2020
A Network of Sputum MicroRNAs is Associated with Neutrophilic Airway Inflammation in Asthma
Gomez JL, Chen A, Diaz MP, Zirn N, Gupta A, Britto C, Sauler M, Yan X, Stewart E, Santerian K, Grant N, Liu Q, Fry R, Rager J, Cohn L, Alexis N, Chupp GL. A Network of Sputum MicroRNAs is Associated with Neutrophilic Airway Inflammation in Asthma. American Journal Of Respiratory And Critical Care Medicine 2020, 0: 51-64. PMID: 32255668, PMCID: PMC7328332, DOI: 10.1164/rccm.201912-2360oc.Peer-Reviewed Original ResearchConceptsEndoplasmic reticulum stressAirway inflammationNeutrophil countClinical featuresT-helper cell type 17Neutrophilic airway inflammationReticulum stressSputum of subjectsLung function impairmentHistory of hospitalizationNumber of neutrophilsPeripheral blood neutrophilsSputum of patientsMicroRNA expressionAsthma severityTh17 pathwayFunction impairmentAirway samplesMicroRNA networkBlood neutrophilsOzone exposureAsthmaSputumCellular sourceClinical phenotype
2019
Opposing Gradients of MicroRNA Expression Temporally Pattern Layer Formation in the Developing Neocortex
Shu P, Wu C, Ruan X, Liu W, Hou L, Fu H, Wang M, Liu C, Zeng Y, Chen P, Yin B, Yuan J, Qiang B, Peng X, Zhong W. Opposing Gradients of MicroRNA Expression Temporally Pattern Layer Formation in the Developing Neocortex. Developmental Cell 2019, 49: 764-785.e4. PMID: 31080058, DOI: 10.1016/j.devcel.2019.04.017.Peer-Reviewed Original Research
2018
Characterization of hepatocellular adenoma and carcinoma using microRNA profiling and targeted gene sequencing
Zheng J, Sadot E, Vigidal J, Klimstra D, Balachandran V, Kingham T, Allen P, D’Angelica M, DeMatteo R, Jarnagin W, Ventura A. Characterization of hepatocellular adenoma and carcinoma using microRNA profiling and targeted gene sequencing. PLOS ONE 2018, 13: e0200776. PMID: 30052636, PMCID: PMC6063411, DOI: 10.1371/journal.pone.0200776.Peer-Reviewed Original ResearchMeSH KeywordsAdenoma, Liver CellAdultAgedAged, 80 and overbeta CateninBiomarkers, TumorCarcinoma, HepatocellularCluster AnalysisDNA Mutational AnalysisFemaleGene Expression Regulation, NeoplasticHumansImmunohistochemistryInflammationLiver NeoplasmsMaleMicroRNAsMiddle AgedPilot ProjectsSequence Analysis, DNASequence Analysis, RNAConceptsMiR-490-3pMiR-520c-3pMiR-515-5pMicroRNA profilesMiR-490MiR-515MiR-1180MiR-766MiR-429MiR-518bMiR-200aMiR-452MiR-517aDrivers of hepatocarcinogenesisMiRNA clusterMicroRNAsMicroRNA expressionHepatocellular adenomaHepatocellular carcinomaMiRNAsNon-neoplastic liverTargeted gene sequencingNormal liverBenign liver tumorsNon-tumor liver tissues
2017
The Role of microRNA Expression in Cortical Development During Conversion to Psychosis
Zheutlin AB, Jeffries CD, Perkins DO, Chung Y, Chekroud AM, Addington J, Bearden CE, Cadenhead KS, Cornblatt BA, Mathalon DH, McGlashan TH, Seidman LJ, Walker EF, Woods SW, Tsuang M, Cannon TD. The Role of microRNA Expression in Cortical Development During Conversion to Psychosis. Neuropsychopharmacology 2017, 42: 2188-2195. PMID: 28186095, PMCID: PMC5603810, DOI: 10.1038/npp.2017.34.Peer-Reviewed Original ResearchConceptsNorth American Prodrome Longitudinal StudyCortical thinningDisease onsetClinical high-risk individualsProinflammatory cytokine levelsHigh-risk individualsGray matter reductionsOnset of psychosisCortical gray matter reductionMicroRNA expressionMicroglial actionCytokine levelsProinflammatory cytokinesCortical maturationImmune cellsHealthy controlsInflammatory responsePeripheral leukocytesCortical developmentHigh riskImmune functionSynaptic plasticityImmune systemConversion statusResident macrophages
2016
Association of BRAFV600E Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers
Han PA, Kim HS, Cho S, Fazeli R, Najafian A, Khawaja H, McAlexander M, Dy B, Sorensen M, Aronova A, Sebo TJ, Giordano TJ, Fahey TJ, Thompson GB, Gauger PG, Somervell H, Bishop JA, Eshleman JR, Schneider EB, Witwer KW, Umbricht CB, Zeiger MA. Association of BRAFV600E Mutation and MicroRNA Expression with Central Lymph Node Metastases in Papillary Thyroid Cancer: A Prospective Study from Four Endocrine Surgery Centers. Thyroid 2016, 26: 532-542. PMID: 26950846, PMCID: PMC4827320, DOI: 10.1089/thy.2015.0378.Peer-Reviewed Original ResearchConceptsCentral lymph node metastasisCentral lymph node dissectionMultivariable logistic regression analysisPapillary thyroid cancerProphylactic central lymph node dissectionLogistic regression analysisLymph node dissectionAggressive clinicopathologic featuresLymph node metastasisEndocrine surgery centersStand-alone markerClinicopathologic featuresMiR-146bNode dissectionIndependent predictorsNode metastasisMiR-222Surgery centersThyroid cancerProphylactic lymph node dissectionRegression analysisIndividual prognostic markersOnly preoperative variablesNode-negative casesMicroRNA expression
2010
Comprehensive Analysis of Rhesus Lymphocryptovirus MicroRNA Expression
Riley K, Rabinowitz GS, Steitz JA. Comprehensive Analysis of Rhesus Lymphocryptovirus MicroRNA Expression. Journal Of Virology 2010, 84: 5148-5157. PMID: 20219930, PMCID: PMC2863793, DOI: 10.1128/jvi.00110-10.Peer-Reviewed Original Research
2007
MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia
Mi S, Lu J, Sun M, Li Z, Zhang H, Neilly MB, Wang Y, Qian Z, Jin J, Zhang Y, Bohlander SK, Le Beau MM, Larson RA, Golub TR, Rowley JD, Chen J. MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia. Proceedings Of The National Academy Of Sciences Of The United States Of America 2007, 104: 19971-19976. PMID: 18056805, PMCID: PMC2148407, DOI: 10.1073/pnas.0709313104.Peer-Reviewed Original ResearchConceptsAcute myeloid leukemiaAcute lymphoblastic leukemiaLymphoblastic leukemiaAcute leukemiaMyeloid leukemiaExpression signaturesCommon acute leukemiaCommon childhood cancerCommon cytogenetic subtypeMicroRNA expression signatureNormal control samplesAcute leukemia samplesBetter prognosisChildhood cancerReal-time PCRCytogenetic subtypesMiR-223LeukemiaMiR-128aLeukemia samplesPromoter hypomethylationMiR-128MicroRNA expressionDiagnosisRegulation of expression
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