2025
Osseous Genioplasty and its Impact on Airway Volume – What is the Evidence?
Kauke-Navarro M, Knoedler L, Stucki L, Klimitz F, Allam O, Knoedler S, Navarro M, Flores-Pérez P, Rancu A, Heiland M, Alperovich M, Safi A. Osseous Genioplasty and its Impact on Airway Volume – What is the Evidence? Aesthetic Surgery Journal Open Forum 2025, ojaf059. DOI: 10.1093/asjof/ojaf059.Peer-Reviewed Original ResearchObstructive sleep apneaChin advancementOsseous genioplastyAirway volumeAirway changesObstructive sleep apnea metricsObstructive sleep apnea symptomsEvaluate long-term resultsAbsolute volume increasePosterior airway spaceApnea-hypopnea indexLong-term resultsAirway enlargementHyoid advancementAirway spaceSleep apneaSnoring severityFacial aestheticsSurgical techniqueAirway dimensionsAirway sizeGenioplastyWeb of ScienceAssociated soft tissuesAirway0740 Loop Gain Predicts Residual Sleep Apnea Events Among People Using Positive Airway Pressure
Eschbach E, Kushida C, Peker Y, Xu Z, Deng A, Azarbarzin A, Wellman A, Yaggi H, Sands S, Zinchuk A. 0740 Loop Gain Predicts Residual Sleep Apnea Events Among People Using Positive Airway Pressure. Sleep 2025, 48: a321-a321. DOI: 10.1093/sleep/zsaf090.0740.Peer-Reviewed Original ResearchPositive airway pressureObstructive sleep apneaPositive airway pressure therapyBody mass indexSleep apneaBaseline AHIPAP therapyAirway pressurePharyngeal collapseIncreased riskOdds ratioPositive airway pressure devicesAssociated with increased riskCoronary artery diseaseSleep apnea eventsEpisodic airway obstructionBaseline polysomnogramRandomized Controlled TrialsBaseline polysomnographyHigh LGAdjunctive therapyAirway obstructionUpper airwayMass indexApnea0728 Predicting Sleep State from Continuous Positive Airway Pressure Flow in Patients with Obstructive Sleep Apnea
Ahsan M, Yaggi H, Anwar A, Chen H, Chen C, Zinchuk A, Wu H. 0728 Predicting Sleep State from Continuous Positive Airway Pressure Flow in Patients with Obstructive Sleep Apnea. Sleep 2025, 48: a316-a317. DOI: 10.1093/sleep/zsaf090.0728.Peer-Reviewed Original ResearchObstructive sleep apneaApnea-hypopnea indexBody mass indexNegative predictive valuePositive predictive valueResidual apnea-hypopnea indexSleep apneaObstructive sleep apnea patientsPredictive valuePositive airway pressureSleep stateFirst-line treatmentFlow signalsCPAP effectsCPAP titrationCPAP adherenceCPAP devicesCPAP levelAirway pressureSleep centerCPAPPolysomnography recordingsMass indexInclusion criteriaRespiratory rate variabilityHealth and Utilization Burden of Obstructive Sleep Apnea among U.S. Active-Duty Military Personnel
Wickwire E, Capaldi V, Herrin J, Stryckman B, Thomas C, Williams S, Werner J, Funk W, Nassif T, Albrecht J. Health and Utilization Burden of Obstructive Sleep Apnea among U.S. Active-Duty Military Personnel. CHEST Journal 2025 PMID: 40368028, DOI: 10.1016/j.chest.2025.05.007.Peer-Reviewed Original ResearchObstructive sleep apneaBurden of obstructive sleep apneaSleep apneaUtilization burdenNewly diagnosed OSAIncreased riskObstructive sleep apnea diagnosisObstructive sleep apnea treatmentMonths of continuous enrollmentAssociated with increased riskHealthcare resource utilizationActive-duty military personnelInternational Classification of DiseasesMilitary Data RepositoryContinuous enrollmentClassification of diseasesPsychological health outcomesWhite racePsychiatric comorbiditiesService membersApneaED encountersHealth outcomesInternational ClassificationMedical outcomesInfluence of Body Mass Index on Hypoglossal Nerve Stimulation Efficacy Depends on the Site of Pharyngeal Collapse in Obstructive Sleep Apnea
Vena D, Kezirian E, Wellman A, Kent D, D'Agostino M, Monteiro J, Azarbarzin A, Sands S, Huyett P. Influence of Body Mass Index on Hypoglossal Nerve Stimulation Efficacy Depends on the Site of Pharyngeal Collapse in Obstructive Sleep Apnea. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a6928-a6928. DOI: 10.1164/ajrccm.2025.211.abstracts.a6928.Peer-Reviewed Original ResearchPhysicians-in-training and advanced practice providers perceptions in managing perioperative obstructive sleep apnea: a multi-institutional survey.
Lyons M, Auckley D, Mokhlesi B, Charchaflieh J, Myers J, Yilmaz M, Williams L, Khan M, Card E, Gelfand B, Pilla M, Loftsgard T, Sawyer A, Matura L, Carlucci M, Sahni A, Glaser K, Al Ghussain D, Brock G, Bhatt N, Magalang U, Rosen I, Gali B. Physicians-in-training and advanced practice providers perceptions in managing perioperative obstructive sleep apnea: a multi-institutional survey. Journal Of Clinical Sleep Medicine 2025, 21: 765-773. PMID: 39745490, PMCID: PMC12048335, DOI: 10.5664/jcsm.11528.Peer-Reviewed Original ResearchObstructive sleep apneaAdvanced practice providersPhysicians-in-trainingSleep apneaClinical roleImproved provider educationPerioperative risk assessmentBreslow-Day testPerioperative complicationsCategories of carePerioperative periodElectronic-mail surveyOdds ratioRisk factorsMulti-institutional surveySleep disordersPatientsPerioperative patientsBreslow-DaySignificant differenceSurgical servicesApneaPractice providersProviders' perceptionsMultiple comparisonsDifferential Cardiovascular Benefit of Positive Airway Pressure in Obstructive Sleep Apnea: A Multi-trial Analysis
Azarbarzin A, Vena D, Esmaeili N, Wellman A, Pinilla Latorre L, Messineo L, Zinchuk A, Alex R, Baumert M, Loffler K, Anderson C, White D, Redline S, Gottlieb D, Barbe F, Peker Y, Sanchez De La Torre M, Mcevoy R, Sands S. Differential Cardiovascular Benefit of Positive Airway Pressure in Obstructive Sleep Apnea: A Multi-trial Analysis. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a5286-a5286. DOI: 10.1164/ajrccm.2025.211.abstracts.a5286.Peer-Reviewed Original ResearchThe Association between All-Cause Mortality and Obstructive Sleep Apnea in Adults: A U-Shaped Curve.
Azarian M, Ramezani A, Sharafkhaneh A, Maghsoudi A, Kryger M, Thomas R, Westover M, Razjouyan J. The Association between All-Cause Mortality and Obstructive Sleep Apnea in Adults: A U-Shaped Curve. Annals Of The American Thoracic Society 2025, 22: 581-590. PMID: 39746198, PMCID: PMC12005042, DOI: 10.1513/annalsats.202407-755oc.Peer-Reviewed Original ResearchApnea-hypopnea indexAll-Cause MortalitySleep apneaBody mass indexAssociated with apnea-hypopnea indexApnea hypopnea index categoriesInterpretation of sleep studiesOdds ratioOdds of all-cause mortalityObstructive sleep apneaSeverity of SAAll-cause mortality ratesElixhauser Comorbidity IndexSleep studiesPropensity-matchedMass indexSevere SAComorbidity indexAll-CauseMortality rateMortalityEffects of ageApneaLogistic regressionAge groupsEvaluation of the relationship between brainstem lesions and apnea hypopnea index in patients with multiple sclerosis
Levit E, Cohen I, Mahajan A, Ulano A, Longbrake E, Solomon A. Evaluation of the relationship between brainstem lesions and apnea hypopnea index in patients with multiple sclerosis. Multiple Sclerosis Journal 2025, 31: 802-812. PMID: 40156308, DOI: 10.1177/13524585251327875.Peer-Reviewed Original ResearchConceptsElevated apnea-hypopnea indexApnea-hypopnea indexObstructive sleep apneaDemyelinating brainstem lesionsClinically isolated syndromeBrainstem lesionsBody mass indexMagnetic resonance imagingMultiple sclerosisSleep study typeYears of polysomnographyAssociated with higher oddsHypopnea indexSleep apneaDemyelinating lesionsMass indexPolysomnographyLesionsResonance imagingBrainstemHigher oddsApneaStudy centersPatientsStudy typeObstructive Sleep Apnea is Associated With Increased Rates of Acute Respiratory Failure, Length of Stay, and Hospital Costs in Patients Undergoing Elective Single-Level Anterior Cervical Discectomy and Fusion.
Mastrokostas P, Said M, Cassar C, Mastrokostas L, Lavi A, Varthi A, Bou Monsef J, Razi A, Ng M. Obstructive Sleep Apnea is Associated With Increased Rates of Acute Respiratory Failure, Length of Stay, and Hospital Costs in Patients Undergoing Elective Single-Level Anterior Cervical Discectomy and Fusion. Global Spine Journal 2025, 21925682251333324. PMID: 40152967, PMCID: PMC11954374, DOI: 10.1177/21925682251333324.Peer-Reviewed Original ResearchObstructive sleep apneaRates of acute respiratory failureSingle-level anterior cervical discectomyLength of staySingle-level ACDFAcute respiratory failureAnterior cervical discectomyNational Inpatient SampleSleep apneaCervical discectomyRespiratory failureHospital costsAssociated with increased respiratory complicationsObstructive sleep apnea cohortObstructive sleep apnea patientsYear of surgeryProlonged length of stayAssociated with increased ratesHigh-risk populationHigher hospital costsMethodsThe National Inpatient SamplePropensity score matchingChi-square testPostoperative complicationsPostoperative outcomesImpact of continuous positive airway pressure therapy on restless legs syndrome in patients with coexistent obstructive sleep apnea: A qualitative systematic review
Srivali N, Thongprayoon C, Cheungpasitporn W, Zinchuk A, Koo B. Impact of continuous positive airway pressure therapy on restless legs syndrome in patients with coexistent obstructive sleep apnea: A qualitative systematic review. Journal Of Clinical Neuroscience 2025, 133: 111075. PMID: 39879879, DOI: 10.1016/j.jocn.2025.111075.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaRestless legs syndromeCoexisting obstructive sleep apneaRestless legs syndrome symptomsCPAP therapyNewcastle-Ottawa Quality ScaleSleep apneaMedication usageRLS symptomsImpact of continuous positive airway pressure therapyContinuous positive airway pressure therapyTreatment of obstructive sleep apneaBenefits of CPAP therapyImpact of CPAP therapyPositive airway pressure therapySystematic reviewInclusion criteriaAirway pressure therapyUpper airway collapseCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsRLS severity scaleConfounding factorsImproving RLS symptomsRegister of Controlled TrialsCHAPTER 18 Remote monitoring of sleep apnea patients
Kongpakpaisarn K, Thapa S, Won C. CHAPTER 18 Remote monitoring of sleep apnea patients. 2025, 169-192. DOI: 10.1016/b978-0-323-87041-2.00027-0.Peer-Reviewed Original Research
2024
Association between high risk of obstructive sleep apnea and inflammatory markers in a population sample of young and middle-aged adults in the Miami Heart Study.
Khosla A, Nasir K, Saxena A, Aneni E, Ali S, Valero-Elizondo J, Cainzos-Achirica M, Feldman T, Fialkow J, Walia H. Association between high risk of obstructive sleep apnea and inflammatory markers in a population sample of young and middle-aged adults in the Miami Heart Study. Journal Of Clinical Sleep Medicine 2024, 20: 1895-1903. PMID: 38975989, PMCID: PMC11609831, DOI: 10.5664/jcsm.11274.Peer-Reviewed Original ResearchHigh risk of obstructive sleep apneaRisk of obstructive sleep apneaObstructive sleep apneaHs-CRPCardiovascular disease risk factorsFree of cardiovascular diseaseInflammatory markersHigh riskCardiovascular diseaseIL-6Sleep apneaLow risk of obstructive sleep apneaTNF-aObstructive sleep apnea screeningLow riskRisk factorsLevels of inflammatory markersLevels of hs-CRPTNF-a levelsCVD-free participantsHeart StudyBerlin questionnaireIndividuals free of cardiovascular diseaseSubclinical inflammationPoisson regression analysisArousal threshold modifies the effect of CPAP on executive function among individuals with obstructive sleep apnoea
Zinchuk A, Kushida C, Walker A, Wellman A, Azarbarzin A, Alex R, Varga A, Sands S, Yaggi H. Arousal threshold modifies the effect of CPAP on executive function among individuals with obstructive sleep apnoea. European Respiratory Journal 2024, 65: 2401183. PMID: 39572221, DOI: 10.1183/13993003.01183-2024.Peer-Reviewed Original ResearchEffect of continuous positive airway pressureContinuous positive airway pressureObstructive sleep apneaSleep apneaArousal thresholdApnea Positive Pressure Long-term Efficacy StudySham continuous positive airway pressureEffect of CPAP treatmentPositive airway pressureLong-term efficacy studiesAssociated with neurocognitive dysfunctionCPAP treatmentAirway pressureSham-controlled trialApneaRandomized trialsSecondary outcomesNeurocognitive dysfunctionNeurocognitive outcomesTotal timeEfficacy studiesNeurocognitive functionSecondary analysisArTHExecutive functionThe Great Controversy of Obstructive Sleep Apnea Treatment for Cardiovascular Risk Benefit: Advancing the Science through Expert Consensus: An Official American Thoracic Society Workshop Report
Cohen O, Kundel V, Barbé F, Peker Y, McEvoy D, Sánchez-de-la-Torre M, Gottlieb D, Bradley T, Suárez-Fariñas M, Zinchuk A, Azarbarzin A, Malhotra A, Schotland H, Gozal D, Jelic S, Ramos A, Martin J, Pamidi S, Johnson D, Mehra R, Somers V, Hoyos C, Jackson C, Alcantara C, Billings M, Bhatt D, Patel S, Redline S, Yaggi H, Shah N. The Great Controversy of Obstructive Sleep Apnea Treatment for Cardiovascular Risk Benefit: Advancing the Science through Expert Consensus: An Official American Thoracic Society Workshop Report. Annals Of The American Thoracic Society 2024, 22: 1-22. PMID: 39513996, PMCID: PMC11708754, DOI: 10.1513/annalsats.202409-981st.Peer-Reviewed Original ResearchObstructive sleep apneaPositive airway pressureRandomized Controlled TrialsCardiovascular diseaseImpact of obstructive sleep apneaPrevalence of obstructive sleep apneaOSA subtypesSubgroup of OSA patientsObstructive sleep apnea syndromeObstructive sleep apnea treatmentIncidence of comorbid conditionsSleep apnea treatmentCardiovascular risk benefitMulti-modality therapeutic approachSleep clinic patientsPersonalized therapeutic strategiesTreat symptomatic patientsResponse to treatmentSecondary CVD eventsCost-effective diagnosisComposite CVD outcomeOSA patientsPAP adherenceSleep apneaAssessment of symptomsTrends in Soft Palate Surgery and Reimbursements for Obstructive Sleep Apnea Among the Medicare Population
Torabi S, Frank M, Patel R, Manes R, Kuan E, Trask D. Trends in Soft Palate Surgery and Reimbursements for Obstructive Sleep Apnea Among the Medicare Population. Annals Of Otology Rhinology & Laryngology 2024, 134: 49-57. PMID: 39445448, DOI: 10.1177/00034894241288435.Peer-Reviewed Original ResearchTHE VALUE OF ADJUNCTIVE THERAPIES IN INDIVIDUALS WITH SEVERE OBSTRUCTIVE SLEEP APNEA TREATED WITH HYPOGLOSSAL NERVE STIMULATOR
BUNTAK V, INAYA A, ZINCHUK A. THE VALUE OF ADJUNCTIVE THERAPIES IN INDIVIDUALS WITH SEVERE OBSTRUCTIVE SLEEP APNEA TREATED WITH HYPOGLOSSAL NERVE STIMULATOR. CHEST Journal 2024, 166: a6173. DOI: 10.1016/j.chest.2024.06.3655.Peer-Reviewed Original ResearchAge‐Related Clinical and Polysomnographic Features of Severe Obstructive Sleep Apnea in Infants
Schild S, Zalzal H, Newman D, Behzadpour H, Nino G, Lawlor C. Age‐Related Clinical and Polysomnographic Features of Severe Obstructive Sleep Apnea in Infants. The Laryngoscope 2024, 135: 958-963. PMID: 39301991, DOI: 10.1002/lary.31762.Peer-Reviewed Original ResearchConceptsObstructive apnea indexSevere OSAMandibular distraction osteogenesisPSG parametersHypopnea indexRisk factorsSevere obstructive sleep apneaObstructive sleep apneaSleep-disordered breathingStepwise multivariate logistic regressionMultivariate logistic regressionAge-stratified analysesMonths of agePSG featuresApnea indexApnea-HypopneaSleep apneaDesaturation indexApneic eventsArousal indexPolysomnographic featuresCraniofacial abnormalitiesSevere hypoxemiaSurgical interventionFollow-upPulmonary embolism with thrombus in transit across a patent foramen ovale
Iyengar S, Stolear A, Dulgher M, Ahmed A, Shkolnik E, Zarich S. Pulmonary embolism with thrombus in transit across a patent foramen ovale. Oxford Medical Case Reports 2024, 2024: omae091. PMID: 39184868, PMCID: PMC11343825, DOI: 10.1093/omcr/omae091.Peer-Reviewed Original ResearchPatent foramen ovalePatent foramen ovale closureImpending paradoxical embolismPulmonary embolismForamen ovaleCritical left anterior descending coronary artery stenosisObstructive sleep apneaCoronary Artery Bypass GraftingOptimal treatment strategySaddle pulmonary embolusAbsence of standard guidelinesDeep vein thrombosisArtery Bypass GraftingLife-threatening conditionCoronary artery stenosisSleep apneaTransesophageal echocardiogramPulmonary emboliSurgical thrombectomyVein thrombosisDiagnostic challengeSurgical interventionRight atriumThrombolytic therapyBypass GraftingSleep apnea in schizophrenia: Estimating prevalence and impact on cognition
Ghazikhanian S, Surti T. Sleep apnea in schizophrenia: Estimating prevalence and impact on cognition. Journal Of Psychiatric Research 2024, 177: 330-337. PMID: 39068777, DOI: 10.1016/j.jpsychires.2024.07.028.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaPrevalence of obstructive sleep apneaCognitive deficits of schizophreniaWorking memory test scoresDeficits of schizophreniaSleep apneaImpaired cognitive domainsSpeed of processingDisabling cognitive deficitsMemory test scoresHigher cognitive capacityFunctional capacity performanceAssociated with lower speedsVerbal learningCognitive domainsCompromised cognitionSchizophreniaRisk of obstructive sleep apneaEffects of sleep apneaCognitive capacityCognitive impairmentPredicting obstructive sleep apneaSelf-ReportMedical illnessFunctional capacity assessment
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