2025
0740 Loop Gain Predicts Residual Sleep Apnea Events Among People Using Positive Airway Pressure
Eschbach E, Kushida C, Peker Y, Xu Z, Deng A, Azarbarzin A, Wellman A, Yaggi H, Sands S, Zinchuk A. 0740 Loop Gain Predicts Residual Sleep Apnea Events Among People Using Positive Airway Pressure. Sleep 2025, 48: a321-a321. DOI: 10.1093/sleep/zsaf090.0740.Peer-Reviewed Original ResearchPositive airway pressureObstructive sleep apneaPositive airway pressure therapyBody mass indexSleep apneaBaseline AHIPAP therapyAirway pressurePharyngeal collapseIncreased riskOdds ratioPositive airway pressure devicesAssociated with increased riskCoronary artery diseaseSleep apnea eventsEpisodic airway obstructionBaseline polysomnogramRandomized Controlled TrialsBaseline polysomnographyHigh LGAdjunctive therapyAirway obstructionUpper airwayMass indexApneaImpact of continuous positive airway pressure therapy on restless legs syndrome in patients with coexistent obstructive sleep apnea: A qualitative systematic review
Srivali N, Thongprayoon C, Cheungpasitporn W, Zinchuk A, Koo B. Impact of continuous positive airway pressure therapy on restless legs syndrome in patients with coexistent obstructive sleep apnea: A qualitative systematic review. Journal Of Clinical Neuroscience 2025, 133: 111075. PMID: 39879879, DOI: 10.1016/j.jocn.2025.111075.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaRestless legs syndromeCoexisting obstructive sleep apneaRestless legs syndrome symptomsCPAP therapyNewcastle-Ottawa Quality ScaleSleep apneaMedication usageRLS symptomsImpact of continuous positive airway pressure therapyContinuous positive airway pressure therapyTreatment of obstructive sleep apneaBenefits of CPAP therapyImpact of CPAP therapyPositive airway pressure therapySystematic reviewInclusion criteriaAirway pressure therapyUpper airway collapseCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsRLS severity scaleConfounding factorsImproving RLS symptomsRegister of Controlled Trials
2024
Testing a Consumer Wearables Program to Promote the Use of Positive Airway Pressure Therapy in Patients With Obstructive Sleep Apnea: Protocol for a Pilot Randomized Controlled Trial
Mak S, Ash G, Liang L, Der-Mcleod E, Ghadimi S, Kewalramani A, Naeem S, Zeidler M, Fung C. Testing a Consumer Wearables Program to Promote the Use of Positive Airway Pressure Therapy in Patients With Obstructive Sleep Apnea: Protocol for a Pilot Randomized Controlled Trial. JMIR Research Protocols 2024, 13: e60769. PMID: 39207912, PMCID: PMC11450346, DOI: 10.2196/60769.Peer-Reviewed Original ResearchObstructive sleep apneaPositive airway pressure therapyPositive airway pressurePositive airway pressure useAirway pressure therapySleep apneaPAP usePressure therapyHistory of obstructive sleep apneaPrimary outcomeObstructive sleep apnea symptomsPositive airway pressure adherenceFirst-line treatmentImmediate interventionOxygen saturation valuesOSA symptomsPAP therapyRandomized Controlled TrialsAirway pressureTwo-sample t-testVeterans Affairs Medical CenterIntention-to-treat designFollow-upAffairs Medical CenterDepartment of Veterans Affairs Medical Center
2023
Morning Chronotype Is Associated with Improved Adherence to Continuous Positive Airway Pressure among Individuals with Obstructive Sleep Apnea.
Knauert M, Adekolu O, Xu Z, Deng A, Chu J, Baldassarri S, Kushida C, Yaggi H, Zinchuk A. Morning Chronotype Is Associated with Improved Adherence to Continuous Positive Airway Pressure among Individuals with Obstructive Sleep Apnea. Annals Of The American Thoracic Society 2023, 20: 1182-1191. PMID: 36917194, PMCID: PMC10405611, DOI: 10.1513/annalsats.202210-885oc.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaCPAP adherenceMorning chronotypeCPAP useSleep apneaClinical trialsMorningness-Eveningness QuestionnaireSleep durationContinuous positive airway pressure therapyPositive airway pressure therapyContinuous positive airway pressureSevere obstructive sleep apneaChronotype of patientsDaily CPAP useAirway pressure therapyPositive airway pressureShort sleep durationCPAP armAirway pressureObese menPressure therapyPoor adherenceWeekend catchAdherence dataEvening chronotypeThe use of continuous positive airway pressure in COPD-OSA overlap syndrome: A systematic review
Srivali N, Thongprayoon C, Tangpanithandee S, Cheungpasitporn W, Won C. The use of continuous positive airway pressure in COPD-OSA overlap syndrome: A systematic review. Sleep Medicine 2023, 108: 55-60. PMID: 37336060, DOI: 10.1016/j.sleep.2023.05.025.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive sleep apneaDefinition of COPDCPAP therapyOverlap syndromeSystematic reviewCOPD exacerbationsCPAP usageClinical outcomesContinuous positive airway pressure therapyPositive airway pressure therapyContinuous positive airway pressureNewcastle-Ottawa Quality ScaleAirway pressure therapyPositive airway pressureObstructive pulmonary diseaseMeta-Analyses (PRISMA) statementPreferred Reporting ItemsComprehensive systematic reviewAirway pressurePulmonary diseaseSleep apneaPressure therapyPatient populationReporting Items
2022
In-office communication about excessive daytime sleepiness associated with treated obstructive sleep apnea: insights from an ethnographic study of physician-patient visits
Won C, Bogan R, Doghramji K, Ojile J, Bujanover S, Hyman D, Hewett K, Thomas R. In-office communication about excessive daytime sleepiness associated with treated obstructive sleep apnea: insights from an ethnographic study of physician-patient visits. Sleep Science And Practice 2022, 6: 4. DOI: 10.1186/s41606-022-00072-y.Peer-Reviewed Original ResearchObstructive sleep apneaProvider-patient communicationSleep apneaDaytime sleepinessPositive airway pressure therapyPhysician-patient visitsAirway pressure therapyExcessive daytime sleepinessEpworth Sleepiness ScaleQuality of lifePost-visit interviewsTherapy initiationAdult patientsAirway therapyPressure therapyPatient educationSleepiness ScalePrimary symptomsPatientsRoutine useScreening toolEDS symptomsVisitsPhysiciansApnea0847 Sleep Disordered Breathing in a case series of 4 children with Trisomy 18
Kochhar R, Brumer E, Canapari C. 0847 Sleep Disordered Breathing in a case series of 4 children with Trisomy 18. Sleep 2022, 45: a364-a365. DOI: 10.1093/sleep/zsac079.841.Peer-Reviewed Original ResearchPositive airway pressure therapyObstructive sleep apneaSevere obstructive sleep apneaCase seriesTrisomy 18Trisomy 21Treatment of OSAModerate obstructive sleep apneaManagement of SDBPrevalence of SDBResolution of hypoxemiaAirway pressure therapyReduced sleep efficiencySmall case seriesNon-syndromic childrenSleep Disordered BreathingTrisomy 18 patientsPAP therapyAdenoid hypertrophyEndoscopic assessmentFourth patientSeizure disorderSleep apneaSupplemental oxygenAggressive interventionPAP Therapy for Sleep Breathing Disorders: Good Policies and Practices
Ali M, Kryger M. PAP Therapy for Sleep Breathing Disorders: Good Policies and Practices. 2022, 95-100. DOI: 10.1007/978-3-030-93146-9_8.ChaptersSleep-disordered breathingPAP adherencePAP therapyPositive airway pressure therapyExtensive patient educationAirway pressure therapySevere sleep apneaSleep breathing disordersTreatment of choiceLong-term usePAP initiationPAP usagePAP useSleep apneaBreathing disordersPressure therapySymptomatic burdenPAP complianceAdequate adherencePatient educationOptimal managementPoor maskPatientsTherapySocioeconomic status
2018
Treating Sleep-Related Breathing Disorders
Won C, Mohsenin V, Kryger M. Treating Sleep-Related Breathing Disorders. 2018, 105-123. DOI: 10.1007/978-1-4939-8607-1_9.Peer-Reviewed Original ResearchPositive airway pressure therapySignificant symptomatic benefitAirway pressure therapySleep-disordered breathingMental health outcomesNeuropsychomotor functionsPAP therapyMainstay treatmentSymptomatic benefitPAP adherenceBreathing disordersPressure therapySide effectsHealth outcomesPatientsTherapyEffective alternativeAdherenceRobust evidenceTolerabilityBreathingSleep
2016
Transoral Robotic Partial Glossectomy and Supraglottoplasty for Obstructive Sleep Apnea
D’Agostino M. Transoral Robotic Partial Glossectomy and Supraglottoplasty for Obstructive Sleep Apnea. Otolaryngologic Clinics Of North America 2016, 49: 1415-1423. PMID: 27742107, DOI: 10.1016/j.otc.2016.07.009.Peer-Reviewed Original ResearchConceptsTransoral robotic surgeryBase of tonguePositive airway pressure therapyObstructive sleep apnea syndromeAirway pressure therapyObstructive sleep apneaSleep apnea syndromeDa Vinci Surgical SystemVinci Surgical SystemPAP therapyApnea syndromeOperative timeSleep apneaPressure therapyPartial glossectomyStandard treatmentTongue baseOpen procedureNeck surgeonsAdvantages of TORSTissue resectionRobotic surgeryExternal scarSurgical systemQuick recoveryPositive Airway Pressure Therapy for Obstructive Sleep Apnea
Weiss P, Kryger M. Positive Airway Pressure Therapy for Obstructive Sleep Apnea. Otolaryngologic Clinics Of North America 2016, 49: 1331-1341. PMID: 27720457, DOI: 10.1016/j.otc.2016.07.004.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPositive airway pressureObstructive sleep apneaAirway pressureSleep apneaMild obstructive sleep apneaPositive airway pressure therapyContinuous positive airway pressureSevere obstructive sleep apneaObstructive sleep apnea syndromeSleep-related breathing disordersConcomitant cardiovascular disordersAirway pressure therapyFirst-line therapySleep apnea syndromeAdaptive support ventilationEvaluation of adherenceEffectiveness of treatmentApnea syndromeSupport ventilationBreathing disordersPressure therapyCardiovascular disordersApneaTherapyPressure supportThe use of positive airway pressure therapy for treatment of resistant hypertension
Won C, Guilleminault C. The use of positive airway pressure therapy for treatment of resistant hypertension. Expert Review Of Cardiovascular Therapy 2016, 14: 505-511. PMID: 26671301, DOI: 10.1586/14779072.2016.1132626.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsPositive airway pressure therapyObstructive sleep apneaAirway pressure therapyBlood pressure controlResistant hypertensionPressure therapyPressure controlSubgroup of patientsHigh-risk populationBlood pressureSleep apneaRisk factorsPathological mechanismsHypertensionNovel targetPatientsTherapyPotential mechanismsApneaMedicationsBreathingSleepTrials
2015
Transoral robotic partial glossectomy and supraglottoplasty for obstructive sleep apnea
D׳Agostino M. Transoral robotic partial glossectomy and supraglottoplasty for obstructive sleep apnea. Operative Techniques In Otolaryngology-Head And Neck Surgery 2015, 26: 211-215. DOI: 10.1016/j.otot.2015.08.007.Peer-Reviewed Original ResearchBase of tongueTransoral robotic surgeryOpen procedurePositive airway pressure therapyObstructive sleep apnea syndromeRobotic surgeryUpper airway surgeryAirway pressure therapyObstructive sleep apneaSleep apnea syndromeDa Vinci Surgical SystemVinci Surgical SystemPAP therapyAirway surgeryApnea syndromeOral appliancesOperative timeSleep apneaPressure therapyPartial glossectomyStandard treatmentTongue baseAlternative therapiesNeck surgeonsTissue resectionImpact of obstructive sleep apnea and continuous positive airway pressure therapy on outcomes in patients with atrial fibrillation—Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF)
Holmqvist F, Guan N, Zhu Z, Kowey PR, Allen LA, Fonarow GC, Hylek EM, Mahaffey KW, Freeman JV, Chang P, Holmes DN, Peterson ED, Piccini JP, Gersh BJ, Investigators O. Impact of obstructive sleep apnea and continuous positive airway pressure therapy on outcomes in patients with atrial fibrillation—Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF). American Heart Journal 2015, 169: 647-654.e2. PMID: 25965712, DOI: 10.1016/j.ahj.2014.12.024.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaBetter Informed TreatmentAtrial fibrillationOutcomes RegistrySleep apneaHigh riskStroke/transient ischemic attackContinuous positive airway pressure (CPAP) treatmentContinuous positive airway pressure therapyPrevalence of OSAInformed TreatmentImpact of OSAPositive airway pressure therapyPositive airway pressure treatmentAF progression rateHierarchical logistic regression modelingMajor cardiovascular outcomesRhythm control therapyAirway pressure therapyTransient ischemic attackLong-term outcomesRisk of deathLogistic regression modelingMore persistent formsCV death
2014
A Matched Cohort Study of Postoperative Outcomes in Obstructive Sleep Apnea
Mutter TC, Chateau D, Moffatt M, Ramsey C, Roos LL, Kryger M. A Matched Cohort Study of Postoperative Outcomes in Obstructive Sleep Apnea. Anesthesiology 2014, 121: 707-718. PMID: 25247853, DOI: 10.1097/aln.0000000000000407.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressure therapyPositive airway pressure therapyObstructive sleep apneaAirway pressure therapySleep apneaPressure therapyOSA patientsCardiovascular complicationsPostoperative outcomesDiagnosis of OSAUndiagnosed obstructive sleep apneaAdult OSA patientsImportant risk modifiersPostoperative cardiovascular complicationsMatched Cohort StudyHealth administrative dataType of surgeryLarger efficacy trialPostoperative complicationsRespiratory complicationsCohort studyOSA severityPostoperative dayPreoperative diagnosisCardiac arrest
2009
Obstructive Sleep Apnea as a Risk Factor for Type 2 Diabetes
Botros N, Concato J, Mohsenin V, Selim B, Doctor K, Yaggi HK. Obstructive Sleep Apnea as a Risk Factor for Type 2 Diabetes. The American Journal Of Medicine 2009, 122: 1122-1127. PMID: 19958890, PMCID: PMC2799991, DOI: 10.1016/j.amjmed.2009.04.026.Peer-Reviewed Original ResearchConceptsMore severe sleep apneaPositive airway pressure useSevere sleep apneaObstructive sleep apneaRisk of diabetesSleep apneaRisk factorsIncident diabetesMAIN OUTCOMEPositive airway pressure therapyType 2 diabetes mellitusVeterans Affairs Connecticut Healthcare SystemAirway pressure therapyObservational cohort studyApnea-hypopnea indexSleep-disordered breathingBody mass indexCross-sectional studyCohort studyDiagnostic polysomnogramGlucose intoleranceConsecutive patientsDiabetes mellitusMass indexPhysician diagnosis
2008
Surgical Treatment of Obstructive Sleep Apnea
Won CH, Li KK, Guilleminault C. Surgical Treatment of Obstructive Sleep Apnea. Annals Of The American Thoracic Society 2008, 5: 193-199. PMID: 18250212, DOI: 10.1513/pats.200708-121mg.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsObstructive sleep apneaPositive airway pressure therapySevere obstructive sleep apneaAirway pressure therapyRadiofrequency ablationMaxillomandibular advancementSleep apneaPressure therapyMaxillomandibular deficiencyUpper airway surgeryUpper airway obstructionImportant treatment optionLaser-assisted uvulopalatoplastyProper patient selectionImportant therapeutic considerationProper procedure selectionGenioglossal advancementRetrolingual obstructionUvulopalatal flapAirway obstructionNasal obstructionSurgical treatmentAirway surgeryPatient selectionMost surgeries
2007
Hypothalamic-Pituitary-Adrenal Axis Activity in Obese Men with and without Sleep Apnea: Effects of Continuous Positive Airway Pressure Therapy
Vgontzas A, Pejovic S, Zoumakis E, Lin H, Bentley C, Bixler E, Sarrigiannidis A, Basta M, Chrousos G. Hypothalamic-Pituitary-Adrenal Axis Activity in Obese Men with and without Sleep Apnea: Effects of Continuous Positive Airway Pressure Therapy. The Journal Of Clinical Endocrinology & Metabolism 2007, 92: 4199-4207. PMID: 17785363, DOI: 10.1210/jc.2007-0774.Peer-Reviewed Original ResearchConceptsContinuous positive airway pressureSleep apneaHypothalamic-pituitary-adrenal axis activityNonobese controlsApneic patientsObese menCRH administrationCortisol secretionLow cortisol secretionImpact of continuous positive airway pressureContinuous positive airway pressure therapyContinuous positive airway pressure useMonths of CPAP usePositive airway pressure therapyAxis activityOvine CRH administrationAirway pressure therapyPositive airway pressureEffects of continuous positive airway pressure therapyHypothalamic-pituitary-adrenal axisSleep apneic patientsCortisol levelsCPAP useACTH responseAirway pressure
1995
Medical treatment of sleep apnea
Wali S, Kryger M. Medical treatment of sleep apnea. Current Opinion In Pulmonary Medicine 1995, 1: 498-503. PMID: 9363089, DOI: 10.1097/00063198-199511000-00012.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSleep apneaContinuous positive airway pressure therapyPositive airway pressure therapyContinuous positive airway pressureAirway pressure therapyPositive airway pressureObstructive sleep apneaCurrent treatment optionsTreatment of choiceAirway pressureNicotine treatmentPressure therapyTreatment optionsCommon disorderMedical treatmentDifficult patientsElectrical stimulationWeight lossDental appliancesApneaTherapyTreatmentUnwanted effectsTracheostomyPatientsThe Effects of Posture Change and Continuous Positive Airway Pressure on Cardiac Natriuretic Peptides in Congestive Heart Failure
Wilkins M, Su X, Palayew M, Yamashiro Y, Bolli P, McKenzie J, Kryger M. The Effects of Posture Change and Continuous Positive Airway Pressure on Cardiac Natriuretic Peptides in Congestive Heart Failure. CHEST Journal 1995, 107: 909-915. PMID: 7705152, DOI: 10.1378/chest.107.4.909.Peer-Reviewed Original ResearchConceptsCongestive heart failureAtrial natriuretic peptideN-CPAP therapyN-CPAPNatriuretic peptideHeart failureANP concentrationNasal continuous positive airway pressure therapyContinuous positive airway pressure therapyChronic congestive heart failureMean plasma ANP concentrationPositive airway pressure therapyContinuous positive airway pressureUpright postureAirway pressure therapyPositive airway pressureMean levelsPeripheral plasma levelsPlasma ANP concentrationCardiac natriuretic peptidesAirway pressureBNP concentrationsPressure therapyPlasma levelsPatients
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