2025
The Association between All-Cause Mortality and Obstructive Sleep Apnea in Adults: A U-Shaped Curve.
Azarian M, Ramezani A, Sharafkhaneh A, Maghsoudi A, Kryger M, Thomas R, Westover M, Razjouyan J. The Association between All-Cause Mortality and Obstructive Sleep Apnea in Adults: A U-Shaped Curve. Annals Of The American Thoracic Society 2025, 22: 581-590. PMID: 39746198, PMCID: PMC12005042, DOI: 10.1513/annalsats.202407-755oc.Peer-Reviewed Original ResearchApnea-hypopnea indexAll-Cause MortalitySleep apneaBody mass indexAssociated with apnea-hypopnea indexApnea hypopnea index categoriesInterpretation of sleep studiesOdds ratioOdds of all-cause mortalityObstructive sleep apneaSeverity of SAAll-cause mortality ratesElixhauser Comorbidity IndexSleep studiesPropensity-matchedMass indexSevere SAComorbidity indexAll-CauseMortality rateMortalityEffects of ageApneaLogistic regressionAge groupsThe association between internet-use-disorder symptoms and loneliness: a systematic review and meta-analysis with a categorical approach
Mestre-Bach G, Paiva U, San Martín Iniguez L, Beranuy M, Martín-Vivar M, Mallorquí-Bagué N, Normand E, Chicote M, Potenza M, Arrondo G. The association between internet-use-disorder symptoms and loneliness: a systematic review and meta-analysis with a categorical approach. Psychological Medicine 2025, 55: e77. PMID: 40071718, PMCID: PMC12080635, DOI: 10.1017/s0033291725000376.Peer-Reviewed Original ResearchConceptsInternet-use disordersSystematic reviewMeta-analysisInternet-useInternet use disorderRandom-effects modelWeb of ScienceDegree of lonelinessUCLA Loneliness ScaleStatistical poolingQuantify associationsOdds ratioCohen's dDisorder symptomsGreater lonelinessMeta-RegressionPooled differenceEffect sizePre-registeredUCLA-LonelinessLonelinessEffects of ageCategorical approachSymptomsGroup of individuals
2024
Large‐scale analysis of structural brain asymmetries during neurodevelopment: Associations with age and sex in 4265 children and adolescents
Kurth F, Schijven D, van den Heuvel O, Hoogman M, van Rooij D, Stein D, Buitelaar J, Bölte S, Auzias G, Kushki A, Venkatasubramanian G, Rubia K, Bollmann S, Isaksson J, Jaspers‐Fayer F, Marsh R, Batistuzzo M, Arnold P, Bressan R, Stewart S, Gruner P, Sorensen L, Pan P, Silk T, Gur R, Cubillo A, Haavik J, Tuura R, Hartman C, Calvo R, McGrath J, Calderoni S, Jackowski A, Chantiluke K, Satterthwaite T, Busatto G, Nigg J, Gur R, Retico A, Tosetti M, Gallagher L, Szeszko P, Neufeld J, Ortiz A, Ghisleni C, Lazaro L, Hoekstra P, Anagnostou E, Hoekstra L, Simpson B, Plessen J, Deruelle C, Soreni N, James A, Narayanaswamy J, Reddy J, Fitzgerald J, Bellgrove M, Salum G, Janssen J, Muratori F, Vila M, Giral M, Ameis S, Bosco P, Remnélius K, Huyser C, Pariente J, Jalbrzikowski M, Rosa P, O'Hearn K, Ehrlich S, Mollon J, Zugman A, Christakou A, Arango C, Fisher S, Kong X, Franke B, Medland S, Thomopoulos S, Jahanshad N, Glahn D, Thompson P, Francks C, Luders E. Large‐scale analysis of structural brain asymmetries during neurodevelopment: Associations with age and sex in 4265 children and adolescents. Human Brain Mapping 2024, 45: e26754. PMID: 39046031, PMCID: PMC11267452, DOI: 10.1002/hbm.26754.Peer-Reviewed Original ResearchConceptsBrain asymmetryBrain regionsSex differencesStructural brain asymmetryCerebral asymmetryFindings lack consistencyBrain featuresEffects of ageSamples to dateEffect sizeBrainDifferential effectsAdolescentsAge effectsChildhoodInvestigate associationsSignificant asymmetryAssociated with ageSexMaleFindingsNeurodevelopmentAssociationDifferencesHemisphereTask–Rest Reconfiguration Efficiency of the Reward Network Across Adolescence and Its Association With Early Life Stress and Depressive Symptoms
Lee Y, Yuan J, Winkler A, Kircanski K, Pine D, Gotlib I. Task–Rest Reconfiguration Efficiency of the Reward Network Across Adolescence and Its Association With Early Life Stress and Depressive Symptoms. Journal Of The American Academy Of Child & Adolescent Psychiatry 2024, 64: 290-300. PMID: 38878818, PMCID: PMC11638404, DOI: 10.1016/j.jaac.2024.04.018.Peer-Reviewed Original ResearchEarly life stressReward networkDepressive symptomsLife stressReconfiguration efficiencyFunctional connectivityExperiences of early life stressExposure to early life stressEffects of early life stressTask-based fMRI scansHigher levels of depressive symptomsLevels of depressive symptomsSevere early life stressReward processingAge-related associationsFMRI scanningAdolescent depressionCommunity sampleTask demandsResting-stateAsymptomatic youthOlder adolescentsEffects of ageRewardBrain statesDopamine D1 Receptor Agonists Rescue Age-related Decline in Temporal Order Memory
Bransom L, Bassett A, Zhou M, Cimino J, Mailman R, Yang Y. Dopamine D1 Receptor Agonists Rescue Age-related Decline in Temporal Order Memory. Neuroscience 2024, 551: 177-184. PMID: 38823551, PMCID: PMC11246218, DOI: 10.1016/j.neuroscience.2024.05.033.Peer-Reviewed Original ResearchTemporal order memoryOrder memoryAge-related declineDopamine D1 receptor agonistTreating age-related cognitive declineAge-related cognitive declineReceptor agonistsSpatial working memoryD1 receptor agonistPoorer memory performanceWorking memoryMemory performanceCognitive declineEffects of ageRecognition taskEffect sizeIndividual ratsMemoryOld ratsOptimal effective doseDopamineImproved therapeutic indexAgonistsTherapeutic indexFunctional selectivityiGATE analysis improves the interpretability of single-cell immune landscape of influenza infection
Hill B, Zak A, Raja S, Bugada L, Rizvi S, Roslan S, Nguyen H, Chen J, Jiang H, Ono A, Goldstein D, Wen F. iGATE analysis improves the interpretability of single-cell immune landscape of influenza infection. JCI Insight 2024, 9: e172140. PMID: 38814732, PMCID: PMC11383363, DOI: 10.1172/jci.insight.172140.Peer-Reviewed Original ResearchInfluenza infectionImmune cell typesCourse of influenza infectionDefective T cell responsesSurvival of C57BL/6 miceCell typesDecreased IL-10 expressionEffect of host genetic backgroundT cell responsesGenetic backgroundTime-of-flight (CyTOFIL-10 expressionInflammatory cell typesCells in silicoHost genetic backgroundC57BL/6 miceAged miceMouse lungHost genotypeInfection susceptibilityHost factorsEffects of ageMiceHealth burdenInfectionPrescription Opioid Dose Change Before Fatal Opioid-Detected Overdose.
Kazemitabar M, Howell B, Becker W, Lin H, Grau L, Heimer R, D'Onofrio G, Hawk K, Fiellin D, Black A. Prescription Opioid Dose Change Before Fatal Opioid-Detected Overdose. Journal Of Studies On Alcohol And Drugs 2024, 85: 815-819. PMID: 38775307, DOI: 10.15288/jsad.24-00026.Peer-Reviewed Original ResearchPrescribed opioidsOpioid dose changesRapid dose increaseNon-HispanicOverdose deathsToxicological resultsNon-prescription opioidsBlack non-HispanicMorphine equivalentsOpioid therapyWhite non-HispanicDose changesDaily doseMean ageDispensed opioidsPrescription opioidsPrescribing patternsOpioidDose increaseOpioid overdose crisisIncreasing dosesStudy investigated patternsEffect of timeEffects of ageSecondary analysisThe effects of genetic and modifiable risk factors on brain regions vulnerable to ageing and disease
Manuello J, Min J, McCarthy P, Alfaro-Almagro F, Lee S, Smith S, Elliott L, Winkler A, Douaud G. The effects of genetic and modifiable risk factors on brain regions vulnerable to ageing and disease. Nature Communications 2024, 15: 2576. PMID: 38538590, PMCID: PMC10973379, DOI: 10.1038/s41467-024-46344-2.Peer-Reviewed Original ResearchConceptsModifiable risk factorsRisk factorsBrain networksUK Biobank participantsTraffic-related air pollutionAlcohol intake frequencyBrain regionsGenome-wide associationBiobank participantsHigher-order brain regionsIntake frequencyXg blood groupEffects of ageCardiovascular deathGenetic influencesUnique contributionsNitrogen dioxideSchizophreniaBrainAgeAir pollutionAlzheimer's diseaseParkinson's diseaseSexAssociationPrevalence of Sleep CALM nocturia factors in a male veteran population
Monaghan T, Fang A, Ksido L, Hachicho C, Muneeb M, Rahman S, Kheir G, Lazar J, Everaert K, Wein A, Weiss J. Prevalence of Sleep CALM nocturia factors in a male veteran population. Neurourology And Urodynamics 2024, 43: 1127-1133. PMID: 38511613, DOI: 10.1002/nau.25410.Peer-Reviewed Original ResearchAssociated with advanced ageFrequency-volume chartUrinary tract dysfunctionSignificant diagnostic challengeMedical history dataMale veteran populationGenitourinary abnormalitiesNocturnal voidsUrinary tractDiagnostic challengeConsensus guidelinesHost of conditionsNocturiaRetrospective analysisUrology settingAdvanced agePatient populationMultifactorial conditionReal-world practiceSleep disordersNocturia patientsDifferential effects of ageEffects of ageMedication useSleepThe Effects of Age and Height on Gait Smoothness in Adolescent Athletes †
Clarke L, Jones R, Hiremath S, Franklin C, Wright W, Tucker C. The Effects of Age and Height on Gait Smoothness in Adolescent Athletes †. Children 2024, 11: 223. PMID: 38397335, PMCID: PMC10887815, DOI: 10.3390/children11020223.Peer-Reviewed Original ResearchGait stabilityPost-fatigueRate of sports injuriesBout of fatiguing exerciseTrials of treadmillQuantify gait stabilityEffects of fatigueWalking speedAdolescent athletesPre-fatigueSports injuriesChronological ageGaitMultiple linear regressionEffects of ageStudy findingsTreadmillSport progressionAdolescent growthAdolescentsLinear regressionWalkingFemale adolescentsFatigueMale heightA late-life neurogenetic signature of exposure to combat stress – A monozygotic discordant twin study
Beucke J, Diez I, Sepulcre J, Mundorf A, Kaufmann C, Orr S, Pitman R, Shin L. A late-life neurogenetic signature of exposure to combat stress – A monozygotic discordant twin study. Journal Of Psychiatric Research 2024, 171: 230-237. PMID: 38316103, PMCID: PMC11113072, DOI: 10.1016/j.jpsychires.2024.01.032.Peer-Reviewed Original ResearchConceptsAmygdalar responsesCombat exposureCombat stressSymptoms of post-traumatic stress disorderPost-traumatic stress disorderTermination of stress exposureCombat-exposed veteransDiscordant twin studiesImpact brain functionAmygdalar functionStress disorderStress exposureAcute stressTwin studiesTwin pairsCombat experienceNeurogenetic mechanismsBrain functionEarly adulthoodEffects of ageConfounding effects of ageTwin siblingsVeteransPsychosocial evidenceGene expressionRole of Early Psychosis Detection in the Relationship Between Personal Income and Duration of Untreated Psychosis
Venkataraman S, Hazan H, Li F, Ferrara M, Harper A, Ma J, Shah J, Musket C, Levine N, Keshavan M, Srihari V. Role of Early Psychosis Detection in the Relationship Between Personal Income and Duration of Untreated Psychosis. Psychiatric Services 2024, 75: 427-433. PMID: 38204369, DOI: 10.1176/appi.ps.20230239.Peer-Reviewed Original ResearchDuration of untreated psychosisFirst-episode psychosis servicesFirst-episode psychosisEarly psychosis detectionLow personal incomeSocioeconomic statusUntreated psychosisOutcome of first-episode psychosisLength of duration of untreated psychosisEffectiveness of early detectionSpecialty care clinicsProlonged duration of untreated psychosisReduce duration of untreated psychosisEffects of ageLow socioeconomic statusPersonal incomeIndicators of disparitiesEarly detection effortsAssociated with younger ageYears of educationSES indicatorsCare clinicsEarly detectionBlack raceHierarchical regression
2023
Testosterone levels mediate the dynamics of motor oscillatory coding and behavior in developing youth
Killanin A, Taylor B, Embury C, Picci G, Wang Y, Calhoun V, Stephen J, Heinrichs-Graham E, Wilson T. Testosterone levels mediate the dynamics of motor oscillatory coding and behavior in developing youth. Developmental Cognitive Neuroscience 2023, 61: 101257. PMID: 37236034, PMCID: PMC10232658, DOI: 10.1016/j.dcn.2023.101257.Peer-Reviewed Original ResearchConceptsMotor performanceEffects of ageSalivary testosterone samplesMotor sequence taskMultiple mediation modelMovement-related beta activityBeta oscillatory dynamicsMeasures of motor performanceYouth aged 9Complex motor performanceLeft primary motor cortexPubertal transition periodBeta activitySequencing taskTestosterone samplesMediation modelMotor planningMotor regionsTask behaviorPrimary motor cortexDevelopmental changesBehavior indexYoung adulthoodTestosterone levelsAged 9Aging brain shows joint declines in brain within-network connectivity and between-network connectivity: a large-sample study (N > 6,000)
Du Y, Guo Y, Calhoun V. Aging brain shows joint declines in brain within-network connectivity and between-network connectivity: a large-sample study (N > 6,000). Frontiers In Aging Neuroscience 2023, 15: 1159054. PMID: 37273655, PMCID: PMC10233064, DOI: 10.3389/fnagi.2023.1159054.Peer-Reviewed Original ResearchFunctional network connectivityWithin-network connectivityCognitive control networkFunctional networksIncreased within-network connectivityDecreased within-network connectivityWhole-brain functional networksControl networkReduced functional network connectivityBetween-network connectivityWhole-brain levelNon-pathological agingSub-cortical networksIndependent component analysisBrain functional networksMode networkAging-related changesSensorimotor networkNeuroimaging dataConnectivity declineVisual networkWhole-brainBrain agingAging BrainEffects of age
2022
Susceptibility of Patients with Inflammatory Bowel Disease to COVID-19 Compared with Their Households
Anushiravani A, Saberzadeh-Ardestani B, Vahedi H, Fakheri H, Mansour-Ghanaei F, Maleki I, Nasseri-Moghaddam S, Vosoghinia H, Ghadir M, Hormati A, Kasaeian A, Radmard A, Khosravi B, Malekzadeh M, Alatab S, Sadeghi A, Aminisani N, Poustchi H, Sima A, Malekzadeh R. Susceptibility of Patients with Inflammatory Bowel Disease to COVID-19 Compared with Their Households. Middle East Journal Of Digestive Diseases 2022, 14: 182-191. PMID: 36619152, PMCID: PMC9489316, DOI: 10.34172/mejdd.2022.271.Peer-Reviewed Original ResearchInflammatory bowel diseaseAnti-TNF monotherapySevere inflammatory bowel diseasePrevalence of COVID-19Susceptibility of patientsSeverity of inflammatory bowel diseaseTreatment of inflammatory bowel diseaseData of patientsMultivariate logistic regressionFrequency of COVID-19Immunosuppressive agentsRisk of coronavirus disease 2019Associated with COVID-19Multivariate analysisMulti-centerBowel diseasePatientsRisk factorsObservational studyCoronavirus disease 2019Effects of ageMonotherapyLogistic regressionCOVID-19 susceptibilityPrevalence
2021
Effects of aging on conditional visuomotor learning for grasping and lifting eccentrically weighted objects
Rao N, Mehta N, Patel P, Parikh P. Effects of aging on conditional visuomotor learning for grasping and lifting eccentrically weighted objects. Journal Of Applied Physiology 2021, 131: 937-948. PMID: 34264127, DOI: 10.1152/japplphysiol.00932.2020.Peer-Reviewed Original ResearchConceptsArbitrary color cuesColor cuesObject CM locationYoung adultsOlder adultsDigit positionConditional visuomotor learningModulate digit placementRate of learningAge-related impairmentTrial-to-trialCM locationLearning trialsConditioned learningAnticipatory scalingDigit forcesAnticipatory modulationVisuomotor learningEffects of ageDigit placementObject tiltCuesImpaired abilityImpairmentObject properties
2014
Mortality benefits of different hemodialysis access types are age dependent
Hicks C, Canner J, Arhuidese I, Zarkowsky D, Qazi U, Reifsnyder T, Black J, Malas M. Mortality benefits of different hemodialysis access types are age dependent. Journal Of Vascular Surgery 2014, 61: 449-456. PMID: 25175630, DOI: 10.1016/j.jvs.2014.07.091.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedAged, 80 and overArteriovenous Shunt, SurgicalCatheterization, Central VenousCatheters, IndwellingCentral Venous CathetersChi-Square DistributionFemaleHumansMaleMiddle AgedMultivariate AnalysisPatient SelectionProportional Hazards ModelsRenal DialysisRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesYoung AdultConceptsArteriovenous fistulaArteriovenous graftsHemodialysis cathetersMortality benefitDialysis accessBenefits of arteriovenous fistulasPredictor of overall mortalityCox proportional hazards modelsEffects of ageAge groupsUnited States Renal Data SystemRisk of deathAccess typeYears of ageProportional hazards modelHemodialysis access typePatient ageHemodialysis initiationRisk-adjusted mortalityOverall mortalityDialysis patientsPatientsHazards modelSpline modelIncreasing age
2010
Real-Time Three-Dimensional Echocardiographic Assessment of Left Ventricular Systolic Dyssynchrony in Healthy Children
Cui W, Gambetta K, Zimmerman F, Freter A, Sugeng L, Lang R, Roberson D. Real-Time Three-Dimensional Echocardiographic Assessment of Left Ventricular Systolic Dyssynchrony in Healthy Children. Journal Of The American Society Of Echocardiography 2010, 23: 1153-1159. PMID: 20864315, DOI: 10.1016/j.echo.2010.08.009.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentChildChild, PreschoolCohort StudiesEchocardiography, Three-DimensionalFeasibility StudiesFemaleHumansImage Interpretation, Computer-AssistedInfantInfant, NewbornMaleObserver VariationReference ValuesReproducibility of ResultsStroke VolumeTachycardia, VentricularVentricular Dysfunction, LeftYoung AdultConceptsLV end-diastolic volumeEnd-diastolic volumeBody surface areaLeft ventricular (LV) systolic dysfunctionLeft ventricular systolic dyssynchronyChildren aged 1 daySeverity of dyssynchronyHeart rateContracting segmentsAged 1 dayCardiac cycle lengthSystolic dyssynchronySystolic dysfunctionEchocardiographic assessmentResynchronization therapyQRS durationInterobserver variabilityIntraobserver variabilityDyssynchronyNormal valuesAdult valuesEffects of ageQuantitative three-dimensionalCycle lengthHealthy children
2001
Prevalence of Sleep-disordered Breathing in Women
BIXLER E, VGONTZAS A, LIN H, TEN HAVE T, REIN J, VELA-BUENO A, KALES A. Prevalence of Sleep-disordered Breathing in Women. American Journal Of Respiratory And Critical Care Medicine 2001, 163: 608-613. PMID: 11254512, DOI: 10.1164/ajrccm.163.3.9911064.Peer-Reviewed Original ResearchConceptsHormone replacement therapyPrevalence of sleep-disordered breathingPrevalence of sleep apneaBody mass indexSleep-disordered breathingSleep apneaPostmenopausal womenPremenopausal womenPresence of sleep apneaAssociated with reduced riskTwo-phase random samplingPhase I subjectsHormone replacementReplacement therapyApneaMass indexI subjectsRisk factorsEffects of agePrevalenceGeneral populationWomenMenopausePhase IPhase II
1989
Aging and long-term ovariectomy alter the cytoarchitecture of the hypothalamic-preoptic area of the C57BL/6J mouse
Miller M, Gould B, Nelson J. Aging and long-term ovariectomy alter the cytoarchitecture of the hypothalamic-preoptic area of the C57BL/6J mouse. Neurobiology Of Aging 1989, 10: 683-690. PMID: 2628780, DOI: 10.1016/0197-4580(89)90005-5.Peer-Reviewed Original ResearchConceptsLong-term ovariectomyArcuate nucleusPreoptic areaNeuronal densitySuprachiasmatic nucleusIntact miceAged female rodentsSizes of gliaHypothalamic-preoptic areaDensity of blood vesselsFemale rodentsMonths of ageArea of nucleolusOvariectomized miceQuantitative light microscopyEffects of agePerikaryal areaOld miceNeuronal areasCoronal sectionsOvariectomyMiceReproductive functionBlood vesselsAge
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