2025
Early sedation with dexmedetomidine in patients with acute myocardial infarction requiring mechanical ventilation
Banna S, Schenck C, Singh A, Safiriyu I, Jimenez J, Franko A, Thomas A, Heck C, Ludmir J, Gage A, Ali T, Katz J, Dudzinski D, Ross J, Miller P. Early sedation with dexmedetomidine in patients with acute myocardial infarction requiring mechanical ventilation. European Heart Journal Acute Cardiovascular Care 2025, 14: 270-278. PMID: 39919040, DOI: 10.1093/ehjacc/zuaf022.Peer-Reviewed Original ResearchInverse probability of treatment weightingAcute myocardial infarctionPrimary diagnosis of acute myocardial infarctionCompared to usual careInvasive mechanical ventilationUsual care groupEstimate adjusted risk differencesAdjusted risk differencesAssociated with lower mortalityDiagnosis of acute myocardial infarctionVentilator-free daysRandomized Controlled TrialsUsual careCare groupClinical data baseMyocardial infarctionProbability of treatment weightingIn-Hospital MortalityIll populationRisk differenceMechanical ventilationDays of invasive mechanical ventilationAnalgesic usePrimary diagnosisEarly sedation
2022
Acute pain pathways: protocol for a prospective cohort study
Jeffery MM, Ahadpour M, Allen S, Araojo R, Bellolio F, Chang N, Ciaccio L, Emanuel L, Fillmore J, Gilbert GH, Koussis P, Lee C, Lipkind H, Mallama C, Meyer T, Moncur M, Nuckols T, Pacanowski MA, Page DB, Papadopoulos E, Ritchie JD, Ross JS, Shah ND, Soukup M, St. Clair CO, Tamang S, Torbati S, Wallace DW, Zhao Y, Heckmann R. Acute pain pathways: protocol for a prospective cohort study. BMJ Open 2022, 12: e058782. PMID: 35790333, PMCID: PMC9258513, DOI: 10.1136/bmjopen-2021-058782.Peer-Reviewed Original ResearchConceptsAcute painOpioid analgesicsMulticentre prospective observational studyLittle high-quality evidenceNon-cancer painOpioid analgesic useResolution of painProspective cohort studyProspective observational studyPatient-centered outcomesElectronic health record dataEvidence-based guidelinesHigh-quality evidenceHealth record dataDiverse clinical settingsLong-term useClinician prescribingLeftover opioidsAnalgesic usePain controlCohort studyPain conditionsPain managementPain treatmentCommon diagnosis
2021
Reductions in endometriosis-associated pain among women treated with elagolix are consistent across a range of baseline characteristics reflective of real-world patients
Abrao MS, Surrey E, Gordon K, Snabes MC, Wang H, Ijacu H, Taylor HS. Reductions in endometriosis-associated pain among women treated with elagolix are consistent across a range of baseline characteristics reflective of real-world patients. BMC Women's Health 2021, 21: 246. PMID: 34134684, PMCID: PMC8210385, DOI: 10.1186/s12905-021-01385-3.Peer-Reviewed Original ResearchConceptsNon-menstrual pelvic painEndometriosis-associated painBaseline characteristicsSubgroup interactionsEndometriosis Health Profile-30Severe endometriosis-associated painGonadotropin-releasing hormone receptor antagonistEfficacy of elagolixPatient-reported reductionsPhase 3 studyHealth-related qualityReal-world patientsHormone receptor antagonistSubgroup of womenSignificant treatmentPercentage of womenAnalgesic usePelvic painMonth 3Receptor antagonistPrevious historyMost subgroupsPainPatient typesEndometriosis diseaseOver-The-Counter Analgesics: A Meta-Synthesis of Pain Self-Management in Adolescents
Kiza A, Manworren R, Cong X, Starkweather A, Kelley P. Over-The-Counter Analgesics: A Meta-Synthesis of Pain Self-Management in Adolescents. Pain Management Nursing 2021, 22: 439-445. PMID: 34127393, DOI: 10.1016/j.pmn.2021.04.010.Peer-Reviewed Original ResearchConceptsOTC analgesic useMeta-SynthesisOTC analgesicsPain Self-ManagementQualitative meta-ethnographyInclusion/exclusion criteriaAnalgesic useMeta-ethnographyConsumption prevalenceSelf-ManagementProQuest DissertationsMeta-ethnographic analysisOTC medicationsPain managementQualitative studyAdolescent useSelf-medicationTreat painAnxiety controlThesis databaseAdolescentsThemesAnxietyInclusion/exclusionPain
2020
Opioid analgesic use and its sequelae: Opioid and other substance use disorders
Rhee TG, Rosenheck RA. Opioid analgesic use and its sequelae: Opioid and other substance use disorders. Early Intervention In Psychiatry 2020, 15: 975-982. PMID: 32930517, DOI: 10.1111/eip.13043.Peer-Reviewed Original ResearchConceptsOpioid use disorderDevelopment of OUDUse of opioidsOpioid useAddictive substancesLifetime opioid useOpioid analgesic useCurrent opioid epidemicNational Epidemiologic SurveyRelated Conditions-IIITreatment development effortsAnalgesic useOpioid usersPotential complicationsRisk factorsOpioid epidemicUS adultsLifetime substanceUse disordersEpidemiologic SurveyEarly interventionOpioidsSubstance useLifetime useMultiple substances
2019
Analgesic use at ovulation and implantation and human fertility
Jukic AMZ, Padiyara P, Bracken MB, McConnaughey DR, Steiner AZ. Analgesic use at ovulation and implantation and human fertility. American Journal Of Obstetrics And Gynecology 2019, 222: 476.e1-476.e11. PMID: 31738897, PMCID: PMC7195999, DOI: 10.1016/j.ajog.2019.11.1251.Peer-Reviewed Original ResearchConceptsNonaspirin nonsteroidal antiinflammatory drugsMedication useNonsteroidal antiinflammatory drugsAnalgesic useMenstrual cycleAntiinflammatory drugsPositive home pregnancy testPregnancy loss historyProspective cohort studyEntire menstrual cycleBody mass indexEffect of aspirinHistory of migraineYears of ageFrequency of intercourseHome pregnancy testsAspirin useFecundability ratiosCohort studyMass indexMedication usageImplantation windowUterine fibroidsClinical trialsPregnancy testAn Evidence-Based Guideline Supporting Restricted Opioid Prescription after Pediatric Appendectomy
Freedman-Weiss MR, Chiu AS, Worhunsky D, Manchisi A, Torres-Maldonado I, Sagnella L, Caty MG, Cowles RA, Ozgediz DE, Christison-Lagay ER, Solomon DG, Stitelman DH. An Evidence-Based Guideline Supporting Restricted Opioid Prescription after Pediatric Appendectomy. Journal Of Pediatric Surgery 2019, 55: 106-111. PMID: 31699433, DOI: 10.1016/j.jpedsurg.2019.09.063.Peer-Reviewed Original ResearchConceptsLaparoscopic appendectomyOpioid prescriptionsPostoperative opioid needsPostoperative telephone interviewsQuantity of opioidsPresence of painYoung adult patientsEvidence-based guidelinesMain outcome measuresOpioid needsAnalgesic useModifiable contributorPain reliefAdequate analgesiaAdult patientsChart reviewHospital dischargeMost patientsPatients 5Pediatric appendectomyYounger patientsPain concernsAverage MMEOpioid epidemicOutcome measuresExternal validation of a prognostic model for overall survival (OS) in men with metastatic castration-resistant prostate cancer (mCRPC).
Halabi S, Dutta S, Araujo J, Logothetis C, Sternberg C, Armstrong A, Carducci M, Chi K, De Bono J, Petrylak D, Fizazi K, Higano C, Small E, Kelly W. External validation of a prognostic model for overall survival (OS) in men with metastatic castration-resistant prostate cancer (mCRPC). Journal Of Clinical Oncology 2019, 37: 5022-5022. DOI: 10.1200/jco.2019.37.15_suppl.5022.Peer-Reviewed Original ResearchMetastatic castration-resistant prostate cancerPrognostic risk groupsMedian overall survivalOverall survivalRisk groupsPrognostic modelCastration-resistant prostate cancerECOG performance statusOpioid analgesic usePhase III trialsHigh groupTime-dependent areaAnalgesic useIII trialsPerformance statusProstate cancerRisk scoreTreatment groupsDisease sitesSpecific subgroupsMonthsCharacteristic curveSimilar resultsMenExternal validation
2018
Implementation of a Quality Improvement Initiative to Decrease Opioid Prescribing After Cesarean Delivery
Prabhu M, Dubois H, James K, Leffert LR, Riley LE, Bateman BT, Henderson M. Implementation of a Quality Improvement Initiative to Decrease Opioid Prescribing After Cesarean Delivery. Obstetrics And Gynecology 2018, 132: 631-636. PMID: 30095765, PMCID: PMC6105442, DOI: 10.1097/aog.0000000000002789.Peer-Reviewed Original ResearchConceptsOpioid refill ratesOpioid tabletsCesarean deliveryOpioid prescribingRefill ratesAnalgesic useMean numberProspective quality improvement studyNonopioid analgesic useDays of dischargeNumber of opioidsPhase 2Quality improvement protocolPhase 1Quality improvement studyQuality improvement initiativesQuality improvement effortsDischarge providersAnalgesic prescriptionOpioid prescriptionsSecondary outcomesDischarge prescriptionsPrimary outcomeΧ analysisOpioidsDecreased Rescue Analgesic Use with Elagolix Treatment in Women with Endometriosis-Associated Pain [35G]
Taylor H, Diamond M, Surrey E, Schwefel B, Snabes M, Peloso P. Decreased Rescue Analgesic Use with Elagolix Treatment in Women with Endometriosis-Associated Pain [35G]. Obstetrics And Gynecology 2018, 131: 84s-85s. DOI: 10.1097/01.aog.0000533583.86343.77.Peer-Reviewed Original ResearchRescue analgesic useEndometriosis-associated painSevere endometriosis-associated painPhase 3 studyAnalgesic usePill countElagolix treatmentPlacebo-controlled phase 3 studyNonmenstrual pelvic painMean percent decreaseElagolix dosesSingle opioidPelvic painOpioid pillsDose groupPainPlaceboPercent changeWomenGreater decreaseBaselinePercent decreaseElagolixTreatmentDoses
2017
(233) Evaluating the agreement between self-reported and documented analgesic use in older veterans with osteoarthritis
Domanski A, Bair M, Balk R, Brandt C, Brody A, Dismore R, Gaetano V, Garrido M, Gittleman D, Kerns R, Krebs E, Linden E, Morrison R, Natividad D, Penrod J, Rinaldi A, Stefanis L, Sun D, Hwang U. (233) Evaluating the agreement between self-reported and documented analgesic use in older veterans with osteoarthritis. Journal Of Pain 2017, 18: s34. DOI: 10.1016/j.jpain.2017.02.125.Peer-Reviewed Original ResearchAnalgesic useOlder veteransUse of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium
Dixon SC, Nagle CM, Wentzensen N, Trabert B, Beeghly-Fadiel A, Schildkraut JM, Moysich KB, deFazio A, Risch H, Rossing M, Doherty J, Wicklund K, Goodman M, Modugno F, Ness R, Edwards R, Jensen A, Kjær S, Høgdall E, Berchuck A, Cramer D, Terry K, Poole E, Bandera E, Paddock L, Anton-Culver H, Ziogas A, Menon U, Gayther S, Ramus S, Gentry-Maharaj A, Pearce C, Wu A, Pike M, Webb P. Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium. British Journal Of Cancer 2017, 116: 1223-1228. PMID: 28350790, PMCID: PMC5418444, DOI: 10.1038/bjc.2017.68.Peer-Reviewed Original ResearchConceptsNonsteroidal anti-inflammatory drugsDisease-specific survivalOvarian cancer survivalAnalgesic useCancer survivalOvarian cancerInvasive epithelial ovarian cancerCommon analgesic medicationsPost-diagnosis usePre-diagnosis useRegular analgesic useEpithelial ovarian cancerOvarian Cancer Association ConsortiumAnti-inflammatory drugsAnalgesic medicationOverall survivalImproved survivalPooled analysisCommon analgesicsSurvival advantageConsortium studyClear associationCancerSurvivalFurther investigation
2016
A Multicenter Evaluation of Emergency Department Pain Care Across Different Types of Fractures
Siddiqui A, Belland L, Rivera-Reyes L, Handel D, Yadav K, Heard K, Eisenberg A, Khelemsky Y, Hwang U. A Multicenter Evaluation of Emergency Department Pain Care Across Different Types of Fractures. Pain Medicine 2016, 18: 41-48. PMID: 27245631, PMCID: PMC5283699, DOI: 10.1093/pm/pnw072.Peer-Reviewed Original ResearchConceptsPain careEmergency departmentType of fractureFracture typeOlder patientsBaseline pain scoresRetrospective cohort studyLong bone fracturesOpioid doseAnalgesic administrationAnalgesic usePain scoresCohort studyTriage acuityFinal diagnosisSubgroup analysisMulticenter evaluationED crowdingPatientsBone fracturesSecondary analysisAge-based differencesCareProcess outcomesGreater likelihood
2015
Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use
Telen M, Wun T, McCavit T, De Castro L, Krishnamurti L, Lanzkron S, Hsu L, Smith W, Rhee S, Magnani J, Thackray H. Randomized phase 2 study of GMI-1070 in SCD: reduction in time to resolution of vaso-occlusive events and decreased opioid use. Blood 2015, 125: 2656-2664. PMID: 25733584, PMCID: PMC4408290, DOI: 10.1182/blood-2014-06-583351.Peer-Reviewed Original ResearchConceptsVaso-occlusive crisisSickle cell diseaseComposite primary end pointPrimary end pointPhase 2 studyEnd pointRandomized phase 2 studySCD vaso-occlusive crisisOpioid analgesic useSecondary end pointsActive treatment groupPhase 3 studyVaso-occlusive eventsAnalgesic usePlacebo groupProspective multicenterStudy drugAdverse eventsOpioid useSymptom reliefMedian timeSCD patientsCell diseaseTreatment groupsAnimal models
2014
Clinical Correlates of Prescription Opioid Analgesic Use in Pregnancy
Smith MV, Costello D, Yonkers KA. Clinical Correlates of Prescription Opioid Analgesic Use in Pregnancy. Maternal And Child Health Journal 2014, 19: 548-556. PMID: 24951127, PMCID: PMC4272915, DOI: 10.1007/s10995-014-1536-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnalgesics, OpioidAnxiety DisordersComorbidityDepressive Disorder, MajorDrug PrescriptionsFemaleHumansIllicit DrugsOpioid-Related DisordersPainPregnancyPrevalenceProspective StudiesRegression AnalysisRisk FactorsStress Disorders, Post-TraumaticSurveys and QuestionnairesUnited StatesYoung AdultConceptsNon-opioid usersPregnant womenOpioid analgesicsClinical correlatesPrescription opioid analgesic useComposite International Diagnostic InterviewAnxiety disordersOpioid analgesic useProspective cohort studyUse of opioidsMajor depressive disorderPercent of womenPost-traumatic stress disorderAnalgesic useCohort studyOpioid useMedication useThird trimesterPsychiatric comorbidityDepressive disorderSmoking cigarettesOpioid addictionAmerican CollegeDiagnostic criteriaPregnancyAspirin, Nonaspirin Nonsteroidal Anti-inflammatory Drug, and Acetaminophen Use and Risk of Invasive Epithelial Ovarian Cancer: A Pooled Analysis in the Ovarian Cancer Association Consortium
Trabert B, Ness RB, Lo-Ciganic WH, Murphy MA, Goode EL, Poole EM, Brinton LA, Webb PM, Nagle CM, Jordan SJ, Group T, Risch H, Rossing M, Doherty J, Goodman M, Lurie G, Kjær S, Hogdall E, Jensen A, Cramer D, Terry K, Vitonis A, Bandera E, Olson S, King M, Chandran U, Anton-Culver H, Ziogas A, Menon U, Gayther S, Ramus S, Gentry-Maharaj A, Wu A, Pearce C, Pike M, Berchuck A, Schildkraut J, Wentzensen N, Consortium O. Aspirin, Nonaspirin Nonsteroidal Anti-inflammatory Drug, and Acetaminophen Use and Risk of Invasive Epithelial Ovarian Cancer: A Pooled Analysis in the Ovarian Cancer Association Consortium. Journal Of The National Cancer Institute 2014, 106: djt431. PMID: 24503200, PMCID: PMC3924755, DOI: 10.1093/jnci/djt431.Peer-Reviewed Original ResearchMeSH KeywordsAcetaminophenAnti-Inflammatory Agents, Non-SteroidalAnticarcinogenic AgentsAspirinAustraliaCarcinoma, Ovarian EpithelialCase-Control StudiesData CollectionDenmarkDrug Administration ScheduleFemaleHumansIncidenceLogistic ModelsNeoplasms, Glandular and EpithelialOdds RatioOvarian NeoplasmsProtective AgentsRiskUnited KingdomUnited StatesConceptsNonaspirin nonsteroidal anti-inflammatory drugsNonaspirin NSAIDsInvasive epithelial ovarian cancerNonsteroidal anti-inflammatory drugsLow-dose aspirinEpithelial ovarian cancerOvarian cancerAnti-inflammatory drugsAspirin useAcetaminophen useOdds ratioPopulation-based case-control studyDaily aspirin usersRegular aspirin useOvarian cancer riskCase-control studyOvarian Cancer Association ConsortiumHigh-dose usageDose of useAspirin regimenAnalgesic useAspirin usersCardiovascular eventsDose aspirinCase patients
2013
Relationship of sipuleucel-T with time to first use of opioid analgesics (TFOA) in patients (pts) with asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC) on the IMPACT trial.
Small E, Higano C, Kantoff P, Whitmore J, Frohlich M, Petrylak D. Relationship of sipuleucel-T with time to first use of opioid analgesics (TFOA) in patients (pts) with asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC) on the IMPACT trial. Journal Of Clinical Oncology 2013, 31: 74-74. DOI: 10.1200/jco.2013.31.6_suppl.74.Peer-Reviewed Original ResearchMetastatic castration-resistant prostate cancerSymptomatic metastatic castration-resistant prostate cancerCase report formsProtocol amendmentMedical reviewIMPACT trialCastration-resistant prostate cancerPrespecified secondary end pointsEnd pointECOG performance status 1Autologous cellular immunotherapyAverage pain scoreOpioid analgesic usePlacebo-treated patientsSecondary end pointsIndependent baseline predictorsPerformance status 1Objective disease progressionVisual analog scaleCox regression modelKaplan-Meier estimatesAsymptomatic ptsPrimary radiotherapyAnalgesic useCancer pain
2009
Use of pain at baseline and pain progression to predict overall survival (OS) in patients (pts) with docetaxel pretreated metastatic castration-refractory prostate cancer (CRPC): Results from the SPARC trial
Sartor A, Petrylak D, Sternberg C, Witjes F, Halabi S, Berry W, Petrone M, McKearn T, Noursalehi M, George M. Use of pain at baseline and pain progression to predict overall survival (OS) in patients (pts) with docetaxel pretreated metastatic castration-refractory prostate cancer (CRPC): Results from the SPARC trial. Journal Of Clinical Oncology 2009, 27: 5148-5148. DOI: 10.1200/jco.2009.27.15_suppl.5148.Peer-Reviewed Original ResearchCastration-refractory prostate cancerOverall survivalPain progressionBaseline painSPARC trialChemotherapy trialsPPI scoresMetastatic castration-refractory prostate cancerFirst-line chemotherapy trialsMcGill-Melzack Pain QuestionnaireFirst-line docetaxelMedian overall survivalNarcotic analgesic usePre-treated patientsDaily pain intensityImportant prognostic indicatorEffect of painUse of painShortened overall survivalAnalgesic useCRPC patientsMedian survivalPain intensityPain QuestionnairePrognostic indicator
2006
Quality of Life and Pain in Advanced Stage Prostate Cancer: Results of a Southwest Oncology Group Randomized Trial Comparing Docetaxel and Estramustine to Mitoxantrone and Prednisone
Berry D, Moinpour C, Jiang C, Ankerst D, Petrylak D, Vinson L, Lara P, Jones S, Taplin M, Burch P, Hussain M, Crawford E. Quality of Life and Pain in Advanced Stage Prostate Cancer: Results of a Southwest Oncology Group Randomized Trial Comparing Docetaxel and Estramustine to Mitoxantrone and Prednisone. Journal Of Clinical Oncology 2006, 24: 2828-2835. PMID: 16782921, DOI: 10.1200/jco.2005.04.8207.Peer-Reviewed Original ResearchConceptsPain palliationMP armProstate cancerMcGill Pain Questionnaire-Short FormPrimary patient-reported outcomesPain Questionnaire-Short FormPresent Pain Intensity scaleAndrogen-independent prostate cancerAdvanced stage prostate cancerProstate cancer moduleMedian overall survivalLife Questionnaire C30Cancer Core QualityPatient-reported outcomesSuperior clinical efficacyDisease-related symptomsStage prostate cancerPain intensity scaleQuality of lifeRandom assignmentQuestionnaire-Short FormBone painDE armAnalgesic useEligible patients
2005
Understanding pain and improving management of sickle cell disease: the PiSCES study.
Smith WR, Bovbjerg VE, Penberthy LT, McClish DK, Levenson JL, Roberts JD, Gil K, Roseff SD, Aisiku IP. Understanding pain and improving management of sickle cell disease: the PiSCES study. Journal Of The National Medical Association 2005, 97: 183-93. PMID: 15712781, PMCID: PMC2568749.Peer-Reviewed Original ResearchConceptsSickle cell diseasePain episodesPain responseHealthcare utilizationCell diseaseSickle Cell Epidemiology StudyDaily pain diaryCare-seeking behaviorSCD painAnalgesic useOverall painAdult patientsFrequent hospitalizationsPain diaryOrgan failureSCD careChronic painTreatment advancesProlonged survivalRelated disabilityTimely carePainBiobehavioral interventionsAdult cohortEpidemiology studies
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