2025
Fish consumption and gastric cancer within the Stomach cancer Pooling (StoP) Project
Franchi C, Ardoino I, Mandelli S, Patel L, Pelucchi C, Bonzi R, Camargo M, Rabkin C, Liao L, Sinha R, Johnson K, Hu J, Zhang Z, Palli D, Ferraroni M, Negri E, Turati F, Yu G, Lunet N, Morais S, López-Carrillo L, Tsugane S, Hidaka A, Malekzadeh R, Zaridze D, Maximovitch D, Vioque J, Gonzalez-Palacios S, Ward M, Aragonés N, Castaño-Vinyals G, Curado M, Dias-Neto E, Hamada G, Hernández-Ramirez R, Pakseresht M, Pourfarzi F, Mu L, Lagiou A, Lagiou P, López-Cervantes M, Dolci A, Boccia S, Pastorino R, Boffetta P, D’Avanzo B, La Vecchia C. Fish consumption and gastric cancer within the Stomach cancer Pooling (StoP) Project. Scientific Reports 2025, 15: 13099. PMID: 40240417, PMCID: PMC12003686, DOI: 10.1038/s41598-025-96658-4.Peer-Reviewed Original ResearchConceptsRisk of gastric cancerCancer riskAssociated with gastric cancer riskFamily history of gastric cancerStomach cancer PoolingStomach cancer riskHistory of gastric cancerGastric cancer riskIncreased intake of fishBody mass indexCase-control studyIntake of fishGeographical differencesFish consumptionGastric cancerPooling ProjectFamily historyMass indexCancer deathCanned fish consumptionFish intakeEnergy intakeMeta-analysisIncreased intakeHelicobacter pylori infectionIncreased risk of colorectal adenoma and benign colorectal polyp associated with Helicobacter pylori infection: a systematic review and meta-analysis
Kim J, Han H, Song J, Kim S, Kim Y, Kim H, Rhee T, Shim S. Increased risk of colorectal adenoma and benign colorectal polyp associated with Helicobacter pylori infection: a systematic review and meta-analysis. Translational Cancer Research 2025, 0: 0-0. PMID: 40386279, PMCID: PMC12079237, DOI: 10.21037/tcr-24-795.Peer-Reviewed Original ResearchBenign colorectal polypsAdvanced colorectal adenomaRisk of colorectal adenomaColorectal adenomasMeta-regression analysisIncreased risk of colorectal adenomaMeta-analysisSystematic reviewMeta-analysis findingsColorectal polypsAssociated with increased probabilityComprehensive literature searchCochrane DatabaseHelicobacter pylori infectionIncreased riskRisk factorsLiterature searchPotential moderatorsSubgroup analysisStatistically significant differenceHistological subtypesEffects of <i>H. pyPylori infectionEthnicityRiskGastrointestinal Bleeding in the Older Adult: Pathophysiology, Evaluation, and Management
Sobani Z, Hung K. Gastrointestinal Bleeding in the Older Adult: Pathophysiology, Evaluation, and Management. Current Treatment Options In Gastroenterology 2025, 23: 4. DOI: 10.1007/s11938-025-00469-5.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsOlder individualsManagement of modifiable risk factorsRisk factorsModifiable risk factorsProportion of individualsOlder adultsYears of ageBleeding riskGI bleedingManagement of GI bleedingRisk scoreTiming of endoscopic interventionPeri-procedural anticoagulation managementNovel risk scoreComorbid conditionsGastrointestinal (GI) bleedingReduce mortalityHelicobacter pylori infectionMitigate bleeding riskMortalityEndoscopic therapyRiskPrevent rebleedingGastrointestinal bleedingAnticoagulation management
2023
Helicobacter pylori–negative mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach: A clinicopathologic analysis
Gu S, Siddon A, Huntington S, Jain D. Helicobacter pylori–negative mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach: A clinicopathologic analysis. American Journal Of Clinical Pathology 2023, 160: 612-619. PMID: 37556379, PMCID: PMC10691190, DOI: 10.1093/ajcp/aqad088.Peer-Reviewed Original ResearchConceptsHP-positive patientsLymphoid tissue lymphomaChronic gastritisMALT lymphomaHP-negative casesTissue lymphomaHelicobacter pylori-negative mucosaPrimary gastric MALT lymphomaB-cell gene rearrangementsAvailable pathology reportsHP-negative patientsGastric MALT lymphomaHP-negative groupHelicobacter pylori infectionReview of slidesMALT lymphoma casesAdditional laboratory testingHP eradicationDisease recurrenceOptimal management strategyClinicopathologic analysisClinicopathologic featuresHistologic gastritisHP-positive casesInitial diagnosisIsotope tracing reveals bacterial catabolism of host-derived glutathione during Helicobacter pylori infection
Baskerville M, Kovalyova Y, Mejías-Luque R, Gerhard M, Hatzios S. Isotope tracing reveals bacterial catabolism of host-derived glutathione during Helicobacter pylori infection. PLOS Pathogens 2023, 19: e1011526. PMID: 37494402, PMCID: PMC10406306, DOI: 10.1371/journal.ppat.1011526.Peer-Reviewed Original ResearchConceptsH. pylori infectionPylori infectionInfected cellsBacterial catabolismGastric pathogen Helicobacter pyloriGSH depletionPathogen Helicobacter pyloriH. pylori-infected cellsMammalian cellsReactive oxygen speciesHelicobacter pylori infectionH. pylori colonizationCellular biomoleculesGSH homeostasisBacterial acquisitionCertain bacteriaVirulence factorsAntioxidant glutathioneIntracellular GSHOxidative damageOxidized GSHΓ-glutamyl transpeptidaseIsotope tracingHost tissuesOxygen species
2022
Vonoprazan Triple and Dual Therapy for Helicobacter pylori Infection in the United States and Europe: Randomized Clinical Trial
Chey WD, Mégraud F, Laine L, López LJ, Hunt BJ, Howden CW. Vonoprazan Triple and Dual Therapy for Helicobacter pylori Infection in the United States and Europe: Randomized Clinical Trial. Gastroenterology 2022, 163: 608-619. PMID: 35679950, DOI: 10.1053/j.gastro.2022.05.055.Peer-Reviewed Original ResearchConceptsEradication rateHelicobacter pylori infectionTriple therapyDual therapyPylori infectionProton pump inhibitor-based triple therapyTreatment-emergent adverse eventsInhibitor-based triple therapyPotassium-competitive acid blockerEfficacy of vonoprazanH pylori eradicationPhase 3 trialOverall study populationAmoxicillin-resistant strainsClarithromycin-resistant strainsH pylori infectionTreatment-naïve adultsPylori eradicationAdverse eventsSecondary outcomesPrimary outcomeStandard treatmentClinical trialsStudy populationAcid blockerSalt intake and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project
Morais S, Costa A, Albuquerque G, Araújo N, Pelucchi C, Rabkin CS, Liao LM, Sinha R, Zhang ZF, Hu J, Johnson KC, Palli D, Ferraroni M, Bonzi R, Yu GP, López-Carrillo L, Malekzadeh R, Tsugane S, Hidaka A, Hamada GS, Zaridze D, Maximovitch D, Vioque J, de la Hera MG, Moreno V, Vanaclocha-Espi M, Ward MH, Pakseresht M, Hernández-Ramirez RU, López-Cervantes M, Pourfarzi F, Mu L, Kurtz RC, Boccia S, Pastorino R, Lagiou A, Lagiou P, Boffetta P, Camargo MC, Curado MP, Negri E, La Vecchia C, Lunet N. Salt intake and gastric cancer: a pooled analysis within the Stomach cancer Pooling (StoP) Project. Cancer Causes & Control 2022, 33: 779-791. PMID: 35304655, DOI: 10.1007/s10552-022-01565-y.Peer-Reviewed Original ResearchConceptsTotal sodium intakeStomach cancer Pooling (StoP) ProjectSalt-preserved foodsGastric cancerSodium intakePooling ProjectSalt taste preferenceTaste preferencesHelicobacter pylori infectionSalty taste preferenceDietary salt exposureIndividual participant dataRandom-effects modelTable saltLowest tertileHighest tertileSalt intakePylori infectionHighest vs.STOP projectAnatomic sitesFood intakePurposePrevious studiesCancer riskSignificant association
2021
Exploring the interactions between Helicobacter pylori (Hp) infection and other risk factors of gastric cancer: A pooled analysis in the Stomach cancer Pooling (StoP) Project
Collatuzzo G, Pelucchi C, Negri E, López‐Carrillo L, Tsugane S, Hidaka A, Hamada G, Hernández‐Ramírez R, López‐Cervantes M, Malekzadeh R, Pourfarzi F, Mu L, Zhang Z, Lunet N, La Vecchia C, Boffetta P. Exploring the interactions between Helicobacter pylori (Hp) infection and other risk factors of gastric cancer: A pooled analysis in the Stomach cancer Pooling (StoP) Project. International Journal Of Cancer 2021, 149: 1228-1238. PMID: 33990950, DOI: 10.1002/ijc.33678.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsStomach cancer Pooling (StoP) ProjectHP infectionRisk factorsGastric cancerSocioeconomic statusCigarette smokingPooled analysisAlcohol drinkingOdds ratioPooling ProjectMultivariate unconditional logistic regressionDietary salt intakeModifiable risk factorsHelicobacter pylori infectionUnconditional logistic regressionGastric cancer preventionConfidence intervalsCase-control studySummary odds ratiosLifestyle modificationHP eradicationSalt intakeTobacco smokingDietary saltHistologic type
2019
Smoking and Helicobacter pylori infection
Ferro A, Morais S, Pelucchi C, Aragonés N, Kogevinas M, López-Carrillo L, Malekzadeh R, Tsugane S, Hamada GS, Hidaka A, Hernández-Ramírez RU, López-Cervantes M, Zaridze D, Maximovitch D, Pourfarzi F, Zhang ZF, Yu GP, Pakseresht M, Ye W, Plymoth A, Leja M, Gasenko E, Derakhshan MH, Negri E, La Vecchia C, Peleteiro B, Lunet N. Smoking and Helicobacter pylori infection. European Journal Of Cancer Prevention 2019, Publish Ahead of Print: &na;. PMID: 30272597, DOI: 10.1097/cej.0000000000000471.Peer-Reviewed Original ResearchConceptsH. pylori seropositivityHelicobacter pylori infectionPylori infectionPylori seropositivityPrevalence ratiosStomach cancer Pooling (StoP) ProjectDuration of smokingH. pylori infectionCase-control studyConfidence intervalsSummary odds ratiosIndividual participant dataOdds ratioEgger's testGastric cancerStratified analysisMajor covariatesPooling ProjectGreater prevalenceSmokingH. pyloriSignificant associationPublication biasSeropositivityInfectionFactors Associated With Adherence to Helicobacter pylori Testing During Hospitalization for Bleeding Peptic Ulcer Disease
Hung KW, Knotts RM, Faye AS, Pont AR, Lebwohl B, Abrams JA, Freedberg DE. Factors Associated With Adherence to Helicobacter pylori Testing During Hospitalization for Bleeding Peptic Ulcer Disease. Clinical Gastroenterology And Hepatology 2019, 18: 1091-1098.e1. PMID: 31352090, DOI: 10.1016/j.cgh.2019.07.037.Peer-Reviewed Original ResearchConceptsPeptic ulcer diseaseIntensive care unitH pyloriUlcer diseaseGastrointestinal bleedingDuodenal ulcerPylori infectionKaplan-Meier analysisH pylori infectionHelicobacter pylori infectionYear of admissionHelicobacter pylori testingElectronic medical recordsEvidence of testsIndex endoscopyCoagulation statusComposite outcomeEndoscopic factorsBlood lossHospital admissionCare unitRetrospective studyMedical recordsMultivariable modelUlcer severitySex differences in the prevalence of Helicobacter pylori infection: an individual participant data pooled analysis (StoP Project)
Ferro A, Morais S, Pelucchi C, Dierssen-Sotos T, Martín V, López-Carrillo L, Malekzadeh R, Tsugane S, Hamada GS, Hidaka A, Hernández-Ramírez RU, López-Cervantes M, Zaridze D, Maximovitch D, Pourfarzi F, Zhang ZF, Yu GP, Pakseresht M, Ye W, Plymoth A, Leja M, Gasenko E, Derakhshan MH, Negri E, La Vecchia C, Peleteiro B, Lunet N. Sex differences in the prevalence of Helicobacter pylori infection: an individual participant data pooled analysis (StoP Project). European Journal Of Gastroenterology & Hepatology 2019, 31: 593-598. PMID: 30839435, DOI: 10.1097/meg.0000000000001389.Peer-Reviewed Original ResearchConceptsH. pylori infectionHelicobacter pylori infectionPylori infectionPrevalence ratiosOdds ratioGastric atrophyIgG serum antibody titersStomach cancer Pooling (StoP) ProjectPublication biasInfection statusSerum antibody titersConfidence intervalsSummary odds ratiosSerum pepsinogen levelsIndividual participant dataLifetime infectionsMultiplex serologyAntibody titersHistological examinationPooling ProjectPepsinogen levelsOlder controlsInfectionParticipant dataStrong association
2017
Secondary antibiotic resistance of Helicobacter pylori isolates in Israeli children and adults
Khoury J, Geffen Y, Shaul R, Sholy H, Chowers Y, Saadi T. Secondary antibiotic resistance of Helicobacter pylori isolates in Israeli children and adults. Journal Of Global Antimicrobial Resistance 2017, 10: 182-185. PMID: 28732784, DOI: 10.1016/j.jgar.2017.05.017.Peer-Reviewed Original ResearchConceptsH. pylori culturePositive H. pylori culturePylori cultureTherapeutic regimensH. pyloriRambam Health Care CampusSecondary antibiotic resistanceHelicobacter pylori infectionHealth Care CampusAntibiotic resistanceH. pylori strainsHelicobacter pylori isolatesStandard therapyPylori infectionGastric biopsiesSecondary antimicrobial resistanceLEV resistancePylori isolatesPatientsAntimicrobial susceptibilityClarithromycinPylori strainsMetronidazoleAmoxicillinAntimicrobial resistanceEnvironmental factors, seven GWAS‐identified susceptibility loci, and risk of gastric cancer and its precursors in a Chinese population
Cai M, Dai S, Chen W, Xia C, Lu L, Dai S, Qi J, Wang M, Wang M, Zhou L, Lei F, Zuo T, Zeng H, Zhao X. Environmental factors, seven GWAS‐identified susceptibility loci, and risk of gastric cancer and its precursors in a Chinese population. Cancer Medicine 2017, 6: 708-720. PMID: 28220687, PMCID: PMC5345626, DOI: 10.1002/cam4.1038.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol DrinkingAMP-Activated Protein KinasesAntigens, NeoplasmAsian PeopleChinaFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGPI-Linked ProteinsHelicobacter InfectionsHumansLogistic ModelsMaleMembrane Transport ProteinsMucin-1Neoplasm ProteinsNerve Tissue ProteinsRisk FactorsSmokingStomach NeoplasmsTranscription FactorsConceptsRisk of GCPylori infectionAlcohol drinkingPRKAA1 rs13361707Intestinal metaplasiaGastric cancerGene-environment interactionsGastric carcinogenesisChinese populationSevere intestinal metaplasiaHelicobacter pylori infectionUnconditional logistic regressionPrecancerous gastric lesionsGastric cancer riskEnvironmental risk factorsGenetic predisposition factorsGenome-wide association studiesSusceptibility lociMUC1 rs4072037Gastric lesionsRisk factorsEffect modificationCancer riskAlcohol consumptionDisease risk
2016
Helicobacter pylori infection, H19 and LINC00152 expression in serum and risk of gastric cancer in a Chinese population
Yang T, Zeng H, Chen W, Zheng R, Zhang Y, Li Z, Qi J, Wang M, Chen T, Lou J, Lu L, Zhou T, Dai S, Cai M, You W, Pan K. Helicobacter pylori infection, H19 and LINC00152 expression in serum and risk of gastric cancer in a Chinese population. Cancer Epidemiology 2016, 44: 147-153. PMID: 27592063, DOI: 10.1016/j.canep.2016.08.015.Peer-Reviewed Original ResearchConceptsH. pylori infectionHelicobacter pylori infectionPylori infectionRisk of GCGastric cancerReverse transcription-quantitative polymerase chain reactionTranscription-quantitative polymerase chain reactionHigh H19 expressionDiagnosis of GCPowerful cancer biomarkersLINC00152 expressionPolymerase chain reactionLong non-coding RNAsElevated riskGastric carcinogenesisPotential biomarkersSignificant associationChinese populationInfectionH19 expressionLINC00152Significant joint effectHigh expressionGC developmentChain reactionPrevalence and Clinical, Endoscopic, and Pathological Features of Duodenitis in Children
Alper A, Hardee S, Rojas‐Velasquez D, Escalera S, Morotti RA, Pashankar DS. Prevalence and Clinical, Endoscopic, and Pathological Features of Duodenitis in Children. Journal Of Pediatric Gastroenterology And Nutrition 2016, 62: 314-316. PMID: 26252915, PMCID: PMC4724230, DOI: 10.1097/mpg.0000000000000942.Peer-Reviewed Original ResearchConceptsAssociated gastritisEndoscopic appearancePathological featuresCeliac diseaseClinical diagnosisDiagnosis of duodenitisPositive celiac serologyInflammatory bowel diseaseHelicobacter pylori infectionPatient's clinical diagnosisCeliac serologyAbdominal painUpper endoscopyVillous changesBowel diseaseCommon indicationUlcerative colitisCommon etiologyCrohn's diseasePylori infectionPathology reportsDuodenitisCommon causeEndoscopic dataLarge cohort
2014
Dieta y cáncer gástrico en México y en el mundo
Hernández-Ramírez RU, López-Carrillo L. Dieta y cáncer gástrico en México y en el mundo. Salud Pública De México 2014, 56: 555-560. PMID: 25604301, DOI: 10.21149/spm.v56i5.7380.Peer-Reviewed Original Research
2012
Do Probiotics have a Role in the Treatment of Helicobacter pylori infection? A Meta-analysis of Randomized Controlled Trials
Devaki P, Njei B, Ditah I, Jaiyeoba C. Do Probiotics have a Role in the Treatment of Helicobacter pylori infection? A Meta-analysis of Randomized Controlled Trials. The American Journal Of Gastroenterology 2012, 107: s60. DOI: 10.14309/00000434-201210001-00141.Peer-Reviewed Original ResearchHelicobacter pylori and the risk of Barrett's esophagus: A meta-analysis.
Salami A, Njei B, Ditah I. Helicobacter pylori and the risk of Barrett's esophagus: A meta-analysis. Journal Of Clinical Oncology 2012, 30: 35-35. DOI: 10.1200/jco.2012.30.4_suppl.35.Peer-Reviewed Original ResearchPublication biasIncreased risk of BERisk of Barrett's esophagusEvidence of publication biasIncreased riskAssociation of BESTATA version 11Risk of BEDirection of associationAdjusted risk estimatesRisk of esophageal adenocarcinomaIncreased risk of esophageal adenocarcinomaCase-control studyHelicobacter pylori infectionPooled risk ratioFixed-effects modelEgger's testIdentified articlesRisk estimatesRisk ratioSystematic searchCochrane LibraryMeta-analysisVersion 11Subgroup analysisHelicobacter pylori infection and the risk of colorectal cancer: A meta-analysis of epidemiologic evidence.
Njei B, Ditah I, Appiah J, Jinjuvadia R, Birk J. Helicobacter pylori infection and the risk of colorectal cancer: A meta-analysis of epidemiologic evidence. Journal Of Clinical Oncology 2012, 30: 408-408. DOI: 10.1200/jco.2012.30.4_suppl.408.Peer-Reviewed Original ResearchRisk of colorectal cancerPublication biasStudy designVisual inspection of funnel plotsInspection of funnel plotsRisk of CRCEvidence of publication biasColorectal cancerMeta-analysisSubgroup analysisHelicobacter pylori infectionRandom-effects modelResidual confoundingEgger's testFunnel plotPooled OREpidemiological evidenceEpidemiological studiesRisk factorsRetrospective studyHigh riskPylori infectionBeggEffects modelPubMed database
2006
Gastric Siderosis
Marginean EC, Bennick M, Cyczk J, Robert ME, Jain D. Gastric Siderosis. The American Journal Of Surgical Pathology 2006, 30: 514-520. PMID: 16625099, DOI: 10.1097/00000478-200604000-00013.Peer-Reviewed Original ResearchConceptsOral iron medicationDiagnosis of hemochromatosisIron medicationGastric biopsiesIron depositionMild gastritisGlandular epitheliumPattern AActive Helicobacter pylori infectionStromal cellsPattern BDiffuse iron depositionIron pill gastritisPattern CSurgical pathology filesHelicobacter pylori infectionConsecutive gastric biopsiesMucosal inflammationLiver biopsyPathology filesClinical featuresMucosal hemorrhageGastric antralPylori infectionGastric inflammation
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