2025
Canadian Association of Gastroenterology Clinical Practice Guideline for the Endoscopic Management of Nonvariceal Nonpeptic Ulcer Upper Gastrointestinal Bleeding
Barkun A, Laine L, Leontiadis G, Gralnek I, Carman N, Ibrahim M, Sey M, Alali A, Carroll M, Hookey L, Borgaonkar M, Armstrong D, Lau J, Forbes N, Pittayanon R, Tse F. Canadian Association of Gastroenterology Clinical Practice Guideline for the Endoscopic Management of Nonvariceal Nonpeptic Ulcer Upper Gastrointestinal Bleeding. Gastroenterology 2025 PMID: 40778886, DOI: 10.1053/j.gastro.2025.04.041.Peer-Reviewed Original ResearchGrading of recommendations assessmentCanadian AssociationRecommendations AssessmentGastric antral vascular ectasiaMallory-Weiss tearEndoscopic band ligationAntral vascular ectasiaEvidence-to-decision frameworkAmerican Society for Gastrointestinal EndoscopyWorld Endoscopy OrganizationEuropean Society of Gastrointestinal EndoscopyGuideline-development processClinical practice guidelinesEndoscopic hemostatic therapyEvidence-based guidelinesAmerican Gastroenterological AssociationBand ligationVascular ectasiaEndoscopic managementDieulafoy's lesionMalignant tumorsThrough-the-scope clipsHemostatic therapyActive bleedingGuideline panelREVISITING INHALED NITRIC OXIDE UTILIZATION IN CONGENITAL DIAPHRAGMATIC HERNIA: A NATIONAL COHORT STUDY OF MAJOR CHILDREN’S HOSPITALS IN THE UNITED STATES
Sescleifer A, Chidiac C, Hellmann Z, McDermott K, Garcia A, Rhee D, Slidell M, Solomon D, Kunisaki S. REVISITING INHALED NITRIC OXIDE UTILIZATION IN CONGENITAL DIAPHRAGMATIC HERNIA: A NATIONAL COHORT STUDY OF MAJOR CHILDREN’S HOSPITALS IN THE UNITED STATES. Journal Of Pediatric Surgery 2025, 162423. PMID: 40562092, DOI: 10.1016/j.jpedsurg.2025.162423.Peer-Reviewed Original ResearchCongenital diaphragmatic herniaExtracorporeal membrane oxygenationCongenital diaphragmatic hernia neonatesMechanical ventilation durationLength of stayINO useVentilation durationEfficacy of inhaled nitric oxideCDH outcomesCongenital diaphragmatic hernia infantsPediatric Health Information System databaseEfficacy of iNOChildren's HospitalHealth Information System databaseHospital chargesHospital length of stayIn-Hospital MortalityIncreased hospital chargesLonger length of stayEvidence-based guidelinesNational cohort studyPulmonary hypertensionCannulation rateProspective trialsDiaphragmatic herniaDevelopment of Evidence-based Guidelines on Assessment and Management of Internal Contamination with Transuranic Actinides
Li C, Kenbayeva Z, Dainiak N, Yepes-Nuñez J, Zeeb H, Gill S, Akashi M, Alves A, Chang A, DiCarlo A, Iddins C, Kazzi Z, Klumpp J, Osamu K, Lopez M, Phan G, Port M, Riddell A, Salame-Alfie A, Sawant P, Tatsuzaki H, Vassilenko V. Development of Evidence-based Guidelines on Assessment and Management of Internal Contamination with Transuranic Actinides. Disaster Medicine And Public Health Preparedness 2025, 19: e156. PMID: 40538032, DOI: 10.1017/dmp.2025.10091.Peer-Reviewed Original ResearchConceptsGuideline development groupDevelopment of evidence-based guidelinesEvidence-based guidelinesEvidence-based recommendationsWorld Health OrganizationPatient-important health outcomesCare management guidelinesHealth outcomesWorking group meetingsWorld Health Organization protocolSystematic reviewGroup meetingsClinical managementHealth OrganizationContextual factorsManagement guidelinesDevelopment groupQuestion formulationGuidelinesRecommendationsCertainty ratingsResearch question formulationOutcomesEmergency respondersAssessmentResponse to: “Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (fifth edition)” by Kopp et al
Kopp S, Vandermeulen E, McBane R, Perlas A, Leffert L, Horlocker T. Response to: “Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (fifth edition)” by Kopp et al. Regional Anesthesia & Pain Medicine 2025, rapm-2025-106881. PMID: 40484652, DOI: 10.1136/rapm-2025-106881.Peer-Reviewed Original ResearchSystematic review and meta-analysis of efficacy of helmet use and helmet laws to reduce mortality and cervical spine injury in adult motorcycle riders: A practice management guideline from the Eastern Association for the Surgery of Trauma.
Ratnasekera A, Seng S, Gardiner S, Butler C, Goldenberg-Sandau A, Lu N, Abdel Aziz H, Appelbaum R, Mashbari H, Hafiz S, Chowdhury S, Soe-Lin H, Reynolds J, Teichman A, Kartiko S, Kaufman E, Murphy P, Kodadek L, Rattan R. Systematic review and meta-analysis of efficacy of helmet use and helmet laws to reduce mortality and cervical spine injury in adult motorcycle riders: A practice management guideline from the Eastern Association for the Surgery of Trauma. Journal Of Trauma And Acute Care Surgery 2025 PMID: 40462278, DOI: 10.1097/ta.0000000000004607.Peer-Reviewed Original ResearchCervical spine injuryIncidence of cervical spine injuriesSpine injuriesInjury-related mortalityDischarge dispositionSystematic reviewHelmet useMeta-analysisSignificant methodological heterogeneityPICO 1PICO-2Eastern Association for the Surgery of TraumaEvidence-based guidelinesRisk of biasCertainty of evidenceSignificant public health concernImproved discharge dispositionEvidence-based recommendationsRiders wear helmetsHelmet lawsImprove mortalityEvidence-based systematic reviewMotorcycle ridersPublic health concernPractice management guidelinesInvestigating practice patterns in bone marrow biopsies for cutaneous T-cell lymphoma: A multicenter clinician survey.
Rashid S, Kim E, Slavinsky V, Sun Y, Pierog O, Gru A, Foss F, Rozati S. Investigating practice patterns in bone marrow biopsies for cutaneous T-cell lymphoma: A multicenter clinician survey. Journal Of Clinical Oncology 2025, 43 DOI: 10.1200/jco.2025.43.16_suppl.e19075.Peer-Reviewed Original ResearchCutaneous T-cell lymphomaBone marrow biopsyT-cell lymphomaMarrow biopsyManagement of cutaneous T-cell lymphomaPrognosis of cutaneous T-cell lymphomaBone marrow biopsy findingsPractice patternsAdvanced disease stageFisher's exact testUnexplained hematologic abnormalitiesInvestigate practice patternsEvidence-based guidelinesPET-CTStaging purposesExtracutaneous involvementPrognostic implicationsT cellsHematologic abnormalitiesSystem involvementAltered managementDifferential diagnosisExact testDisease stagePatient managementAmerican Society of Hematology/International Society on Thrombosis and Haemostasis 2024 updated guidelines for treatment of venous thromboembolism in pediatric patients
Monagle P, Azzam M, Bercovitz R, Betensky M, Bhat R, Biss T, Branchford B, Brandão L, Chan A, Faustino E, Jaffray J, Jones S, Kawtharany H, Kerlin B, Kucine N, Kumar R, Male C, Pelland-Marcotte M, Raffini L, Raulji C, Sartain S, Takemoto C, Tarango C, van Ommen C, Velez M, Vesely S, Wiernikowski J, Williams S, Wilson H, Woods G, Zia A, Mustafa R. American Society of Hematology/International Society on Thrombosis and Haemostasis 2024 updated guidelines for treatment of venous thromboembolism in pediatric patients. Blood Advances 2025, 9: 2587-2636. PMID: 40423983, DOI: 10.1182/bloodadvances.2024015328.Peer-Reviewed Original ResearchConceptsPediatric venous thromboembolismGRADE Evidence-to-Decision frameworksEvidence-to-decision frameworkMultidisciplinary guideline panelHealth care professionalsGuideline development processAmerican Society of HematologyUniversity of Kansas Health SystemVenous thromboembolismEvidence-based guidelinesCare professionalsPatient representativesHealth systemPediatric patientsGuideline panelTreatment of pediatric venous thromboembolismManagement of pediatric patientsPediatric guidelinesTreatment of venous thromboembolismTreatment trialsInternational Society on ThrombosisAmerican SocietyGuidelinesImplementation guidancePotential biasACR Appropriateness Criteria® Acute Respiratory Illness in Immunocompetent Patients: 2024 Update
Imaging P, Batra K, Walker C, Little B, Bang T, Bartel T, Brixey A, Christensen J, Cox C, Hanak M, Khurana S, Madan R, Merchant N, Moore W, Pandya S, Sanchez L, Shroff G, Zagurovskaya M, Chung J. ACR Appropriateness Criteria® Acute Respiratory Illness in Immunocompetent Patients: 2024 Update. Journal Of The American College Of Radiology 2025, 22: s14-s35. PMID: 40409874, DOI: 10.1016/j.jacr.2025.02.014.Peer-Reviewed Original ResearchConceptsAcute respiratory illnessRespiratory illnessManagement of acute respiratory illnessesAmerican College of Radiology Appropriateness CriteriaRAND/UCLA Appropriateness Method User ManualSelf-limiting viral infectionEvidence-based guidelinesEstablished methodology principlesImmunocompetent adult patientsChronic obstructive pulmonary disease exacerbationsAppropriateness of imagingPublic health issuePeer-reviewed journalsFollow-up imagingMultidisciplinary expert panelSuspected pneumonia casesPeer-reviewed literatureGuideline developmentRecommendations AssessmentImmunocompetent patientsOccult malignancyHealth issuesExpert panelAdult patientsAppropriateness CriteriaHow Cannabis Use is Associated with the Physical and Mental Health of Older Adults: A US Population-Based Study
You E, Sarkar S, Pietrzak R, Monin J, Poghosyan H. How Cannabis Use is Associated with the Physical and Mental Health of Older Adults: A US Population-Based Study. International Journal Of Mental Health And Addiction 2025, 1-22. DOI: 10.1007/s11469-025-01475-5.Peer-Reviewed Original ResearchCannabis useMental healthDaily cannabis usersPhysical healthDays of poor physical healthBehavioral Risk Factor Surveillance SystemRisk Factor Surveillance SystemIncreased oddsUS population-based studyAssociated with poor healthPhysical and Mental HealthPoor physical healthLack health insurance coverageMultivariate multinomial logistic regression analysisCannabis usersPopulation-based studyEvidence-based guidelinesMultinomial logistic regression analysisHealth insurance coverageLogistic regression analysisPoor healthOlder adultsCannabisInsurance coveragePromote awarenessAirway Safety During Mechanical Ventilation: Survey of ICU Clinicians Practices and Perceptions
Tanios M, Stocking J, Charchaflieh J, Miller A, Patel J, Vilella A, Nguyen H, Epstein S, Beltran A, Devlin J. Airway Safety During Mechanical Ventilation: Survey of ICU Clinicians Practices and Perceptions. Critical Care Explorations 2025, 7: e1234. PMID: 40126919, PMCID: PMC11936560, DOI: 10.1097/cce.0000000000001234.Peer-Reviewed Original ResearchConceptsUnplanned extubationAdult ICUsSociety of Critical Care MedicineEvidence-based guidelinesCritical care medicineAirway management practicesPressure injuriesSurvey of membersClinician practiceManagement beliefsSafety practicesCare medicineICU settingRisk factorsManagement practicesPediatric ICUResponsibility assignmentICUSurveyRespondentsPracticeEffects of Sweeteners and Cinnamon Flavor on Oral Nicotine Choice Behaviors
Bagdas D, Sedaille J, Khan M, Okpala N, Addy N. Effects of Sweeteners and Cinnamon Flavor on Oral Nicotine Choice Behaviors. Nicotine & Tobacco Research 2025, ntaf037. PMID: 40097606, DOI: 10.1093/ntr/ntaf037.Peer-Reviewed Original ResearchOral nicotine productsNicotine preferenceFemale adult Sprague-Dawley ratsBitter solutionsAdult Sprague-Dawley ratsNicotine delivery methodsChoice behaviorSprague-Dawley ratsDose-response analysisEvidence-based guidelinesTested nicotineNicotine solutionInfluence addictionSweet solutionsPresence of sweetenersBehavioral studiesNicotineSaccharinNicotine productsHarm reduction strategiesCombination of cinnamaldehydeRatsDifferential preferenceDelivery methodsMaleStandardization of Bone Marrow Reporting for Myelodysplastic Syndromes/Neoplasms on Behalf of the International Consortium for Myelodysplastic Syndromes/Neoplasms.
Gisriel S, Aakash F, Bennett J, Hasserjian R, Loghavi S, DeZern A, Santini V, Savona M, Brunner A, Buckstein R, Wei A, Della Porta M, Komrokji R, Borate U, Sekeres M, Platzbecker U, Fenaux P, Roboz G, van de Loosdrecht A, Zeidan A, Xu M. Standardization of Bone Marrow Reporting for Myelodysplastic Syndromes/Neoplasms on Behalf of the International Consortium for Myelodysplastic Syndromes/Neoplasms. Archives Of Pathology & Laboratory Medicine 2025 PMID: 40059041, DOI: 10.5858/arpa.2024-0322-ra.Peer-Reviewed Original ResearchData extractionHealth care professionalsEvidence-based guidelinesBone marrowCare professionalsClinical decision-makingReporting guidelinesEfficient data extractionStandard bone marrowBone marrow specimensBone marrow reportsMarrow specimensInstitutional databaseClinical hematologistsHematologists-oncologistsClinical trialsGuidelinesHematopathologistsDecision-makingMarrowCollege of American Pathologists PathologyBoneHealthRegistryProfessionalsDiagnosis, screening, and follow-up of patients with familial interstitial lung disease: Results from an international survey
Moen E, Prior T, Kreuter M, Wuyts W, Molina-Molina M, Wijsenbeek M, Morais A, Tzouvelekis A, Ryerson C, Caro F, Buendia-Roldan I, Magnusson J, Lee J, Morisett J, Oldham J, Troy L, Funke-Chambour M, Alberti M, Borie R, Walsh S, Rajan S, Kondoh Y, Khor Y, Bendstrup E. Diagnosis, screening, and follow-up of patients with familial interstitial lung disease: Results from an international survey. BMC Pulmonary Medicine 2025, 25: 59. PMID: 39901224, PMCID: PMC11792556, DOI: 10.1186/s12890-025-03532-0.Peer-Reviewed Original ResearchConceptsGenetic testing methodsMultidisciplinary teamGenetic testingFamily historyInterstitial lung diseaseHistory of interstitial lung diseaseRecommended genetic testingScreening of first-degree relativesFamilial interstitial lung diseaseEvidence-based guidelinesGenetic screening of relativesScreening of relativesFirst-degree relativesCharacteristics of respondentsInternational surveyPathogenic genetic variantsScreening toolLung transplantationInsufficient evidenceLung diseaseConsensus statementGenetic variantsFollow-up of patientsStandard programRespondentsRegional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (fifth edition)
Kopp S, Vandermeulen E, McBane R, Perlas A, Leffert L, Horlocker T. Regional anesthesia in the patient receiving antithrombotic or thrombolytic therapy: American Society of Regional Anesthesia and Pain Medicine Evidence-Based Guidelines (fifth edition). Regional Anesthesia & Pain Medicine 2025, rapm-2024-105766. PMID: 39880411, DOI: 10.1136/rapm-2024-105766.Peer-Reviewed Original ResearchAmerican Society of Regional AnesthesiaDeep venous thrombosisEvidence-based guidelinesRegional anesthesiaThrombolytic therapyComplications associated with regional anesthesiaRecurrent deep venous thrombosisAmerican SocietyRandomized Controlled TrialsAnticoagulant doseNeural blockadeVenous thrombosisCase seriesCatastrophic complicationPatient characteristicsClinical trialsHigh dosesPatientsPublished guidelinesControlled TrialsPainAnesthesiaPatient safetyTherapyDose
2024
Phenylalanine hydroxylase deficiency diagnosis and management: A 2023 evidence-based clinical guideline of the American College of Medical Genetics and Genomics (ACMG)
Smith W, Berry S, Bloom K, Brown C, Burton B, Demarest O, Jenkins G, Malinowski J, McBride K, Mroczkowski H, Scharfe C, Vockley J, Board of Directors A. Phenylalanine hydroxylase deficiency diagnosis and management: A 2023 evidence-based clinical guideline of the American College of Medical Genetics and Genomics (ACMG). Genetics In Medicine 2024, 27: 101289. PMID: 39630157, DOI: 10.1016/j.gim.2024.101289.Peer-Reviewed Original ResearchAmerican College of Medical Genetics and GenomicsRecent American College of Medical GeneticsPractice guidelinesEvidence-based clinical guidelinesEvidence-to-decision frameworkAmerican College of Medical GeneticsClinical practice guidelinesEvidence-based guidelinesPrevent pregnancy complicationsPhenylalanine hydroxylasePhenylalanine hydroxylase deficiencyIntellectual outcomeEvidence summaryStandard of careRecommendations AssessmentGuideline workgroupClinical guidelinesPregnancy complicationsSystematic reviewGenetic testingMedical GeneticsAmerican CollegeConfirm diagnosisPractice recommendationsPAH variantsBarriers to Recruitment and Retention Among Underrepresented Populations in Cancer Clinical Trials: A Qualitative Study of the Perspectives of Clinical Trial Research Coordinating Staff at a Cancer Center
Yousafi S, Rangachari P, Holland M. Barriers to Recruitment and Retention Among Underrepresented Populations in Cancer Clinical Trials: A Qualitative Study of the Perspectives of Clinical Trial Research Coordinating Staff at a Cancer Center. Journal Of Healthcare Leadership 2024, 16: 427-441. PMID: 39502080, PMCID: PMC11537200, DOI: 10.2147/jhl.s488426.Peer-Reviewed Original ResearchCancer clinical trialsCancer CenterCoordination staffProvision of high-quality healthcareHigh-quality healthcareNon-patient-facing staffAcademic cancer centerEvidence-based guidelinesSemi-structured interviewsLearning CollaborativeStaff shortagesLack of resourcesStaff interviewsExamined barriersGeneralizability of findingsThematic analysisQualitative studyParticipant diversityCharacteristics of clinical trialsClinical trialsInadequate systemsStaffParticipation incentivesEquitable representationInterview dataClinical Implementation of fMRI and EEG to Detect Cognitive Motor Dissociation
Bodien Y, Fecchio M, Freeman H, Sanders W, Meydan A, Lawrence P, Kirsch J, Fischer D, Cohen J, Rubin E, He J, Schaefer P, Hochberg L, Rapalino O, Cash S, Young M, Edlow B. Clinical Implementation of fMRI and EEG to Detect Cognitive Motor Dissociation. Neurology Clinical Practice 2024, 15: e200390. PMID: 39473967, PMCID: PMC11515113, DOI: 10.1212/cpj.0000000000200390.Peer-Reviewed Original ResearchCognitive motor dissociationTask-based functional MRIMotor dissociationLanguage functionEvidence-based guidelinesBehavioral evidenceFunctional MRIEEG assessmentClinical careBrain injuryEvidence baseClinical assessmentPatient selectionClinical implementationPatientsReports lessonsEEGFMRIUnited StatesEffective strategyAssessmentEthical implicationsCareBrainManagement of Patients with Advanced Prostate Cancer. Report from the 2024 Advanced Prostate Cancer Consensus Conference (APCCC)
Gillessen S, Turco F, Davis I, Efstathiou J, Fizazi K, James N, Shore N, Small E, Smith M, Sweeney C, Tombal B, Zilli T, Agarwal N, Antonarakis E, Aparicio A, Armstrong A, Bastos D, Attard G, Axcrona K, Ayadi M, Beltran H, Bjartell A, Blanchard P, Bourlon M, Briganti A, Bulbul M, Buttigliero C, Caffo O, Castellano D, Castro E, Cheng H, Chi K, Clarke C, Clarke N, de Bono J, De Santis M, Duran I, Efstathiou E, Ekeke O, El Nahas T, Emmett L, Fanti S, Fatiregun O, Feng F, Fong P, Fonteyne V, Fossati N, George D, Gleave M, Gravis G, Halabi S, Heinrich D, Herrmann K, Hofman M, Hope T, Horvath L, Hussain M, Jereczek-Fossa B, Jones R, Joshua A, Kanesvaran R, Keizman D, Khauli R, Kramer G, Loeb S, Mahal B, Maluf F, Mateo J, Matheson D, Matikainen M, McDermott R, McKay R, Mehra N, Merseburger A, Morgans A, Morris M, Mrabti H, Mukherji D, Murphy D, Murthy V, Mutambirwa S, Nguyen P, Oh W, Ost P, O'Sullivan J, Padhani A, Parker C, Poon D, Pritchard C, Rabah D, Rathkopf D, Reiter R, Renard-Penna R, Ryan C, Saad F, Sade J, Sandhu S, Sartor O, Schaeffer E, Scher H, Sharifi N, Skoneczna I, Soule H, Spratt D, Srinivas S, Sternberg C, Suzuki H, Taplin M, Thellenberg-Karlsson C, Tilki D, Türkeri L, Uemura H, Ürün Y, Vale C, Vapiwala N, Walz J, Yamoah K, Ye D, Yu E, Zapatero A, Omlin A. Management of Patients with Advanced Prostate Cancer. Report from the 2024 Advanced Prostate Cancer Consensus Conference (APCCC). European Urology 2024, 87: 157-216. PMID: 39394013, DOI: 10.1016/j.eururo.2024.09.017.Peer-Reviewed Original ResearchConceptsAdvanced Prostate Cancer Consensus ConferenceProstate Cancer Consensus ConferenceAdvanced prostate cancerProstate cancerClinical managementLack high-level evidenceConsensus conferenceManagement of patientsHigh-level evidenceEvidence-based guidelinesModified Delphi processCancer characteristicsClinical evidenceClinical trialsImpact daily practiceTreatment decisionsWeb-based surveyConsensus questionsPC expertsPatientsMeta-analysisCancerDelphi processDaily practicePanel membersPeri-Arthroscopic Management of Immunosuppressive Medications in Patients with Rheumatic Disease A Survey of Practice Trends Among Rheumatologists and Sports Medicine Orthopedic Surgeons.
Vasavada K, Jazrawi L, Samuels J. Peri-Arthroscopic Management of Immunosuppressive Medications in Patients with Rheumatic Disease A Survey of Practice Trends Among Rheumatologists and Sports Medicine Orthopedic Surgeons. Bulletin Of The NYU Hospital For Joint Disease 2024, 82: 186-193. PMID: 39150872.Peer-Reviewed Original ResearchConceptsJanus kinase inhibitorsRheumatic disease patientsHigh-risk surgeryAnterior cruciate ligamentRisk surgeryOrthopedic surgeonsDisease patientsRisk of disease flarePreferred patientsRisk of postoperative infectionJanus kinaseDose of rituximabUse of immunosuppressantsManagement of immunosuppressionFellowship-trained orthopedic surgeonsManagement of immunosuppressive medicationsSynthetic diseasemodifying antirheumatic drugsSports medicine surgeonsSports medicine orthopedic surgeonsAnti-rheumatic medicationsEvidence-based guidelinesImmunosuppressive medicationsPostoperative infectionDisease flareAntirheumatic drugsReduction in Unindicated Cervical Cancer Screening in Adolescents in a Large Health Care System
Geng B, Oliveira C, Hosier H, Sheth S, Vash-Margita A. Reduction in Unindicated Cervical Cancer Screening in Adolescents in a Large Health Care System. Journal Of Lower Genital Tract Disease 2024, 28: 345-350. PMID: 39037856, DOI: 10.1097/lgt.0000000000000831.Peer-Reviewed Original ResearchBest practice advisoryCervical cancer screeningElectronic medical recordsHealth care systemCancer screeningPap testCare systemLarger health care systemPre/post intervention studyEvidence-based guidelinesProvider notificationPostinterventionPractice advisoryIntervention studiesPreinterventionFisher's exact testHuman papillomavirus test resultsLogistic regressionRetrospective chart reviewReproductive healthMedical recordsHuman papillomavirus testingPatient characteristicsChart reviewKruskal-Wallis test
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply