2025
Temporal Trends in Opioid Use and Associated Outcomes for Patients Living with Advanced Cancer
Jairam V, Lindsay M, Soulos P, Gross C, Prsic E, Baum L, Park H. Temporal Trends in Opioid Use and Associated Outcomes for Patients Living with Advanced Cancer. Journal Of Pain And Symptom Management 2025 PMID: 40403779, DOI: 10.1016/j.jpainsymman.2025.05.007.Peer-Reviewed Original ResearchPain-related ED visitsOpioid useGabapentinoid useOpioid-related encountersAdvanced cancerOpioid prescribingED visitsAdvanced solid tumor cancersEnd Results (SEER)-Medicare databaseHigh-risk opioid useNonopioid pain medicationsMultivariate logistic regression modelNon-cancer patientsSolid tumor cancersPain controlPain medicationInvestigate time trendsIndex dateLogistic regression modelsCancer cohortOpioidNoncancer patientsOpioid epidemicPatientsNoncancer cohortCharacteristics and Trends of NIH-Funded Opioid Use Disorder Clinical Trials During the Opioid Epidemic With a Focus on Gender
Yermal J, Costa G, Weleff J, Koomson W, Barnett B, Anand A. Characteristics and Trends of NIH-Funded Opioid Use Disorder Clinical Trials During the Opioid Epidemic With a Focus on Gender. Cureus 2025, 17: e82227. PMID: 40370901, PMCID: PMC12076528, DOI: 10.7759/cureus.82227.Peer-Reviewed Original ResearchOpioid use disorderNational Institutes of HealthOpioid epidemicClinical trialsStatistically significant differenceKruskal-Wallis testOpioidNational Institutes of Health fundingPrincipal investigatorUse disorderInstitutes of HealthNational Institutes of Health RePORTERKruskal-WallisSignificant differenceStatistical differenceMale principal investigatorsTrialsNon-parametric statistical analysisNIH initiativesNational InstituteEpidemicFemale principal investigatorsStatistical analysisGenderMedian
2024
Association Between Clubfoot and Neonatal Abstinence Syndrome in the United States, 2018–2022
Dhodapkar M, Jonnalagadda A, Socci A, Franklin C. Association Between Clubfoot and Neonatal Abstinence Syndrome in the United States, 2018–2022. Journal Of Pediatric Orthopaedics 2024, 45: e55-e58. PMID: 39210523, DOI: 10.1097/bpo.0000000000002798.Peer-Reviewed Original ResearchDiagnosis of neonatal abstinence syndromeNeonatal abstinence syndromePediatric Hospital Information SystemLength of stayGestational ageAbstinence syndromeIndependent oddsIncidence of neonatal abstinence syndromeComorbidity burdenPatients of Asian raceIncreased length of stayMultivariate logistic regressionInternational Classification of Diseases (ICD)-9Opioid useAsian raceMultivariate analysisWhite patientsNon-Hispanic blacksOpioid epidemicPatientsClubfoot diagnosisClubfootDiagnosisLogistic regressionInvestigate associationsImaging Utilization and Cost of Substance Use in an Urban Academic Medical Center During the Contemporary Opioid Epidemic
Blinick R, Felsen A, Ye K, Lewis A, Kargoli F, Bellin E, Naji L, Haramati L. Imaging Utilization and Cost of Substance Use in an Urban Academic Medical Center During the Contemporary Opioid Epidemic. Academic Radiology 2024, 31: 5217-5225. PMID: 38582686, DOI: 10.1016/j.acra.2024.02.023.Peer-Reviewed Original ResearchPositive urine toxicologyUrine toxicologyComparison cohortInstitutional review boardAcademic medical centerNegative urine toxicologyEmergency departmentMedical CenterImaging utilizationGroup of ED patientsIn-Hospital MortalityCharlson Comorbidity IndexSubstance useICD codesRetrospective studyUrban academic medical centerUnderserved urban populationIllicit substance useComorbidity indexContemporary opioid epidemicED patientsOpioid epidemicImaging studiesPatientsED populationPreferences and decisional considerations relating to opioid agonist therapy among Ukrainian people who use drugs: A conjoint analysis survey.
Bromberg D, Madden L, Fraenkel L, Muthulingam D, Rhoades D, Dvoriak S, Dumchev K, Pykalo I, Altice F. Preferences and decisional considerations relating to opioid agonist therapy among Ukrainian people who use drugs: A conjoint analysis survey. PLOS Global Public Health 2024, 4: e0002725. PMID: 38277422, PMCID: PMC10817130, DOI: 10.1371/journal.pgph.0002725.Peer-Reviewed Original ResearchOpioid agonist therapyWithdrawal symptomsAdverse side effectsAgonist therapySide effectsOpioid use disorderQuality-of-life improvementUse disorderCombined HIVHIV incidenceClinical decision-makingDosing frequencyRespondent-driven samplingOpioidOpioid epidemicAssess preferencesClinical concernPatient preferencesPatientsDelivery strategiesTherapyDisordersHIVPatient concernsWithdrawal
2023
Validation of Two Diagnostic Assessments for Opioid and Stimulant Use Disorder for Use by Non‐Clinicians
Di Paola A, Farabee D, Springer S. Validation of Two Diagnostic Assessments for Opioid and Stimulant Use Disorder for Use by Non‐Clinicians. Psychiatric Research And Clinical Practice 2023, 5: 78-83. PMID: 37711754, PMCID: PMC10499189, DOI: 10.1176/appi.prcp.20230022.Peer-Reviewed Original ResearchStimulant use disorderUse disordersSevere opioid use disorderMini International Neuropsychiatric InterviewDiagnostic assessmentOpioid use disorderDisorder assessmentInternational Neuropsychiatric InterviewDSM-IV criteriaHarm reduction interventionsNon-clinical staffTraditional diagnostic assessmentInternal consistencyDSM-5 versionValid measureOpioid dependenceOpioid misuseImmediate treatmentNeuropsychiatric InterviewOpioid epidemicDisorder modulesOverdose deathsReduction interventionsNon cliniciansRapid diagnosisPreferences in medications for patients seeking treatment for opioid use disorder: A conjoint analysis
Muthulingam D, Hassett T, Madden L, Bromberg D, Fraenkel L, Altice F. Preferences in medications for patients seeking treatment for opioid use disorder: A conjoint analysis. Journal Of Substance Use And Addiction Treatment 2023, 154: 209138. PMID: 37544510, DOI: 10.1016/j.josat.2023.209138.Peer-Reviewed Original ResearchConceptsOpioid use disorderRoute of administrationPatient preferencesUse disordersSymptom reliefTreatment preferencesSide effectsCross-sectional observational studyTreatment-seeking peopleChi-squared analysisOral medicationsPublic health crisisOUD treatmentTreatment uptakeWithdrawal symptomsOpioid epidemicObservational studyTreatment decisionsSTROBE checklistSustainability of treatmentPatientsMedicationsHealth professionalsUtility scoresLarger studyEarly OxyContin Marketing Linked To Long-Term Spread Of Infectious Diseases Associated With Injection Drug Use
Dennett J, Gonsalves G. Early OxyContin Marketing Linked To Long-Term Spread Of Infectious Diseases Associated With Injection Drug Use. Health Affairs 2023, 42: 1081-1090. PMID: 37467441, PMCID: PMC10521060, DOI: 10.1377/hlthaff.2023.00146.Peer-Reviewed Original ResearchConceptsInjection drug useDrug useAdverse long-term outcomesInfectious diseasesReformulation of OxyContinAcute hepatitis ALong-term outcomesOpioid-related overdosesInitial marketingFatal drug overdosesBacterial complicationsHepatitis ADrug overdosesEffects of exposureOpioid epidemicViral infectionGreater burdenIllicit drugsLow exposureComplicationsHigh exposureOverdosesOutcomesDiseaseOxyContinChallenges to Achieving HCV Micro-Elimination in People With HIV in the United States: Provider Perspectives and the Role of Implicit Bias
DiDomizio E, Chandra D, Nichols L, Villanueva M, Altice F. Challenges to Achieving HCV Micro-Elimination in People With HIV in the United States: Provider Perspectives and the Role of Implicit Bias. Health Promotion Practice 2023, 24: 998-1008. PMID: 37440258, DOI: 10.1177/15248399231169928.Peer-Reviewed Original ResearchConceptsNominal group techniqueHealth care decisionsProvider perspectivesEligibility criteriaHIV/HCVEffective antiviral medicationsPatient eligibility criteriaFacilitators of treatmentMicro-EliminationHCV treatmentAntiviral medicationsOpioid epidemicProvider knowledgePatient involvementPatient engagementDifferent clinicsRelated stigmaHCVCare decisionsHIVPatientsTreatmentGroup sessionsMost barriersFocus group sessionsThe Current Status of Medical Student Education on Opioids
Jegede O, Na P, Petrakis I, Muvvala S. The Current Status of Medical Student Education on Opioids. 2023, 121-138. DOI: 10.1093/oxfordhb/9780197618431.013.5.Peer-Reviewed Original ResearchManaging opioid waste, cost, and opportunity for drug diversion in the emergency department
Coleska A, Oh A, Rothenberg C, Dinh D, Parwani V, Venkatesh A. Managing opioid waste, cost, and opportunity for drug diversion in the emergency department. The American Journal Of Emergency Medicine 2023, 69: 195-199. PMID: 37172559, DOI: 10.1016/j.ajem.2023.05.001.Peer-Reviewed Original ResearchConceptsDrug diversionContext of opioidEmergency department visitsManagement of painSingle health systemLogistic regression modelsHealth care systemOpioid ordersIntravenous opioidsSevere painDepartment visitsOpioid diversionEmergency departmentIncorrect doseOpioid epidemicOpioidsPrimary analysisMorphineDose orderHealth systemDoseHydromorphoneCare systemDrug shortagesPainInternal and Environmental Predictors of Physician Practice Use of Screening and Medications for Opioid Use Disorders
Miller-Rosales C, Busch S, Meara E, King A, D’Aunno T, Colla C. Internal and Environmental Predictors of Physician Practice Use of Screening and Medications for Opioid Use Disorders. Medical Care Research And Review 2023, 80: 410-422. PMID: 37036056, PMCID: PMC10949918, DOI: 10.1177/10775587231162681.Peer-Reviewed Original ResearchConceptsOngoing opioid epidemicOpioid use disorderOpioid useUse disordersHealth information technology functionalityAvailability of MOUDPrimary careOpioid epidemicMOUDMultispecialty practicePhysician practicesMedicationsBehavioral cliniciansDemonstrated effectivenessDisordersPractice useScreeningCliniciansCareChronic use of benzodiazepines: The problem that persists
Louie D, Jegede O, Hermes G. Chronic use of benzodiazepines: The problem that persists. The International Journal Of Psychiatry In Medicine 2023, 58: 426-432. PMID: 36972700, DOI: 10.1177/00912174231166252.Peer-Reviewed Original ResearchBuilding medication for opioid use disorder prescriber capacity during the opioid epidemic: Prescriber recruitment trends and methods
Molfenter T, Jacobson N, Kim J, Horst J, Kim H, Madden L, Brown R, Haram E, Knudsen H. Building medication for opioid use disorder prescriber capacity during the opioid epidemic: Prescriber recruitment trends and methods. Journal Of Substance Use And Addiction Treatment 2023, 147: 208975. PMID: 36804353, PMCID: PMC10833474, DOI: 10.1016/j.josat.2023.208975.Peer-Reviewed Original ResearchConceptsRecruitment strategiesAdvanced nurse practitionersSUD treatment servicesSUD clinicsPhysician prescribersOpioid epidemicPhysician recruitmentNurse practitionersTreatment servicesPhysician assistantsPatient carePrescribing capacityPrescribersStudy settingClinical resourcesDisorder settingsStudy periodPhysiciansTreatment sitesYear 3Dedicated budgetIndividual factorsBuprenorphineMedicationsClinicChanging Trends in Demographics, Risk Factors, and Clinical Features of Patients With Infective Endocarditis–Related Stroke, 2005–2015
Ridha M, Flaherty M, Aziz Y, Ades L, Alwell K, Khoury J, Woo D, Ferioli S, Adeoye O, Khatri P, De Los Rios La Rosa F, Mistry E, Demel S, Mackey J, Martini S, Coleman E, Jasne A, Slavin S, Walsh K, Star M, Haverbusch M, Madsen T, Broderick J, Kissela B, Kleindorfer D. Changing Trends in Demographics, Risk Factors, and Clinical Features of Patients With Infective Endocarditis–Related Stroke, 2005–2015. Neurology 2023, 100: e1555-e1564. PMID: 36746635, PMCID: PMC10103121, DOI: 10.1212/wnl.0000000000206865.Peer-Reviewed Original ResearchConceptsRisk factorsOpioid epidemicClinical characteristicsClinical featuresGreater Cincinnati/Northern Kentucky regionStudy periodRetrospective cohort studyRates of hypertensionIntravenous drug useIntravenous drug usersICD-10 codesCochran-Armitage testPerioperative strokeAcute strokeCohort studyDefinite endocarditisDuke criteriaHypertension prevalenceIschemic strokeYounger patientsStroke populationInfective endocarditisAtrial fibrillationEpidemiologic descriptionUnadjusted comparisonsOpioid Use Disorder With Chronic Pain Increases Disease Burden and Service Use
MacLean RR, Sofuoglu M, Stefanovics E, Rosenheck R. Opioid Use Disorder With Chronic Pain Increases Disease Burden and Service Use. Psychological Services 2023, 20: 157-165. PMID: 34968125, PMCID: PMC9358616, DOI: 10.1037/ser0000607.Peer-Reviewed Original ResearchConceptsOpioid use disorderChronic painMental health diagnosesService useUse disordersHealth AdministrationConcurrent opioid use disorderHealth diagnosisOngoing opioid epidemicOutpatient service useVeterans Health AdministrationMental health disordersSubstance use diagnosesSingle disorder groupsClinical service useOpioid prescriptionsAdditional comorbiditiesMultinomial regression analysisDisease burdenMedication fillsOpioid epidemicPrescription opiatesMedical conditionsMedical disordersUse diagnosesMultidisciplinary Management of Opioid Use–Related Infective Endocarditis: Treatment, QTc Values, and Cardiac Arrests due to Ventricular Fibrillation
Rosenfeld L, Jain S, Amabile A, Geirsson A, Krane M, Weimer M. Multidisciplinary Management of Opioid Use–Related Infective Endocarditis: Treatment, QTc Values, and Cardiac Arrests due to Ventricular Fibrillation. Journal Of Clinical Medicine 2023, 12: 882. PMID: 36769531, PMCID: PMC9917424, DOI: 10.3390/jcm12030882.Peer-Reviewed Original ResearchCardiac arrestVentricular fibrillationOpioid useGroup IMOUD useInfective endocarditisYale-New Haven HospitalGroup II patientsCardiac surgeryMultidisciplinary managementQTc prolongationII patientsCS patientsInjection useOpioid epidemicHistorical groupLong-term effectsDisorder treatmentPatientsQTc measurementsQTcHospitalizationEndocarditisSurgeryArrestClinical Trial Design Challenges and Opportunities for Emerging Treatments for Opioid Use Disorder
Kiluk B, Kleykamp B, Comer S, Griffiths R, Huhn A, Johnson M, Kampman K, Pravetoni M, Preston K, Vandrey R, Bergeria C, Bogenschutz M, Brown R, Dunn K, Dworkin R, Finan P, Hendricks P, Houtsmuller E, Kosten T, Lee D, Levin F, McRae-Clark A, Raison C, Rasmussen K, Turk D, Weiss R, Strain E. Clinical Trial Design Challenges and Opportunities for Emerging Treatments for Opioid Use Disorder. JAMA Psychiatry 2023, 80: 84-92. PMID: 36449315, PMCID: PMC10297827, DOI: 10.1001/jamapsychiatry.2022.4020.Peer-Reviewed Original ResearchConceptsOpioid use disorderOUD treatmentUse disordersClinical trial design challengesAddiction Clinical Trial TranslationsΜ-opioid receptor systemNetworks (ACTTION) public-private partnershipTrial design challengesOngoing opioid epidemicTrial design considerationsClinical trial design considerationsRole of treatmentQuality of lifeAntagonist medicationsEmerging TreatmentsAdverse eventsOpioid usePrimary outcomeStages of treatmentPatient preferencesMOR agonistsOpioid epidemicConsensus recommendationsCurrent evidenceTreatment retentionEstablishing an Integrative Chronic Pain Management Clinic Within an Academic Medical Practice
Morse M, Carrasco A, Tobin D. Establishing an Integrative Chronic Pain Management Clinic Within an Academic Medical Practice. 2023, 211-232. DOI: 10.1007/978-3-031-40273-9_15.Peer-Reviewed Original ResearchChronic non-cancer painPrimary care physiciansNon-cancer painAcademic medical practiceMedical directorsIntegrated pain management programPain managementChronic pain management clinicPain management programMedical practicePain management clinicCare physiciansHealthcare utilizationPsychosocial componentsBiopsychosocial approachManagement clinicBiopsychosocial modelClinician expertiseLower satisfactionTrainee educationOutpatient settingBiomedical perspectiveNonpharmacologic therapiesCNCP conditionsOpioid epidemicThe Opioid Overdose Epidemic and Response
Weleff J, Knio L, Capurso N. The Opioid Overdose Epidemic and Response. 2023, 62-76. DOI: 10.1016/b978-0-323-95702-1.00025-7.Peer-Reviewed Original Research
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