2025
Neighborhood social fragmentation in relation to impaired mismatch negativity among youth at clinical high risk for psychosis and healthy comparisons
Ku B, Hamilton H, Yuan Q, Parker D, Roach B, Bachman P, Belger A, Carrión R, Duncan E, Johannesen J, Light G, Niznikiewicz M, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Perkins D, Stone W, Woods S, Walker E, Mathalon D. Neighborhood social fragmentation in relation to impaired mismatch negativity among youth at clinical high risk for psychosis and healthy comparisons. Neuropsychopharmacology 2025, 1-9. PMID: 40175526, DOI: 10.1038/s41386-025-02093-4.Peer-Reviewed Original ResearchNeighbourhood social fragmentationClinical high riskCHR-PMismatch negativitySocial fragmentationHealthy comparisonDouble-deviant MMNHigh riskCHR-P groupImpaired mismatch negativityMismatch negativity impairmentsSchizophrenia-like behaviorsMMN-like responsesAuditory oddball paradigmParental history of psychosisHigh-risk individualsHistory of psychosisNorth American Prodrome Longitudinal Study Phase 2Pitch-deviantsMMN amplitudeStudy phase 2Animal studiesParental historyOddball paradigmNeighborhood povertyThe role of childhood social fragmentation and perceived discrimination on maladaptive core schemas later in life among young adults at clinical high risk for psychosis and healthy comparisons
Diomino A, Yuan Q, Cadenhead K, Addington J, Bearden C, Cannon T, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S, Ku B. The role of childhood social fragmentation and perceived discrimination on maladaptive core schemas later in life among young adults at clinical high risk for psychosis and healthy comparisons. Schizophrenia Research 2025, 279: 71-78. PMID: 40174486, PMCID: PMC12035737, DOI: 10.1016/j.schres.2025.03.023.Peer-Reviewed Original ResearchConceptsClinical high riskCore schemasHealthy comparisonNeighbourhood social fragmentationNorth American Prodrome Longitudinal Study 2Perceived DiscriminationSocial fragmentationIn adulthoodNegative-self schemaPoor social functioningCross-sectional studyLongitudinal Study 2High riskU.S. Census dataNegative-selfStudy 2Design interventionsSchema formationSocial functioningPsychosisBaseline dataYoung adultsCensus dataAdulthoodChildhoodRelations of temporoparietal connectivity with neighborhood social fragmentation in youth at clinical high-risk for psychosis
Aberizk K, Sefik E, Yuan Q, Cao H, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Woods S, Walker E, Ku B. Relations of temporoparietal connectivity with neighborhood social fragmentation in youth at clinical high-risk for psychosis. Schizophrenia Research 2025, 277: 151-158. PMID: 40068446, PMCID: PMC11970632, DOI: 10.1016/j.schres.2025.02.012.Peer-Reviewed Original ResearchConceptsClinical high riskCHR-PCHR-P.Functional connectivityNorth American Prodrome Longitudinal StudyPatterns of brain connectivitySchizophrenia spectrum conditionsSocial engagementAutobiographical memory recallTemporoparietal brain regionsSuperior temporal poleBrain functional correlatesHippocampal functional connectivityTemporoparietal brain areasNeighbourhood social fragmentationArea-level characteristicsTemporal lobe abnormalitiesSocial fragmentationHealthy comparisonPsychotic disordersNeurobiological mechanismsHigh riskTemporal poleMemory recallBrain areas
2024
Neighborhood ethnoracial diversity and positive psychotic symptoms among youth at high-risk and healthy comparisons
Ku B, Yuan Q, Haardörfer R, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Woods S, Druss B, Walker E, Anglin D. Neighborhood ethnoracial diversity and positive psychotic symptoms among youth at high-risk and healthy comparisons. Psychiatry Research 2024, 342: 116222. PMID: 39378539, PMCID: PMC11617269, DOI: 10.1016/j.psychres.2024.116222.Peer-Reviewed Original ResearchHealthy comparisonPositive symptomsCHR-PPeer victimizationNorth American Prodrome Longitudinal StudyScale of Prodromal SymptomsAttenuated positive symptomsPositive psychotic symptomsClinical high riskFewer life eventsAssociated with schizophreniaEthnoracial diversityPsychotic symptomsHigh riskPrevent psychosisDepressive symptomsStructural equation modelingLife eventsProdromal symptomsPsychosisDiscriminatory experiencesEthnoracial minoritiesSocial determinantsNeighborhood povertyEthnoracial groupsCognitive performance in functional seizures compared with epilepsy and healthy controls: a systematic review and meta analysis
Van Patten R, Austin T, Cotton E, Chan L, Bellone J, Mordecai K, Altalib H, Correia S, Twamley E, Jones R, Sawyer K, LaFrance W. Cognitive performance in functional seizures compared with epilepsy and healthy controls: a systematic review and meta analysis. The Lancet Psychiatry 2024, 11: 516-525. PMID: 38879275, DOI: 10.1016/s2215-0366(24)00132-9.Peer-Reviewed Original ResearchConceptsRisk of biasSystematic reviewHealthy comparisonGlobal cognitionMeta-analysisCognitive performanceDepartment of Veterans AffairsVeterans Health AdministrationFunctional seizuresIndividual studiesCognitive domainsModerate effect sizeProportion of womenNewcastle-Ottawa ScaleLeft Temporal Lobe EpilepsyWeb of ScienceCognitive test dataWidespread cognitive impairmentVeterans AffairsEffects of multiple covariatesHealth AdministrationGrey literatureSeizure groupNewcastle-OttawaInclusion criteriaDeficits in prefrontal metabotropic glutamate receptor 5 are associated with functional alterations during emotional processing in bipolar disorder
Asch R, Worhunsky P, Davis M, Holmes S, Cool R, Boster S, Carson R, Blumberg H, Esterlis I. Deficits in prefrontal metabotropic glutamate receptor 5 are associated with functional alterations during emotional processing in bipolar disorder. Journal Of Affective Disorders 2024, 361: 415-424. PMID: 38876317, PMCID: PMC11250898, DOI: 10.1016/j.jad.2024.06.025.Peer-Reviewed Original ResearchMetabotropic glutamate receptor 5Bipolar disorderGlutamate receptor 5Positron emission tomographyFear processingEmotional processingAssociated with greater activationEmotion processing taskAssociated with impulsivityFunctional brain differencesAssociated with functional alterationsParietal brain regionsPathology of BDIncreased cortical activityAssociated with difficultiesDepressive disorderHealthy comparisonReceptor availabilityBrain differencesPre/postcentral gyriAttention difficultiesGreater activationBrain regionsPsychomotor functionTreatment development
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