2023
Distinct neural networks predict cocaine versus cannabis treatment outcomes
Lichenstein S, Kohler R, Ye F, Potenza M, Kiluk B, Yip S. Distinct neural networks predict cocaine versus cannabis treatment outcomes. Molecular Psychiatry 2023, 28: 3365-3372. PMID: 37308679, PMCID: PMC10713861, DOI: 10.1038/s41380-023-02120-0.Peer-Reviewed Original ResearchConceptsConnectome-based predictive modelingCognitive behavior therapyCognitive behavioral therapySubstance use disordersCannabis abstinenceNeural mechanismsBehavior therapyDistinct neural networksComputer-based trainingCannabis use disorderFMRI scanningNeural predictorsStudy 1Study 2Treatment outcomesContingency managementPrior workComparison subjectsNetwork strengthUse disordersNovel treatment targetsAbstinenceIndependent samplesCocaine abstinenceTreatment respondersOxytocin as a Biomarker of Differential Effects to SPACE vs. CBT Treatment of Child Anxiety Disorders
Zilcha-Mano S, Orbach M, Malka M, Lebowitz E. Oxytocin as a Biomarker of Differential Effects to SPACE vs. CBT Treatment of Child Anxiety Disorders. Journal Of Clinical Child & Adolescent Psychology 2023, 54: 220-228. PMID: 37166402, PMCID: PMC10638466, DOI: 10.1080/15374416.2023.2188557.Peer-Reviewed Original ResearchSalivary OT levelsLine of researchAnxiety treatmentPositive mother-child interactionsChild anxiety treatmentChild anxiety disordersChildhood anxiety treatmentMother-child interactionMother-child dyadsHigher baseline levelsChildhood anxietyCBT treatmentGreater treatment efficacyDyadic interactionsAnxiety disordersTarget of treatmentOutcome moderatorsDisorder ScalePeripheral oxytocinEmotional Disorders (SCARED) scaleOT levelsNovel treatment targetsCBTModeratorMixed results
2022
Accelerated cortical thinning precedes and predicts conversion to psychosis: The NAPLS3 longitudinal study of youth at clinical high-risk
Collins M, Ji J, Chung Y, Lympus C, Afriyie-Agyemang Y, Addington J, Goodyear B, Bearden C, Cadenhead K, Mirzakhanian H, Tsuang M, Cornblatt B, Carrión R, Keshavan M, Stone W, Mathalon D, Perkins D, Walker E, Woods S, Powers A, Anticevic A, Cannon T. Accelerated cortical thinning precedes and predicts conversion to psychosis: The NAPLS3 longitudinal study of youth at clinical high-risk. Molecular Psychiatry 2022, 28: 1182-1189. PMID: 36434057, PMCID: PMC10005940, DOI: 10.1038/s41380-022-01870-7.Peer-Reviewed Original ResearchConceptsCHR-NCPercent thickness changeCortical thinningPsychosis onsetHealth controlsProgressive grey matter lossNorth American Prodrome Longitudinal StudyClinical high-risk individualsGray matter lossHigh-risk individualsLongitudinal studyGreater percent decreaseNovel treatment targetsParietal cortical regionsTargeted early interventionsCortical thicknessCortical areasMRI scansCHR individualsTreatment targetsEarly interventionCortical regionsLeft hemisphere regionsROC analysisHC participantsInhibition of MEK-ERK signaling reduces seizures in two mouse models of tuberous sclerosis complex
Nguyen LH, Leiser SC, Song D, Brunner D, Roberds SL, Wong M, Bordey A. Inhibition of MEK-ERK signaling reduces seizures in two mouse models of tuberous sclerosis complex. Epilepsy Research 2022, 181: 106890. PMID: 35219048, PMCID: PMC8930622, DOI: 10.1016/j.eplepsyres.2022.106890.Peer-Reviewed Original ResearchConceptsTuberous sclerosis complexMouse modelTSC mouse modelsDevelopmental brain malformationsMEK-ERKNovel treatment targetsMEK inhibitor PD0325901Intractable epilepsySeizure activityTSC patientsSeizure suppressionBrain malformationsMTOR inhibitorsTreatment targetsMEK-ERK activitySeizuresTSC neuropathologyPotential alternative strategyMEK-ERK inhibitionInhibitor PD0325901Monogenic disordersInhibitionMTORTreatmentEverolimus
2021
Leveraging big data to map neurodevelopmental trajectories in pediatric anxiety
Zacharek SJ, Kribakaran S, Kitt ER, Gee DG. Leveraging big data to map neurodevelopmental trajectories in pediatric anxiety. Developmental Cognitive Neuroscience 2021, 50: 100974. PMID: 34147988, PMCID: PMC8225701, DOI: 10.1016/j.dcn.2021.100974.Peer-Reviewed Original ResearchConceptsPediatric anxietyNeurodevelopmental trajectoriesAnxiety disordersNormative brain developmentPrevalent psychiatric conditionAge-related differencesAnxious youthSafety learningUnderstanding of neurodevelopmentAnxietyInconsistent findingsBrain structuresLongitudinal studyNeural structuresPsychiatric conditionsNovel treatment targetsMarker of riskBrain developmentTreatment targetsEarly risk identificationYouthFuture directionsDisordersAdolescenceNeurobiologyEmotion and Emotion Preferences in Daily Life: The Role of Anxiety
Vanderlind WM, Everaert J, Caballero C, Cohodes EM, Gee DG. Emotion and Emotion Preferences in Daily Life: The Role of Anxiety. Clinical Psychological Science 2021, 10: 109-126. PMID: 35174008, PMCID: PMC8845725, DOI: 10.1177/21677026211009500.Peer-Reviewed Original ResearchEmotion preferencesEcological momentary assessmentTrait anxietyLow-anxiety counterpartsSymptom severityAnxiety symptom severityMeasures of anxietyRole of anxietyState emotionsEmotion dysfunctionIndividual differencesSubsequent anxietySevere anxiety symptomsState anxietyAnxiety symptomsMomentary assessmentEmotionsAnxietyCurrent findingsNovel treatment targetsGreater preferenceCurrent studyTreatment targetsDifferent associationsDaily life
2020
Understanding positive emotion deficits in depression: From emotion preferences to emotion regulation
Vanderlind WM, Millgram Y, Baskin-Sommers AR, Clark MS, Joormann J. Understanding positive emotion deficits in depression: From emotion preferences to emotion regulation. Clinical Psychology Review 2020, 76: 101826. PMID: 32058881, DOI: 10.1016/j.cpr.2020.101826.Peer-Reviewed Original ResearchConceptsPositive emotionsEmotion regulationEmotion preferencesNegative affectEmotion regulation strategy useEmotion regulation strategiesRegulation strategy useEmotion regulation modelUse of strategiesEmotion processesEmotion deficitsEmotion dysfunctionPositive affectRegulation strategiesIndividual differencesStrategy useImportant empirical gapEmotionsHabitual useAffectPrior researchRegulation modelNovel treatment targetsExtant literatureEmpirical gap
2019
The role of limited salience of speech in selective attention to faces in toddlers with autism spectrum disorders
Shic F, Wang Q, Macari SL, Chawarska K. The role of limited salience of speech in selective attention to faces in toddlers with autism spectrum disorders. Journal Of Child Psychology And Psychiatry 2019, 61: 459-469. PMID: 31471912, PMCID: PMC7048639, DOI: 10.1111/jcpp.13118.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderDirect gazeAutism symptomsSpectrum disorderImpact of speechAudiovisual speechSelective attentionSpeech cuesTD toddlersNonverbal skillsNonverbal levelEye contactEye trackingPoor attentionInteractive partnersEye regionMouth regionSpeechToddlersSalienceLimited salienceNovel treatment targetsEarly childhoodCuesTreatment targets
2017
Impaired Value Learning for Faces in Preschoolers With Autism Spectrum Disorder
Wang Q, DiNicola L, Heymann P, Hampson M, Chawarska K. Impaired Value Learning for Faces in Preschoolers With Autism Spectrum Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2017, 57: 33-40. PMID: 29301667, PMCID: PMC5757250, DOI: 10.1016/j.jaac.2017.10.014.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderNonsocial domainsNonsocial tasksSelective attentionSpectrum disorderValue learningSocial attention deficitsDomain-specific impairmentObject valuesTD childrenNonsocial conditionTD controlsTD groupAttention deficitsNonhuman primate studiesSelection of objectsSocial domainsSocial objectsTaskNovel treatment targetsPreschoolersGroup comparisonsPrimate studiesTreatment targetsChildren
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