2025
Stereotactic Anterior Cingulotomy in a Patient With a Sacral Giant Cell Tumor
Ostas A, Prsic E. Stereotactic Anterior Cingulotomy in a Patient With a Sacral Giant Cell Tumor. Journal Of Pain And Symptom Management 2025, 69: e656. DOI: 10.1016/j.jpainsymman.2025.02.346.Peer-Reviewed Original ResearchAmerican Society of Pain and NeuroscienceRefractory cancer painAnterior cingulotomyCancer painCancer-related painGiant cell tumorAnterior cingulate cortexIntractable painCell tumorsPain reliefInterventional therapyManagement of cancer-associated painNeurosurgical interventionMedically refractory cancer painSacral giant cell tumorTreatment of chronic intractable painTreatment of cancer-related painEmotional processing of painEpidural steroid injectionsIntractable cancer painTumor-related complicationsChronic intractable painAdequate pain reliefCancer-associated painProcessing of painPsychedelics for Cancer Pain and Associated Psychological Distress: A Narrative Review of a Potential Strategy
Belitzky E, Carvalho L, Taylor M, Ortiz C, Baum L, Fiellin D, Lustberg M. Psychedelics for Cancer Pain and Associated Psychological Distress: A Narrative Review of a Potential Strategy. Cancer Medicine 2025, 14: e70586. PMID: 40052631, PMCID: PMC11886891, DOI: 10.1002/cam4.70586.Peer-Reviewed Original ResearchConceptsManagement of cancer painPsychological distressCancer painSymptom burdenUndertreatment of cancer painLevels of psychological distressFear of recurrenceSymptoms of cancerAssociated symptom burdenImprove pain managementMitigate psychological distressQuality of life challengesCancer-related painMitigate painAssociated psychological distressTreatment of cancer painNon-pharmacological approachesDiagnosis of cancerEfficacy of psychedelicsFear of deathLevel of evidenceCurrent level of evidenceBehavioral counselingCancer populationPain management
2024
AGREE II Evaluation of Clinical Practice Guidelines on Generalized Cancer Pain Management
Rizvi F, Rizvi A, Chorath K, Suresh N, Ng J, Harris J, Lakshmipathy D, Xavier-Barrette L, Rajasekaran K. AGREE II Evaluation of Clinical Practice Guidelines on Generalized Cancer Pain Management. Pain Management Nursing 2024, 26: 163-170. PMID: 39419671, DOI: 10.1016/j.pmn.2024.09.006.Peer-Reviewed Original ResearchClinical practice guidelinesIntraclass correlation coefficientImprove quality of carePractice guidelinesDomains of clarity of presentationCancer painEvaluation of clinical practice guidelinesQuality of careCancer pain managementAGREE II evaluationAppraisal of GuidelinesRigor of developmentMeasuring quality outcomesAGREE II instrumentAGREE II appraisalPreferred Reporting ItemsClarity of presentationLow qualityStakeholder involvementSystematic literature searchClinical decision-makingEditorial independenceReporting ItemsInterrater reliabilityQuality outcomesSafe and Effective Treatment of Refractory Cancer Pain with Chronic Oral Ketamine: A Case Series
Kozhevnikov D, Kareem L, Bui T. Safe and Effective Treatment of Refractory Cancer Pain with Chronic Oral Ketamine: A Case Series. Palliative Medicine Reports 2024, 5: 475-480. DOI: 10.1089/pmr.2024.0049.Peer-Reviewed Original ResearchRefractory cancer painOral ketamineCancer painPain scoresCase seriesTreatment of refractory cancer painTreating refractory cancer painEfficacy of long-term treatmentImproved pain scoresRoutine follow-up visitsNumerical rating scaleCancer-related painFollow-up visitLong-term treatmentOff-label useAdult cancer painKetamine treatmentChronic painChronic treatmentPainEffective treatmentPalliative carePatientsGrowing body of evidenceClinical experienceOpioid prescribing trends and pain scores among adult patients with cancer in a large health system.
Baum L, Soulos P, KC M, Jeffery M, Ruddy K, Lerro C, Lee H, Graham D, Liberatore M, Rivera D, Leapman M, Jairam V, Dinan M, Gross C, Park H. Opioid prescribing trends and pain scores among adult patients with cancer in a large health system. Journal Of Clinical Oncology 2024, 42: 11059-11059. DOI: 10.1200/jco.2024.42.16_suppl.11059.Peer-Reviewed Original ResearchDocumented painHealth systemOpioid prescribingOpioid prescriptionsOpioid prescribing trendsYale New Haven Health SystemPrescribing trendsMetastatic cancerDocumented pain scoresUS health systemOpioid usePain scoresAdult patientsCalculated predicted probabilitiesFlowsheet dataRetrospective cohort studyRelated harmSolid tumor malignanciesCohort studyCancer painPrescribingContext of cancer treatmentStudy criteriaPainSurgery cohortIdentifying provider, patient and practice factors that shape long-term opioid prescribing for cancer pain: a qualitative study of American and Australian providers
Fereydooni S, Lorenz K, Azarfar A, Luckett T, Phillips J, Becker W, Giannitrapani K. Identifying provider, patient and practice factors that shape long-term opioid prescribing for cancer pain: a qualitative study of American and Australian providers. BMJ Open 2024, 14: e082033. PMID: 38514141, PMCID: PMC10961503, DOI: 10.1136/bmjopen-2023-082033.Peer-Reviewed Original ResearchConceptsPractice-related factorsLong-term opioid prescribingPrescribed long-term opioid therapyQualitative studyOpioid prescribingQuality of careProvider-related factorsLong-term prescribingPatient’s social contextLong-term opioid therapyAlternative pain therapiesCancer-related painConcurrent qualitative studyDisadvantaged patientsHealthcare interventionsExacerbate disparitiesIdentified providersAustralian providersOpioid practicesSocioeconomic statusSecondary analysisPrescribed opioidsCancer painProvidersPrescribing
2023
Strong opioids-induced cardiac, neurologic, and respiratory disorders: a real-world study from 2004 to 2023 based on FAERS
Dai M, Dou X, Chen M, Yang J, Long J, Lin Y. Strong opioids-induced cardiac, neurologic, and respiratory disorders: a real-world study from 2004 to 2023 based on FAERS. Naunyn-Schmiedeberg's Archives Of Pharmacology 2023, 397: 4105-4121. PMID: 38032491, DOI: 10.1007/s00210-023-02844-4.Peer-Reviewed Original ResearchAcute adverse drug reactionsEmpirical Bayesian geometric meanAdverse eventsSystem organ classReporting odds ratioProportional reporting ratioAdverse Event Reporting System databaseFDA Adverse Event Reporting System (FAERS) databaseSevere cancer painAdverse drug reactionsNervous system disordersReal-world studyUS FDA Adverse Event Reporting System (FAERS) databaseReporting System databasePostoperative analgesiaCancer painRespiratory depressionChronic painToxic leukoencephalopathyGeneral anesthesiaMediastinal diseaseDrug reactionsMediastinal disordersOdds ratioRespiratory disordersT65. GENES IN POSTMORTEM BRAIN TISSUE DIFFERENTIALLY EXPRESSED IN CHRONIC PAIN
Collier L, Seah C, Kozik E, Group T, Girgenti M, Huckins L, Johnston K. T65. GENES IN POSTMORTEM BRAIN TISSUE DIFFERENTIALLY EXPRESSED IN CHRONIC PAIN. European Neuropsychopharmacology 2023, 75: s196-s197. DOI: 10.1016/j.euroneuro.2023.08.350.Peer-Reviewed Original ResearchChronic painBackground Chronic painBone cancer painPain-related conditionsVEGF BFalse discovery rate correctionCancer painEndometrial cancerRheumatoid arthritisBrain gene expression datasetsGene expressionPainPsychiatric conditionsLinear regression modelsMultiple testingSpecific cell typesGene expression analysisCell typesRate correctionRegression modelsSurrogate variablesDifferential gene expression analysisDACCMeasured variablesExpression
2022
Is central anticholinergic syndrome linked to opioid use for cervical cancer pain?
Choi A, Bui T, Y. Pan E, Ozcan M. Is central anticholinergic syndrome linked to opioid use for cervical cancer pain? Anaesthesia Pain & Intensive Care 2022, 26: 831-835. DOI: 10.35975/apic.v26i6.2068.Peer-Reviewed Original ResearchCentral anticholinergic syndromeMorphine equivalent doseCancer-related painAnticholinergic syndromeMagnetic resonance imagingOpioid antagonistOpioid useCancer painNeurological symptomsAnticholinergic medicationsWorld Health OrganizationEmergency departmentExposure to anticholinergic medicationsPeripheral neurological symptomsMRI magnetic resonance imagingWHO - World Health OrganizationOpioid exposureAnticholinergic toxicityCase reportPain managementOpioidPersistent symptomsPainIncomplete responseEquivalent doseExpert Panel Consensus on Management of Advanced Cancer-related Pain in Individuals with Opioid Use Disorder
Merlin J, Khodyakov D, Arnold R, Bulls H, Dao E, Kapo J, King C, Meier D, Paice J, Ritchie C, Liebschutz J. Expert Panel Consensus on Management of Advanced Cancer-related Pain in Individuals with Opioid Use Disorder. Journal Of Pain 2022, 23: 60. DOI: 10.1016/j.jpain.2022.03.226.Peer-Reviewed Original ResearchBuprenorphine/naloxoneFull agonist opioidsUncertain appropriatenessAdvanced cancerPalliative careCancer pain management strategiesCancer-related painAdvanced cancer painPain management strategiesOpioid use disorderExpert panel consensusConsensus-based guidanceCancer painDay dosingBuprenorphine/Optimal dosingMethadone clinicsUse disordersPatientsNaloxonePanel consensusPrognosisMethadoneHealth FoundationPainA Descriptive Survey Study of Patient Needs and Preferences for Cancer Pain Self-Management Support.
Anderson A, Starkweather A, Cong X, Xu W, Judge M, Schulman-Green D, Zhang Y, Salner A, Dornelas E. A Descriptive Survey Study of Patient Needs and Preferences for Cancer Pain Self-Management Support. Oncology Nursing Forum 2022, 49: 46-57. PMID: 34914676, DOI: 10.1188/22.onf.46-57.Peer-Reviewed Original ResearchConceptsSelf-management supportPain intensityCancer carePatient needsPredictors of pain intensityVARIABLES">ACross-sectional survey studyBrief Pain Inventory-Short FormDescriptive survey studyAverage pain intensityCare transitionsCancer ScaleHome settingPain outcomesCancer painDichotomous questionsCareCancer CenterSurvey studyPainHospitalHomeOptimal outcomesParticipantsNeeds
2021
Expert Panel Consensus on Management of Advanced Cancer–Related Pain in Individuals With Opioid Use Disorder
Merlin JS, Khodyakov D, Arnold R, Bulls HW, Dao E, Kapo J, King C, Meier D, Paice J, Ritchie C, Liebschutz JM. Expert Panel Consensus on Management of Advanced Cancer–Related Pain in Individuals With Opioid Use Disorder. JAMA Network Open 2021, 4: e2139968. PMID: 34962565, DOI: 10.1001/jamanetworkopen.2021.39968.Peer-Reviewed Original ResearchConceptsOpioid use disorderFull agonist opioidsAdvanced cancerUncertain appropriatenessCancer painPalliative careUse disordersCancer pain managementAppropriateness of managementExpert panel consensusConsensus-based guidanceImportant comorbidityOpioid medicationsPain managementMethadone clinicsPainPatientsPanel consensusPrognosisCancerMethadoneDelphi processExpert panelMonthsOpioidsSelf-Efficacy Survey Study of Pain Self-Management in Patients with Cancer
Anderson A, Starkweather A, Cong X, Kim K, Schulman-Green D, Judge M, Xu W, Zhang Y. Self-Efficacy Survey Study of Pain Self-Management in Patients with Cancer. Pain Management Nursing 2021, 23: 486-493. PMID: 34794885, DOI: 10.1016/j.pmn.2021.10.002.Peer-Reviewed Original ResearchConceptsPain self-efficacyCancer pain severitySelf-EfficacyPain severitySelf-management supportPain Self-ManagementImprove pain outcomesProportion of patientsEnhance self-efficacyCross-sectional surveyPain severity levelsPerceptions of self-efficacyQuality of lifeTreatment related characteristicsPain prevalenceCancer outpatientsSelf-ManagementPain outcomesPain managementUnmet needsLower satisfactionCancer diagnosisCancer painCorrelation statistical analysisPainCross Disciplinary Role Agreement is Needed When Coordinating Long‐Term Opioid Prescribing for Cancer: a Qualitative Study
Giannitrapani K, Silveira M, Azarfar A, Glassman P, Singer S, Asch S, Midboe A, Zenoni M, Gamboa R, Becker W, Lorenz K. Cross Disciplinary Role Agreement is Needed When Coordinating Long‐Term Opioid Prescribing for Cancer: a Qualitative Study. Journal Of General Internal Medicine 2021, 36: 1867-1874. PMID: 33948790, PMCID: PMC8298631, DOI: 10.1007/s11606-021-06747-z.Peer-Reviewed Original ResearchConceptsPrimary care providersCancer pain managementOpioid pain managementPain managementCancer painCare providersChronic cancer-related painLong-term opioid prescribingCommunity-based outpatient clinicsLarge integrated healthcare systemCancer-related painVA Medical CenterIntegrated healthcare systemResearch team consensusOpioid prescribingOncology providersMultiple prescribersOutpatient clinicPrimary careCare coordinationMedical CenterInterdisciplinary providersPainInterdisciplinary cliniciansProvider experienceExploring Cancer Pain Self-Management Needs and Preferences: A Meta-Ethnography
Anderson A, Starkweather A, Cong X, Kyounghae K, Judge M, Schulman-Green D. Exploring Cancer Pain Self-Management Needs and Preferences: A Meta-Ethnography. Qualitative Health Research 2021, 31: 1609-1621. PMID: 33834931, DOI: 10.1177/1049732321998975.Peer-Reviewed Original ResearchConceptsSelf-management support needsCancer painMeta-SynthesisSelf-management of cancer painSupport needsSelf-management of chronic diseasesSelf-management supportManagement of cancer painSelf-management knowledgeSelf-management needsHealth care practitionersQualitative research articlesMeta-ethnographyCare practitionersChronic diseasesContextual factorsDay-to-day basisPainNeedsIncreased understandingCancerNoblitPatientsResearch articlesHealthHow Patients and Providers Weigh the Risks and Benefits of Long-Term Opioid Therapy for Cancer Pain
Giannitrapani KF, Fereydooni S, Silveira MJ, Azarfar A, Glassman PA, Midboe A, Zenoni M, Becker WC, Lorenz KA. How Patients and Providers Weigh the Risks and Benefits of Long-Term Opioid Therapy for Cancer Pain. JCO Oncology Practice 2021, 17: e1038-e1047. PMID: 33534632, DOI: 10.1200/op.20.00679.Peer-Reviewed Original ResearchConceptsLong-term opioid therapyOpioid therapyCancer painPain managementPatient decision‐making factorsAdequate pain managementOpioid usePatient characteristicsOpioid analgesicsVeteran patientsPatient goalsPrimary carePatient concernsInterdisciplinary providersPatientsPainThematic qualitative methodsProvider experienceTranscribed interview dataPractice settingsSubstance abuseCancer treatmentProvider decisionsOpioidsTherapy
2016
Minding the Gaps in Cancer Pain Management Education: A Multicenter Study of Clinical Residents and Fellows in a Low- Versus High-Resource Setting
Odonkor CA, Osei-Bonsu E, Tetteh O, Haig A, Mayer RS, Smith TJ. Minding the Gaps in Cancer Pain Management Education: A Multicenter Study of Clinical Residents and Fellows in a Low- Versus High-Resource Setting. Journal Of Global Oncology 2016, 2: 387-396. PMID: 28717725, PMCID: PMC5493248, DOI: 10.1200/jgo.2015.003004.Peer-Reviewed Original ResearchPain management educationHigh-resource countriesLow-resource countriesCancer pain managementPalliative care interventionsInterventional pain proceduresPain management trainingMajor academic medical centerHigh-resource settingsAcademic medical centerPain trainingCancer painPostoperative painPain managementMulticenter studyPain proceduresCancer careCare interventionsMedical CenterResponse rateMajor causeFellowship trainingPhysiciansMedical school trainingClinical residents
2015
A Pilot Study of a Mobile Health Pain Coping Skills Training Protocol for Patients With Persistent Cancer Pain
Somers TJ, Abernethy AP, Edmond SN, Kelleher SA, Wren AA, Samsa GP, Keefe FJ. A Pilot Study of a Mobile Health Pain Coping Skills Training Protocol for Patients With Persistent Cancer Pain. Journal Of Pain And Symptom Management 2015, 50: 553-558. PMID: 26025279, PMCID: PMC4592787, DOI: 10.1016/j.jpainsymman.2015.04.013.Peer-Reviewed Original ResearchConceptsPhysical symptomsPain managementPhysical functioningPsychological distressPersistent cancer painMHealth technologiesPost-treatment decreaseDiagnosis of breastMeasures of painPost-intervention changesSkills training protocolMobile health technologyFour-session interventionSignificant preinterventionCancer painPersistent painColorectal cancerCancer patientsPatient satisfactionPostintervention differencesPainPatientsSkills training interventionsPilot studyAcceptable option
2014
Focal Injection of Incobotulinum Toxin A Improves Refractory Local Cancer Pain at the Site of Radiation/Surgery (P3.315)
Rostami R, Machado D, Richardson D, Jabbari B. Focal Injection of Incobotulinum Toxin A Improves Refractory Local Cancer Pain at the Site of Radiation/Surgery (P3.315). Neurology 2014, 82 DOI: 10.1212/wnl.82.10_supplement.p3.315.Peer-Reviewed Original Research
2013
Relationship of sipuleucel-T with time to first use of opioid analgesics (TFOA) in patients (pts) with asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC) on the IMPACT trial.
Small E, Higano C, Kantoff P, Whitmore J, Frohlich M, Petrylak D. Relationship of sipuleucel-T with time to first use of opioid analgesics (TFOA) in patients (pts) with asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC) on the IMPACT trial. Journal Of Clinical Oncology 2013, 31: 74-74. DOI: 10.1200/jco.2013.31.6_suppl.74.Peer-Reviewed Original ResearchMetastatic castration-resistant prostate cancerSymptomatic metastatic castration-resistant prostate cancerCase report formsProtocol amendmentMedical reviewIMPACT trialCastration-resistant prostate cancerPrespecified secondary end pointsEnd pointECOG performance status 1Autologous cellular immunotherapyAverage pain scoreOpioid analgesic usePlacebo-treated patientsSecondary end pointsIndependent baseline predictorsPerformance status 1Objective disease progressionVisual analog scaleCox regression modelKaplan-Meier estimatesAsymptomatic ptsPrimary radiotherapyAnalgesic useCancer pain
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