2025
Proteins associated with rehospitalization, mortality and diuretic resistance in acutely decompensated heart failure
Hubbell K, Rao V, Scherzer R, Shlipak M, Ivery‐Miranda J, Bansal N, Cox Z, Testani J, Estrella M. Proteins associated with rehospitalization, mortality and diuretic resistance in acutely decompensated heart failure. ESC Heart Failure 2025 PMID: 40504107, DOI: 10.1002/ehf2.15342.Peer-Reviewed Original ResearchAcute decompensated heart failureDecompensated heart failureDiuretic responseHeart failureHF rehospitalizationRisk of HF rehospitalizationBiomarker modelAssociated with poor outcomesAssociated with decreased riskAssociated with increased riskAssociated with cardiometabolic diseasesAssociated with mortalityAssociated with rehospitalizationDiuretic resistanceMedian ageResistance cohortClinical factorsPoor outcomeSociodemographic/lifestyle factorsPrognostic toolCombined biomarkersCardiometabolic diseasesPatientsAmbulatory settingMortality riskPredictors and prognostic implication of early lactate clearance among patients with cardiogenic shock
Cordovez C, Rali A, Katz J, Gastanadui M, Safiriyu I, Dudzinski D, Senman B, Alviar C, Elliott A, Gage A, Tavazzi G, Miller P. Predictors and prognostic implication of early lactate clearance among patients with cardiogenic shock. European Heart Journal Acute Cardiovascular Care 2025, 14: zuaf044.123. DOI: 10.1093/ehjacc/zuaf044.123.Peer-Reviewed Original ResearchEarly lactate clearancePulmonary artery catheterDay of admissionIn-Hospital MortalityCardiogenic shockLactate clearancePrognostic implicationsAssociated with lactate clearanceLogistic regressionDiagnosis of CSAssociated with lower in-hospital mortalityLower In-Hospital MortalityAssociated with improved mortalityHospital-level variablesIn-Hospital DeathMultivariate logistic regressionAssociated with mortalityClinical data baseArtery catheterElevated lactateLower oddsImprove mortalityMultivariable adjustmentMultivariate analysisPatientsIncidence, Prevalence, and Trends in Mortality and Stroke Among Medicare Beneficiaries With Atrial Fibrillation: 2013 to 2019
Rogovoy N, Kearing S, Zhou W, Freeman J, Piccini J, Al-Khatib S, Zeitler E. Incidence, Prevalence, and Trends in Mortality and Stroke Among Medicare Beneficiaries With Atrial Fibrillation: 2013 to 2019. Circulation Cardiovascular Quality And Outcomes 2025, 18: e011365. PMID: 40184151, PMCID: PMC12092179, DOI: 10.1161/circoutcomes.124.011365.Peer-Reviewed Original ResearchConceptsMedicare beneficiariesIncident AFFemale beneficiariesAge- and sex-adjusted mortalityIncident cohortAtrial fibrillationAF incidenceSex-adjusted mortalityAssociated with increased risk of strokeAssociated with increased riskPrevalence of AFAssociated with mortalityRisk of strokeWhite beneficiariesDemographic subgroupsMortality riskAF prevalenceRate of strokeMedicareEvaluate trendsBeneficiariesUrban dwellingRisk factorsStudy cohortAge groupsAssociations of self-identified race and ethnicity and genetic ancestry with mortality among cancer survivors
Vo J, Brown D, Buller I, Shing J, Synnott N, Jones R, Landi M, Huang W, Machiela M, de González A, Nolan T, Kraft P, Williams F, Freedman N. Associations of self-identified race and ethnicity and genetic ancestry with mortality among cancer survivors. Journal Of The National Cancer Institute 2025, djaf066. PMID: 40112084, DOI: 10.1093/jnci/djaf066.Peer-Reviewed Original ResearchBreast cancer survivorsCancer survivorsGenetic ancestryAssociated with mortalitySelf-identified raceOvarian Screening TrialProstate cancer survivorsPopulation-level socioeconomic statusAssociated with disparitiesIndividual-level factorsMultiple risk factorsMultilevel adjustmentHealth outcomesSocioeconomic statusScreening TrialMortality differencesMortality riskCancer diagnosisRisk factorsSurvivorsColorectalSocial factorsMortalityEthnicityAssociationThe PRO‐AGE Tool and Its Association With Post Discharge Outcomes in Older Adults Admitted From the Emergency Department
Cohen I, Curiati P, Morinaga C, Han L, Gandhi T, Araujo K, Avelino‐Silva T, Bianco L, Brandt C, Capelli S, Carpenter C, Cruz D, Dresden S, Fishman I, Gipson K, Gray E, Hastings S, Hung W, Kang R, Lockhart M, Meeker D, Ohuabunwa U, Ottilie‐Kovelman S, Platts‐Mills T, Sandoval J, Sifnugel N, Taylor Z, Tomasino D, Vaughan C, Aliberti M, Hwang U. The PRO‐AGE Tool and Its Association With Post Discharge Outcomes in Older Adults Admitted From the Emergency Department. Journal Of The American Geriatrics Society 2025, 73: 1419-1428. PMID: 39843218, PMCID: PMC12101947, DOI: 10.1111/jgs.19374.Peer-Reviewed Original ResearchActivities of daily livingEmergency departmentFunctional declineActivities of daily living disabilityInstrumental activities of daily livingRisk scorePro-agingPatients admitted to hospitalPost-discharge outcomesUnited StatesInstrumental ADLRisk of deathProportional hazards modelDaily livingAssociated with mortalityCharlson comorbidity scoreOlder adultsDischarge outcomesDecline outcomesDiverse populationsMultiple hospitalsComorbidity scoreHazards modelOlder patientsMulticenter observational study
2024
Distinct comorbidity phenotypes among post‐9/11 Veterans with epilepsy are linked to diverging outcomes and mortality risks
Pugh M, Clary H, Myers M, Kennedy E, Amuan M, Swan A, Hinds S, LaFrance W, Altalib H, Towne A, Henion A, White A, Baca C, Wang C. Distinct comorbidity phenotypes among post‐9/11 Veterans with epilepsy are linked to diverging outcomes and mortality risks. Epilepsia 2024, 66: 170-183. PMID: 39487827, PMCID: PMC11742646, DOI: 10.1111/epi.18170.Peer-Reviewed Original ResearchVeterans Health AdministrationCause of deathService membersLatent class analysisPost-9/11 service membersVeterans receiving careContinuity of careInterdisciplinary health teamComorbid phenotypesPost-9/11 veteransOverall patient careMitigate adverse outcomesHealth teamsEpilepsy diagnosisAssociated with mortalityHealth trajectoriesHealth AdministrationPatient carePost-traumatic stress disorderMortality outcomesDescriptive statisticsAnnual diagnosesChronic diseasesNational cohortMortality riskNo association of posttraumatic stress disorder with epigenetic aging in women at mid-life: A longitudinal cohort study
Roberts A, Ratanatharathorn A, Chibnik L, Zhu Y, Jha S, Kang J, Wolf E, Kubzansky L, Koenen K. No association of posttraumatic stress disorder with epigenetic aging in women at mid-life: A longitudinal cohort study. Brain Behavior And Immunity 2024, 123: 672-680. PMID: 39424013, PMCID: PMC11653203, DOI: 10.1016/j.bbi.2024.10.003.Peer-Reviewed Original ResearchPosttraumatic stress disorderBody mass indexAssociation of posttraumatic stress disorderPhysical activityDiet qualityAssociated with epigenetic agingEpigenetic ageAncestry principal componentsStress disorderReference group of womenHigher Body Mass IndexLongitudinal cohort studySelf-reported raceCo-occurring depressionDiseases of agingCross-sectional analysisMiddle-aged womenGroup of womenAssociated with mortalityDepression statusHealth factorsLongitudinal associationsMid-lifeDunedinPoAmCohort studyMechanical ventilation guided by driving pressure optimizes local pulmonary biomechanics in an ovine model
Lagier D, Zeng C, Kaczka D, Zhu M, Grogg K, Gerard S, Reinhardt J, Ribeiro G, Rashid A, Winkler T, Vidal Melo M. Mechanical ventilation guided by driving pressure optimizes local pulmonary biomechanics in an ovine model. Science Translational Medicine 2024, 16: eado1097. PMID: 39141699, DOI: 10.1126/scitranslmed.ado1097.Peer-Reviewed Original ResearchConceptsPositive end-expiratory pressureMechanical ventilationFour-dimensional computed tomographyParenchymal strainsVentilator-induced lung injuryAcute respiratory distress syndromeRespiratory system driving pressureManagement of mechanical ventilationPositive end-expiratory pressure valuesRespiratory distress syndromeTidal overdistensionEnd-expiratory pressureAssociated with mortalityPulmonary complicationsLung biomechanicsLung massDistress syndromeClinical outcomesLung injuryComputed tomographyClinical managementGeneral anesthesiaLung collapseDriving pressureLungRegional variations in morbidity and mortality among neonates with intraventricular hemorrhage: a national database analysis
Sayeed S, Theriault B, Hengartner A, Serrato P, Sadeghzadeh S, Belkasim S, Ahsan N, Elsamadicy E, DiLuna M, Elsamadicy A. Regional variations in morbidity and mortality among neonates with intraventricular hemorrhage: a national database analysis. Child's Nervous System 2024, 40: 3571-3580. PMID: 38955900, DOI: 10.1007/s00381-024-06514-5.Peer-Reviewed Original ResearchNational Inpatient SampleIntraoperative variablesLong-term neurodevelopmental outcomesLow gestational ageMultivariate logistic regression analysisPermanent CSF shuntNational database analysisLow birth weightPercentage of patientsRetrospective cohort studyAssociated with decreased oddsImpact of insurance statusAssociated with reduced oddsMedian total costAssociated with mortalityLogistic regression analysisBackgroundIntraventricular hemorrhageNeonatal IVHGestational ageIntraventricular hemorrhageNeurodevelopmental outcomesCSF diversionCSF shuntingCost of admissionBirth weightPrevalence and prognostic importance of exercise limitation and physical inactivity in COPD
Vaes A, Burtin C, Casaburi R, Celli B, Evans R, Lareau S, Nici L, Rochester C, Troosters T. Prevalence and prognostic importance of exercise limitation and physical inactivity in COPD. Breathe 2024, 20: 230179. PMID: 38873237, PMCID: PMC11167648, DOI: 10.1183/20734735.0179-2023.Peer-Reviewed Original ResearchPhysical inactivityExercise limitationWalk testExercise performanceEndurance shuttle walk testExercise capacityMeasures of exercise performanceShuttle walk testAssess exercise capacityAssociated with mortalityExerciseDisease burdenInactivityPredictive of adverse outcomesAdverse outcomesCOPDAdditional resourcesNegative outcomesOutcomesTreadmillRespiratory impairmentEnduranceCliniciansPrevalenceBurdenContribution of Potentially Inappropriate Medications to Polypharmacy-Associated Risk of Mortality in Middle-Aged Patients: A National Cohort Study
Guillot J, Justice A, Gordon K, Skanderson M, Pariente A, Bezin J, Rentsch C. Contribution of Potentially Inappropriate Medications to Polypharmacy-Associated Risk of Mortality in Middle-Aged Patients: A National Cohort Study. Journal Of General Internal Medicine 2024, 39: 3261-3270. PMID: 38831248, PMCID: PMC11618606, DOI: 10.1007/s11606-024-08817-4.Peer-Reviewed Original ResearchMiddle-aged patientsRisk of mortalityVeterans AffairsChronic medicationsVA patient populationIntegrated healthcare systemNational cohort studyAssociated with increased mortalityMiddle-aged individualsMechanism of injuryMiddle-aged peopleAssociated with mortalityInappropriate medicationsBeers criteriaHealthcare systemAttenuate riskCohort studyClinical characteristicsGeneral populationHyperpolypharmacyFollow-upPolypharmacyPatient populationBackgroundThe roleCox modelHealthy lifestyle change and all-cause and cancer mortality in the European Prospective Investigation into Cancer and Nutrition cohort
Matta K, Viallon V, Botteri E, Peveri G, Dahm C, Nannsen A, Olsen A, Tjønneland A, Elbaz A, Artaud F, Marques C, Kaaks R, Katzke V, Schulze M, Llanaj E, Masala G, Pala V, Panico S, Tumino R, Ricceri F, Derksen J, Nøst T, Sandanger T, Borch K, Quirós J, Castro-Espin C, Sánchez M, Atxega A, Cirera L, Guevara M, Manjer J, Tin Tin S, Heath A, Touvier M, Goldberg M, Weiderpass E, Gunter M, Freisling H, Riboli E, Ferrari P. Healthy lifestyle change and all-cause and cancer mortality in the European Prospective Investigation into Cancer and Nutrition cohort. BMC Medicine 2024, 22: 210. PMID: 38807179, PMCID: PMC11134634, DOI: 10.1186/s12916-024-03362-7.Peer-Reviewed Original ResearchConceptsHealthy lifestyle indexAssociated with all-causeHealthy lifestyle changesEuropean Prospective InvestigationRisk of deathCancer mortalityFollow-up questionnaireAll-CauseLifestyle changesProspective InvestigationRate advancement periodsUnhealthy lifestyle changesRisk of noncommunicable diseasesCancer and NutritionCancer-free adultsBody mass indexBackgroundHealthy lifestylesLifestyle behaviorsNutrition CohortLifestyle indexLifestyle ProfilePhysical activityAssociated with mortalityNoncommunicable diseasesChange scoresShock Index is a Stronger Predictor of Outcomes in Older Compared to Younger Patients
Rafieezadeh A, Prabhakaran K, Kirsch J, Klein J, Shnaydman I, Bronstein M, Con J, Zangbar B. Shock Index is a Stronger Predictor of Outcomes in Older Compared to Younger Patients. Journal Of Surgical Research 2024, 300: 8-14. PMID: 38788482, DOI: 10.1016/j.jss.2024.04.064.Peer-Reviewed Original ResearchConceptsBlood transfusionSurgical interventionShock indexAssociated with mortalityGroup AGroup CPredictors of unfavorable outcomeGeriatric patientsQuality Improvement Program databaseTrauma Quality Improvement Program databaseRate of group CPredictors of outcomeRetrospective studyYounger patientsUnfavorable outcomeProgram databaseGroup BPrimary outcomeTransfusionSecondary outcomesPatientsSevere traumaMortality rateAge groupsBloodTreatment of Refractory Status Epilepticus With Continuous Intravenous Anesthetic Drugs
Au Y, Kananeh M, Rahangdale R, Moore T, Panza G, Gaspard N, Hirsch L, Fernandez A, Shah S. Treatment of Refractory Status Epilepticus With Continuous Intravenous Anesthetic Drugs. JAMA Neurology 2024, 81: 534-548. PMID: 38466294, DOI: 10.1001/jamaneurol.2024.0108.Peer-Reviewed Original ResearchAssociated with mortalityRefractory status epilepticusTreatment of refractory status epilepticusOutcome variablesPreferred Reporting ItemsAssociated with lower mortalityRisk of biasCompare outcome measuresPeer-reviewed studiesNon-English articlesStatus epilepticusBinary logistic regressionWeb of ScienceRSE etiologyReporting ItemsOutcome measuresSTUDY SELECTIONPredictors of mortalitySystematic reviewLogistic regressionManual searchIntravenous anesthetic drugsRefractory status epilepticus treatmentTreatment goalsIndependent extraction0757 Association of Insomnia with Objective Short Sleep Duration and Other Phenotypes with Mortality in Older Persons
Miner B, Pan Y, Cho G, Knauert M, Yaggi H, Gill T, Stone K, Ensrud K, Zeitzer J, Yaffe K, Doyle M. 0757 Association of Insomnia with Objective Short Sleep Duration and Other Phenotypes with Mortality in Older Persons. Sleep 2024, 47: a324-a325. DOI: 10.1093/sleep/zsae067.0757.Peer-Reviewed Original ResearchAssociated with increased mortality riskAssociation of insomniaMortality riskOlder personsShort sleep durationOsteoporotic fracturesAdjusted modelsStudy of Osteoporotic FracturesSleep durationHigher mortality riskCox proportional hazards modelsMen Sleep StudyNormal sleepProportional hazards modelAssociated with mortalitySevere sleep-disordered breathingUnadjusted modelsUnadjusted analysisCausal pathwaysSleep-disordered breathingFollow-up timePrevalence ratesReference groupHazards modelRisk phenotypesPre-COVID-19 hospital quality and hospital response to COVID-19: examining associations between risk-adjusted mortality for patients hospitalised with COVID-19 and pre-COVID-19 hospital quality
Peter D, Li S, Wang Y, Zhang J, Grady J, McDowell K, Norton E, Lin Z, Bernheim S, Venkatesh A, Fleisher L, Schreiber M, Suter L, Triche E. Pre-COVID-19 hospital quality and hospital response to COVID-19: examining associations between risk-adjusted mortality for patients hospitalised with COVID-19 and pre-COVID-19 hospital quality. BMJ Open 2024, 14: e077394. PMID: 38553067, PMCID: PMC10982775, DOI: 10.1136/bmjopen-2023-077394.Peer-Reviewed Original ResearchConceptsHospital qualityPatient experiencePre-COVID-19Medicare patientsShort-term acute care hospitalsCritical access hospitalsAcute care hospitalsFuture public health emergenciesHigher odds of mortalityIn-HospitalRisk-adjusted mortalityOdds of mortalityCare deliveryAccess hospitalsEffective careCOVID-19-related deathsAssociated with mortalityCare structuresHospital characteristicsPublic health emergencySummary scoreMedicare beneficiariesHigher oddsHospital responseRSMRsFRailty in Australian patients admitted to Intensive care unit after eLective CANCER-related SURGery: a retrospective multicentre cohort study (FRAIL-CANCER-SURG study)
Ling R, Ueno R, Alamgeer M, Sundararajan K, Sundar R, Bailey M, Pilcher D, Subramaniam A. FRailty in Australian patients admitted to Intensive care unit after eLective CANCER-related SURGery: a retrospective multicentre cohort study (FRAIL-CANCER-SURG study). British Journal Of Anaesthesia 2024, 132: 695-706. PMID: 38378383, DOI: 10.1016/j.bja.2024.01.020.Peer-Reviewed Original ResearchConceptsElective surgeryCohort studyMulticentre retrospective cohort studyRetrospective multicentre cohort studyPatients admitted to intensive care unitsAssociated with poor outcomesAssociated with similar effectsAssociated with lower survivalCancer-related surgeryMulticentre cohort studyRetrospective cohort studyLong-term outcomesIntensive care unitAssociated with mortalityPoor outcomeFollow-upICU admissionPrimary outcomeCare unitSurgeryPatientsSurvival informationCancerFrailtyICUP-19 CHARACTERIZATION, PROGNOSTIC FACTORS, AND SURVIVAL IN MODERATE ALCOHOL-ASSOCIATED HEPATITIS: A MULTICENTER STUDY
Idalsoaga F, Díaz L, Corsi O, Ayares G, Arnold J, Dunn W, Li Y, Singal A, Simonetto D, Ayala-Valverde M, Ramirez C, Morales-Arraez D, Zhang W, Qian S, Ahn J, Buryska S, Mehta H, Waleed M, Stefanescu H, Horhat A, Bumbu A, Attar B, Agrawal R, Cabezas J, Cuyàs B, Poca M, Pastor G, Sarin S, Maiwall R, Jalal P, La Tijera M, Kulkarni A, Rao N, Salazar P, Skladaný L, Bystrianska N, Prado V, Clemente-Sanchez A, Rincón D, Haider T, Chacko K, Romero G, Pollarsky F, Restrepo J, Toro L, Yaquich P, Mendizabal M, Garrido M, Marciano S, Dirchwolf M, Vargas V, Jimenez C, García-Tsao G, Ortiz G, Abraldes J, Kamath P, Shah V, Bataller R, Arab J. P-19 CHARACTERIZATION, PROGNOSTIC FACTORS, AND SURVIVAL IN MODERATE ALCOHOL-ASSOCIATED HEPATITIS: A MULTICENTER STUDY. Annals Of Hepatology 2024, 29: 101206. DOI: 10.1016/j.aohep.2023.101206.Peer-Reviewed Original ResearchRenal replacement therapyVariables associated with mortalityModerate AHAlcohol-associated hepatitisPrognostic factorsLiver transplantationMaddrey's discriminant functionAssociated with high mortalityMultiple organ failureRetrospective cohort studyMultivariate-adjusted modelsShort-term mortalityAssociated with mortalityCompeting-risks modelMedian ageCause of deathReplacement therapyMulticenter studyMELD scoreOrgan failureUnivariate analysisCohort studyFrequent causeSevere entitySurvival rateP- 40 PENTOXIFYLLINE USE IN PATIENTS WITH ALCOHOL-ASSOCIATED HEPATITIS ADMITTED WITH ACUTE KIDNEY INJURY COULD DECREASE SURVIVAL: A GLOBAL STUDY
Idalsoaga F, Diaz L, Corsi O, Ayares G, Arnold J, Dunn W, Li Y, Singal A, Simonetto D, Ayala-Valverde M, Ramirez C, Morales-Arraez D, Zhang W, Qian S, Ahn J, Buryska S, Mehta H, Waleed M, Stefanescu H, Horhat A, Bumbu A, Agrawal B, Agrawal R, Cabezas J, Cuyàs B, Poca M, Pastor G, Sarin S, Maiwall R, Jalal P, La Tijera M, Kulkarni A, Rao N, Salazar P, Skladaný L, Bystrianska N, Prado V, Clemente-Sanchez A, Rincón D, Haider T, Chacko K, Romero G, Pollarsky F, Restrepo J, Toro L, Yaquich P, Mendizabal M, Garrido M, Marciano S, Dirchwolf M, Vargas V, Jimenez C, García-Tsao G, Ortiz G, Abraldes J, Kamath P, Shah V, Bataller R, Arab J. P- 40 PENTOXIFYLLINE USE IN PATIENTS WITH ALCOHOL-ASSOCIATED HEPATITIS ADMITTED WITH ACUTE KIDNEY INJURY COULD DECREASE SURVIVAL: A GLOBAL STUDY. Annals Of Hepatology 2024, 29: 101227. DOI: 10.1016/j.aohep.2023.101227.Peer-Reviewed Original ResearchAlcohol-associated hepatitisAcute kidney injurySevere AHPentoxifylline useLiver transplantationKidney injuryMaddrey's discriminant functionAssociated with increased mortalityHistory of cirrhosisSubgroup of patientsRetrospective cohort studyMultivariate-adjusted modelsEffect of pentoxifyllineAssociated with mortalityCompeting-risks modelMedian ageSerum creatinineMELD scoreUnivariate analysisCohort studyFemale sexPentoxifyllineDecreased survivalSevere entityPatientsGlobal, regional, and national burden of mortality associated with cold spells during 2000–19: a three-stage modelling study
Gao Y, Huang W, Zhao Q, Ryti N, Armstrong B, Gasparrini A, Tong S, Pascal M, Urban A, Zeka A, Lavigne E, Madureira J, Goodman P, Huber V, Forsberg B, Kyselý J, Sera F, Guo Y, Li S, Network M, Gao Y, Huang W, Zhao Q, Ryti N, Armstrong B, Gasparrini A, Tong S, Pascal M, Urban A, Zeka A, Lavigne E, Madureira J, Goodman P, Huber V, Forsberg B, Kyselý J, Sera F, Bell M, Hales S, Honda Y, Jaakkola J, Tobias A, Vicedo-Cabrera A, Abrutzky R, de Sousa Zanotti Stagliorio Coelho M, Saldiva P, Correa P, Ortega N, Kan H, Osorio S, Roye D, Orru H, Indermitte E, Schneider A, Katsouyanni K, Analitis A, Carlsen H, Mayvaneh F, Roradeh H, Raz R, Michelozzi P, de'Donato F, Hashizume M, Kim Y, Alahmad B, Cauchy J, Diaz M, Arellano E, De la Cruz Valencia C, Overcenco A, Houthuijs D, Ameling C, Rao S, Carrasco G, Seposo X, Chua P, da Silva S, Nunes B, Holobaca I, Cvijanovic I, Mistry M, Scovronick N, Acquaotta F, Kim H, Lee W, Íñiguez C, Åström C, Ragettli M, Guo Y, Pan S, Colistro V, Zanobetti A, Schwartz J, Dang T, Van Dung, Guo Y, Li S. Global, regional, and national burden of mortality associated with cold spells during 2000–19: a three-stage modelling study. The Lancet Planetary Health 2024, 8: e108-e116. PMID: 38331527, DOI: 10.1016/s2542-5196(23)00277-2.Peer-Reviewed Original ResearchConceptsAssociated with cold spellsGlobal mortality burdenExcess death rateMortality burdenExcess deathsMeta-regression modelsMortality associationsDeath rateAnnual excess deathsMultivariate meta-regression modelExposure to cold spellsDeath ratioQuasi-Poisson regressionAssociated with mortalityNational burdenPublic health threatBurdenAssociationHealth threatMortalityCold spellsDeath
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply