2025
Infants’ Resting-State Functional Connectivity and Event-Related Potentials: A Multimodal Approach to Investigating the Neural Basis of Infant Novelty Detection
Kanel D, Morales S, Altman K, Richards J, Winkler A, Pine D, Fox N, Filippi C. Infants’ Resting-State Functional Connectivity and Event-Related Potentials: A Multimodal Approach to Investigating the Neural Basis of Infant Novelty Detection. Developmental Psychology 2025, 61: 1397-1411. PMID: 39760730, DOI: 10.1037/dev0001892.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingEvent-related potentialsEvent-related potential dataResting-state functional connectivityMismatch responsesFunctional connectivityRegions-of-interestRs-FCThree-stimulus auditory oddball taskResting-state functional magnetic resonance imagingFunctional magnetic resonance imaging dataSuperior parietal cortexPosterior cingulate cortexVentral attention networkSuperior parietal lobuleBilateral auditory corticesAuditory oddball taskNovelty detectionNovelty processingCingulate cortexNeural basisParietal lobuleNovel stimuliP3 responseSomatomotor networkSuccessful Evidence-Based Parenting Programs are Associated With Brain Changes and Improved Reward Processing in Boys With Conduct Problems
Sethi A, O’Brien S, Blair J, Viding E, Shani D, Robinson O, Mehta M, Ecker C, Petrinovic M, Catani M, Blackwood N, Doolan M, Murphy D, Scott S, Craig M. Successful Evidence-Based Parenting Programs are Associated With Brain Changes and Improved Reward Processing in Boys With Conduct Problems. Biological Psychiatry 2025 PMID: 40541593, DOI: 10.1016/j.biopsych.2025.06.008.Peer-Reviewed Original ResearchVentromedial prefrontal cortexAntisocial behaviorConduct problemsParenting behaviorsParenting interventionsAssociated with brain changesReward processing regionsReward learning taskPosterior cingulate cortexIncreased neural activityTask-based fMRIReinforcement learning parametersEarly interventionGroup parenting interventionEarly parenting interventionsReduce antisocial behaviorPersistent CPReward/punishment sensitivityInsula activationNeurocognitive mechanismsReward processingPrefrontal cortexCingulate cortexBrain changesAction biasExploring the Influence of Synaptic Density and Anxiety on Pain Perception: Evidence from a [11C]UCB-J PET Imaging Study
Moisieienko K, Asch R, Davis M, Pietrzak R, Esterlis I. Exploring the Influence of Synaptic Density and Anxiety on Pain Perception: Evidence from a [11C]UCB-J PET Imaging Study. The International Journal Of Neuropsychopharmacology 2025, pyaf040. PMID: 40511849, DOI: 10.1093/ijnp/pyaf040.Peer-Reviewed Original ResearchAnterior cingulate cortexDorsolateral prefrontal cortexFusiform gyrusAnxiety symptomsSV2A densitySynaptic densityState anxietyMediation analysisPain sensitivityAssociated with greater pain sensitivityAssociated with painState anxiety symptomsFunctional brain alterationsMedically healthy subjectsIndirect effectsPrefrontal cortexCingulate cortexPlasma input functionBrain alterationsOne-tissue compartment modelPET imaging studiesGyrusAnxietyRegional volumesHigher pain sensitivityDysregulated responses to stress and alcohol cues in cortico-striatal-limbic regions in social drinkers with early trauma
Heilner E, Sinha R, Eringros N, Constable R, Seo D. Dysregulated responses to stress and alcohol cues in cortico-striatal-limbic regions in social drinkers with early trauma. Journal Of Neural Transmission 2025, 1-16. PMID: 40500419, DOI: 10.1007/s00702-025-02961-9.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingAlcohol cuesEarly traumaSocial drinkersResponse to stressNeurobehavioral responses to stressDysregulated responses to stressNeutral cue exposureReward processing regionsReward-related disordersEmotional provocation taskPosterior cingulate cortexAlcohol-related disordersDecreased activityCraving ratingsDorsolateral PFCPrefrontal regulationAnterior PFCCue exposureReward processingEmotional reactivityPrefrontal regionsCingulate cortexNeural correlatesCue responsesBrain-wide connectivity changes due to social–emotional regulation during a naturalistic fMRI task
Hyatt C, Wexler B, Diefenbach G, Dichter G, Mazefsky C, Uscatescu L, Wolf J, Sahl R, Pittman B, Pearlson G, Assaf M. Brain-wide connectivity changes due to social–emotional regulation during a naturalistic fMRI task. Cerebral Cortex 2025, 35: bhaf118. PMID: 40401354, PMCID: PMC12096004, DOI: 10.1093/cercor/bhaf118.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexEmotion regulationFC differencesFunctional connectivityEmotion typeLeft temporoparietal junctionSocial emotion regulationLeft supramarginal gyrusMedial posterior regionsMultivariate pattern analysisSignificant FC differencesFMRI taskPrefrontal involvementER strategiesNegative stimuliReappraisal strategiesCingulate cortexNeutral storyTemporoparietal junctionSupramarginal gyrusFunctional neuroimagingNeural substratesFunctional MRISignificant emotionsSocial interactionContrasting patterns of extrasynaptic NMDAR-GluN2B expression in macaque subgenual cingulate and dorsolateral prefrontal cortices
Joyce M, Datta D, Arellano J, Duque A, Morozov Y, Morrison J, Arnsten A. Contrasting patterns of extrasynaptic NMDAR-GluN2B expression in macaque subgenual cingulate and dorsolateral prefrontal cortices. Frontiers In Neuroanatomy 2025, 19: 1553056. PMID: 40255911, PMCID: PMC12006084, DOI: 10.3389/fnana.2025.1553056.Peer-Reviewed Original ResearchSubgenual cingulate cortexDorsolateral prefrontal cortexPrefrontal cortexPutative pyramidal neuronsN-methyl-D-aspartate receptorsN-methyl-D-aspartateSporadic Alzheimer's diseaseSubgenual cingulateCingulate cortexWorking memoryMacaque dlPFCDLPFCNMDAR antagonistsGluN2B subunitVulnerable to alterationsCortexSynaptic expressionPyramidal neuronsSynaptic functionAlzheimer's diseaseNeurodegenerative processesExtrasynaptic sitesTau pathologySchizophreniaCingulateDiminished reward circuit response underlies pain avoidance learning deficits in problem drinkers
Le T, Oba T, Li C. Diminished reward circuit response underlies pain avoidance learning deficits in problem drinkers. NeuroImage Clinical 2025, 45: 103762. PMID: 40009903, PMCID: PMC11908557, DOI: 10.1016/j.nicl.2025.103762.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexAvoidance learningReward circuitDrinking severityReward deficiencyLearning deficitsPain avoidanceProblem drinkersAlcohol useAvoidance learning deficitMedial orbitofrontal cortexReward circuit dysfunctionVentral tegmental areaPoor avoidance learningAssociated with problem drinkingOrbitofrontal cortexTegmental areaGo/NoGo taskCingulate cortexNeural correlatesBehavioral findingsCircuit dysfunctionAdult drinkersBrain regionsNeural processesNeural, Motivational, and Psychological Measures of Pain Avoidance Predict Future Alcohol Use in Adult Drinkers
Le T, Hughes F, Oba T, Li C. Neural, Motivational, and Psychological Measures of Pain Avoidance Predict Future Alcohol Use in Adult Drinkers. Addiction Biology 2025, 30: e70020. PMID: 39952897, PMCID: PMC11828665, DOI: 10.1111/adb.70020.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexDrinking motivesAlcohol usePsychological measuresPercentage of heavy drinking daysRisk of alcohol use disorderAlcohol use severityAnterior cingulate cortexHeavy drinking daysAlcohol use disorderPain-related psychological measuresParticipants' alcohol usePromote alcohol usePainful electric shocksLevels of drinkingPain sensitivityAlcohol cravingDrinking severityGo/NoGo taskCingulate cortexNeural correlatesDrinking daysUse disorderAdult drinkersOvert actionsTHE ANTERIOR CINGULATE CORTEX LINKS SEROTONIN TRANSPORTER GENETICS AND EMOTION PROCESSING
Kloebl *, Murgaš M, Reed M, Silberbauer L, Hartmann A, Godbersen G, Hahn A, Gryglewski G, Rujescu D, Lanzenberger R. THE ANTERIOR CINGULATE CORTEX LINKS SEROTONIN TRANSPORTER GENETICS AND EMOTION PROCESSING. The International Journal Of Neuropsychopharmacology 2025, 28: i18-i19. PMCID: PMC11814669, DOI: 10.1093/ijnp/pyae059.032.Peer-Reviewed Original ResearchAnterior cingulate cortex activationAnterior cingulate cortexEmotional processingSerotonin reuptake inhibitorsSerotonin transporterSerotonin transporter expressionBrain functionHappy facesNeutral facesCingulate cortexReuptake inhibitorsBrain activitySerotonin transporter binding potentialMeasures of emotional processingSingle nucleotide polymorphism rs25531Anterior cingulate cortex connectivityImpact of 5-HTTLPRAssess attributional styleSituational Attributions QuestionnaireAcute tryptophan depletionFacial emotion processingIncreased amygdala activationSerotonin transporter bindingSerotonin transporter polymorphismEffect of citalopramUnderstanding depression in autism: the role of subjective perception and anterior cingulate cortex volume
Hao Y, Banker S, Trayvick J, Barkley S, Peters A, Thinakaran A, McLaughlin C, Gu X, Schiller D, Foss-Feig J. Understanding depression in autism: the role of subjective perception and anterior cingulate cortex volume. Molecular Autism 2025, 16: 9. PMID: 39930465, PMCID: PMC11812218, DOI: 10.1186/s13229-025-00638-4.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexAutism spectrum disorderSelf-reported depressionAnterior cingulate cortex volumeCo-occurring depressionAmygdala volumeAutism symptomsSocial functioningCingulate cortex volumeSocial interaction taskSocial interactionSocial interaction behaviorClinically diagnosed depressionHeterogeneity of autism spectrum disorderSubjective perceptionHeightened self-awarenessAutistic young adultsASD adultsDepressive phenotypeSocial deficitsCingulate cortexCross-sectional natureSocial impairmentPrevalence of depressionASD individualsPolygenic risk for depression and resting-state functional connectivity of subgenual anterior cingulate cortex in young adults
Chen Y, Li H, Luo X, Li G, Ide J, Li C. Polygenic risk for depression and resting-state functional connectivity of subgenual anterior cingulate cortex in young adults. Journal Of Psychiatry And Neuroscience 2025, 50: e31-e44. PMID: 39809531, PMCID: PMC11737878, DOI: 10.1503/jpn.240087.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityPolygenic risk scoresSubgenual anterior cingulate cortexAnterior cingulate cortexDepression severityCingulate cortexSubclinical depressionHealthy young adultsSomatic complaintsYoung adultsPolygenic riskAssociated with depression severitySeverity of somatic complaintsSeverity of depressive symptomsAssociated with polygenic riskWhole-brain regressionAlcohol use severityMarkers of depressionManifestations of depressionHuman Connectome ProjectDepressive disorderSubclinical populationsMode networkDepressive symptomsBrain structuresDifferential gray matter correlates and machine learning prediction of abuse and internalizing psychopathology in adolescent females
Heyn S, Keding T, Cisler J, McLaughlin K, Herringa R. Differential gray matter correlates and machine learning prediction of abuse and internalizing psychopathology in adolescent females. Scientific Reports 2025, 15: 651. PMID: 39753729, PMCID: PMC11698963, DOI: 10.1038/s41598-024-84616-5.Peer-Reviewed Original ResearchConceptsGray matter volumeVoxel-based morphometryInternalizing psychopathologyChildhood abuseAbuse experiencesPrefrontal cortexCingulate cortexAssociated with increased GMVVoxel-based morphometry analysisInterpersonal violenceDorsal prefrontal cortexDevelopment of psychopathologyAnterior cingulate cortexChildhood abuse historyChildhood abuse exposureT1 structural MRIDifferentiating gray matterPredictive of abuseAdolescent femalesSeverity of abuseDegree of overlapSupramarginal gyrusTrauma exposureStudy of interpersonal violenceIndividual psychopathology
2024
Exploration of (R)-[11C]YH168 as a PET tracer for imaging monoacylglycerol lipase in the brain: from mice to non-human primates
He Y, Zheng M, Gu J, Reichert L, Trimborn J, Zhang H, Keller C, Crosby M, Collin L, Heer D, Pavlovic A, Topp A, Wittwer M, Grether U, Gobbi L, Schibli R, Huang Y, Mu L. Exploration of (R)-[11C]YH168 as a PET tracer for imaging monoacylglycerol lipase in the brain: from mice to non-human primates. European Journal Of Nuclear Medicine And Molecular Imaging 2024, 52: 1556-1565. PMID: 39673602, PMCID: PMC11839854, DOI: 10.1007/s00259-024-07013-0.Peer-Reviewed Original ResearchMonoacylglycerol lipaseNon-human primatesIn vitro autoradiographyBrain regionsMice to non-human primatesMAGL knockoutNon-displaceable binding potentialRhesus monkeysNon-human primate brainRegional non-displaceable binding potentialsRegional time-activity curvesMouse brainCingulate cortexFrontal cortexEndocannabinoid systemLevels of radioactive uptakeMouse brain slicesOccipital cortexBrains of miceOne-tissue compartment modelBinding potentialMAGL expressionPET scansKnockout micePrimate brainSingle-nucleus multi-omics analyses reveal cellular and molecular innovations in the anterior cingulate cortex during primate evolution
Yuan J, Dong K, Wu H, Zeng X, Liu X, Liu Y, Dai J, Yin J, Chen Y, Guo Y, Luo W, Liu N, Sun Y, Zhang S, Su B. Single-nucleus multi-omics analyses reveal cellular and molecular innovations in the anterior cingulate cortex during primate evolution. Cell Genomics 2024, 4: 100703. PMID: 39631404, PMCID: PMC11701334, DOI: 10.1016/j.xgen.2024.100703.Peer-Reviewed Original ResearchConceptsChromatin accessibilitySingle-nucleusGene expressionTranscription factor bindingPatterns of gene expressionSingle-nucleus resolutionCell lineage originACC gene expressionPrimate evolutionMulti-omics analysisAnterior cingulate cortexFactor bindingEvolutionary roleFunctional innovationSequence changesMolecular innovationsVon Economo neuronsMolecular regulationMarker genesPublished mouse dataCell typesChromatinMolecular identityHuman originCingulate cortexChanges in hoarding-related beliefs and associated neural changes during a simulated discarding task after cognitive-behavioral treatment for hoarding disorder
Knowles K, Stevens M, Levy H, Tolin D. Changes in hoarding-related beliefs and associated neural changes during a simulated discarding task after cognitive-behavioral treatment for hoarding disorder. Journal Of Psychiatric Research 2024, 180: 473-481. PMID: 39547046, PMCID: PMC11606758, DOI: 10.1016/j.jpsychires.2024.11.017.Peer-Reviewed Original ResearchCognitive-behavioral therapyHoarding-related beliefsFunctional magnetic resonance imagingHoarding DisorderNeural activityMaladaptive beliefsCourse of CBTGroup cognitive-behavioral therapyLeft anterior cingulate cortexLeft middle frontal gyrusAssociated with cognitive changesCognitive-behavioral treatmentAssociated with increased activityAnterior ventral insulaAnterior cingulate cortexMiddle frontal gyrusInferior temporal lobeLeft middle insulaCognitive-behavioralAssociated with specific changesFrontal gyrusCingulate cortexMiddle insulaNeural regionsVentral insulaW69. ALTERNATIVE SPLICING DYNAMICS IN HUMAN PREFRONTAL CORTEX SUBREGIONS
Nunez D, Martinez-Magana J, Nagamatsu S, Andrade-Brito D, Hernandez-Amaya L, Montalvo-Ortiz J. W69. ALTERNATIVE SPLICING DYNAMICS IN HUMAN PREFRONTAL CORTEX SUBREGIONS. European Neuropsychopharmacology 2024, 87: 138-139. DOI: 10.1016/j.euroneuro.2024.08.278.Peer-Reviewed Original ResearchDorsal anterior cingulate cortexPrefrontal cortex subregionsPrefrontal cortexOrbitofrontal cortexDifferential transcript usagePercent-spliced-inSubgenual prefrontal cortexPrefrontal cortex regionsAnterior cingulate cortexDorsolateral prefrontal cortexDSM-IV criteriaAS eventsTranscript usageSynaptic processesExon skippingDSM-IVSCID-1Cingulate cortexIntron retentionMood disordersPsychiatric disordersSplice siteAlternative splicingCognitive functionNon-psychiatric diagnosesDistinct 5-HT receptor subtypes regulate claustrum excitability by serotonin and the psychedelic, DOI
Anderson T, Keady J, Songrady J, Tavakoli N, Asadipooya A, Neeley R, Turner J, Ortinski P. Distinct 5-HT receptor subtypes regulate claustrum excitability by serotonin and the psychedelic, DOI. Progress In Neurobiology 2024, 240: 102660. PMID: 39218140, PMCID: PMC11444019, DOI: 10.1016/j.pneurobio.2024.102660.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexEffects of 5-HTExcitatory postsynaptic currentsPsychedelic hallucinogensLevels of serotonin (5-HTSerotonin (5-HTPsychedelic drug actionReceptor-mediated excitatory postsynaptic currentsClaustrum activationCingulate cortexSerotonergic regulationSerotonin receptorsBehavioral responsesGlutamatergic neuronsClaustrumClaustrum neuronsNeuronal activityReceptor subtypesCortical targetsPostsynaptic currentsPsychedelicsElectrophysiological recordingsDOIDrug actionHallucinogensProgressive alterations of resting-state hypothalamic dysconnectivity in schizophrenia
Li X, Zeng J, Liu N, Yang C, Tao B, Sun H, Gong Q, Zhang W, Li C, Lui S. Progressive alterations of resting-state hypothalamic dysconnectivity in schizophrenia. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2024, 135: 111127. PMID: 39181307, DOI: 10.1016/j.pnpbp.2024.111127.Peer-Reviewed Original ResearchHypothalamic functional connectivityBilateral anterior cingulate cortexAnterior cingulate cortexFunctional connectivityFES patientsCingulate cortexFC decreaseRight thalamusChronically treated schizophrenia patientsHealthy controlsSeed-based functional connectivityFirst-episode patientsPathogenesis of schizophreniaNature of schizophreniaAge-related declineAntipsychotic treatmentAntipsychotic medicationRight caudateLeft putamenIllness durationAnalysis of covarianceSchizophreniaDiagnostic groupsHC groupHypothalamus dysfunctionHuman adolescent brain similarity development is different for paralimbic versus neocortical zones
Dorfschmidt L, Váša F, White S, Romero-García R, Kitzbichler M, Alexander-Bloch A, Cieslak M, Mehta K, Satterthwaite T, Consortium T, Bethlehem R, Seidlitz J, Vértes P, Bullmore E, Bullmore E, Dolan R, Goodyer I, Fonagy P, Jones P, Moutoussis M, Hauser T, Neufeld S, Romero-Garcia R, St Clair M, Vértes P, Whitaker K, Inkster B, Prabhu G, Ooi C, Toseeb U, Widmer B, Bhatti J, Villis L, Alrumaithi A, Birt S, Bowler A, Cleridou K, Dadabhoy H, Davies E, Firkins A, Granville S, Harding E, Hopkins A, Isaacs D, King J, Kokorikou D, Maurice C, McIntosh C, Memarzia J, Mills H, O’Donnell C, Pantaleone S, Scott J, Kiddle B, Polek E, Fearon P, Suckling J, van Harmelen A, Kievit R, Chamberlain S, Bethlehem R. Human adolescent brain similarity development is different for paralimbic versus neocortical zones. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2314074121. PMID: 39121162, PMCID: PMC11331068, DOI: 10.1073/pnas.2314074121.Peer-Reviewed Original ResearchConceptsMorphometric similarity networksFunctional connectivityNeocortical areasCortical areasFunctional MRI scansCourse of adolescenceAccelerated longitudinal designMagnetic resonance imagingStructure-function couplingCingulate cortexParalimbic areasInteroceptive functionAssociated with increased strengthIncreased hubnessFMRI networksStructural scansLongitudinal designCortical thinningDevelopment of human brainAdolescent developmentMorphometric similarityHealthy adolescentsAssociated with reduced strengthHuman brainCortexCortical structure and subcortical volumes in conduct disorder: a coordinated analysis of 15 international cohorts from the ENIGMA-Antisocial Behavior Working Group
Gao Y, Staginnus M, Group E, Gao Y, Staginnus M, Townend S, Arango C, Bajaj S, Banaschewski T, Barker E, Benegal V, Berluti K, Bernhard A, Blair R, Boateng C, Bokde A, Brandeis D, Buitelaar J, Burt S, Cardinale E, Castro-Fornieles J, Chen H, Chen X, Chester S, Colins O, Cornwell H, Craig M, Cubillo A, Desrivieres S, Díaz D, Dietrich A, Dong D, Dykstra A, Franke B, Freitag C, Glennon J, Gonzalez-Madruga K, Hagan C, Hoekstra P, Holla B, Hyde L, Ibrahim K, Jabeen N, Jackson R, Jiang Y, Kohls G, Konrad K, Kypta-Vivanco A, Lamers K, Ma R, Marsh A, Martinelli A, Martinot J, Michalska K, Ming Q, Minosse S, Mitchell C, Monk C, Murphy D, Mycue L, Naaijen J, Oosterling M, Passamonti L, Pauli R, Alonso M, Phillips H, Ploe M, Raschle N, Roberts R, Rogers J, Rosa-Justicia M, Sagar-Ouriaghli I, Schulze U, Schumann G, Sethi A, Smaragdi A, Sonuga-Barke E, Stadler C, Stevens M, Sukhodolsky D, Sully K, Sun X, Toschi N, Townsend C, van der Wee N, Vermeiren R, Viding E, Wang X, Westerman H, Wu Q, Yao S, Zhang J, Zhou J, Zhou J, Jahanshad N, Thomopoulos S, Ching C, Kang M, Thompson P, Klapwijk E, Pine D, Baskin-Sommers A, Cecil C, Aghajani M, Walton E, Fairchild G, De Brito S. Cortical structure and subcortical volumes in conduct disorder: a coordinated analysis of 15 international cohorts from the ENIGMA-Antisocial Behavior Working Group. The Lancet Psychiatry 2024, 11: 620-632. PMID: 39025633, DOI: 10.1016/s2215-0366(24)00187-1.Peer-Reviewed Original ResearchConceptsGroup-by-age interactionCallous-unemotional traitsConduct disorder groupConduct disorderBrain structural alterationsSubcortical volumesDisorder groupDiagnosis of conduct disorderCaudal anterior cingulate cortexAnalysis of structural MRI dataCortical thicknessT1-weighted MRI brain scansBrain structural correlatesAnterior cingulate cortexSuperior temporal sulcusStructural MRI dataAssess group differencesMRI brain scansNucleus accumbensADHD comorbidityCingulate cortexDisorder subtypesSmaller amygdalaBrain alterationsTemporal sulcus
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply