2025
The Impact of Chiropractic Care on Opioid Prescriptions in Veterans Health Administration Patients Receiving Low Back Pain Care
Lisi A, Bastian L, Brandt C, Coleman B, Fenton B, King J, Goulet J. The Impact of Chiropractic Care on Opioid Prescriptions in Veterans Health Administration Patients Receiving Low Back Pain Care. Journal Of General Internal Medicine 2025, 1-9. PMID: 40394439, DOI: 10.1007/s11606-025-09556-w.Peer-Reviewed Original ResearchLow back painPrimary care providersVeterans Health AdministrationChiropractic careOpioid prescriptionsCare usersLow back pain careLow back pain visitsVA primary care providersElectronic health record dataVeterans Health Administration patientsBack pain careDesignCross-sectional analysisHealth record dataReceipt of opioid prescriptionsPain careCare providersPropensity-matched sampleFollow-upBack painHealthcare servicesVHA patientsHealth AdministrationVA patientsPotential confoundersUnintended Prolonged Opioid Use: Protocol for a Case-Controlled Trial
Hooten W, Erickson D, Chawarski M, Scholz N, Waljee J, Brummett C, Jeffery M. Unintended Prolonged Opioid Use: Protocol for a Case-Controlled Trial. JMIR Research Protocols 2025, 14: e72032. PMID: 39992690, PMCID: PMC11976181, DOI: 10.2196/72032.Peer-Reviewed Original ResearchConceptsINTERNATIONAL REGISTERED REPORT IDENTIFIERElectronic health record systemsPatient recruitmentPractice environment characteristicsPrescribing opioids to patientsOpioid prescriptionsHealth record systemsPatient characteristicsContinuation of opioid therapyIndividual practice environmentsOpioids to patientsOpioid-naive adultsOpioid-naive patientsProlonged opioid useSelf-report surveyNational administrative claims databaseMisuse of prescription opioidsCOVID-19 pandemicPublic health problemClinician recruitmentCase-control trialShort-term useAdministrative claims databaseMayo Clinic sitesCTSA programDeclining Postoperative 90-Day Opioid Prescriptions From 2010 to 2021 Following Hip Arthroscopy for Femoroacetabular Impingement Syndrome
Day W, Halperin S, Surucu S, Jimenez A, Katsnelson B, Zhu J, Grauer J. Declining Postoperative 90-Day Opioid Prescriptions From 2010 to 2021 Following Hip Arthroscopy for Femoroacetabular Impingement Syndrome. Arthroscopy Sports Medicine And Rehabilitation 2025, 7: 101078. PMID: 40297098, PMCID: PMC12034067, DOI: 10.1016/j.asmr.2025.101078.Peer-Reviewed Original ResearchPostoperative opioid prescriptionsFemoroacetabular impingement syndromeOpioid prescriptionsPostoperative MMEElixhauser Comorbidity IndexHip arthroscopyNinety-dayHistory of chronic painImpingement syndromeAmount of narcoticsNational administrative databaseChronic painAdult patientsPatient sexPostoperative recoveryMultivariate linear regressionComorbidity indexMultivariate analysisComorbidity burdenClinical relevancePatientsExclusion criteriaSurgeryPatient variablesAdministrative databasesFrom Chronic Opioids for Pain to Microgram Buprenorphine: Key Factors in an Increasingly Recommended Transition.
Hickey T, Hitt J. From Chronic Opioids for Pain to Microgram Buprenorphine: Key Factors in an Increasingly Recommended Transition. Pain Physician Journal 2025, 28: 59-67. PMID: 39903018.Peer-Reviewed Original ResearchConceptsOpioid therapyBuprenorphine exposureTotal dose of opioidsVeterans Health AdministrationChronic opioid therapyDoses of opioidsChronic pain managementOutpatient opioid prescriptionsReducing opioid useFull-agonist opioidsPrescription of buprenorphineTransition to buprenorphineAssociated with lower oddsVeterans Affairs Corporate Data WarehouseBaseline opioidChronic opioidsOpioid doseAgonist opioidsOpioid exposureHealth AdministrationOpioid prescriptionsOpioid useSurrogate markerLarge-scale observational studiesBuprenorphine initiation
2024
Opioid Prescribing Trends Following Lumbar Discectomy.
Rancu A, Gouzoulis M, Winter A, Katsnelson B, Ansah-Twum J, Grauer J. Opioid Prescribing Trends Following Lumbar Discectomy. Journal Of The American Academy Of Orthopaedic Surgeons 2024 PMID: 39706160, DOI: 10.5435/jaaos-d-24-00908.Peer-Reviewed Original ResearchMorphine Milligram EquivalentsOpioid prescriptionsLumbar diskectomyElixhauser Comorbidity IndexComorbidity indexPrescribing patternsAssociated with prescribing opioidsPrescribed morphine milligram equivalentsDiagnosis of chronic painMedian morphine milligram equivalentsSame-day diagnosisProportion of patientsOpioid prescribing trendsPatterns of opioidsPrescribing patterns of opioidsDiagnosis of neoplasmsAssociated with lower ageMultivariate regression analysisMilligram equivalentsPrescribed opioidsLumbar discectomySpine proceduresChronic painFemale sexPrescribing trendsBariatric surgery targeting opioid prescribing: a national model for effectively reducing opioid use after bariatric surgery
Petrick A, Shah T, Gadaleta D, Gould J, Morton J, Smith A, Evans-Labok K, Knapp L, Ko C, Brethauer S. Bariatric surgery targeting opioid prescribing: a national model for effectively reducing opioid use after bariatric surgery. Surgery For Obesity And Related Diseases 2024, 21: 402-410. PMID: 39753417, DOI: 10.1016/j.soard.2024.11.011.Peer-Reviewed Original ResearchMedian morphine milligram equivalentsOpioid useBariatric surgeryOpioid prescriptionsOpioid prescribingPrescription opioidsMBSAQIP-accredited centersOpioid naive patientsOutpatient opioid useChronic opioid usersChronic opioid useInpatient opioid useMorphine Milligram EquivalentsBariatric Surgery AccreditationReduce opioid prescribingOpioid-related deathsMilligram equivalentsOpioid usersPrescription habitsOpioidSurgeryProtocol adherenceInpatient stayPrescription guidelinesBariatricOpioid Use Following Open Reduction and Internal Fixation of Mandibular Fractures
Rancu A, Salib A, Kammien A, Lizardi J, Allam O, Grauer J, Alperovich M. Opioid Use Following Open Reduction and Internal Fixation of Mandibular Fractures. Journal Of Craniofacial Surgery 2024, 36: 503-507. PMID: 39601551, DOI: 10.1097/scs.0000000000010930.Peer-Reviewed Original ResearchMorphine Milligram EquivalentsMandible fracturesProportion of patientsOpioid useOpioid prescriptionsInternal fixationInternal fixation of mandibular fracturesPrescribing patternsFixation of mandibular fracturesMedian morphine milligram equivalentsHistory of chronic painOpioid Prescribing PatternsDecreased proportion of patientsPost-fractureDays post-fractureLong bone fracturesTraumatic craniofacial injuriesMilligram equivalentsMandibular fracturesPrescribed narcoticsPostoperative painChronic painCraniofacial injuriesOpen reductionOpioidImpact of complementary health approaches on opioid prescriptions among veterans with musculoskeletal disorders – A retrospective cohort study
Han L, Goulet J, Skanderson M, Redd D, Brandt C, Zeng-Treitler Q. Impact of complementary health approaches on opioid prescriptions among veterans with musculoskeletal disorders – A retrospective cohort study. Journal Of Pain 2024, 26: 104695. PMID: 39384145, PMCID: PMC11781976, DOI: 10.1016/j.jpain.2024.104695.Peer-Reviewed Original ResearchIntegrative health approachesHealth approachOpioid prescriptionsMusculoskeletal disordersAdministration electronic health recordComplementary health approachesPrimary care visitsElectronic health recordsPharmacy dispensing recordsCIH approachesCare visitsDispensed opioid prescriptionsHealth recordsRetrospective cohort studyDispensing recordsPatient's painAnalytic sampleIndex diagnosisExposure groupCohort studyVeteransOpioid initiationQuasi-experimental investigationCIHPrescription117. Opioid prescription patterns following single-level lumbar discectomy: a national database study
Rancu A, Gouzoulis M, Winter A, Katsnelson B, Ansah-Twum J, Grauer J. 117. Opioid prescription patterns following single-level lumbar discectomy: a national database study. The Spine Journal 2024, 24: s60-s61. DOI: 10.1016/j.spinee.2024.06.560.Peer-Reviewed Original ResearchMorphine Milligram EquivalentsSingle-level lumbar discectomyMedian morphine milligram equivalentsOpioid prescriptionsLumbar discectomyPrescribed morphine milligram equivalentsDiagnosis of chronic painPostoperative opioid prescriptionsOpioid Prescribing PatternsOpioid prescription patternsPostoperative pain controlPostoperative pain managementProportion of patientsNational database studyMultivariate linear regression analysisWilcoxon rank sum testDiagnosis of neoplasmsMultivariate logistic regressionRank sum testExcess opioidsPrescription percentageMilligram equivalentsPostoperative opioidsChronic painSpine proceduresThe Association of Surgical Setting With Opioid Prescribing Patterns Following Wide-Awake Trigger Finger Release
Kammien A, Shvedova M, Allam O, Prsic A, Grauer J, Colen D. The Association of Surgical Setting With Opioid Prescribing Patterns Following Wide-Awake Trigger Finger Release. Annals Of Plastic Surgery 2024, 93: e45-e49. PMID: 38984645, DOI: 10.1097/sap.0000000000004030.Peer-Reviewed Original ResearchPerioperative opioid prescriptionMorphine Milligram EquivalentsOpioid prescriptionsPain controlSurgical settingPostoperative painOffice-based surgeryOperating roomMultivariate analysisPerception of postoperative painOpioid Prescribing PatternsPostoperative pain controlReducing opioid prescriptionsNational administrative claims databaseElixhauser comorbidity index scoreChronic back/neck painHand surgeryComorbidity Index scoreAdministrative claims databaseMonitored Anesthesia CareMilligram equivalentsPostoperative dataPrescribed opioidsPerioperative opioidsPreoperative dataDo veterans with risky substance use (RSU) use distinct pain treatment modalities?
Meshberg‐Cohen S, Gilstad‐Hayden K, Martino S, Lazar C, Sellinger J, Rosen M. Do veterans with risky substance use (RSU) use distinct pain treatment modalities? American Journal On Addictions 2024, 33: 675-684. PMID: 38849976, DOI: 10.1111/ajad.13620.Peer-Reviewed Original ResearchRisky substance usePain treatment modalitiesTreatment modalitiesPain treatmentPrescribed opioidsPain treatment utilizationSubstance Involvement TestNonopioid pain treatmentPain treatment outcomesSubstance useOver-the-counter medicationsNumerical rating scalePrimary careMusculoskeletal conditionsAssociated with numberPain serviceNonopioid treatmentsPrescription medicationsOpioid medicationsChronic painOpioid prescriptionsOver-the-counterVeteransDisability claimsOpioidOpioid prescribing trends and pain scores among adult patients with cancer in a large health system.
Baum L, Soulos P, KC M, Jeffery M, Ruddy K, Lerro C, Lee H, Graham D, Liberatore M, Rivera D, Leapman M, Jairam V, Dinan M, Gross C, Park H. Opioid prescribing trends and pain scores among adult patients with cancer in a large health system. Journal Of Clinical Oncology 2024, 42: 11059-11059. DOI: 10.1200/jco.2024.42.16_suppl.11059.Peer-Reviewed Original ResearchDocumented painHealth systemOpioid prescribingOpioid prescriptionsOpioid prescribing trendsYale New Haven Health SystemPrescribing trendsMetastatic cancerDocumented pain scoresUS health systemOpioid usePain scoresAdult patientsCalculated predicted probabilitiesFlowsheet dataRetrospective cohort studyRelated harmSolid tumor malignanciesCohort studyCancer painPrescribingContext of cancer treatmentStudy criteriaPainSurgery cohortGlial modulators as novel therapeutics for comorbid pain and opioid use disorder
Schwartz E, De Aquino J, Sofuoglu M. Glial modulators as novel therapeutics for comorbid pain and opioid use disorder. British Journal Of Clinical Pharmacology 2024, 90: 3054-3066. PMID: 38752593, DOI: 10.1111/bcp.16094.Peer-Reviewed Original ResearchOpioid use disorderChronic painGlial modulationNovel treatment approachesComorbid painPublic health problemTreatment approachesImproved pain measuresLiterature search of PubMedIncreased opioid prescriptionsSearch of PubMedAddiction-related outcomesSignificant public health problemComorbid disordersOpioid prescriptionsGoogle Scholar databasesPain measuresHealth problemsPain managementClinical studiesTreatment challengesClinical trialsPatient populationPainGlial activationThe Correlation of Surgical Setting With Perioperative Opioid Prescriptions for Wide-Awake Carpal Tunnel Release.
Kammien A, Hu K, Collar J, Rancu A, Zhao K, Grauer J, Colen D. The Correlation of Surgical Setting With Perioperative Opioid Prescriptions for Wide-Awake Carpal Tunnel Release. Hand 2024, 15589447241247247. PMID: 38654508, PMCID: PMC11571719, DOI: 10.1177/15589447241247247.Peer-Reviewed Original ResearchCarpal tunnel releasePerioperative opioid prescriptionOpioid prescriptionsAssociation of opioid prescriptionsSurgical settingOpioid utilizationPerioperative opioid utilizationMorphine Milligram EquivalentsAdministrative claims databaseOpioid dependence/abuseMilligram equivalentsPostoperative dataElixhauser Comorbidity IndexPain controlPreoperative dataBilateral surgeryTraditional anesthesiaBack/neck painMatched CohortOffice-based surgeryComorbidity indexMultivariate analysisOpioidSurgeryAnesthetic techniquePost-Traumatic Stress Disorder Is Associated With Increased Emergency Department Services and Similar Rates of Opioid Prescriptions Following Primary Total Hip Arthroplasty: A Propensity Matched Analysis
Monahan P, Martinazzi B, Pahapill N, Graefe S, Jimenez A, Mason M. Post-Traumatic Stress Disorder Is Associated With Increased Emergency Department Services and Similar Rates of Opioid Prescriptions Following Primary Total Hip Arthroplasty: A Propensity Matched Analysis. The Journal Of Arthroplasty 2024, 39: s287-s292.e1. PMID: 38492824, DOI: 10.1016/j.arth.2024.03.012.Peer-Reviewed Original ResearchPost-traumatic stress disorderPost-traumatic stress disorder patientsHealth care utilizationStress disorderPrimary total hip arthroplastyRate of postoperative complicationsCare utilizationTotal hip arthroplastyRate of opioid prescriptionsPrescribed opioid analgesicsPropensity matched analysisRates of health care utilizationSimilarity ratingsEmergency department servicesEmergency department visitsHip arthroplastyPreoperative characteristicsPostoperative prescriptionOpioid analgesicsPostoperative complicationsOpioid prescriptionsOpioid prescribingPsychiatric diagnosisPeer Comparison or Guideline-Based Feedback and Postsurgery Opioid Prescriptions
Wagner Z, Kirkegaard A, Mariano L, Doctor J, Yan X, Persell S, Goldstein N, Fox C, Brummett C, Romanelli R, Bouskill K, Martinez M, Zanocco K, Meeker D, Mudiganti S, Waljee J, Watkins K. Peer Comparison or Guideline-Based Feedback and Postsurgery Opioid Prescriptions. JAMA Health Forum 2024, 5: e240077. PMID: 38488780, PMCID: PMC10943416, DOI: 10.1001/jamahealthforum.2024.0077.Peer-Reviewed Original ResearchConceptsCluster randomized clinical trialPeer comparison interventionOpioid prescribingEmail feedbackGuideline interventionComparison interventionIntervention periodHealth care delivery systemRandomized clinical trialsOpioid prescriptionsCare delivery systemPeer comparisonExcessive opioid prescribingSocial norm-based interventionsControl groupIntervention monthsMain OutcomesQuantity of opioidsClinical trialsDischarged patientsPeer surgeonsPrescribingOpioid misuseInterventionSurgical specialtiesVariation in Intraoperative Opioid Administration by Patient, Clinician, and Hospital Contribution
Burns M, Hilliard P, Vandervest J, Mentz G, Josifoski A, Varghese J, Fisher C, Kheterpal S, Shah N, Bicket M. Variation in Intraoperative Opioid Administration by Patient, Clinician, and Hospital Contribution. JAMA Network Open 2024, 7: e2351689. PMID: 38227311, PMCID: PMC10792468, DOI: 10.1001/jamanetworkopen.2023.51689.Peer-Reviewed Original ResearchConceptsIntraoperative opioid administrationOral morphine equivalentsOpioid administrationSurgical proceduresHospital levelElectronic health record dataIntraclass correlationCohort studyAnalgesic categoriesSurgical categoriesHealth record dataQuality-improvement programHospital-level factorsPatient-level factorsNeuraxial analgesic techniquesCardiac surgical proceduresKnee surgical proceduresOpioid-reducing strategiesElective surgical proceduresMain OutcomesHospital contributionMorphine equivalentsOpioid exposureSurgical characteristicsOpioid prescriptions
2023
Effects of Opioid-Limiting Legislation in the State of Ohio on Opioid Prescriptions After Shoulder Arthroscopy
Strony J, Raji Y, Trivedi N, McMellen C, Yu J, Calcei J, Voos J, Gillespie R. Effects of Opioid-Limiting Legislation in the State of Ohio on Opioid Prescriptions After Shoulder Arthroscopy. Orthopaedic Journal Of Sports Medicine 2023, 11: 23259671231202242. PMID: 38021300, PMCID: PMC10664433, DOI: 10.1177/23259671231202242.Peer-Reviewed Original ResearchOpioid prescriptionsCumulative MMEsShoulder arthroscopyOpioid dosingOpioid naïvePostoperative dayPostoperative periodRisk factorsGamma-aminobutyric acid (GABA) analogueOpioid-tolerant patientsPostoperative opioid dosageProlonged opioid useConsumption of opioidsDate of surgeryImmediate postoperative periodDay of surgeryData of patientsLevel of evidenceGABA analoguesCertain orthopedic proceduresCovariate-adjusted regression analysesFisher's exact testHigher MMEPreoperative opioidsMedical comorbiditiesOpioid prescription and risk of atrial fibrillation in younger veterans
Chui P, Khokhar A, Gordon K, Dziura J, Burg M, Brandt C, Haskell S, Malm B, Bastian L, Gandhi P. Opioid prescription and risk of atrial fibrillation in younger veterans. American Heart Journal 2023, 268: 61-67. PMID: 37949420, DOI: 10.1016/j.ahj.2023.11.001.Peer-Reviewed Original ResearchTime-updated Cox regressionIncident atrial fibrillationAtrial fibrillationOpioid exposureVeterans Health AdministrationOpioid typeCox regressionOpioid prescriptionsICD-9-CM diagnostic codesIncidence of AFDevelopment of AFPrescription opioid exposureModifiable risk factorsPrimary care visitsPrescribed opioidsCare visitsOpioid useRisk factorsDiagnostic codesTime-dependent variablesOpioidsHealth AdministrationYounger veteransBaseline periodStudy sampleLeveraging a Learning Collaborative Model to Develop and Pilot Quality Measures to Improve Opioid Prescribing in the Emergency Department
Hawk K, Weiner S, Rothenberg C, Bernstein E, D'Onofrio G, Herring A, Hoppe J, Ketcham E, LaPietra A, Nelson L, Perrone J, Ranney M, Samuels E, Strayer R, Sharma D, Goyal P, Schuur J, Venkatesh A. Leveraging a Learning Collaborative Model to Develop and Pilot Quality Measures to Improve Opioid Prescribing in the Emergency Department. Annals Of Emergency Medicine 2023, 83: 225-234. PMID: 37831040, DOI: 10.1016/j.annemergmed.2023.08.490.Peer-Reviewed Original ResearchAtraumatic back painCommunity EDED visitsBack painOpioid prescribing practicesFirst-line treatmentEmergency department patientsOpioid use disorderQuality improvement projectEvidence-based resourcesOpioid administrationOpioid prescriptionsDental painSafe analgesiaDepartment patientsOpioid pillsPrescribing practicesEmergency departmentAmerican CollegeUse disordersMedication safety educationPainOpioidsImprovement projectVisits
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