2025
The Five-Item Modified Frailty Index Predicts Adverse Surgical Outcomes in Patients Undergoing Mastectomy
Chiarella L, Huelsboemer L, Diatta F, Klimitz F, Kammien A, Kochen A, Boroumand S, Allam O, Kauke-Navarro M, Pomahac B. The Five-Item Modified Frailty Index Predicts Adverse Surgical Outcomes in Patients Undergoing Mastectomy. Annals Of Surgical Oncology 2025, 32: 4829-4837. PMID: 40342005, DOI: 10.1245/s10434-025-17105-2.Peer-Reviewed Original ResearchConceptsHigh-risk patientsMFI-5Surgical complicationsFrail patientsPredicting adverse surgical outcomesNational Surgical Quality Improvement Program dataIncreased risk of complicationsQuality Improvement Program dataMethodsThis retrospective cohort studyPredicting surgical complicationsDependent functional statusHigher Body Mass IndexAdverse surgical outcomesOdds of complicationsRetrospective cohort studyAcute kidney failureRisk of complicationsAdult female patientsCongestive heart failurePostoperative complication riskAdjusted multivariable logistic regressionBody mass indexChronic obstructive pulmonary diseaseHigh-risk groupMultivariate logistic regressionPreoperative Multivariable Model for Risk Stratification of Hypoxemia During One-Lung Ventilation
Zorrilla-Vaca A, Grant M, Mendez-Pino L, Rehman M, Sarin P, Nasra S, Varelmann D. Preoperative Multivariable Model for Risk Stratification of Hypoxemia During One-Lung Ventilation. Anesthesia & Analgesia 2025, 140: 1029-1036. PMID: 39773746, DOI: 10.1213/ane.0000000000007306.Peer-Reviewed Original ResearchOne-lung ventilationArea under the receiver operating curveRisk of hypoxemiaIntraoperative hypoxemiaRisk stratificationClinical variablesRisk of intraoperative hypoxemiaEpisodes of oxygen desaturationBody mass index >Preoperative clinical variablesStratification modelLung perfusion scanElective lung surgeryLateral decubitus positionPositive predictive valueRetrospective cohort studyCongestive heart failureHighest Youden indexPreoperative multivariable modelLogistic regressionRisk stratification modelRight-sided surgeryMultivariate logistic regressionIncidence of hypoxemiaDouble lumen tubeIdentification of Patients With Congestive Heart Failure From the Electronic Health Records of Two Hospitals: Retrospective Study
Sumsion D, Davis E, Fernandes M, Wei R, Milde R, Veltink J, Kong W, Xiong Y, Rao S, Westover T, Petersen L, Turley N, Singh A, Buss S, Mukerji S, Zafar S, Das S, Moura V, Ghanta M, Gupta A, Kim J, Stone K, Mignot E, Hwang D, Trotti L, Clifford G, Katwa U, Thomas R, Westover M, Sun H. Identification of Patients With Congestive Heart Failure From the Electronic Health Records of Two Hospitals: Retrospective Study. JMIR Medical Informatics 2025, 13: e64113. PMID: 40208662, PMCID: PMC12022513, DOI: 10.2196/64113.Peer-Reviewed Original ResearchConceptsElectronic health recordsNatural language processingICD codesHealth recordsMedical recordsArea under the receiver operating characteristic curveClinic visit notesGeneral hospital dataManual chart reviewLogistic regression modelsCause of hospital admissionDiagnosis of congestive heart failureVisit notesNatural language processing modelsAnalysis of medical recordsCongestive heart failureHospital dataHospital admissionLogistic regressionHospital sampleMachine learning modelsMedical Center dataOverall estimation errorRandom samplePrecision-recall curveVariations in Antithrombotic Prescriptions and Evaluation of Extended Clopidogrel Therapy After Lower Extremity Revascularization for Peripheral Artery Disease
Wells N, Alameddine D, Dhanda U, Tran L, Silva D, Slade M, Guzman R, Ochoa Chaar C. Variations in Antithrombotic Prescriptions and Evaluation of Extended Clopidogrel Therapy After Lower Extremity Revascularization for Peripheral Artery Disease. Journal Of Vascular Surgery 2025 PMID: 40122313, DOI: 10.1016/j.jvs.2025.03.183.Peer-Reviewed Original ResearchLower extremity revascularizationPeripheral arterial diseaseDuration of clopidogrel therapyClopidogrel therapyAntithrombotic prescriptionAntithrombotic combinationsAntithrombotic therapyExtremity revascularizationArtery diseasePatients treated with clopidogrelAssociated with improved survivalClinical characteristics of patientsMedical records of patientsLong-term follow-upChronic renal insufficiencyMACE-free survivalAssociated with bleedingElectronic medical records of patientsAdverse cardiac eventsKaplan-Meier curvesRecords of patientsTertiary care centerCongestive heart failureLong-term outcomesComparison of patientsAllele-specific electrical genotyping for diagnosis of transthyretin amyloidosis
Tayyab M, Gandotra N, Sui J, Scharfe C, Javanmard M. Allele-specific electrical genotyping for diagnosis of transthyretin amyloidosis. Communications Engineering 2025, 4: 47. PMID: 40082707, PMCID: PMC11906782, DOI: 10.1038/s44172-025-00385-7.Peer-Reviewed Original ResearchAllele-specific polymerase chain reactionDNA input requirementsClinical genetic testingDNA variantsWest African ancestryVariant detectionOligonucleotide primersPCR productsGel electrophoresisVariant allelesAfrican ancestryGenetic testingDNA concentrationPolymerase chain reactionDNACongestive heart failureGenotypesChain reactionMicrofluidic impedance cytometryHereditary transthyretinTransthyretin amyloidosisHeart failureImpedance cytometryTransthyretinPrimersHeartfelt Progress: The Triumphs Of Non-invasive Remote Patient Monitoring In Mitigating Heart Failure Readmissions
REHAN M, ABDULLAH A, LANCASTER G. Heartfelt Progress: The Triumphs Of Non-invasive Remote Patient Monitoring In Mitigating Heart Failure Readmissions. Journal Of Cardiac Failure 2025, 31: 303. DOI: 10.1016/j.cardfail.2024.10.310.Peer-Reviewed Original ResearchCongestive heart failureCongestive heart failure patientsRemote patient monitoring programReadmission ratesOutpatient monitoringHospital data of patientsImplantable pulmonary artery pressure monitorPulmonary artery pressure monitoringComparison to patientsData of patientsArterial pressure monitoringHeart failure readmissionDecreased 30-day readmissionsHeart failureBaseline parametersCompare outcomesBlood pressureCardioMEMSPatientsPressure monitoringWeeks post-dischargePatient monitoringMedical costsReadmissionVital signs
2024
Bladder Symptoms Provoked by Short, Rapid-Acting Loop Diuretics: A Frequent but Often Overlooked Problem
Wilcox C, Pourafshar N, Han K, Shah S, Sussman R, Testani J, Packer M, Rossignol P, Zannad F, Pitt B, Shah S. Bladder Symptoms Provoked by Short, Rapid-Acting Loop Diuretics: A Frequent but Often Overlooked Problem. American Journal Of Hypertension 2024, 38: 100-103. PMID: 39485998, DOI: 10.1093/ajh/hpae139.Peer-Reviewed Original ResearchCongestive heart failureChronic kidney diseaseBladder dysfunctionOveractive bladderLoop diureticsCardiovascular diseaseFormulations of loop diureticsSymptoms of overactive bladderSymptoms of urinary urgencyUrinary tract symptomsExtended-release formulationType 2 inhibitorsImpaired quality of lifeWorsening of symptomsPatients seeking careAdult US populationResistant hypertensionUrinary urgencyBladder symptomsReceptor antagonistBladder contractionsSodium-glucoseUrinary incontinenceHeart failureDiureticsDiastolic Stress Echocardiography in Patients With Hypertrophy Cardiomyopathy: Association With Exercise Capacity
Fava A, Popovic Z, Alashi A, Thamilarasan M, Xu B, Desai M. Diastolic Stress Echocardiography in Patients With Hypertrophy Cardiomyopathy: Association With Exercise Capacity. The American Journal Of Cardiology 2024, 232: 34-40. PMID: 39307332, DOI: 10.1016/j.amjcard.2024.09.017.Peer-Reviewed Original ResearchTreadmill exercise echocardiographyHypertrophic cardiomyopathyCongestive heart failureDiastolic parametersExercise capacityStress echocardiographyAssociated with reduced exercise capacityPrecipitate congestive heart failureLeft ventricular (LVAsymptomatic/minimally symptomatic patientsDiastolic stress echocardiographyMultivariate logistic regression analysisSymptomatic HCM patientsEtiology of dyspneaHigher Body Mass IndexBody mass indexReduced exercise capacityExercise functional capacityLogistic regression analysisAssociated with <Incremental diagnostic utilityHigher LAViLVOT gradientE/e' ratioDiastolic dysfunctionDeep-learning generated B-line score mirrors clinical progression of disease for patients with heart failure
Baloescu C, Chen A, Varasteh A, Hall J, Toporek G, Patil S, McNamara R, Raju B, Moore C. Deep-learning generated B-line score mirrors clinical progression of disease for patients with heart failure. The Ultrasound Journal 2024, 16: 42. PMID: 39283362, PMCID: PMC11405569, DOI: 10.1186/s13089-024-00391-4.Peer-Reviewed Original ResearchB-line scoreComposite congestion scoreCongestion scoreHeart failureSeverity scoreB-linesCongestive heart failurePatients suspectedPulmonary congestionLung zonesClinical progressionRothman IndexClinical assessmentDisease severityPatientsPresence of artifactsEvaluate changesLungDetect fluidUltrasound experienceMixed effects modelsScoresDiseaseInterstitial spaceUltrasound systemAssociation of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) With an Increased Risk of Congestive Heart Failure in Hospitalized Patients With Cirrhosis: A Propensity Score-Matched Analysis
Ugwendum D, Mohamed M, Al-Ajlouni Y, Nso N, Njei B. Association of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) With an Increased Risk of Congestive Heart Failure in Hospitalized Patients With Cirrhosis: A Propensity Score-Matched Analysis. Cureus 2024, 16: e62441. PMID: 39011212, PMCID: PMC11249195, DOI: 10.7759/cureus.62441.Peer-Reviewed Original ResearchCongestive heart failureIn-Hospital MortalityCongestive heart failure riskOdds ratioMortality odds ratioCirrhotic patientsHeart failureClinical practice implicationsIn-patient mortalityLiver diseaseIncreased risk of congestive heart failureNational Inpatient SampleRisk of congestive heart failurePrevalence of congestive heart failureSteatotic liver diseaseHealth outcomesHospitalized cirrhotic patientsPost-matchPropensity Score Matching AnalysisHospital stay lengthStudy of patientsObese/overweight individualsInpatient SampleLogistic regressionDischarge status#2598 Risk of vascular access complications in haemodialysis patients initiating dialysis with arteriovenous fistula or arteriovenous graft
Willetts J, Usvyat L, Chaudhuri S, Niklason L, Maddux F. #2598 Risk of vascular access complications in haemodialysis patients initiating dialysis with arteriovenous fistula or arteriovenous graft. Nephrology Dialysis Transplantation 2024, 39: gfae069-1550-2598. DOI: 10.1093/ndt/gfae069.1550.Peer-Reviewed Original ResearchVascular access complication ratesArteriovenous fistulaEnd-stage kidney diseaseArteriovenous graftsVA complicationsVascular accessIn-Center HemodialysisInitial VAComorbid conditionsDuration of follow-upAssociated with increased riskComplication eventsHistory of myocardial infarctionCongestive heart failureVascular access complicationsDiabetic ptsRisk of vascular access complicationsComplication rateDemographic characteristicsIncreased BMIDocumented thrombosisIn-Center Hemodialysis PatientsContinuous hemodialysisHigher BMIHaemodialysis patientsAnticoagulation in Patients with Premature Peripheral Artery Disease Undergoing Lower Extremity Revascularization
Kim T, DeWan A, Murray M, Wang H, Mani A, Mena-Hurtado C, Guzman R, Ochoa Chaar C. Anticoagulation in Patients with Premature Peripheral Artery Disease Undergoing Lower Extremity Revascularization. Annals Of Vascular Surgery 2024, 105: 150-157. PMID: 38593922, DOI: 10.1016/j.avsg.2024.02.006.Peer-Reviewed Original ResearchPremature peripheral arterial diseaseAntiplatelet therapyVascular Quality InitiativeArtery diseaseAdjunct to antiplatelet therapyReturn to the operating roomPost-operative anticoagulationCompared to patientsPostoperative antiplatelet therapyOne-year outcomesCongestive heart failureLower extremity revascularizationMajor adverse limb eventsCoronary artery diseaseEffects of anticoagulantsAmputation-free survivalEarly onset of diseaseAdverse limb eventsPeripheral vascular interventionsOnset of diseasePeripheral arterial diseaseLower-extremity revascularizationPropensity score matchingPerioperative mortalityBaseline characteristicsAssociation of cardiovascular diseases with cognitive performance in older adults
Park D, Jamil Y, Babapour G, Kim J, Campbell G, Akman Z, Kochar A, Sen S, Samsky M, Sikand N, Frampton J, Damluji A, Nanna M. Association of cardiovascular diseases with cognitive performance in older adults. American Heart Journal 2024, 273: 10-20. PMID: 38575050, PMCID: PMC11162917, DOI: 10.1016/j.ahj.2024.03.016.Peer-Reviewed Original ResearchAnimal Fluency TestOlder adultsCERAD-DRDSST scoresCardiovascular diseaseNational Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveyCongestive heart failureFree of cardiovascular diseaseFluency testCardiovascular disease subtypesNutrition Examination SurveyAssociation of cardiovascular diseaseAnimal Fluency test scoreCognitive performanceLower cognitive performanceCoronary heart diseaseHeart failureCVD subtypesExamination SurveyAssess cognitive performanceAdultsCognitive functionHeart diseaseScoresEstimates of 30-day postoperative pulmonary complications after gastrointestinal endoscopic procedures: A retrospective cohort analysis of a health system population
Carr Z, Li J, Agarkov D, Gazura M, Karamchandani K. Estimates of 30-day postoperative pulmonary complications after gastrointestinal endoscopic procedures: A retrospective cohort analysis of a health system population. PLOS ONE 2024, 19: e0299137. PMID: 38394250, PMCID: PMC10889900, DOI: 10.1371/journal.pone.0299137.Peer-Reviewed Original ResearchConceptsPostoperative pulmonary complicationsGastrointestinal endoscopic proceduresCongestive heart failurePropensity score matchingEndoscopic proceduresPulmonary complicationsSecondary outcomesPropensity score matching adjustmentRetrospective cohort studyRetrospective cohort analysisPulmonary circulatory disordersMultivariate logistic regressionAlcohol abuse disordersUpper endoscopic proceduresHealth system populationPulmonary emboliUpper endoscopyRespiratory failureLower endoscopyElectrolyte disordersHeart failureCohort studyConscious sedationPrimary outcomeCohort analysisThe Use and Impact of Cilostazol on Patients Undergoing Endovascular Peripheral Interventions
Alameddine D, Damara F, Pinto Rodriguez P, Huttler J, Slade M, Arhuidese I, Aboian E, Ochoa Chaar C. The Use and Impact of Cilostazol on Patients Undergoing Endovascular Peripheral Interventions. Annals Of Vascular Surgery 2024, 103: 47-57. PMID: 38387798, DOI: 10.1016/j.avsg.2023.12.071.Peer-Reviewed Original ResearchImpact of cilostazolPeripheral vascular interventionsPeripheral arterial diseaseTreatment of intermittent claudicationRates of long-term mortalityPeripheral vascular interventional proceduresKaplan-Meier methodCongestive heart failureLong-term mortalityLong-term outcomesEndovascular peripheral interventionsRenal complicationsPatient demographicsBaseline characteristicsHeart failureDiabetes mellitusArtery diseaseIntermittent claudicationCilostazolPatientsVascular interventionsPeripheral interventionsClaudicationOutcomesInterventionEvaluation of short-term mortality in patients with Medicare undergoing endovascular interventions for chronic limb-threatening ischemia
Cleman J, Romain G, Callegari S, Scierka L, Jacque F, Smolderen K, Mena-Hurtado C. Evaluation of short-term mortality in patients with Medicare undergoing endovascular interventions for chronic limb-threatening ischemia. Vascular Medicine 2024, 29: 172-181. PMID: 38334045, DOI: 10.1177/1358863x231224335.Peer-Reviewed Original ResearchChronic limb-threatening ischemiaPeripheral vascular interventionsAssisted careLimb-threatening ischemiaCongestive heart failureFunctional status variablesCrude mortality ratePredictive variablesMortality rateStatus variablesRandom survival forest modelShort-term mortalityStage 5 chronic kidney diseaseQuality InitiativeRandom survival forestTreatment conversionMedical comorbiditiesShort-term outcomesHarrell's C-indexVascular Quality InitiativeCareDementiaInterventionMortalityRisk stratificationComparison of brain imaging and physical health between research and clinical neuroimaging cohorts of ageing
Mossa-Basha M, Andre J, Yuh E, Hunt D, LaPiana N, Howlett B, Krakauer C, Crane P, Nelson J, DeZelar M, Meyers K, Larson E, Ralston J, Mac Donald C. Comparison of brain imaging and physical health between research and clinical neuroimaging cohorts of ageing. British Journal Of Radiology 2024, 97: 614-621. PMID: 38303547, PMCID: PMC11027291, DOI: 10.1093/bjr/tqae004.Peer-Reviewed Original ResearchConceptsCommon data elementsMRI groupThought (ACTClinical health measuresResearch MRIAging populationWhite matter hyperintensityPrevalence of hypertensionBrain MRI measuresMRI scansNeuroimaging cohortMRI participantsAdult ChangesPhysical healthHealth measuresOverall healthOutcome measuresResearch cohortBrain imagingWMH burdenCongestive heart failureData elementsBrainMRI measurementsMRI metricsCombining Charlson comorbidity and VACS indices improves prognostic accuracy for all-cause mortality for patients with and without HIV in the Veterans Health Administration
McGinnis K, Justice A, Marconi V, Rodriguez-Barradas M, Hauser R, Oursler K, Brown S, Bryant K, Tate J, Study F. Combining Charlson comorbidity and VACS indices improves prognostic accuracy for all-cause mortality for patients with and without HIV in the Veterans Health Administration. Frontiers In Medicine 2024, 10: 1342466. PMID: 38356736, PMCID: PMC10864663, DOI: 10.3389/fmed.2023.1342466.Peer-Reviewed Original ResearchCharlson Comorbidity IndexVACS IndexHIV RNAVeterans Health AdministrationComorbid diseasesNon-AIDS conditionsCongestive heart failureAssociated with CD4Risk of mortalityMedian ageHepatitis C.Older age groupsCharlson comorbidityCD4Prognostic accuracyHeart failurePWOHComorbidity indexVA careKidney diseasePWHHIVMatched comparatorsBaseline predictorsClinical biomarkers
2023
The Utilization of Protamine during Peripheral Vascular Interventions in the VQI
Ali S, Shebl F, Aboian E, Strosberg D, Fischer U, Cardella J, Guzman R, Ochoa Chaar C. The Utilization of Protamine during Peripheral Vascular Interventions in the VQI. Annals Of Vascular Surgery 2023, 101: 72-79. PMID: 38110083, DOI: 10.1016/j.avsg.2023.10.019.Peer-Reviewed Original ResearchPeripheral vascular interventionsAdjusted rate ratiosProtamine useCardiac complicationsPropensity matchingVascular interventionsChronic obstructive pulmonary diseasePropensity scoreCharacteristics of patientsPeripheral arterial diseaseCongestive heart failureObstructive pulmonary diseaseMultivariable Poisson regressionUse of protamineSignificant differencesMedical comorbiditiesP2Y12 inhibitorsPerioperative bleedingPerioperative medicationsPerioperative outcomesDistal embolizationPatient comorbiditiesCarotid surgeryHeart failurePulmonary diseaseFragmentation of Care After Geriatric Trauma: A Nationwide Analysis of outcomes and Predictors
Gogna S, Zangbar B, Rafieezadeh A, Hanna K, Shnaydman I, Con J, Bronstein M, Klein J, Prabhakaran K. Fragmentation of Care After Geriatric Trauma: A Nationwide Analysis of outcomes and Predictors. The American Surgeon 2023, 90: 1007-1014. PMID: 38062751, DOI: 10.1177/00031348231220569.Peer-Reviewed Original ResearchConceptsCongestive heart failureFragmentation of careGeriatric traumaSevere head and neck traumaTrauma patientsHead and neck traumaAssociated with high mortalityMultivariate binary logistic regression analysisElderly trauma patientsMultivariate logistic regressionBinary logistic regression analysisNationwide Readmissions DatabaseLogistic regression analysisTrauma patient outcomesAnalysis of outcomesRate of deathHealth care systemNon-index hospitalsNeck traumaElderly patientsHeart failureIndex hospitalizationReadmissions DatabaseFragmented careFemale gender
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