2025
Daylight Savings Time and Acute Myocardial Infarction
Rymer J, Li S, Chiswell K, Kansal A, Nanna M, Gutierrez J, Feldman D, Rao S, Swaminathan R. Daylight Savings Time and Acute Myocardial Infarction. JAMA Network Open 2025, 8: e2530442. PMID: 40924425, PMCID: PMC12421335, DOI: 10.1001/jamanetworkopen.2025.30442.Peer-Reviewed Original ResearchConceptsIncidence of acute myocardial infarctionSpring daylight savings timeAcute myocardial infarctionIncidence ratiosIncidence rate of acute myocardial infarctionChest Pain-MI RegistryIncidence rateRate of acute myocardial infarctionAcute myocardial infarction casesCross-sectional studyDaylight saving timeMI registryIn-hospital mortality rateMain OutcomesIn-Hospital MortalityIn-Hospital OutcomesClinical outcomesIn-hospital clinical outcomesIn-hospital clinical eventsPatient characteristicsIncidence of patientsMortality rateStudy periodMyocardial infarctionOutcomesMultimorbidity Profiles and Severe In-Hospital Outcomes in Adults With Respiratory Syncytial Virus
C K, Surie D, Zhu Y, Grijalva C, Blair P, Safdar B, Ginde A, Peltan I, Brown S, Gaglani M, Ghamande S, Columbus C, Mohr N, Gibbs K, Hager D, Prekker M, Gong M, Mohamed A, Johnson N, Steingrub J, Khan A, Hough C, Duggal A, Gordon A, Qadir N, Chang S, Mallow C, Busse L, Kwon J, Exline M, Vaughn I, Ramesh M, Lauring A, Martin E, Leis A, Mosier J, Harris E, Baughman A, Johnson C, Casey J, Halasa N, Chappell J, Lewis N, Ellington S, Self W, Dawood F. Multimorbidity Profiles and Severe In-Hospital Outcomes in Adults With Respiratory Syncytial Virus. Clinical Infectious Diseases 2025, ciaf405. PMID: 40708527, DOI: 10.1093/cid/ciaf405.Peer-Reviewed Original ResearchRespiratory syncytial virusICU admission riskSyncytial virusRSV prevention strategiesRecognition of high-risk patientsRSV diseaseSevere outcomesHigh-risk patientsMinimal prevalenceChronic pulmonary diseaseFrequent heart failureIn-Hospital OutcomesRisk of severe outcomesChronic kidney diseaseAcute respiratory infectionsRisk of critical illnessHematologic malignanciesRare prevalenceAdmission riskTransplant receiptHeart failureRespiratory infectionsKidney diseasePulmonary diseaseCritical illnessInpatient Outcomes for Patients With Peripheral Artery Disease Hospitalized for Acute Myocardial Infarction
Gusdorf J, Faridi K, Wang T, Mena-Hurtado C, Smolderen K, Rymer J, Curtis J, Li S, Secemsky E. Inpatient Outcomes for Patients With Peripheral Artery Disease Hospitalized for Acute Myocardial Infarction. Journal Of The American Heart Association 2025, 14: e040526. PMID: 40497502, PMCID: PMC12229116, DOI: 10.1161/jaha.124.040526.Peer-Reviewed Original ResearchConceptsAcute myocardial infarction typesPeripheral arterial diseaseAcute myocardial infarctionIn-Hospital MortalityPeripheral artery disease hospitalizationsIn-Hospital OutcomesAcute myocardial infarction hospitalizationsCardiac arrestHigh-risk populationAssociated with increased ratesLong-term riskRevascularized PatientsInpatient outcomesMultivariable adjustmentHeart failureArtery diseasePrimary outcomeAdverse cardiovascular outcomesUS sitesHeightened riskAge groupsSecondary end pointsSubgroup analysisDialysis initiationCoronary artery diseaseImpact of Mean Blood Pressure Profiles in Percutaneous Left Ventricular Assist Device‐Supported High‐Risk Percutaneous Coronary Intervention: The PROTECT III Study
Bonnet G, Rommel K, Falah B, Lansky A, Zhang Y, Schonning M, Redfors B, Burkhoff D, Cohen D, Basir M, O'Neill W, Granada J. Impact of Mean Blood Pressure Profiles in Percutaneous Left Ventricular Assist Device‐Supported High‐Risk Percutaneous Coronary Intervention: The PROTECT III Study. Journal Of The American Heart Association 2025, 14: e036367. PMID: 40371603, PMCID: PMC12184586, DOI: 10.1161/jaha.124.036367.Peer-Reviewed Original ResearchConceptsIn-Hospital OutcomesBP categoriesPercutaneous coronary interventionHigh-risk percutaneous coronary interventionMean blood pressureBaseline BP levelsCoronary interventionIn-Hospital DeathAssociated with higher ratesVentricular assist device supportStroke/transient ischemic attackLeft ventricular assist device supportCerebrovascular eventsAssist device supportPercutaneous left ventricular assist device supportHistory of heart failureIn-HospitalInterventionHemodynamic profileAdverse outcomesBP levelsPrevent hypotensionPercutaneous left ventricular assist deviceMyocardial infarctionBlood pressureAssociation Between Three-Dimensional Right Ventricular Ejection Fraction and In-Hospital Outcomes in Patients Undergoing Cardiac Surgery: A Multicenter Study
Posada-Martinez E, Ivey-Miranda J, Ortiz-Leon X, Arias-Godinez J, Fritche-Salazar J, Rodriguez-Zanella H, Ruiz Esparza-Dueñas M, Romero-Zertuche D, Silvestre-Flores I, Morales-Portano J, Orea-Tejeda A, Rojas-Serrano J, McNamara R, Reyes Lopez P, Sugeng L. Association Between Three-Dimensional Right Ventricular Ejection Fraction and In-Hospital Outcomes in Patients Undergoing Cardiac Surgery: A Multicenter Study. Journal Of The American Society Of Echocardiography 2025, 38: 685-693. PMID: 39984139, DOI: 10.1016/j.echo.2025.02.008.Peer-Reviewed Original ResearchRight ventricular ejection fractionRV function parametersVentricular ejection fractionCardiac surgeryEuroSCORE IIPrimary outcomeEjection fractionMechanical ventilationMulticenter study of adult patientsRight ventricular (RV) functionParameters of RV systolic functionPredictors of in-hospital mortalityStudy of adult patientsFunction parametersRV systolic functionProspective multicenter studyAssociated with shorter timeAccurate risk stratificationEvaluation of patientsIn-Hospital MortalityIn-Hospital OutcomesTemporary ventricular assist devicesTransesophageal echocardiogramExploratory endpointsPrimary endpointSex differences in in-hospital outcomes and readmission rates after percutaneous coronary intervention
Gomez J, Park D, Eder M, An S, Lowenstern A, Kelsey M, Rymer J, Douglas P, Nanna M. Sex differences in in-hospital outcomes and readmission rates after percutaneous coronary intervention. Baylor University Medical Center Proceedings 2025, 38: 159-169. PMID: 39990004, PMCID: PMC11845020, DOI: 10.1080/08998280.2025.2452113.Peer-Reviewed Original ResearchIn-Hospital OutcomesIn-Hospital MortalitySecondary outcomesReadmission ratesOdds of in-hospital mortalityPercutaneous coronary interventionCalculate odds ratiosInpatient percutaneous coronary interventionHazard of readmissionUnited States National Readmission DatabaseIn-Hospital Adverse OutcomesPropensity score matchingHealth systemHospital characteristicsOdds of cardiac arrestSocioeconomic statusReimbursement implicationsSex differencesYears of ageOdds ratioReadmission riskCox proportional-hazardsLogistic regressionIn-Hospital ComplicationsScore matching
2024
Effectiveness of Original Monovalent and Bivalent COVID‐19 Vaccines Against COVID‐19‐Associated Hospitalization and Severe In‐Hospital Outcomes Among Adults in the United States, September 2022–August 2023
DeCuir J, Surie D, Zhu Y, Lauring A, Gaglani M, McNeal T, Ghamande S, Peltan I, Brown S, Ginde A, Steinwand A, Mohr N, Gibbs K, Hager D, Ali H, Frosch A, Gong M, Mohamed A, Johnson N, Srinivasan V, Steingrub J, Khan A, Busse L, Duggal A, Wilson J, Qadir N, Chang S, Mallow C, Kwon J, Exline M, Shapiro N, Columbus C, Vaughn I, Ramesh M, Safdar B, Mosier J, Casey J, Talbot H, Rice T, Halasa N, Chappell J, Grijalva C, Baughman A, Womack K, Rhoads J, Swan S, Johnson C, Lewis N, Ellington S, Dawood F, McMorrow M, Self W, Network F. Effectiveness of Original Monovalent and Bivalent COVID‐19 Vaccines Against COVID‐19‐Associated Hospitalization and Severe In‐Hospital Outcomes Among Adults in the United States, September 2022–August 2023. Influenza And Other Respiratory Viruses 2024, 18: e70027. PMID: 39496339, PMCID: PMC11534416, DOI: 10.1111/irv.70027.Peer-Reviewed Original ResearchConceptsCOVID-19-associated hospitalizationIn-Hospital OutcomesVaccine effectivenessMonovalent dosesAbsolute VETest-negative case-control designInvasive mechanical ventilationCOVID-19 vaccineMultivariate logistic regressionSevere COVID-19Case patientsCase-control designControl patientsMechanical ventilationUnvaccinated patientsPatientsMonovalent vaccineCOVID-19-like illnessDoseCOVID-19 vaccine effectivenessBivalent vaccineLogistic regressionAdmission dateVaccineHospitalAtrial Fibrillation: Prevalence and Association With Outcome in Patients With Stroke Undergoing Mechanical Thrombectomy in the United States
Otite F, Patel S, Hoffman H, Aneni E, Anikpezie N, Akano E, Wee C, Burke D, Albright K, Beutler T, Latorre J, Sonig A, Singla A, Morris N, Chaturvedi S, Khandelwal P. Atrial Fibrillation: Prevalence and Association With Outcome in Patients With Stroke Undergoing Mechanical Thrombectomy in the United States. Stroke Vascular And Interventional Neurology 2024, 4 DOI: 10.1161/svin.123.001248.Peer-Reviewed Original ResearchAcute ischemic strokeAF prevalenceJoinpoint regressionAtrial fibrillationIn-Hospital DeathIn-Hospital OutcomesMechanical thrombectomyDemographic subgroupsMultivariable-adjusted generalized linear modelsDemographic subgroups of patientsOdds of in-hospital deathCross-sectional studyNegative binomial regressionPrevalence of atrial fibrillationRoutine home dischargeNational Inpatient SampleAcute ischemic stroke populationAssociation of AFUnited StatesSubgroup of patientsHome dischargeBinomial regressionMultivariable adjustmentRacial subgroupsInpatient SampleRacial, ethnic and sex disparity in acute heart failure patients with COVID-19: A nationwide analysis
Hashem A, Khalouf A, Mohamed M, Nayfeh T, Elkhapery A, Zahid S, Altibi A, Thyagaturu H, Kashou A, Anavekar N, Gulati M, Balla S. Racial, ethnic and sex disparity in acute heart failure patients with COVID-19: A nationwide analysis. Heliyon 2024, 10: e34513. PMID: 39157311, PMCID: PMC11327804, DOI: 10.1016/j.heliyon.2024.e34513.Peer-Reviewed Original ResearchAcute heart failureImpact of raceNational Inpatient SampleCOVID-19 infectionWhite malesHispanic malesDiagnosis of acute heart failureOutcomes of acute heart failureOdds of cardiac arrestAcute heart failure patientsCOVID-19Sex disparitiesWhite femalesOdds of in-hospital mortalityEthnicityRaceDisparitiesMultivariate logistic regression modelIn-Hospital MortalityIn-Hospital OutcomesHeart failure patientsLogistic regression modelsHispanic ethnicityHeart failureCardiac arrestIn-Hospital Outcomes and 30-Day Readmission Rate After Transcatheter and Surgical Aortic Valve Replacement in Liver Cirrhosis: A Contemporary Propensity-Matched Analysis
Aggarwal A, Jang S, Vardhan S, Webber F, Alam M, Vardhan M, Lancaster G, Ahmad Y, Vora A, Zarich S, Inglessis-Azuaje I, Elmariah S, Forrest J, Davila C. In-Hospital Outcomes and 30-Day Readmission Rate After Transcatheter and Surgical Aortic Valve Replacement in Liver Cirrhosis: A Contemporary Propensity-Matched Analysis. Structural Heart 2024, 8: 100327. PMID: 39670045, PMCID: PMC11632700, DOI: 10.1016/j.shj.2024.100327.Peer-Reviewed Original ResearchSurgical aortic valve replacementTranscatheter aortic valve replacementAortic valve replacementTranscatheter aortic valve replacement groupValve replacementIn-Hospital MortalityHepatorenal syndromeReadmission ratesCardiogenic shockLiver cirrhosisVascular complicationsIn-HospitalOutcomes of transcatheter aortic valve replacementSurgical risk prediction modelsSurgical aortic valve replacement groupAssociated with significantly lower ratesRates of in-hospital mortalityLimited contemporary dataIn-Hospital OutcomesSignificantly lower ratesNationwide Readmissions DatabaseCardiac surgeryPeriprocedural morbidityTherapeutic optionsClinical characteristicsIn-hospital outcomes and postdischarge mortality in patients with acute coronary syndrome and atrial fibrillation
Saleh M, Coleman K, Fishbein J, Gandomi A, Yang B, Kossack A, Varrias D, Jauhar R, Lasic Z, Kim M, Mihelis E, Ismail H, Sugeng L, Singh V, Epstein L, Kuvin J, Mountantonakis S. In-hospital outcomes and postdischarge mortality in patients with acute coronary syndrome and atrial fibrillation. Heart Rhythm 2024, 21: 1658-1668. PMID: 38823670, DOI: 10.1016/j.hrthm.2024.05.045.Peer-Reviewed Original ResearchConceptsAcute coronary syndromePostdischarge mortalityAtrial fibrillationIn-Hospital OutcomesPostdischarge adverse outcomesOral anticoagulantsPatients admitted with acute coronary syndromeNorthwell Health hospitalsCoronary syndromeAdverse outcomesRisk of in-hospitalIntroduction of novel oral anticoagulantsIncreased risk of in-hospitalAcute coronary syndrome patientsManagement of acute coronary syndromesConcomitant atrial fibrillationNovel oral anticoagulantsHealth HospitalIndependent risk factorHierarchical generalized linear mixed modelsLinear mixed modelsIncidence of AFIn-Hospital MortalityMarginal Cox regression modelsIn-Hospital BleedingAssociation Between Frailty and Management and Outcomes of Acute Myocardial Infarction Complicated by Cardiogenic Shock
Jamil Y, Park D, Rao S, Ahmad Y, Sikand N, Bosworth H, Coles T, Damluji A, Nanna M, Samsky M. Association Between Frailty and Management and Outcomes of Acute Myocardial Infarction Complicated by Cardiogenic Shock. JACC Advances 2024, 3: 100949. PMID: 38938859, PMCID: PMC11198471, DOI: 10.1016/j.jacadv.2024.100949.Peer-Reviewed Original ResearchAcute myocardial infarctionAMI-CSIn-Hospital OutcomesDo-not-resuscitate statusPatients admitted with acute myocardial infarctionOdds of in-hospital mortalitySkilled nursing facilityPrevalence of frailtyProportion of hospitalsAssociated with in-hospital outcomesIn-Hospital Adverse EventsCompare in-hospital outcomesRisk score cut-offNational Inpatient SampleNursing facilitiesIn-Hospital MortalityScore cut-offAssociated with adverse outcomesInpatient SampleFrailtyCardiogenic shockIn-hospital morbidityMyocardial infarction complicationsNonfrail groupOddsE-2 | Prevalence and Clinical Correlates of Obstructive Sleep Apnea on In-hospital Outcomes following Transcatheter Aortic Valve Replacement: Results from National Inpatient Sample Database 2016-2020
Aggarwal A, Garcia A, Vasquez M, Vardhan S, Ahmed A, Vardhan M, Batlle J, Zarich S, Davila C. E-2 | Prevalence and Clinical Correlates of Obstructive Sleep Apnea on In-hospital Outcomes following Transcatheter Aortic Valve Replacement: Results from National Inpatient Sample Database 2016-2020. Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 3: 101758. DOI: 10.1016/j.jscai.2024.101758.Peer-Reviewed Original ResearchImpact of anemia on outcomes and resource utilization in patients with myocardial infarction: A national database analysis
Jhand A, Abusnina W, Tak H, Ahmed A, Ismayl M, Altin S, Sherwood M, Alexander J, Rao S, Abbott J, Carson J, Goldsweig A. Impact of anemia on outcomes and resource utilization in patients with myocardial infarction: A national database analysis. International Journal Of Cardiology 2024, 408: 132111. PMID: 38697401, DOI: 10.1016/j.ijcard.2024.132111.Peer-Reviewed Original ResearchLength of stayNational Inpatient SampleMyocardial infarctionDiagnosis codesAnemic patientsAdverse eventsPatients admitted with MIAssociated with higher in-hospital mortalityAssociated with high mortalityAssociated with increased mortalityNational database analysisHigher In-Hospital MortalityAssociation of anemiaHigher mortalityImpact of anemiaIn-Hospital Adverse EventsPrimary diagnosis codeSecondary diagnosis codesLonger length of stayMultivariate logistic regressionIn-Hospital MortalityIn-Hospital OutcomesMI hospitalizationConcomitant anemiaBlood transfusionFrailty and In-Hospital Outcomes for Management of Cardiogenic Shock without Acute Myocardial Infarction
Park D, Jamil Y, Ahmad Y, Coles T, Bosworth H, Sikand N, Davila C, Babapour G, Damluji A, Rao S, Nanna M, Samsky M. Frailty and In-Hospital Outcomes for Management of Cardiogenic Shock without Acute Myocardial Infarction. Journal Of Clinical Medicine 2024, 13: 2078. PMID: 38610842, PMCID: PMC11012362, DOI: 10.3390/jcm13072078.Peer-Reviewed Original ResearchDo-not-resuscitate statusOdds of in-hospital mortalitySkilled nursing facilityIn-Hospital Adverse EventsRelationship of frailtyCompare in-hospital outcomesNon-frail groupRisk score cut-offNational Inpatient SampleAssociated with increased rates of morbidityNursing facilitiesMyocardial infarctionAssociated with increased ratesFrail adultsIn-Hospital MortalityIn-Hospital OutcomesAcute myocardial infarctionFrail groupScore cut-offFrailtyInpatient SampleCardiogenic shockRisk factorsCardiovascular diseaseHospital
2023
Impact of same-admission percutaneous coronary intervention on periprocedural outcomes of transcatheter aortic valve implantation
Park D, An S, Arif A, Saini A, Golzar Y. Impact of same-admission percutaneous coronary intervention on periprocedural outcomes of transcatheter aortic valve implantation. Baylor University Medical Center Proceedings 2023, 37: 7-13. PMID: 38174009, PMCID: PMC10761096, DOI: 10.1080/08998280.2023.2273742.Peer-Reviewed Original ResearchAssociated with higher oddsHigher oddsPercutaneous coronary interventionCompare in-hospital outcomesAssociated with longer lengthNational Inpatient SamplePropensity score matchingCoronary artery diseaseIn-Hospital MortalityIn-Hospital OutcomesAcute myocardial infarctionArtery diseaseInpatient SampleScore matchingCoronary interventionHospital costsCardiac arrestTranscatheter aortic valve implantationCurrent guidelinesOddsMyocardial infarctionInterventionLonger lengthControl groupHospitalTCT-67 Comparison of In-Hospital Outcomes and 30-Day Readmission Rates Between Patients Who Underwent TAVR Versus SAVR for Aortic Stenosis in Liver Cirrhosis: A Propensity-Matched Analysis
Aggarwal A, Jang S, Vardhan S, Webber F, Lancaster G, Zarich S, Vora A, Elmariah S, Davila C. TCT-67 Comparison of In-Hospital Outcomes and 30-Day Readmission Rates Between Patients Who Underwent TAVR Versus SAVR for Aortic Stenosis in Liver Cirrhosis: A Propensity-Matched Analysis. Journal Of The American College Of Cardiology 2023, 82: b27. DOI: 10.1016/j.jacc.2023.09.072.Peer-Reviewed Original ResearchIn-Hospital OutcomesReadmission ratesAortic stenosisLiver cirrhosisCirrhosisTAVRStenosisPatientsSAVRIn‐hospital outcomes in patients with and without epilepsy diagnosed with COVID‐19—A cohort study
Ufongene C, Van Hyfte G, Agarwal P, Blank L, Goldstein J, Mathew B, Lin J, Navis A, McCarthy L, Gururangan K, Peschansky V, Kwon C, Cohen A, Chan A, Dhamoon M, Deng P, Gutzwiller E, Hao Q, He C, Nunez W, Klenofsky B, Lemus H, Marcuse L, Roberts M, Schorr E, Singh A, Tantillo G, Young J, Balchandani P, Festa J, Naasan G, Charney A, Nadkarni G, Jetté N. In‐hospital outcomes in patients with and without epilepsy diagnosed with COVID‐19—A cohort study. Epilepsia 2023, 64: 2725-2737. PMID: 37452760, DOI: 10.1111/epi.17715.Peer-Reviewed Original ResearchConceptsLength of stayNon-routine dischargeCharlson Comorbidity IndexIn-Hospital OutcomesHigher Charlson comorbidity indexFactors associated with higher oddsIntensive care unitInternational Classification of DiseasesOlder ageAssociated with COVID-19 mortalityRegression modelsClassification of diseasesDecreased LOSLonger length of stayLogistic regression modelsAssociated with mortalityHealth systemOrdinary least squares regression modelsCOVID-19 mortalityOlder adultsRetrospective study of patientsInternational ClassificationHigher oddsMulticenter health systemEvaluate in-hospital outcomesCOMPARISON OF IN - HOSPITAL OUTCOMES AND THIRTY - DAY READMISSION RATES BETWEEN PATIENTS WHO UNDERWENT TAVR VERSUS SAVR FOR AORTIC STENOSIS IN LIVER CIRRHOSIS: RESULTS FROM NATIONWIDE READMISSIONS DATABASE
Aggarwal A, Jang S, Webber F, Shkolnik E, Pinto E, Lancaster G, Zarich S. COMPARISON OF IN - HOSPITAL OUTCOMES AND THIRTY - DAY READMISSION RATES BETWEEN PATIENTS WHO UNDERWENT TAVR VERSUS SAVR FOR AORTIC STENOSIS IN LIVER CIRRHOSIS: RESULTS FROM NATIONWIDE READMISSIONS DATABASE. Journal Of The American College Of Cardiology 2023, 81: 1020. DOI: 10.1016/s0735-1097(23)01464-x.Peer-Reviewed Original ResearchAbstract TP47: Impact Of Prehospital Care And Patient Presentation On In-hospital Treatment Of Acute Ischemic Stroke
DYLLA L, Higgins H, Ravare B, Jeppson K, Bina H, Rice J, Herson P, Monte A, Poisson S. Abstract TP47: Impact Of Prehospital Care And Patient Presentation On In-hospital Treatment Of Acute Ischemic Stroke. Stroke 2023, 54: atp47-atp47. DOI: 10.1161/str.54.suppl_1.tp47.Peer-Reviewed Original ResearchEmergency medicine servicesDoor-to-CT timeAmerican Heart AssociationLinear regression modelsDoor-to-computed tomographyIn-hospital quality of careQuality-of-care metricsGuideline concordant careQuality of careAcute stroke careDoor-to-CTIn-Hospital CareRegression modelsMultivariate linear regression modelConcordant careProvider compliancePrehospital careStroke careStroke guidelinesIschemic stroke patientsMedicine serviceStroke symptomsIn-Hospital OutcomesComprehensive stroke centerAcute ischemic stroke patients
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