2025
Associations between PM2.5 exposure and birth outcomes and effect modification by extreme heat events during pregnancy in a North Carolina cohort
Krajewski A, Alman B, Vaidyanathan A, Warren J, Luben T, Rappazzo K. Associations between PM2.5 exposure and birth outcomes and effect modification by extreme heat events during pregnancy in a North Carolina cohort. Atmospheric Environment 2025, 362: 121500. DOI: 10.1016/j.atmosenv.2025.121500.Peer-Reviewed Original ResearchBirth outcomesPreterm birthPM2.5 exposureExposure to extreme heat eventsPoor health outcomesBirth registry dataEffect measure modificationAdverse birth outcomesInteraction termsNorth Carolina cohortEntire pregnancyHealth outcomesGeocoded addressesSingleton birthsMeasure modificationEffect modificationBirth recordsCensus tractsRegistry dataTLBWRisk differenceNeonatal mortalityEnvironmental exposuresExposure dataWeeks gestationBenzodiazepine Initiation Effect on Mortality Among Medicare Beneficiaries Post‐Acute Ischemic Stroke
Sankaranarayanan M, Donahue M, Sun S, Brooks J, Schwamm L, Newhouse J, Hsu J, Blacker D, Haneuse S, Moura L. Benzodiazepine Initiation Effect on Mortality Among Medicare Beneficiaries Post‐Acute Ischemic Stroke. Pharmacoepidemiology And Drug Safety 2025, 34: e70194. PMID: 40706600, DOI: 10.1002/pds.70194.Peer-Reviewed Original ResearchConceptsDays post-dischargeRisk differencePost-dischargeBaseline dementiaRisk of deathMedicare beneficiariesOlder adultsAcute ischemic strokeMortality riskSample of Medicare beneficiariesOlder stroke survivorsMortality risk differencesOlder Medicare beneficiariesPost-acute ischemic strokeHigh riskOlder age groupsHigher risk of deathIschemic strokeStroke survivorsBenzodiazepine initiationTrial emulationVulnerable patientsDementiaDay mortality riskPrimary outcomeEstimating the Effects of Hypothetical Ambient PM2.5 Interventions on the Risk of Dementia Using the Parametric g-Formula in the UK Biobank Cohort
Lin C, Liu R, Sutton C, DeWan A, Forastiere L, Chen K. Estimating the Effects of Hypothetical Ambient PM2.5 Interventions on the Risk of Dementia Using the Parametric g-Formula in the UK Biobank Cohort. Environmental Health Perspectives 2025, 133: 047007. PMID: 40062909, PMCID: PMC12010936, DOI: 10.1289/ehp14723.Peer-Reviewed Original ResearchConceptsRisk of dementiaParametric g-formulaUK Biobank cohortG-formulaBiobank cohortLate lifeFree of dementiaUK Biobank participantsModifiable risk factorsParticulate matterAerodynamic diameter <Annual average standardBiobank participantsHypothetical interventionAmbient particulate matterNo interventionDementiaRisk differenceInterventionRisk factorsHealth benefitsPotential health benefitsCohortRiskParticipantsComparative effectiveness of long-acting injectable versus oral antipsychotic medication after a first episode of psychosis
Szmulewicz A, Martínez-Alés G, Logan R, Joober R, Ferrara M, Kelly C, Fredrikson D, Thorpe L, Conderino S, Díaz-Caneja C, Srihari V, Yatham L, Sarpal D, Shinn A, Arango C, Shah J, Öngür D, Hernán M. Comparative effectiveness of long-acting injectable versus oral antipsychotic medication after a first episode of psychosis. Nature Mental Health 2025, 3: 421-428. DOI: 10.1038/s44220-025-00407-5.Peer-Reviewed Original ResearchEpisode of psychosisPsychotic relapseLong-actingTarget trialsRisk of psychotic relapseLong-acting antipsychoticsOral antipsychotic medicationEffects of long-actingLAI therapyAntipsychotic therapyAntipsychotic medicationSchizophrenia trialsTherapy initiationRisk of relapseOral therapyPsychosisRisk differenceFEPObservational cohort of peopleHospitalization riskCohort of peopleNetwork meta-analysesNo risk reductionNon-adherenceRelapseBenzodiazepine Initiation and the Risk of Falls or Fall-Related Injuries in Older Adults Following Acute Ischemic Stroke
Sun S, Lomachinsky V, Smith L, Newhouse J, Westover M, Blacker D, Schwamm L, Haneuse S, Moura L. Benzodiazepine Initiation and the Risk of Falls or Fall-Related Injuries in Older Adults Following Acute Ischemic Stroke. Neurology Clinical Practice 2025, 15: e200452. PMID: 40144887, PMCID: PMC11936338, DOI: 10.1212/cpj.0000000000200452.Peer-Reviewed Original ResearchFall-related injuriesRisk of fallsOlder adultsAcute ischemic strokeRisk differenceAcute ischemic stroke admissionsElectronic health recordsHypothetical randomized trialInverse probability weightingIschemic strokeRecovery periodHealth recordsBenzodiazepine initiationPoststroke periodConfounding biasImmortal timeMild strokeBenzodiazepine prescriptionsBZD useDay of admissionProbability weightingSubgroup analysisAnalyzed dataStrokeAdultsSeverity and Long-Term Mortality of COVID-19, Influenza, and Respiratory Syncytial Virus
Bajema K, Bui D, Yan L, Li Y, Rajeevan N, Vergun R, Berry K, Huang Y, Lin H, Aslan M, Ioannou G. Severity and Long-Term Mortality of COVID-19, Influenza, and Respiratory Syncytial Virus. JAMA Internal Medicine 2025, 185: 324-334. PMID: 39869355, PMCID: PMC11773409, DOI: 10.1001/jamainternmed.2024.7452.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusLong-term mortalitySARS-CoV-2Syncytial virusCohort studyAssociated with higher long-term mortalityRisk differenceIntensive care unit admissionSeasonal influenza vaccineRetrospective cohort studyDisease severity of COVID-19Long-term deathAssociated with more severe disease outcomesRisk of deathCompare disease severitySevere disease outcomesRisk of hospitalizationSeverity of COVID-19Same-day testingInfluenza vaccineInverse probability weightingUnit admissionCumulative incidenceMortality of COVID-19Primary outcomeTime to direct-acting antiviral initiation and liver-related events in people with HIV and hepatitis C virus
Chalouni M, Van Santen D, Berenguer J, Jarrin I, Miro J, Klein M, Young J, Torgersen J, Rentsch C, Gill M, Epstein R, Linas B, Zangerle R, Surial B, Rauch A, Touloumi G, Papadopoulos A, Wittkop L, Van Der Valk M, Boyd A, Monforte A, Puoti M, Logan R, Rein S, Hernán M, Lodi S. Time to direct-acting antiviral initiation and liver-related events in people with HIV and hepatitis C virus. AIDS 2025, 39: 1074-1079. PMID: 39970192, PMCID: PMC12122233, DOI: 10.1097/qad.0000000000004161.Peer-Reviewed Original ResearchRisk of liver-related eventsDirect-acting antivirals initiationHIV-HCV co-infectionLiver-related eventsDirect-acting antiviralsHIV virologic suppressionAntiretroviral treatmentVirologic suppressionHIV-HCVCo-InfectionHistory of injection drug useInjection drug useHepatitis C virusAntiviral initiationSuppress HIVDAA initiationHCV transmissionC virusEarly initiationCure HCVDelayed initiationHIVRisk differenceClinical practiceDrug useIndividualized Net Benefit of Intensive Blood Pressure Lowering Among Community‐Dwelling Older Adults in SPRINT
Jamshidian M, Scherzer R, Estrella M, Kravitz R, Boxer R, Tancredi D, Berry J, de Lemos J, Ginsberg C, Ix J, Shlipak M, Ascher S. Individualized Net Benefit of Intensive Blood Pressure Lowering Among Community‐Dwelling Older Adults in SPRINT. Journal Of The American Geriatrics Society 2025, 73: 1441-1453. PMID: 39967308, PMCID: PMC12100678, DOI: 10.1111/jgs.19395.Peer-Reviewed Original ResearchSystolic Blood Pressure Intervention TrialCommunity-dwelling older adultsIntensive blood pressureSystolic BP targetOlder adultsBlood pressureIndividual net benefitsIntensive BPBP targetsAdvanced ageSystolic Blood Pressure Intervention Trial participantsBenefits of BPOptimal blood pressureTreatment-related harmsCategories of ageAdverse eventsPositive net benefitsFrailty statusCardiovascular outcomesCognitive outcomesIntervention trialsCox modelRisk differenceSystolicPolypharmacyEarly sedation with dexmedetomidine in patients with acute myocardial infarction requiring mechanical ventilation
Banna S, Schenck C, Singh A, Safiriyu I, Jimenez J, Franko A, Thomas A, Heck C, Ludmir J, Gage A, Ali T, Katz J, Dudzinski D, Ross J, Miller P. Early sedation with dexmedetomidine in patients with acute myocardial infarction requiring mechanical ventilation. European Heart Journal Acute Cardiovascular Care 2025, 14: 270-278. PMID: 39919040, DOI: 10.1093/ehjacc/zuaf022.Peer-Reviewed Original ResearchInverse probability of treatment weightingAcute myocardial infarctionPrimary diagnosis of acute myocardial infarctionCompared to usual careInvasive mechanical ventilationUsual care groupEstimate adjusted risk differencesAdjusted risk differencesAssociated with lower mortalityDiagnosis of acute myocardial infarctionVentilator-free daysRandomized Controlled TrialsUsual careCare groupClinical data baseMyocardial infarctionProbability of treatment weightingIn-Hospital MortalityIll populationRisk differenceMechanical ventilationDays of invasive mechanical ventilationAnalgesic usePrimary diagnosisEarly sedationSex Differences in Long COVID
Shah D, Thaweethai T, Karlson E, Bonilla H, Horne B, Mullington J, Wisnivesky J, Hornig M, Shinnick D, Klein J, Erdmann N, Brosnahan S, Lee-Iannotti J, Metz T, Maughan C, Ofotokun I, Reeder H, Stiles L, Shaukat A, Hess R, Ashktorab H, Bartram L, Bassett I, Becker J, Brim H, Charney A, Chopra T, Clifton R, Deeks S, Erlandson K, Fierer D, Flaherman V, Fonseca V, Gander J, Hodder S, Jacoby V, Kotini-Shah P, Krishnan J, Kumar A, Levy B, Lieberman D, Lin J, Martin J, McComsey G, Moukabary T, Okumura M, Peluso M, Rosen C, Saade G, Shah P, Sherif Z, Taylor B, Tuttle K, Urdaneta A, Wallick J, Wiley Z, Zhang D, Horwitz L, Foulkes A, Singer N, Han J, Marconi V, Ofotokun I, Patzer R, Walker T, Abraham R, Aguilar F, Ahmadi-Izad G, Ahmed D, Alvarez A, Anderson B, Asencios W, Beaty C, Bedi B, Berry J, Boone D, Bower M, Bremner J, Brent C, Brown-Smith K, Bull R, Capo G, Carl-Igwe K, Chitadze C, Chukwumerije N, Clyburn E, Collins S, Costello J, Couture G, Craft A, Cui X, del Rio C, Detelich J, Dixon C, Dow J, Doyle D, Elchommali J, Elsey I, Franks N, Gallini J, Gutter E, Harding J, Hernandez L, Holloway C, Ifejika C, Jasarevic R, Javia V, Jeter M, Joseph Y, Juarez M, Kirkpatrick C, Koumanelis A, Krishnan S, Leon J, Lew V, Maier C, Makkaoui N, Maroney M, Martin C, Mbogo L, McCaslin A, McIntyre J, Moanna A, Montoya M, Morales E, Moran C, Murray C, Nelson R, Nguyen T, Ojoawo B, Osinski E, Oviedo S, Paredes-Gaitan Y, Prude M, Ramakrishnan G, Rebolledo P, Roberts M, Robinson K, Rogers C, Rouphael N, Searles C, Segall M, Shah A, Silva R, Simpson C, Simpson-Derrell K, Sirajud-Deen T, Stroud J, Suthar M, Sylber C, Sylvera A, Teunis L, Thomas K, Titanji K, Toy C, Truong A, Vaccarino V, Varney K, Vyas K, Vyas K, Walkow M, Wesley T, Winston J, Winter T, Wongtrakool C, Cribbs S, Francis A, Hang T, Ingram K, Lainez J, Wiley Z, Ager A, Atha M, Gray N, Grimes A, Hewitt L, Huerta C, Johnson B, Khalil L, Kleinhenz D, Koumanelis A, Kozoman R, Lee M, Lewis K, Litvack M, Maramba T, Mehta C, Panganiban B, Rahman K, Smith V, Stringer A, Tolbert M, Traenkner J, Unterberger K, Wang H, Wimberly E, Yang Q, Gander J, Neuman R, Bush P, Hudgins A, Kolailat I, Martinez M, Thompson S, Agu C, Pemu P, Afani A, Ariri C, Dandy A, Harper K, Ibeawuchi C, Lawrence B, Morgan-Billingslea J, Ojemakinde E, Smith K, Levy B, Aikawa M, Baden L, Baslet G, Bennett L, Bhattacharyya S, Buring J, Cagnina R, Chen L, Clark C, Cohen P, Czeisler C, Estill P, Gay E, Hong J, Lamas D, Lay S, Levy-Carrick N, Manson J, Monafrared T, Redline S, Remis E, Schilkrut D, Sesso H, Solomon S, Sparks J, Spencer L, Systrom D, Thu P, Walt D, Washko G, Whittelsey M, Wiener R, Bassett I, Alba G, Aung T, Ginns L, Haas J, Hu Y, Juelg B, Kanjilal D, Kim A, Klerman E, Lewis G, Musa A, Ojikutu B, Perlis R, Rosand J, Wallace Z, Xerras D, Zionts D, Mullington J, Collier A, Fong T, Haack M, Hauser K, Maley J, Quintana Y, Shaughnessy L, Stephenson K, Thomas R, Torres R, Marathe J, Duffy E, Hamburg N, Kobayashi M, O'Connor G, Shepherd F, Williams C, Zhang H, John J, Ticotsky A, Ward H, Blazey-Martin D, Ghamloush M, Jordan M, Kogelman L, Erdmann N, Levitan E, Tita A, Armstrong D, Binkley S, Blackwell K, Causey A, Cook F, Domingo J, Donahue C, Eady M, Edberg J, Forehand K, Frazier P, Garcia-McClaney N, Garner M, Gray B, Hall W, Hart C, Hebson C, Hidalgo B, Holtzapfel K, Jinright A, Judd S, Kennedy T, Kirkwood L, Maier M, McCormack P, Mitchell K, Montgomery A, Peralta-Carcelen M, Pilco J, Powell L, Royster J, Shevin R, Skipworth S, Spurgeon L, Steele C, Vines J, Ware G, Wilson R, Woodruff D, Young B, Gillespie M, Daniel C, Hansel J, Wu J, Carton T, Miele L, Brown T, Sutherland E, Fuloria J, Datri P, Hagensee M, Leggio C, Perkins A, Trauth A, Trotter S, Van Deerlin A, Weiser S, Young M, Ashktorab H, Brim H, Laiyemo A, Sherif Z, Durrani S, Nezamloo A, Ngwa J, Njoku N, Gentil M, Mehari A, Solemani A, Chang L, Thuluvath P, Alemu M, Anderson J, Chauhan M, Cho S, Goodman K, Lanke G, Lebron R, Maheshwari A, Ok J, To C, Hodder S, Bardes J, Dominique-Villanueva D, Juskowich J, Reece R, Sarwari A, Shellito J, Greenway F, Kirwan J, Rodemann G, Rosen C, Arruda A, Brunet T, Emery I, Roelke T, Berger P, Hoover S, Black L, Tjarks B, Fonseca V, Gupta S, Longo M, Yang M, Shikuma C, Chow D, MarGangcuangco L, Castro M, Bengtson C, Howard T, Koontz B, Spikes L, Simmons C, Whiteheart S, Garvy B, Wood J, Marshall G, Garla V, Kuebler J, Nandi U, Vasey A, Warren D, Dickinson J, VanWagoner T, Bogie A, Heyanka D, James J, Scott J, Sukhera F, Luciano Roman C, Perez Frontera S, Santana Bagur J, Klein J, Krishnan J, Lin J, Muramatsu N, Prabhakar B, Prendergast H, Vanden Hoek T, Adams D, Baker A, Barbera S, Basu S, Bleasdale S, Boyd A, Breiter T, Buhimschi I, Carrithers M, Chalamalla R, Chestek D, Cook J, Darbar D, Dasgupta R, Davis Blakley F, DeLisa J, Diviak K, Donlon M, Dworkin M, Ellison A, Flanigan C, Freedman M, Gerald L, Giles W, Gordon H, Hammad B, Hasek S, Hasse W, Hryniewicka M, Illendula S, Ismail N, Jain A, Jennette K, Kadubek G, Kent D, Kent D, Kim K, Kotini-Shah P, Large L, Lash J, Lu J, Mahamed A, Malchenko S, Martinez M, Mauntel-Medici C, McCauley M, Menchaca M, Mermelstein R, Moreno D, Morrissy L, Musick H, Norwick L, Novak R, Ortiz M, Patel K, Perez N, Pliskin N, Pope S, Prasad B, Predki B, Quigley J, Ramchandran R, Ramirez A, Rappe S, Rehman J, Rowley M, Rudraraju G, Rutherfoord M, Sculley J, Smith-Mack J, Sun J, Tartt N, Villanueva L, Warfield Kelly S, Yazici C, Certa M, Chessier E, Everett E, Kindred E, Harris P, Sudhindra P, Olds L, Aponte-Soto L, Del Rios M, Diaz M, Ibanez A, Rolon C, Cranford S, Brown D, Dixon J, Gale L, Hammerl S, Hartwig K, Madineni A, Swearingen P, Hendrickson M, Noland S, Terlinde T, Hobbs B, Stewart de Ramirez S, Bolliger D, Boyineni J, Chebrolu P, Curry H, Donohue S, Edmonds S, Kelly S, Maholovich P, Sader S, Thompson T, Welter H, Woolley B, Hafner J, Hanson K, Hutton R, Charney A, Kovatch P, Merad M, Nadkarni G, Wisnivesky J, Aberg J, Ascolillo S, Bagiella E, Bartram L, Becker J, Beckmann N, Bendl A, Chen B, Civil A, Crawford G, Dhar K, Evo-Ortega L, Fierer D, Gallagher E, Garcia-Sastre A, Gnjatic S, Gray I, Guliyeva S, Harvey-Ingram L, Herrera-Moreno J, Hill M, Horowitz C, Jackson R, Kastrat D, Lala-Trindade A, Lin J, Macaluso N, Marcon K, Meyer D, Morinigo J, Natelson B, Nussenzweig M, Padua T, Putrino D, Richardson L, Russo S, Seifert A, Serri A, Walker J, Yee M, Bateman L, Hess R, Truong D, Alekhina N, Barlocker J, Brown J, Cortez M, Donohue D, Facelli J, Ford I, Gouripeddi R, Hermansen J, Johnny J, Lindsay A, Ling L, Lloyd J, Lu Y, Medina J, Morimoto S, Pace L, Powell J, Scholand M, Shah K, Sharareh N, Spivak A, Stringham C, Trinity J, Velinder M, Weaver L, Vernon S, Deakyne Davies S, Gardner E, Bryan T, Buck K, Hawkins K, Oakes J, Horne B, Knowlton K, Woller S, Aguirre B, Anderson J, Bair T, Bosh L, Evans L, Garrett C, Harris D, Herrera K, Iverson L, Jensen M, Juan J, Knight S, Leither L, Maestas H, May H, Najarian G, Webb T, Zubal S, Erlandson K, Sokol R, Brightman M, Davis D, Feuerriegel E, Fudge H, Garg L, Higgins J, Jolley S, Lockie T, McCandless S, Pitch C, Reusch J, Thurman B, Tran H, West S, Friedman N, Ludwig K, Decker L, Raissy H, Adolphi N, Archuleta D, Bradfute S, Brito R, Elifritz J, Garcia-Soberanez N, Gentry F, Harkins M, Martinez N, Montoya L, Parada A, Quinn D, Ramos A, Sheehan E, Treacher I, McComsey G, Adams C, Andrefsky J, Atieh O, Baissary J, Boldt N, Conrad A, D’Anza B, Koberssy Z, Daher J, Dawson S, DiFrancesco K, Durieux J, Foster (Rodgers) T, Gallagher M, Gupta A, Harrill J, Harris P, Hernandez C, Ialacci S, Jacono F, Kelly J, Kumar R, Labbato D, Lesco E, Lim J, Pettinato K, Rodgers M, Rosolia B, Roy A, Scott S, Smith B, Tejani V, Tribout M, Yendewa G, Zhang D, Singer N, Ayache M, Barnboym E, Brown A, Chesnick H, Edminston M, Greenwood C, Haghiac M, Kaufman E, Lengu K, Lowenthal R, Malakooti S, Oleson C, Pearman A, Rizea A, Smith C, Washington M, Weinberger E, Heath J, Brennan C, Edmark R, Gutierrez V, Hadlock J, Li S, Magis A, McDonald C, Murray K, Rowen L, Yuan D, Chen P, Caudill A, Chopra T, Contreras F, Dahlke L, Gudipudi L, Jackman S, Modes M, Muttera N, Nelson C, Parimon T, Salinas N, Tadeo J, Torbati S, Watson S, Tuttle K, Alicic R, Baxter J, Emerson S, Hood S, Kuykendall K, White S, Wilcox L, Goldman J, Algren H, Del Alcazar J, Duven A, Kaneko J, Kim C, Manner P, Mason C, Okada A, Poussier R, Satira R, Wallick J, Chu H, Elias-Warren A, Harteloo A, Logue J, McCaffrey K, Nguyen H, Nambiar A, Patterson T, Potter J, Salehi M, Sharma K, Verduzco-Gutierrez M, Anderson R, Arellanes A, Barajas R, Chauhan S, Clarke G, Farner C, Fischer M, Goldberg M, Hastings G, Heard P, Hernandez J, Herrera I, Infante E, Johnson H, Jones J, Kellogg D, Kraig E, Longoria L, Okafor E, Patterson J, Pinones A, Reeves W, Scholler I, Seshadri S, Shah P, Shah D, Smith M, Soileau B, Solis P, Stoebner C, Sullivan M, Taylor B, Tragus R, Tsevat J, Hasbani K, Saade G, Sharma K, Paredes C, Alvarado S, Kumar A, Maldonado Y, Utz P, Blish C, Go M, Jagannathan P, Singh U, Ahuja N, Blomkalns A, Bonilla H, Brotherton R, Clinton K, Dingankar V, Geng L, Haddad F, Jamero C, Jee K, Jia X, Khurana N, Miglis M, O'Conor E, Olszewski K, Pathak D, Quintero O, Saperia C, Scott J, Urdaneta A, Varkey M, Nikolich J, Parthasarathy S, Ernst K, Esquivel D, Harris D, Harris S, Hernandez M, Hsu H, James M, Karnafel M, Knox K, Koleski A, LaFleur B, Lambert B, LaRue S, Lutrick K, Merchant N, Morton C, Mosier J, Olorunnisola T, Peralta J, Pilling W, Pogreba-Brown K, Rischard F, Ryan L, Smith T, Snyder M, Subbian V, Suhr K, Velarde D, Reiman E, Lee-Iannotti J, Autry L, Beydoun H, Borwege S, Copeland J, DiLise-Russo M, Fadden S, Gomez I, Grischo G, Hartley W, Hillier L, Ismail H, Iusim S, Kala M, Kim D, Murthy G, Unzek S, Vadovicky S, Veres S, Bime C, Hansen L, Hughes T, Lieberman D, Soto F, Wilson C, Zapien A, Deeks S, Kelly J, Martin J, Peluso M, Anderson G, Anglin K, Argueta U, Asare K, Buitrago M, Chang Song C, Clark A, Conway E, Del Castillo N, Deswal M, Durstenfeld M, Eilkhani E, Eun A, Fehrman E, Figueroa T, Flores D, Grebe H, Henrich T, Hoh R, Hsue P, Huang B, Ibrahim R, Kerbleski M, Kirtikar R, Lew M, Lombardo J, Lopez M, Luna M, Marquez C, Munter S, Ngo L, Pineda-Ramirez J, Prather A, Rhoads K, Rodriguez A, Romero J, Ryder D, So M, Somsouk M, Tai V, Tran B, Uy J, Valdivieso D, Verma D, Williams M, Zamora A, Newman L, Abella J, Barnette Q, Bevc C, Beverly J, Ceger P, Croxford J, Cunningham E, Enger M, Fain K, Farris T, Hanlon S, Hines D, Johnson-Lawrence V, Jordan K, Lefebvre C, Linas B, Luukinen B, Mandal M, McKoy N, Nance S, Oakland A, Pasquarelli D, Quiner C, Sembajwe R, Shaw G, Thornburg V, Tosco K, Wright H, Gross R, Hochman J, Horwitz L, Katz S, Troxel A, Adler L, Akinbo P, Almenana R, Bello O, Bhuiyan S, Blachman N, Branski R, Briscoe J, Brosnahan S, Bueler E, Burgos Y, Caplin N, Chaplin D, Chen Y, Cheng S, Choe P, Choi J, Chung A, Church R, Cobos S, Croft N, Cruz Irving A, Del Boccio P, Díaz I, Doshi V, Dreyer B, Ebel S, Faustin A, Febres E, Fine J, Fink S, Frontera J, Gallagher R, Gonzalez-Duarte A, Hasson D, Hill S, Islam S, Johnson S, Kansal N, Kenney R, Kewlani D, Lamendola-Essel M, Laynor G, Leon T, Lewczak Z, Linton J, Logan M, Malik N, Mamistvalova L, Mandel H, Maranga G, Mathews P, Mattoo A, Mei T, Mendelsohn A, Mercier E, Millar Vernetti P, Miller M, Mitchell M, Moreira A, Mudumbi P, Nahin E, Nair N, Nekulak J, Owens K, Parent B, Patibandla N, Petrov P, Postelnicu R, Randall I, Rao P, Rapkiewicz A, Rizzo J, Rosas J, Rose C, Saint-Jean C, Santacatterina M, Shah B, Shaukat A, Simon N, Simsir A, Stinson M, Tang W, Tatapudi V, Thawani S, Thomas M, Thorpe L, Tom M, Treiha E, Truong J, Udosen M, Velazquez-Perez J, Vernetti P, Vidal C, Viswanathan A, Wong C, Wood M, Wuller S, Yin S, Young C, Zaretsky J, Zavlunova S, Foulkes A, Karlson E, Murphy S, Ahirwar S, Ahmed S, Ainsworth L, Atchley-Challenner R, Avilach P, Balan T, Benik N, Benoit B, Bind M, Bonaventura W, Boutin N, Brion B, Cagan A, Cai T, Cao T, Castro V, Cerretani X, Chan J, Cheng D, Chibnik L, Ciriello M, Costenbader K, Dimitrov D, Estiri H, Fayad M, Feldman C, Gainer V, Ghosh B, Gollub R, Guan Z, Harris A, Helmer K, Hendrix A, Holzbach A, Huang W, Kaufman D, Keogh D, Kerr J, Klann J, Krishnamoorthy A, Lasky-Su J, Liao K, MacFadden D, Maram A, Martel M, Mendis M, Metta R, Monteiro J, Morales E, Morse R, Nazaire M, Neils G, Nguyen A, Norman J, Paik H, Pant D, Park H, Rabideau D, Reeder H, Rossi-Roh K, Santacroce L, Schlepphorst K, Schulte C, Selvaggi C, Shinnick D, Simons W, Simpson L, St. Jean Flanders M, Strasser Z, Thakrar M, Thaweethai T, Thorn M, Trewett P, Van Fleet D, Wagholikar K, Wang T, Wattanasin N, Weber G, Williams M, Zhang R, Cerda M, Clash V, Taylor B, Zissis M, Akintonwa T, Blancero F, Brown H, Carmilani M, Copeland D, Hall Y, kondo K, Lerma L, Lindsay J, Marti H, Maughan C, Minor T, Vincent H, Burns J, Spudich S, Bailey C, Cicek M, Cortez M, Foulkes A, Goff D, Lasky-Su J, Metz T, Ofotokun I, Stockwell M, Stone J, Taylor B, Utz P, Williams N, Anderson B, Bardhan S, Castro-Baucom L, Chisolm D, Corchado C, Dehority W, Dinwiddie G, Goldman Rosas L, Thomas G, Lopez K, MacDonald Pinkett S, Regino L, Valencia C, Vangeepuram N, Walden A, Burton P, Catallozzi M, Dworetzky B, Edwards B, Ferrer R, Freeland C, Laury S, Pearson G, Rothman R, Wagner L, Wallace A, Aragon L, Bander B, Bishof K, Carignan E, Castro Baucom L, Clash V, Coombs K, Corchado C, Davis H, Diggs M, Dunn M, Fisher L, Fitzgerald M, Gage Witvliet M, Gustafson T, Holmes V, Hornig M, Hornig M, Jain N, Lam J, Letts R, Lewis J, Martinez T, McCorkell L, McGrath R, Nguyen K, Nichols L, O'Brien L, Peddie A, Perlowski A, Phillips-Lorenzo E, Prentiss L, Raytselis N, Rockwell M, Rutter J, Seibert E, Sekar A, Taylor E, Wilensky R, Williams M, Williams N, Williams-Dawson K, Wylam A. Sex Differences in Long COVID. JAMA Network Open 2025, 8: e2455430. PMID: 39841477, PMCID: PMC11755195, DOI: 10.1001/jamanetworkopen.2024.55430.Peer-Reviewed Original ResearchConceptsRisk of long COVIDRisk ratioFemale sexSocial determinants of healthCohort studyManagement of long COVIDLong COVIDDeterminants of healthFemale participantsSymptom-based questionnaireEstimate risk ratiosProspective cohort studyAssociated with higher riskStates plus WashingtonNational Institutes of Health (NIHSocial determinantsSelf-reported sexEvaluate sex differencesMain OutcomesPost-COVID conditionsNonpregnant participantsRisk differenceMale participantsMenopausal statusCOVID risk
2024
The effect of a Veterans Affairs rapid rehousing and homelessness prevention program on long‐term housing instability
Chapman A, Scharfstein D, Byrne T, Montgomery A, Suo Y, Effiong A, Shorter C, Huebler S, Greene T, Tsai J, Gelberg L, Kertesz S, Nelson R. The effect of a Veterans Affairs rapid rehousing and homelessness prevention program on long‐term housing instability. Health Services Research 2024, 60: e14428. PMID: 39739599, PMCID: PMC12052498, DOI: 10.1111/1475-6773.14428.Peer-Reviewed Original ResearchSupportive Services for Veteran FamiliesElectronic health recordsHousing instabilityPrevention programsVA Corporate Data WarehouseStructured data elementsTarget trial emulation frameworkHousing outcomesCorporate Data WarehouseHomeless-experienced individualsRisk of housing instabilityHomelessness prevention programImprove housing outcomesHealth recordsVeteran familiesHousing statusRisk differenceEligibility criteriaUnique patientsVisit timeVeteransData elementsProgram designAnalyzed dataEligibilityRacial and Ethnic Discrimination and Medical Students’ Identity Formation
Venkataraman S, Nguyen M, Chaudhry S, Desai M, Hajduk A, Mason H, Webber A, Boatright D. Racial and Ethnic Discrimination and Medical Students’ Identity Formation. JAMA Network Open 2024, 7: e2439727. PMID: 39412803, PMCID: PMC11581615, DOI: 10.1001/jamanetworkopen.2024.39727.Peer-Reviewed Original ResearchConceptsBlack studentsWhite studentsCross-sectional studyMedical schoolsProfessional developmentMedical studentsMedical educationStudent identity formationHolistic student developmentIdentity formationUS medical studentsProfessional identity formationEthnic discriminationEthnic groupsRetrospective cross-sectional studyStudent developmentInclusive environmentMain OutcomesStudentsSchoolDeidentified dataRisk differenceLikert scaleEducationCombat discriminationIncorporating Individual‐Level Treatment Effects and Outcome Preferences Into Personalized Blood Pressure Target Recommendations
Ascher S, Kravitz R, Scherzer R, Berry J, de Lemos J, Estrella M, Tancredi D, Killeen A, Ix J, Shlipak M. Incorporating Individual‐Level Treatment Effects and Outcome Preferences Into Personalized Blood Pressure Target Recommendations. Journal Of The American Heart Association 2024, 13: e033995. PMID: 39136305, PMCID: PMC11963924, DOI: 10.1161/jaha.124.033995.Peer-Reviewed Original ResearchNet benefitsSPRINT participantsIndividual-level treatment effectsPositive net benefitsBlood pressureIndividual treatment effectsTargeted recommendationsTreatment effectsSimulated preferencesRisk of adverse eventsAdverse eventsCognitive impairmentPreference weightsRisk differenceDecision-making frameworkAE riskPatient riskSprintSimulation benefitsParticipantsPredicted riskHigh riskCox modelBP loweringRiskBrief Report: Protease Inhibitors Versus Nonnucleoside Reverse Transcriptase Inhibitors and the Risk of Cancer Among People With HIV
Coburn S, Pimentel N, Leyden W, Kitahata M, Moore R, Althoff K, Gill M, Lang R, Horberg M, D'Souza G, Hussain S, Dubrow R, Novak R, Rabkin C, Park L, Sterling T, Neugebauer R, Silverberg M, AIDS F. Brief Report: Protease Inhibitors Versus Nonnucleoside Reverse Transcriptase Inhibitors and the Risk of Cancer Among People With HIV. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2024, 96: 393-398. PMID: 39720558, PMCID: PMC11665951, DOI: 10.1097/qai.0000000000003436.Peer-Reviewed Original ResearchNon-AIDS-defining cancersAIDS-defining cancersCancer riskAntiretroviral therapyAntiretroviral therapy classNorth American AIDS Cohort CollaborationCompare cancer riskCancer risk differencesLoss to follow-upInfection-related cancersFollow-upMarginal structural modelsIncident cancerIndividual cancer typesAntiretroviral therapy initiationLonger-term follow-upDuration of follow-upCohort CollaborationCohort studyHazard ratioRisk differenceMonths follow-upPP trialINSTI-based ARTPWHLongitudinal Patterns of Systolic Blood Pressure, Diastolic Blood Pressure, Cardiorespiratory Fitness, and Their Association With Dementia Risk: The HUNT Study
Lerfald M, Allore H, Nilsen T, Eldholm R, Martinez-Velilla N, Selbæk G, Ernstsen L. Longitudinal Patterns of Systolic Blood Pressure, Diastolic Blood Pressure, Cardiorespiratory Fitness, and Their Association With Dementia Risk: The HUNT Study. The Journals Of Gerontology Series A 2024, 79: glae161. PMID: 38894618, PMCID: PMC11266981, DOI: 10.1093/gerona/glae161.Peer-Reviewed Original ResearchEstimated cardiorespiratory fitnessCardiorespiratory fitnessDementia riskHUNT StudyRisk differenceAssociated with reduced dementia riskPopulation-based HUNT StudyAssociated with dementia riskOdds ratioPoor cardiorespiratory fitnessHigher cardiorespiratory fitnessRisk of dementiaEstimate odds ratiosRisk factorsModifiable risk factorsAge groupsAPOE e4 statusProspective cohort studyBlood pressureMultivariate logistic regressionHigh blood pressureMiddle-aged groupLongitudinal patternsE4 statusSystolic blood pressureAntipsychotic drugs in first-episode psychosis: a target trial emulation in the FEP-CAUSAL Collaboration
Szmulewicz A, Martínez-Alés G, Logan R, Ferrara M, Kelly C, Fredrikson D, Gago J, Conderino S, Díaz-Caneja C, Galvañ J, Thorpe L, Srihari V, Yatham L, Sarpal D, Shinn A, Arango C, Öngür D, Hernán M, Collaboration O. Antipsychotic drugs in first-episode psychosis: a target trial emulation in the FEP-CAUSAL Collaboration. American Journal Of Epidemiology 2024, 193: 1081-1087. PMID: 38576166, DOI: 10.1093/aje/kwae029.Peer-Reviewed Original ResearchFirst-episode psychosisFirst-generation agentsAntipsychotic therapyAntipsychotic drugsPsychosis onsetPsychotic disordersEpisode psychosisAripiprazolePaliperidoneRisk of hospitalizationPsychosisTarget trialsRisperidoneOlanzapineFirst-line therapyTreatment discontinuationEUFESTObservational cohortAntipsychoticsQuetiapineRandomized trialsPrimary outcomeAbsolute riskRisk differenceClinical questions
2023
Stroke reduction by cerebral embolic protection devices in transcatheter aortic valve implantation: a systematic review and Bayesian meta-analysis
Heuts S, Gabrio A, Veenstra L, Maesen B, Kats S, Maessen J, Walton A, Nanayakkara S, Lansky A, van 't Hof A, Vriesendorp P. Stroke reduction by cerebral embolic protection devices in transcatheter aortic valve implantation: a systematic review and Bayesian meta-analysis. Heart 2023, 110: 757-765. PMID: 37996242, DOI: 10.1136/heartjnl-2023-323359.Peer-Reviewed Original ResearchTranscatheter aortic valve implantationCerebral embolic protectionAbsolute risk differenceAortic valve implantationRelative riskTAVI patientsValve implantationSystematic reviewCerebral embolic protection devicesMedian relative riskEmbolic protection devicesMultiple sensitivity analysesEmbolic protectionPrimary outcomeFuture trialsStandard treatmentStroke reductionBaseline riskRisk differenceElectronic databasesExpert consensusNew-generation devicesSecondary analysisStrokeRelevant reductionAssociations between weekly gestational exposure of fine particulate matter, ozone, and nitrogen dioxide and preterm birth in a North Carolina Birth Cohort, 2003–2015
Krajewski A, Luben T, Warren J, Rappazzo K. Associations between weekly gestational exposure of fine particulate matter, ozone, and nitrogen dioxide and preterm birth in a North Carolina Birth Cohort, 2003–2015. Environmental Epidemiology 2023, 7: e278. PMID: 38912391, PMCID: PMC11189686, DOI: 10.1097/ee9.0000000000000278.Peer-Reviewed Original ResearchPreterm birthGestational exposureWeeks of pregnancyRisk of PTBInterquartile range increasePM 2.5 exposurePoisson regression modelsGestational weeksPotential confoundersFine particulate matterAssociation magnitudeRisk differenceNull associationBirth cohortExposure windowsResidential addressesMultipollutant modelsBirthWeeksPositive associationAssociationExposurePM 2.5Regression modelsCensus tractsIntegrase strand-transfer inhibitor use and cardiovascular events in adults with HIV: an emulation of target trials in the HIV-CAUSAL Collaboration and the Antiretroviral Therapy Cohort Collaboration
Rein S, Lodi S, Logan R, Touloumi G, Antoniadou A, Wittkop L, Bonnet F, van Sighem A, van der Valk M, Reiss P, Klein M, Young J, Jarrin I, Monforte A, Tavelli A, Meyer L, Tran L, Gill M, Lang R, Surial B, Haas A, Justice A, Rentsch C, Phillips A, Sabin C, Miro J, Trickey A, Ingle S, Sterne J, Hernán M, Collaboration A. Integrase strand-transfer inhibitor use and cardiovascular events in adults with HIV: an emulation of target trials in the HIV-CAUSAL Collaboration and the Antiretroviral Therapy Cohort Collaboration. The Lancet HIV 2023, 10: e723-e732. PMID: 37923486, PMCID: PMC10695103, DOI: 10.1016/s2352-3018(23)00233-3.Peer-Reviewed Original ResearchConceptsART-experienced individualsCardiovascular eventsTarget trialsART regimensRisk ratioTreatment strategiesRisk differenceEligibility criteriaIntegrase strand transfer inhibitor useAntiretroviral Therapy Cohort CollaborationIntegrase strand transfer inhibitorsPooled logistic modelART-naive individualsHIV RNA measurementsHIV-CAUSAL CollaborationNational InstituteStrand transfer inhibitorsLogistic regression modelsART regimenCohort CollaborationAntiretroviral therapyInhibitor useBlood pressureINSTI useClinical dataClinical phenotypes and outcomes in children with multisystem inflammatory syndrome across SARS-CoV-2 variant eras: a multinational study from the 4CE consortium
Sperotto F, Gutiérrez-Sacristán A, Makwana S, Li X, Rofeberg V, Cai T, Bourgeois F, Omenn G, Hanauer D, Sáez C, Bonzel C, Bucholz E, Dionne A, Elias M, García-Barrio N, González T, Issitt R, Kernan K, Laird-Gion J, Maidlow S, Mandl K, Ahooyi T, Moraleda C, Morris M, Moshal K, Pedrera-Jiménez M, Shah M, South A, Spiridou A, Taylor D, Verdy G, Visweswaran S, Wang X, Xia Z, Zachariasse J, EHR T, Aaron J, Adam A, Agapito G, Albayrak A, Albi G, Alessiani M, Alloni A, Amendola D, Angoulvant F, Anthony L, Aronow B, Ashraf F, Atz A, Avillach P, Panickan V, Azevedo P, Badenes R, Balshi J, Batugo A, Beaulieu-Jones B, Beaulieu-Jones B, Bell D, Bellasi A, Bellazzi R, Benoit V, Beraghi M, Bernal-Sobrino J, Bernaux M, Bey R, Bhatnagar S, Blanco-Martínez A, Boeker M, Bonzel C, Booth J, Bosari S, Bourgeois F, Bradford R, Brat G, Bréant S, Brown N, Bruno R, Bryant W, Bucalo M, Bucholz E, Burgun A, Cai T, Cannataro M, Carmona A, Cattelan A, Caucheteux C, Champ J, Chen J, Chen K, Chiovato L, Chiudinelli L, Cho K, Cimino J, Colicchio T, Cormont S, Cossin S, Craig J, Cruz-Bermúdez J, Cruz-Rojo J, Dagliati A, Daniar M, Daniel C, Das P, Devkota B, Dionne A, Duan R, Dubiel J, DuVall S, Esteve L, Estiri H, Fan S, Follett R, Ganslandt T, García-Barrio N, Garmire L, Gehlenborg N, Getzen E, Geva A, Goh R, González T, Gradinger T, Gramfort A, Griffier R, Griffon N, Grisel O, Gutiérrez-Sacristán A, Guzzi P, Han L, Hanauer D, Haverkamp C, Hazard D, He B, Henderson D, Hilka M, Ho Y, Holmes J, Honerlaw J, Hong C, Huling K, Hutch M, Issitt R, Jannot A, Jouhet V, Kainth M, Kate K, Kavuluru R, Keller M, Kennedy C, Kernan K, Key D, Kirchoff K, Klann J, Kohane I, Krantz I, Kraska D, Krishnamurthy A, L'Yi S, Leblanc J, Lemaitre G, Lenert L, Leprovost D, Liu M, Loh N, Long Q, Lozano-Zahonero S, Luo Y, Lynch K, Mahmood S, Maidlow S, Makoudjou A, Makwana S, Malovini A, Mandl K, Mao C, Maram A, Maripuri M, Martel P, Martins M, Marwaha J, Masino A, Mazzitelli M, Mazzotti D, Mensch A, Milano M, Minicucci M, Moal B, Ahooyi T, Moore J, Moraleda C, Morris J, Morris M, Moshal K, Mousavi S, Mowery D, Murad D, Murphy S, Naughton T, Neto C, Neuraz A, Newburger J, Ngiam K, Njoroge W, Norman J, Obeid J, Okoshi M, Olson K, Omenn G, Orlova N, Ostasiewski B, Palmer N, Paris N, Patel L, Pedrera-Jiménez M, Pfaff A, Pfaff E, Pillion D, Pizzimenti S, Priya T, Prokosch H, Prudente R, Prunotto A, Quirós-González V, Ramoni R, Raskin M, Rieg S, Roig-Domínguez G, Rojo P, Romero-Garcia N, Rubio-Mayo P, Sacchi P, Sáez C, Salamanca E, Samayamuthu M, Sanchez-Pinto L, Sandrin A, Santhanam N, Santos J, Vidorreta F, Savino M, Schriver E, Schubert P, Schuettler J, Scudeller L, Sebire N, Serrano-Balazote P, Serre P, Serret-Larmande A, Shah M, Abad Z, Silvio D, Sliz P, Son J, Sonday C, South A, Sperotto F, Spiridou A, Strasser Z, Tan A, Tan B, Tan B, Tanni S, Taylor D, Terriza-Torres A, Tibollo V, Tippmann P, Toh E, Torti C, Trecarichi E, Vallejos A, Varoquaux G, Vella M, Verdy G, Vie J, Visweswaran S, Vitacca M, Wagholikar K, Waitman L, Wang X, Wassermann D, Weber G, Wolkewitz M, Wong S, Xia Z, Xiong X, Ye Y, Yehya N, Yuan W, Zachariasse J, Zahner J, Zambelli A, Zhang H, Zöller D, Zuccaro V, Zucco C, Newburger J, Avillach P. Clinical phenotypes and outcomes in children with multisystem inflammatory syndrome across SARS-CoV-2 variant eras: a multinational study from the 4CE consortium. EClinicalMedicine 2023, 64: 102212. PMID: 37745025, PMCID: PMC10511777, DOI: 10.1016/j.eclinm.2023.102212.Peer-Reviewed Original ResearchSystemic inflammatory response syndromeSARS-CoV-2 eraMultisystem inflammatory syndromeLower lymphocyte countsLower troponinInflammatory syndromeLymphocyte countRisk differenceClinical phenotypeLower C-reactive proteinSARS-CoV-2 infectionPooled risk differenceInflammatory response syndromeLength of hospitalizationObservational retrospective studyC-reactive proteinElectronic health record dataSARS-CoV-2 variantsOutcomes of MISHealth record dataEffect sizeAnticoagulation therapyClinical characteristicsRespiratory symptomsRare complication
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply