2025
0728 Predicting Sleep State from Continuous Positive Airway Pressure Flow in Patients with Obstructive Sleep Apnea
Ahsan M, Yaggi H, Anwar A, Chen H, Chen C, Zinchuk A, Wu H. 0728 Predicting Sleep State from Continuous Positive Airway Pressure Flow in Patients with Obstructive Sleep Apnea. Sleep 2025, 48: a316-a317. DOI: 10.1093/sleep/zsaf090.0728.Peer-Reviewed Original ResearchObstructive sleep apneaApnea-hypopnea indexBody mass indexNegative predictive valuePositive predictive valueResidual apnea-hypopnea indexSleep apneaObstructive sleep apnea patientsPredictive valuePositive airway pressureSleep stateFirst-line treatmentFlow signalsCPAP effectsCPAP titrationCPAP adherenceCPAP devicesCPAP levelAirway pressureSleep centerCPAPPolysomnography recordingsMass indexInclusion criteriaRespiratory rate variabilityObstructive Sleep Apnea is Associated With Increased Rates of Acute Respiratory Failure, Length of Stay, and Hospital Costs in Patients Undergoing Elective Single-Level Anterior Cervical Discectomy and Fusion.
Mastrokostas P, Said M, Cassar C, Mastrokostas L, Lavi A, Varthi A, Bou Monsef J, Razi A, Ng M. Obstructive Sleep Apnea is Associated With Increased Rates of Acute Respiratory Failure, Length of Stay, and Hospital Costs in Patients Undergoing Elective Single-Level Anterior Cervical Discectomy and Fusion. Global Spine Journal 2025, 21925682251333324. PMID: 40152967, PMCID: PMC11954374, DOI: 10.1177/21925682251333324.Peer-Reviewed Original ResearchObstructive sleep apneaRates of acute respiratory failureSingle-level anterior cervical discectomyLength of staySingle-level ACDFAcute respiratory failureAnterior cervical discectomyNational Inpatient SampleSleep apneaCervical discectomyRespiratory failureHospital costsAssociated with increased respiratory complicationsObstructive sleep apnea cohortObstructive sleep apnea patientsYear of surgeryProlonged length of stayAssociated with increased ratesHigh-risk populationHigher hospital costsMethodsThe National Inpatient SamplePropensity score matchingChi-square testPostoperative complicationsPostoperative outcomes
2022
Sensorimotor Cortical Activity during Respiratory Arousals in Obstructive Sleep Apnea
Bahr-Hamm K, Koirala N, Hanif M, Gouveris H, Muthuraman M. Sensorimotor Cortical Activity during Respiratory Arousals in Obstructive Sleep Apnea. International Journal Of Molecular Sciences 2022, 24: 47. PMID: 36613490, PMCID: PMC9820672, DOI: 10.3390/ijms24010047.Peer-Reviewed Original ResearchConceptsModerate OSA patientsSevere OSASensorimotor cortical activityOSA patientsRespiratory arousalsCortical activityObstructive sleep apnea patientsSevere OSA patientsObstructive sleep apneaSignificant decreaseSleep apnea patientsSleep stagesRaw electroencephalography dataModerate OSASleep apneaRespiratory eventsApnea patientsDifferential diagnosisSleep stage N1PatientsAutonomic activationStage N1Cortical arousalPathophysiologic traitsOSAReduced Cross-Frequency Coupling and Daytime Sleepiness in Obstructive Sleep Apnea Patients
Gouveris H, Koirala N, Anwar A, Ding H, Ludwig K, Huppertz T, Matthias C, Groppa S, Muthuraman M. Reduced Cross-Frequency Coupling and Daytime Sleepiness in Obstructive Sleep Apnea Patients. Biology 2022, 11: 700. PMID: 35625429, PMCID: PMC9138271, DOI: 10.3390/biology11050700.Peer-Reviewed Original ResearchRespiratory disturbance indexObstructive sleep apneaCortical sensorimotor areasOSA patientsSensorimotor areasRespiratory distressCross-frequency couplingObstructive sleep apnea patientsEpworth Sleepiness ScaleSleep apnea patientsSleep stagesDistinct sleep stagesMotor dysfunctionSleep apneaPatient groupApnea patientsDaytime sleepinessSleepiness ScalePatientsPolysomnography recordingsObjective markersSubjective sleepinessDisturbance indexSleepinessDistress
2019
Guideline-directed therapies for comorbidities and clinical outcomes among individuals with atrial fibrillation
Loring Z, Shrader P, Allen LA, Blanco R, Chan PS, Ezekowitz MD, Fonarow GC, Freeman JV, Gersh BJ, Mahaffey KW, Naccarelli GV, Pieper K, Reiffel JA, Singer DE, Steinberg BA, Thomas LE, Peterson ED, Piccini JP. Guideline-directed therapies for comorbidities and clinical outcomes among individuals with atrial fibrillation. American Heart Journal 2019, 219: 21-30. PMID: 31710841, PMCID: PMC7285625, DOI: 10.1016/j.ahj.2019.10.008.Peer-Reviewed Original ResearchMeSH KeywordsAgedAtrial FibrillationCardiovascular DiseasesCause of DeathComorbidityCoronary Artery DiseaseDiabetes MellitusDisease ProgressionEmbolismFemaleGuideline AdherenceHeart FailureHumansHyperlipidemiasHypertensionIntracranial EmbolismMalePeripheral Nervous System DiseasesPeripheral Vascular DiseasesRegistriesSleep Apnea, ObstructiveTreatment OutcomeConceptsGuideline-directed therapyAtrial fibrillationCause mortalityHeart failureAF progressionLower riskNew-onset heart failureObstructive sleep apnea patientsCox proportional hazards modelBetter Informed TreatmentObstructive sleep apneaSleep apnea patientsProportional hazards modelAF patientsDiabetes mellitusNeurovascular eventsClinical outcomesOutcomes RegistrySleep apneaApnea patientsComorbiditiesHazards modelNonsignificant trendPatientsLower mortality
2002
What Are Obstructive Sleep Apnea Patients Being Treated for Prior to This Diagnosis?
Smith R, Ronald J, Delaive K, Walld R, Manfreda J, Kryger MH. What Are Obstructive Sleep Apnea Patients Being Treated for Prior to This Diagnosis? CHEST Journal 2002, 121: 164-172. PMID: 11796446, DOI: 10.1378/chest.121.1.164.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeBody mass indexChronic obstructive airways diseaseObstructive airways diseaseHealth care utilizationSleep apnea patientsControl subjectsApnea patientsAirway diseaseOSAS patientsCardiovascular diseaseObstructive sleep apnea patientsHealth care utilization measuresApnea-hypopnea indexCongestive heart failureEffect of obesityIschemic heart diseaseSleep apnea syndromeDegree of hypoxemiaSignificant independent predictorsLogistic regression analysisCertain cardiovascular disordersHealth care resourcesRegression analysisApnea syndrome
1998
Obstructive sleep apnea patients use more health care resources ten years prior to diagnosis.
Ronald J, Delaive K, Roos L, Manfreda J, Kryger M. Obstructive sleep apnea patients use more health care resources ten years prior to diagnosis. Sleep Research Online : SRO 1998, 1: 71-4. PMID: 11382859.Peer-Reviewed Original ResearchConceptsOSA patientsObstructive sleep apnea syndrome (OSAS) patientsHealth care utilization recordsPatient health care utilizationSleep apnea syndrome patientsObstructive sleep apnea patientsHealth care utilizationSleep apnea patientsOSAS patientsMore hospitalizationsCare utilizationApnea patientsOSAS diagnosisSyndrome patientsGeneral populationPatientsUtilization recordsTen yearsDiagnosisTen-year periodYearsTen-year intervalsComorbiditiesHospitalizationHeavy users
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