures
2019
Alterations in White Matter Network and Microstructural Integrity Differentiate Parkinson’s Disease Patients and Healthy Subjects
Koirala N, Anwar A, Ciolac D, Glaser M, Pintea B, Deuschl G, Muthuraman M, Groppa S. Alterations in White Matter Network and Microstructural Integrity Differentiate Parkinson’s Disease Patients and Healthy Subjects. Frontiers In Aging Neuroscience 2019, 11: 191. PMID: 31404311, PMCID: PMC6676803, DOI: 10.3389/fnagi.2019.00191.Peer-Reviewed Original ResearchPD patientsHealthy subject groupParkinson's diseaseNetwork-based statisticsDisease patientsHealthy controlsHealthy subjectsWhite matterMiddle-aged healthy controlsNetwork alterationsProbabilistic tractography analysisParkinson's disease patientsWhite matter changesSubject groupsWhite matter microstructural integrityElderly healthy controlsDistinct brain areasPD pathophysiologyWhite matter networksCorticospinal tractCorpus callosumCorona radiataMatter changesPatientsBrain areas
2013
Rituximab, Methotrexate, Procarbazine, and Vincristine Followed by Consolidation Reduced-Dose Whole-Brain Radiotherapy and Cytarabine in Newly Diagnosed Primary CNS Lymphoma: Final Results and Long-Term Outcome
Morris PG, Correa DD, Yahalom J, Raizer JJ, Schiff D, Grant B, Grimm S, Lai RK, Reiner AS, Panageas K, Karimi S, Curry R, Shah G, Abrey LE, DeAngelis LM, Omuro A. Rituximab, Methotrexate, Procarbazine, and Vincristine Followed by Consolidation Reduced-Dose Whole-Brain Radiotherapy and Cytarabine in Newly Diagnosed Primary CNS Lymphoma: Final Results and Long-Term Outcome. Journal Of Clinical Oncology 2013, 31: 3971-3979. PMID: 24101038, PMCID: PMC5569679, DOI: 10.1200/jco.2013.50.4910.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAntibodies, Monoclonal, Murine-DerivedAntineoplastic Combined Chemotherapy ProtocolsCentral Nervous System NeoplasmsChemoradiotherapyCranial IrradiationCytarabineDisease-Free SurvivalFemaleHumansLymphomaMaleMethotrexateMiddle AgedProcarbazineRituximabTimeTreatment OutcomeVincristineConceptsProgression-free survivalMedian progression-free survivalMedian overall survivalPrimary CNS lymphomaOverall survivalR-MPVComplete responseCNS lymphomaMedian Karnofsky performance scoreMulticenter phase II studyLong-term disease controlEnd pointApparent diffusion coefficientExploratory end pointsKarnofsky performance scorePhase II studyPrimary end pointWhole brain radiotherapyLong-term outcomesWhite matter changesHigh response rateInduction chemotherapyStandard WBRTBrain radiotherapyII studyAnti-epileptogenesis: Electrophysiology, diffusion tensor imaging and behavior in a genetic absence model
van Luijtelaar G, Mishra AM, Edelbroek P, Coman D, Frankenmolen N, Schaapsmeerders P, Covolato G, Danielson N, Niermann H, Janeczko K, Kiemeneij A, Burinov J, Bashyal C, Coquillette M, Lüttjohann A, Hyder F, Blumenfeld H, van Rijn CM. Anti-epileptogenesis: Electrophysiology, diffusion tensor imaging and behavior in a genetic absence model. Neurobiology Of Disease 2013, 60: 126-138. PMID: 23978468, PMCID: PMC3952020, DOI: 10.1016/j.nbd.2013.08.013.Peer-Reviewed Original ResearchConceptsDays post treatmentWAG/Rij ratsCritical treatment periodDuration of ADDepressive-like behaviorDepressive-like symptomsEarly pharmacological treatmentPost treatmentTreatment of patientsWhite matter changesGenetic absence modelCortical network activityDiffusion tensor imagingChronic epilepsySymptom onsetInternal capsulaCortical excitabilityPharmacological treatmentDecreased immobilitySwim testControl ratsTreatment periodCorpus callosumMatter changesPotential amplitude
2012
Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers
Patel KT, Stevens MC, Pearlson GD, Winkler AM, Hawkins KA, Skudlarski P, Bauer LO. Default mode network activity and white matter integrity in healthy middle-aged ApoE4 carriers. Brain Imaging And Behavior 2012, 7: 60-67. PMID: 23011382, DOI: 10.1007/s11682-012-9187-y.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnxietyApolipoprotein E4BrainData Interpretation, StatisticalDepressionDiffusion Tensor ImagingDNAFemaleGenotypeHeterozygoteHumansImage Processing, Computer-AssistedIntelligence TestsMagnetic Resonance ImagingMaleMiddle AgedNerve NetNeuropsychological TestsPrincipal Component AnalysisSmokingWechsler ScalesConceptsAPOE4 carriersMagnetic resonance imagingAlzheimer's diseaseFractional anisotropyFunctional MRI abnormalitiesUnderlying neuropathologic changesWhite matter fractional anisotropyWhite matter changesDefault mode network connectivityDefault mode network activityGenetic risk factorsMode network connectivityMiddle-aged adultsWhite matter integrityMRI abnormalitiesNeuropathologic changesRisk factorsApolipoprotein EMatter changesCognitive declineResonance imagingOlder ageFunctional connectivityGenetic riskDMN regions
2007
Fractal dimension and white matter changes in multiple sclerosis
Esteban F, Sepulcre J, de Mendizábal N, Goñi J, Navas J, de Miras J, Bejarano B, Masdeu J, Villoslada P. Fractal dimension and white matter changes in multiple sclerosis. NeuroImage 2007, 36: 543-549. PMID: 17499522, DOI: 10.1016/j.neuroimage.2007.03.057.Peer-Reviewed Original ResearchConceptsMultiple sclerosisHealthy controlsCentrum semiovale levelWhite matterConventional MR imagingGray-white matter interfaceMR imaging sectionsVoxel-based morphometry approachCentral nervous systemConventional magnetic resonanceWhite matter changesWM abnormalitiesPatientsMR imagingMS lesionsNervous systemBrain white matterMatter changesMagnetic resonanceNAWMBrain WMBrains of patientsLesionsBrainEarly phase
2005
HIV leucoencephalopathy and TNFα expression in neurones
Rostasy K, Monti L, Lipton S, Hedreen J, Gonzalez R, Navia B. HIV leucoencephalopathy and TNFα expression in neurones. Journal Of Neurology Neurosurgery & Psychiatry 2005, 76: 960. PMID: 15965202, PMCID: PMC1739718, DOI: 10.1136/jnnp.2004.036889.Peer-Reviewed Original ResearchMeSH KeywordsAdultAIDS Dementia ComplexAnti-Retroviral AgentsBasal GangliaBiopsyBrainDiffusion Magnetic Resonance ImagingDisease ProgressionFollow-Up StudiesFrontal LobeHIV Envelope Protein gp41HumansMacrophagesMaleMicrogliaMiddle AgedNeurologic ExaminationNeuronsNeuropsychological TestsSaquinavirStavudineTreatment OutcomeTumor Necrosis Factor-alphaZidovudineConceptsAIDS dementia complexPathogenesis of ADCImaging studiesMicroglia/macrophage activationProgressive formDeep white matter changesMicroglia/macrophagesExpression of TNFalphaWhite matter changesNecrosis factor alphaMeans of immunohistochemistryViral protein expressionNeuroradiological featuresAntiretroviral treatmentHIV infectionThird patientBrain biopsyProgressive dementiaDementia complexTreatment regimensBasal gangliaClinical historyFactor alphaTNFα expressionFrontal cortex
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