2022
Development of a dynamic machine learning algorithm to predict clinical pregnancy and live birth rate with embryo morphokinetics
Yang L, Peavey M, Kaskar K, Chappell N, Zhu L, Devlin D, Valdes C, Schutt A, Woodard T, Zarutskie P, Cochran R, Gibbons W. Development of a dynamic machine learning algorithm to predict clinical pregnancy and live birth rate with embryo morphokinetics. F&S Reports 2022, 3: 116-123. PMID: 35789724, PMCID: PMC9250114, DOI: 10.1016/j.xfre.2022.04.004.Peer-Reviewed Original ResearchClinical pregnancy ratePregnancy rateClinical pregnancyAcademic fertility clinicRetrospective cohort analysisLive birth rateTertiary hospital settingLive birth outcomesPositive predictive valueBirth outcomesCohort analysisHospital settingFertility clinicsPredictive valueSecondary analysisPregnancyEmbryo morphokineticsBirth rateMorphokineticsTime-lapse microscopySimilar resultsPatientsClinic
2019
External validation of a prognostic model for overall survival (OS) in men with metastatic castration-resistant prostate cancer (mCRPC).
Halabi S, Dutta S, Araujo J, Logothetis C, Sternberg C, Armstrong A, Carducci M, Chi K, De Bono J, Petrylak D, Fizazi K, Higano C, Small E, Kelly W. External validation of a prognostic model for overall survival (OS) in men with metastatic castration-resistant prostate cancer (mCRPC). Journal Of Clinical Oncology 2019, 37: 5022-5022. DOI: 10.1200/jco.2019.37.15_suppl.5022.Peer-Reviewed Original ResearchMetastatic castration-resistant prostate cancerPrognostic risk groupsMedian overall survivalOverall survivalRisk groupsPrognostic modelCastration-resistant prostate cancerECOG performance statusOpioid analgesic usePhase III trialsHigh groupTime-dependent areaAnalgesic useIII trialsPerformance statusProstate cancerRisk scoreTreatment groupsDisease sitesSpecific subgroupsMonthsCharacteristic curveSimilar resultsMenExternal validationImpact of midazolam vs. saline on effect size estimates in controlled trials of ketamine as a rapid-acting antidepressant
Wilkinson ST, Farmer C, Ballard E, Mathew SJ, Grunebaum MF, Murrough JW, Sos P, Wang G, Gueorguieva R, Zarate CA. Impact of midazolam vs. saline on effect size estimates in controlled trials of ketamine as a rapid-acting antidepressant. Neuropsychopharmacology 2019, 44: 1233-1238. PMID: 30653192, PMCID: PMC6785710, DOI: 10.1038/s41386-019-0317-8.Peer-Reviewed Original ResearchConceptsTrial of ketamineEffectiveness of midazolamRapid acting antidepressantsSaline-controlled studyPatient-level analysisEffects of ketamineImpact of midazolamClinical outcomesMidazolam dosesKetamine dosesKetamine studiesMood disordersMidazolamResponse rateModel-estimated rateKetamineTrial outcomesSalineEffect size estimatesGreater improvementEffect sizeDosesControl conditionOutcomesSimilar results
2017
How well does early-career investigators' cardiovascular outcomes research training align with funded outcomes research?
Crowley MJ, Al-Khatib SM, Wang TY, Khazanie P, Kressin NR, Krumholz HM, Kiefe CI, Wells BL, O'Brien SM, Peterson ED, Sanders GD. How well does early-career investigators' cardiovascular outcomes research training align with funded outcomes research? American Heart Journal 2017, 196: 163-169. PMID: 29421009, DOI: 10.1016/j.ahj.2017.09.008.Peer-Reviewed Original ResearchConceptsOutcomes researchEarly career investigatorsCardiovascular Outcomes ResearchFunded grantsCost-effectiveness researchBlood InstituteNational HeartClinical epidemiologySystematic reviewPrior trainingCommunity-engaged researchResearch training programsDissemination researchInvestigator trainingCompetency areasObservational researchCore competency areasInvestigators' interestOutcomes researchersInvestigatorsTraining programHealth informaticsSimilar resultsLungEpidemiology
2014
Benchmarking of Trauma Care Worldwide: The Potential Value of an International Trauma Data Bank (ITDB)
Haider A, Hashmi Z, Gupta S, Zafar S, David J, Efron D, Stevens K, Zafar H, Schneider E, Voiglio E, Coimbra R, Haut E. Benchmarking of Trauma Care Worldwide: The Potential Value of an International Trauma Data Bank (ITDB). World Journal Of Surgery 2014, 38: 1882-1891. PMID: 24817407, DOI: 10.1007/s00268-014-2629-5.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBenchmarkingDatabases, FactualDeveloped CountriesDeveloping CountriesFeasibility StudiesFemaleFranceGlobal HealthHospital MortalityHumansLogistic ModelsMaleMiddle AgedPakistanRegistriesTrauma CentersWounds, NonpenetratingWounds, PenetratingYoung AdultConceptsTrauma Data BankTrauma mortalityTrauma centerMortality ratioTrauma outcomesNational Trauma Data BankTrauma dataE mortality ratioNational Trauma RegistryMultivariable logistic regressionBlunt/Worse survivalTrauma registrySubset analysisPatient outcomesTrauma carePatientsLMIC centerLogistic regressionKey covariatesOutcomesInjuryMortalityPredictorsSimilar resultsImpact of Early Extubation and Reintubation on the Incidence of Bronchopulmonary Dysplasia in Neonates
Berger J, Mehta P, Bucholz E, Dziura J, Bhandari V. Impact of Early Extubation and Reintubation on the Incidence of Bronchopulmonary Dysplasia in Neonates. American Journal Of Perinatology 2014, 31: 1063-1072. PMID: 24683068, DOI: 10.1055/s-0034-1371702.Peer-Reviewed Original ResearchMeSH KeywordsAirway ExtubationApgar ScoreBirth WeightBronchopulmonary DysplasiaDisease-Free SurvivalDuctus Arteriosus, PatentFemaleGestational AgeHumansIncidenceInfant, NewbornIntracranial HemorrhagesIntubation, IntratrachealKaplan-Meier EstimateMaleProportional Hazards ModelsRespiratory Distress Syndrome, NewbornRetinopathy of PrematurityRetreatmentRetrospective StudiesTime Factors
2012
Genotoxic and Anti-Genotoxic Effects of Vanillic Acid Against Mitomycin C-Induced Genomic Damage in Human Lymphocytes In Vitro
Erdem M, Cinkilic N, Vatan O, Yilmaz D, Bagdas D, Bilaloglu R. Genotoxic and Anti-Genotoxic Effects of Vanillic Acid Against Mitomycin C-Induced Genomic Damage in Human Lymphocytes In Vitro. Asian Pacific Journal Of Cancer Prevention 2012, 13: 4993-4998. PMID: 23244097, DOI: 10.7314/apjcp.2012.13.10.4993.Peer-Reviewed Original ResearchConceptsAnti-genotoxic effectsMitomycin CHuman blood lymphocyte culturesCytokinesis-block micronucleus testBlood lymphocyte culturesLow doseHigh doseLymphocyte culturesHuman lymphocytesMicronucleus testAlkaline cometDoseGenotoxic damageGenotoxic effectsStrong antioxidantNegative controlOxidative damageGenomic damageVanillic acidChromosome levelPresent studyRates of DNADNA damageDamageSimilar results
2010
Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells
Bai Q, Xu L, Kakiyama G, Runge-Morris MA, Hylemon PB, Yin L, Pandak WM, Ren S. Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells. Atherosclerosis 2010, 214: 350-356. PMID: 21146170, PMCID: PMC3031658, DOI: 10.1016/j.atherosclerosis.2010.11.021.Peer-Reviewed Original ResearchMeSH KeywordsCells, CulturedCholesterol EstersChromatography, High Pressure LiquidEndothelial CellsFatty Acids, NonesterifiedGene Expression RegulationHumansHydrocarbons, FluorinatedHydroxycholesterolsLiver X ReceptorsOrphan Nuclear ReceptorsRNA, MessengerSignal TransductionSterol Regulatory Element Binding Protein 1SulfonamidesSulfotransferasesTime FactorsTransfectionTriglyceridesConceptsHuman aortic endothelial cellsLipid metabolismAortic endothelial cellsSULT2B1b overexpressionSREBP-1cEndothelial cellsIntracellular lipid homeostasisOxysterol sulfotransferaseReceptor agonistLipid levelsPresence of T0901317Cellular lipid levelsLipid homeostasisRecombinant adenovirusACC-1Protein levelsSULT2B1bSulfated metabolitesMetabolismCellular lipidsOverexpressionKey regulatorSimilar resultsCells
2006
Triggered sampling could help improve longitudinal studies of persons with elevated mortality risk
Dubin JA, Han L, Fried TR. Triggered sampling could help improve longitudinal studies of persons with elevated mortality risk. Journal Of Clinical Epidemiology 2006, 60: 288-293. PMID: 17292023, DOI: 10.1016/j.jclinepi.2006.06.012.Peer-Reviewed Original ResearchConceptsElevated mortality riskMortality riskChronic obstructive pulmonary diseaseLongitudinal studyCongestive heart failureObstructive pulmonary diseaseMixed effects modelsLongitudinal observational studyLongitudinal clinical studyStudy design featuresEffects modelHeart failurePulmonary diseaseAdvanced illnessTreatment preferencesClinical studiesObservational studyFirst triggerStudy designPatientsRiskValuable additionMean preferenceSimilar resultsIllness
2005
Patient-Based Outcomes Following Clubfoot Surgery
Vitale MG, Choe JC, Vitale MA, Lee FY, Hyman JE, Roye DP. Patient-Based Outcomes Following Clubfoot Surgery. Journal Of Pediatric Orthopaedics 2005, 25: 533-538. PMID: 15958910, DOI: 10.1097/01.bpo.0000157999.38424.ba.Peer-Reviewed Original ResearchConceptsPatient-based measuresClubfoot surgeryChild Health QuestionnaireDisease-specific instrumentLong-term outcomesPatient-based outcomesDisease-specific measuresCohort of adolescentsQuality of lifePrimary endpointSurgical repairPractice patternsHealth QuestionnaireAppropriate treatmentAuthors' institutionRadiographic measuresHealth outcomesTreatment resultsHealthy feetYoung athletesPatientsSurgeryOutcomesOngoing controversySimilar resultsFactors associated with exclusive breastfeeding in Accra, Ghana
Aidam B, Pérez-Escamilla R, Lartey A, Aidam J. Factors associated with exclusive breastfeeding in Accra, Ghana. European Journal Of Clinical Nutrition 2005, 59: 789-796. PMID: 15870819, DOI: 10.1038/sj.ejcn.1602144.Peer-Reviewed Original ResearchConceptsChild health clinicsInfant feeding patternsHigher likelihoodTimes higher likelihoodExclusive breastfeedingCross-sectional designInfants 0Health clinicsPolyclinicPositive attitudesRented accommodationFeeding patternsWomenBirthDeliverySecondary school educationBiocultural factorsSimilar resultsBreastfeedingClinicInfantsEBFFactorsNegative attitudesAccra
2004
An Adapted Version of the U.S. Department of Agriculture Food Insecurity Module Is a Valid Tool for Assessing Household Food Insecurity in Campinas, Brazil
Pérez-Escamilla R, Segall-Corrêa A, Maranha L, de Fátima Archanjo Sampaio M, Marín-León L, Panigassi G. An Adapted Version of the U.S. Department of Agriculture Food Insecurity Module Is a Valid Tool for Assessing Household Food Insecurity in Campinas, Brazil. Journal Of Nutrition 2004, 134: 1923-1928. PMID: 15284377, DOI: 10.1093/jn/134.8.1923.Peer-Reviewed Original ResearchConceptsHousehold food insecurityFood insecurity instrumentDose-response mannerMeat/fishFood insecurityIncome strataDaily intakeBalanced mealsPopulation of CampinasValid toolFace validityChronbach's alphaContent expertsProgram eligibilityRepresentative sampleEradication programVaried dietSeverity levelsAlphaCity of CampinasIndependent survey samplesSimilar resultsRural areasAdapted versionAutomated detection of immunofluorescently labeled cytomegalovirus‐infected cells in isolated peripheral blood leukocytes using decision tree analysis
Ladanyi A, Sher AC, Herlitz A, Bergsrud DE, Kraeft S, Kepros J, McDaid G, Ferguson D, Landry ML, Chen LB. Automated detection of immunofluorescently labeled cytomegalovirus‐infected cells in isolated peripheral blood leukocytes using decision tree analysis. Cytometry Part A 2004, 58A: 147-156. PMID: 15057968, DOI: 10.1002/cyto.a.20016.Peer-Reviewed Original ResearchConceptsPeripheral blood leukocytesBlood leukocytesPatient samplesDecision tree analysisImage cytometryCytomegalovirus-infected cellsCMV infectionCytomegalovirus infectionAntiviral therapyViral antigensCellular featuresCytospin preparationsLeukocytesInfectionCytometryManual microscopic analysisImage cytometerRare cellsCellsSimilar resultsPatientsCMVTherapyAntigenDiagnosis
1998
GABA-Dependent Firing of Glutamate-Evoked Action Potentials at AMPA/Kainate Receptors in Developing Hypothalamic Neurons
Gao X, Chen G, van den Pol A. GABA-Dependent Firing of Glutamate-Evoked Action Potentials at AMPA/Kainate Receptors in Developing Hypothalamic Neurons. Journal Of Neurophysiology 1998, 79: 716-726. PMID: 9463435, DOI: 10.1152/jn.1998.79.2.716.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidAction potentialsHypothalamic neuronsAMPA/kainate receptorsN-methyl-D-aspartate receptorsGlutamate-mediated excitationAdult mammalian CNSFire action potentialsMajor inhibitory roleExcitatory functionGlutamate responseGlutamate receptorsKainate receptorsMammalian CNSMaximal effectSlight temporal delayNeuronal circuitsInhibitory roleNeuronsReceptorsBroad time windowDepolarizationGlutamatePresent studySimilar results
1996
Impairments in Physical Performance and Cognitive Status as Predisposing Factors for Functional Dependence Among Nondisabled Older Persons
Gill T, Williams C, Richardson E, Tinetti M. Impairments in Physical Performance and Cognitive Status as Predisposing Factors for Functional Dependence Among Nondisabled Older Persons. The Journals Of Gerontology Series A 1996, 51A: m283-m288. PMID: 8914500, DOI: 10.1093/gerona/51a.6.m283.Peer-Reviewed Original ResearchConceptsCognitive statusPhysical performanceOlder personsCommunity-living older adultsSlow functional declineWorse physical performanceCommunity-living adultsComplete outcome dataChronic conditionsPredisposing factorsFunctional declineDaily livingOutcome dataCognitive testingOlder adultsImpairmentRiskProbability sampleSubjectsStatusAdultsYearsComprehensive assessmentSimilar resultsFollow
1990
The Injured Canine Cervical Spine After Six Months of Healing
CRISCO J, PANJABI M, WANG E, PRICE M, PELKER R. The Injured Canine Cervical Spine After Six Months of Healing. Spine 1990, 15: 1047-1052. PMID: 2263970, DOI: 10.1097/00007632-199015100-00012.Peer-Reviewed Original ResearchConceptsC4-C5 levelCervical spineMonths of healingDegree of severityFlexion-extension rangeCommon siteSpinal injuryInjury severityCanine cervical spineCanine modelControl groupIntervertebral motionBiomechanical testingSpineMonthsBiomechanical characteristicsInjurySeverityCanine spineHealingLateral bendingVivo behaviorAxial rotationPure momentsSimilar resultsThe Injured Canine Cervical Spine After Six Months of Healing
CRISCO J, PANJABI M, WANG E, PRICE M, PELKER R. The Injured Canine Cervical Spine After Six Months of Healing. Spine 1990, 15: 1047-1052. DOI: 10.1097/00007632-199010000-00012.Peer-Reviewed Original ResearchC4-C5 levelCervical spineMonths of healingDegree of severityFlexion-extension rangeCommon siteSpinal injuryInjury severityCanine cervical spineCanine modelControl groupIntervertebral motionBiomechanical testingSpineMonthsBiomechanical characteristicsInjurySeverityCanine spineHealingLateral bendingVivo behaviorAxial rotationPure momentsSimilar results
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