2025
Care Models to Improve Pain and Reduce Opioids Among Patients Prescribed Long-Term Opioid Therapy
Krebs E, Becker W, Nelson D, DeRonne B, Jensen A, Kats A, Morasco B, Frank J, Makris U, Allen K, Naylor J, Mixon A, Bohnert A, Reznik T, Painter J, Hudson T, Hagedorn H, Manuel J, Borsari B, Purcell N, Hammett P, Amundson E, Kerns R, Barbosa M, Garvey C, Jones E, Noh M, Okere J, Bhushan S, Pinsonnault J, Williams B, Herbst E, Lagisetty P, Librodo S, Mapara P, Son E, Tat C, Marraffa R, Seys R, Baxley C, Seal K, Abelleira A, Adams M, Anicich A, Ankawi B, Arnold S, Aryal A, Atkins D, Atkinson T, Backe K, Bair M, Bajpai S, Baller K, Bangerter A, Barnett S, Bartlett S, Bartnik M, Baskin J, Blehm R, Bloechl P, Boening N, Boesch N, Bolander S, Bolf M, Bonchak J, Booth K, Bordanea M, Borowa D, Bowden M, Britnell S, Broderick D, Bronars C, Brooks K, Brown C, Brudvik E, Buchanan K, Buesgens C, Buonora M, Burch R, Burton C, Butler C, Byerly S, Byrd C, Byrd G, Campbell E, Cariveau D, Carmody S, Carr M, Carr T, Cervone D, Chandler M, Clarke K, Clay M, Coy W, Craine M, Culver D, Cutting A, Dadabayev A, Daly D, Degerstrom R, Denietolis A, DePesa N, Desmet P, Devlin A, Dike D, Diokpa C, Dogra M, Drexler K, Drum-Oden A, Duvall T, Eads F, Edmond S, Eichelsdoerfer E, Ellifritz C, Ellison J, Erwin K, Escobedo C, Feighner L, Feuchs A, Fike A, Finetti T, Franchina L, Freeman J, Frontera R, Galvan R, Gayle S, Givens C, Glenn R, Godwin K, Goldstein M, Gosselin K, Graham S, Grimm K, Gumidyala A, Hagerman C, Hale A, Hall L, Harden J, Hawkins J, Hepton S, Herynk A, Heuermann B, Hidalgo N, Hoffmann J, Holland-deguire C, Hope K, Horowitz D, Huang A, Huffman K, Hunt N, Hyde S, Jacobson K, Johnson E, Kaiser B, Kauzlarich K, Kavathekar R, Knutson R, Kross T, LaHaie E, Lahidji S, Le G, Lelovic M, Lewis M, Linden E, Lindsay D, Lively-Brindley L, Lorenzo J, Luciani L, Lusk C, Mahal-Lichty J, Maloy P, Marcolivio K, Marcy B, Marek L, Mason B, McCamish N, McKissack M, Miller E, Moon J, Morris H, Mundt J, Nazario M, Nelson A, Nichols A, Njau E, Nolan C, Nolan P, Nugent S, Oakley J, Ofstad H, Olney R, Olson J, Ortolan V, Osborne J, Osler B, Packard-Milam M, Palyo S, Patel A, Wiener C, Peter D, Philippe M, Reddy S, Reed J, Rettmann N, Rezaei D, Roberti A, Robinson V, Roca H, Romano E, Rosema T, Rouse R, Rozzero P, Rutks I, Sabet R, Sacra E, Sadowski N, Salameh H, Sandbrink F, Sauve C, Schopmeyer K, Schroeder A, Sculley M, Sellinger J, Sewell K, Shah Barman M, Sharpe P, Sides T, Silver K, Siver M, Sloan J, Smith C, Stevens S, Stoll J, Stoll S, Stoner T, Strand M, Sumner J, Surginer B, Svabek K, Swanson G, Tappainer C, Taylor B, Theis A, Thomas L, Thomas G, Tiene K, Udouj R, Ugbo E, Varughese S, Venkatraman S, Viera K, Walker J, Walker J, Wang G, Watson K, Watson E, Westmoreland W, Wilbur E, Wolfman A, Woloszyn M, Zanga J, Zuniga S. Care Models to Improve Pain and Reduce Opioids Among Patients Prescribed Long-Term Opioid Therapy. JAMA Internal Medicine 2025, 185: 208-220. PMID: 39652356, PMCID: PMC11791716, DOI: 10.1001/jamainternmed.2024.6683.Peer-Reviewed Original ResearchIntegrated Pain TeamLong-term opioid therapyPatients prescribed long-term opioid therapyVeterans Affairs primary care clinicsOpioid therapyPrescribed long-term opioid therapyRandomized comparative effectiveness trialPharmacist care managementCollaborative care interventionPain care planPrimary care clinicsPoor quality of lifeMental health cliniciansOpioid dosageComparative effectiveness trialPain responseDaily dosageModerate to severe chronic painQuality of lifePain careCare modelCare planningCare interventionsCare clinicsOpioid dose reduction
2024
Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals
Korem N, Hillmer A, D’Souza D, Nia A, Levy I, Pietrzak R, Harpaz-Rotem I. Amygdala Cannabinoid 1 Receptor, Pain Response, and Emotional Numbing in Trauma-Exposed Individuals. JAMA Network Open 2024, 7: e2432387. PMID: 39250156, PMCID: PMC11385051, DOI: 10.1001/jamanetworkopen.2024.32387.Peer-Reviewed Original ResearchAssessing pain in persons with opioid use disorder: Approaches, techniques and special considerations
Nunes J, Costa G, Weleff J, Rogan M, Compton P, De Aquino J. Assessing pain in persons with opioid use disorder: Approaches, techniques and special considerations. British Journal Of Clinical Pharmacology 2024, 90: 2985-3002. PMID: 38556851, DOI: 10.1111/bcp.16055.Peer-Reviewed Original ResearchOpioid use disorderAssess painPain assessmentPain experienceConcomitant chronic painChronic opioid therapyQuantitative sensory testingVisual analogue scalePain assessment methodsPain assessment toolsComplex psychosocial backgroundImprove pain assessmentOpioid therapyOpioid usePain responseChronic painAnalogue scaleTraditional self-report methodsPainRisk factorsUse disorderOpioidNarrative reviewSelf-report methodsMultidisciplinary team
2023
A Randomized Trial Of Pain Care Delivery Models For Patients On Long-Term Opioids In VA Primary Care
Krebs E, Becker W, Nelson D, Kats A, Hammett P, Deronne B, Nugent S, Jensen A, Seal K. A Randomized Trial Of Pain Care Delivery Models For Patients On Long-Term Opioids In VA Primary Care. Journal Of Pain 2023, 24: 58. DOI: 10.1016/j.jpain.2023.02.175.Peer-Reviewed Original ResearchIntegrated Pain TeamLong-term opioidsBrief Pain InventoryDose reductionPain responsePatients prescribed long-term opioidsCare management interventionCare delivery modelsVA primary careInterdisciplinary team interventionsBrief Pain Inventory scoresOpioid daily dosePain response ratesModerate-severe painReducing opioid useRandomized to 1Pain carePrimary carePain teamTeam interventionPragmatic trialImprove painMultimodal therapyChronic painOpioid use
2022
Emotional numbing in PTSD is associated with lower amygdala reactivity to pain
Korem N, Duek O, Ben-Zion Z, Kaczkurkin AN, Lissek S, Orederu T, Schiller D, Harpaz-Rotem I, Levy I. Emotional numbing in PTSD is associated with lower amygdala reactivity to pain. Neuropsychopharmacology 2022, 47: 1913-1921. PMID: 35945274, PMCID: PMC9485255, DOI: 10.1038/s41386-022-01405-2.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAmygdala reactivityLower amygdala reactivityHigher pain responseLower amygdala activationAltered pain perceptionAmygdala activationProcessing of painAmygdala responseEmotional numbingPain correlateMild painPain processingPain thresholdPain responsePain perceptionPainControl groupPTSD groupStress disorderRobust reductionAmygdala activityCombat controlsAmygdalaEmotional numbing symptoms
2019
Rat NaV1.7 loss-of-function genetic model: Deficient nociceptive and neuropathic pain behavior with retained olfactory function and intra-epidermal nerve fibers
Grubinska B, Chen L, Alsaloum M, Rampal N, Matson D, Yang C, Taborn K, Zhang M, Youngblood B, Liu D, Galbreath E, Allred S, Lepherd M, Ferrando R, Kornecook T, Lehto S, Waxman S, Moyer B, Dib-Hajj S, Gingras J. Rat NaV1.7 loss-of-function genetic model: Deficient nociceptive and neuropathic pain behavior with retained olfactory function and intra-epidermal nerve fibers. Molecular Pain 2019, 15: 1744806919881846. PMID: 31550995, PMCID: PMC6831982, DOI: 10.1177/1744806919881846.Peer-Reviewed Original ResearchConceptsOlfactory functionNav1.7 proteinPain behaviorPain responseRat modelSmall-diameter dorsal root ganglion neuronsNormal intraepidermal nerve fibre densityIntraepidermal nerve fiber densityIntra-epidermal nerve fibersDorsal root ganglion neuronsNeuropathic pain behaviorsNeuropathic pain responsesSpinal nerve ligationNerve fiber densityDorsal root gangliaAction potential firingPeripheral nervous systemEarly postnatal developmentGenetic animal modelsNav1.7 lossNerve ligationPain targetsNeuropathic conditionsGanglion neuronsRoot ganglia
2018
Stereotactic Radiosurgery for Trigeminal Neuralgia in Patients With Multiple Sclerosis: A Multicenter Study.
Xu Z, Mathieu D, Heroux F, Abbassy M, Barnett G, Mohammadi AM, Kano H, Caruso J, Shih HH, Grills IS, Lee K, Krishnan S, Kaufmann AM, Lee JYK, Alonso-Basanta M, Kerr M, Pierce J, Kondziolka D, Hess JA, Gerrard J, Chiang V, Lunsford LD, Sheehan JP. Stereotactic Radiosurgery for Trigeminal Neuralgia in Patients With Multiple Sclerosis: A Multicenter Study. Neurosurgery 2018, 84: 499-505. PMID: 29688562, DOI: 10.1093/neuros/nyy142.Peer-Reviewed Original ResearchConceptsRecurrence-free rateTrigeminal neuralgiaStereotactic radiosurgeryPain responsePain controlMultiple sclerosisMS-related trigeminal neuralgiaFavorable initial responseReasonable pain controlRetrospective cohort studyMedian latency periodLarge patient seriesGamma Knife CenterFacial pain responsesFacial numbnessCohort studyClinical outcomesMedical managementPatient seriesMulticenter studySurgical interventionPatientsLatency periodRisk profileInitial response
2017
Altered Functional Connectivity in Sickle Cell Disease Exists at Rest and During Acute Pain Challenge
Zempsky W, Stevens M, Santanelli J, Gaynor A, Khadka S. Altered Functional Connectivity in Sickle Cell Disease Exists at Rest and During Acute Pain Challenge. The Clinical Journal Of Pain 2017, 33: 1060-1070. PMID: 28272117, DOI: 10.1097/ajp.0000000000000492.Peer-Reviewed Original ResearchConceptsSickle cell diseaseChronic pain disordersPain challengePain disordersCell diseaseSomatosensory networkBrain regionsAltered functional connectivityFunctional connectivity abnormalitiesSubcortical brain regionsLower functional integrationDefault mode networkCentral sensitizationRed blood cellsNociceptive informationPain sensitizationChronic painPain responseParietal lobe regionsPressure algometerPainful stimuliNeurodevelopmental abnormalitiesSCD controlsConnectivity abnormalitiesSalience networkStereotactic body radiotherapy for de novo spinal metastases: systematic review.
Husain ZA, Sahgal A, De Salles A, Funaro M, Glover J, Hayashi M, Hiraoka M, Levivier M, Ma L, Martínez-Alvarez R, Paddick JI, Régis J, Slotman BJ, Ryu S. Stereotactic body radiotherapy for de novo spinal metastases: systematic review. Journal Of Neurosurgery Spine 2017, 27: 295-302. PMID: 28598293, DOI: 10.3171/2017.1.spine16684.Peer-Reviewed Original ResearchConceptsStereotactic body radiation therapyComplete pain responseSpinal metastasesSystematic reviewPain responseComplete pain response ratesPain response ratesUntreated spinal metastasesLocal control rateSerious adverse eventsLocal tumor controlVertebral compression fracturesStereotactic body radiotherapyBody radiation therapySearch of MEDLINEMeta-Analyses (PRISMA) guidelinesDose fractionation schemesPreferred Reporting ItemsFull-text articlesGy/5 fxCommon toxicitiesMedian followAdverse eventsNeurologic injuryBody radiotherapyTransient Receptor Potential Cation Channel Subfamily M Member 8 channels mediate the anti‐inflammatory effects of eucalyptol
Caceres AI, Liu B, Jabba SV, Achanta S, Morris JB, Jordt S. Transient Receptor Potential Cation Channel Subfamily M Member 8 channels mediate the anti‐inflammatory effects of eucalyptol. British Journal Of Pharmacology 2017, 174: 867-879. PMID: 28240768, PMCID: PMC5387001, DOI: 10.1111/bph.13760.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnti-Infective AgentsAnti-Inflammatory AgentsCyclohexanolsDose-Response Relationship, DrugEdemaEucalyptolFemaleHEK293 CellsHumansInflammationInflammation MediatorsMaleMiceMice, Inbred C57BLMice, KnockoutMonoterpenesRandom AllocationTransient Receptor Potential ChannelsTRPM Cation ChannelsConceptsAnti-inflammatory effectsComplete Freund's adjuvantTRPM8 channelsPulmonary inflammationLeukocyte infiltrationNovel anti-inflammatory agentsInflammatory pain responsesSelective TRPM8 agonistsAdministration of LPSAnti-inflammatory propertiesChannel-deficient miceAnti-inflammatory agentsEffect of eucalyptolProduction of TNFTRP cation channelsMechanical allodyniaChemokine levelsTRPM8 agonistMyeloperoxidase activityFootpad inflammationFreund's adjuvantPain responseIL-1βIL-6Inflammatory cytokines
2016
Assessment of pain in adolescents: Influence of gender, smoking status and tobacco abstinence
Bagot KS, Wu R, Cavallo D, Krishnan-Sarin S. Assessment of pain in adolescents: Influence of gender, smoking status and tobacco abstinence. Addictive Behaviors 2016, 67: 79-85. PMID: 28061378, PMCID: PMC5965278, DOI: 10.1016/j.addbeh.2016.12.010.Peer-Reviewed Original ResearchConceptsLower pain toleranceMale smokersFemale nonsmokersPain thresholdFemale smokersPain toleranceCold pressor taskMinimal deprivationAcute smoking abstinenceLower pain thresholdPain-related factorsHigher pain intensityAssessment of painEffect of painPain 15Pain intensitySmoking statusMale nonsmokersPain responseSmoking deprivationSubjective painSmoking abstinenceTobacco abstinenceAdolescent smokersNonsmokersStable, synthetic analogs of diadenosine tetraphosphate inhibit rat and human P2X3 receptors and inflammatory pain
Viatchenko-Karpinski V, Novosolova N, Ishchenko Y, Azhar M, Wright M, Tsintsadze V, Kamal A, Burnashev N, Miller A, Voitenko N, Giniatullin R, Lozovaya N. Stable, synthetic analogs of diadenosine tetraphosphate inhibit rat and human P2X3 receptors and inflammatory pain. Molecular Pain 2016, 12: 1744806916637704. PMID: 27030723, PMCID: PMC4955970, DOI: 10.1177/1744806916637704.Peer-Reviewed Original ResearchConceptsInflammatory painAntinociceptive effectChronic painHigh-affinity desensitizationPeripheral sensory neuronsRat brain cellsWeak partial agonistHuman P2X3 receptorsPotent analgesic agentVivo inflammation modelsDiadenosine tetraphosphateWhole-cell currentsWeak partial agonismThermal hyperalgesiaP2X3 receptorsDorsal rootsPain responseSimilar inhibitory activityAnalgesic agentsBody of evidenceInflammation modelSensory neuronsBrain cellsP2X3RsPain
2015
Early Life Experience and Gut Microbiome
Cong X, Henderson W, Graf J, McGrath J. Early Life Experience and Gut Microbiome. Advances In Neonatal Care 2015, 15: 314-323. PMID: 26240939, PMCID: PMC4583334, DOI: 10.1097/anc.0000000000000191.Peer-Reviewed Original ResearchConceptsGut microbiomeHigh-risk infantsStressful early life experiencesCentral nervous systemSignaling systemPreterm infantsIntestinal innate immunityPain responseBrain-gut-microbiota axisNeonatal careEarly life experiencesNeuroimmune systemMicrobial speciesNervous systemInnate immunityRegulation mechanismInfantsGutMicrobiomeTargeted interventionsRegulationModulating stressPretermState-of-the-science reviewComplex mechanisms
2013
The stress model of chronic pain: evidence from basal cortisol and hippocampal structure and function in humans
Vachon-Presseau E, Roy M, Martel M, Caron E, Marin M, Chen J, Albouy G, Plante I, Sullivan M, Lupien S, Rainville P. The stress model of chronic pain: evidence from basal cortisol and hippocampal structure and function in humans. Brain 2013, 136: 815-827. PMID: 23436504, DOI: 10.1093/brain/aws371.Peer-Reviewed Original ResearchConceptsChronic back painChronic painHippocampal volumeBack painControl subjectsParahippocampal gyrusPain-evoked activityPersistent pain statesAnterior parahippocampal gyrusHealthy control subjectsSmaller hippocampal volumesChronic pain intensityEndocrine stress responsePain statesPain intensityPain responseBasal cortisolPainHippocampal structureCortisol levelsMaladaptive physiological responsesHigher cortisolHippocampal complexConsecutive daysPatientsErgonomic Procedure for Heel Sticks and Shots in Kangaroo Care (Skin-to-Skin) Position
Cong X, Ludington-Hoe S, Vazquez V, Zhang D, Zaffetti S. Ergonomic Procedure for Heel Sticks and Shots in Kangaroo Care (Skin-to-Skin) Position. Neonatal Network The Journal Of Neonatal Nursing 2013, 32: 353-358. PMID: 23985473, DOI: 10.1891/0730-0832.32.5.353.Peer-Reviewed Original Research
2012
Effects of Skin-to-Skin Contact on Autonomic Pain Responses in Preterm Infants
Cong X, Cusson R, Walsh S, Hussain N, Ludington-Hoe S, Zhang D. Effects of Skin-to-Skin Contact on Autonomic Pain Responses in Preterm Infants. Journal Of Pain 2012, 13: 636-645. PMID: 22595172, DOI: 10.1016/j.jpain.2012.02.008.Peer-Reviewed Original ResearchConceptsAutonomic pain responsesIncubator carePreterm infantsHeel stickLow frequency powerHigh frequency powerPain responseSpectral power analysis of heart rate variabilityEffect of skin-to-skin contactNeonatal intensive care unitSkin-to-skin contactLF/HF ratioHeart rateEffective pain interventionIntensive care unitAnalysis of heart rate variabilityKC conditionsBeat-to-beat heart rateRandomized crossover trialSpectral power analysisAffected infantsKangaroo carePretermPain interventionsCrossover trial
2011
Kangaroo Care and Behavioral and Physiologic Pain Responses in Very-Low-Birth-Weight Twins: A Case Study
Cong X, Cusson R, Hussain N, Zhang D, Kelly S. Kangaroo Care and Behavioral and Physiologic Pain Responses in Very-Low-Birth-Weight Twins: A Case Study. Pain Management Nursing 2011, 13: 127-138. PMID: 22929600, DOI: 10.1016/j.pmn.2010.10.035.Peer-Reviewed Original ResearchConceptsPreterm Infant Pain ProfilePhysiological pain responsesHeel stickPain responseKangaroo careInfant BVery-low-birth-weightPainful proceduresGestational age twinsIncidence of apneaLF/HF ratioSympathetic-parasympathetic balanceHeart rate variability indicesPreterm infantsIncubator careLow-frequency powerPain ProfilePain scoresHigh-frequency powerCrying timeBradycardia episodesBaseline levelsInfantsPretermIC conditions
2010
Randomized Crossover Trial of Kangaroo Care to Reduce Biobehavioral Pain Responses in Preterm Infants: A Pilot Study
Cong X, Ludington-Hoe S, Walsh S. Randomized Crossover Trial of Kangaroo Care to Reduce Biobehavioral Pain Responses in Preterm Infants: A Pilot Study. Biological Research For Nursing 2010, 13: 204-216. PMID: 21196428, DOI: 10.1177/1099800410385839.Peer-Reviewed Original ResearchConceptsPremature Infant Pain ProfileKangaroo careHeel stickPreterm infantsIncubator carePain responseSerum cortisolPremature Infant Pain Profile scoresSkin-to-skin contactBlunt pain responseHeel stick procedureBiobehavioral responsesRandomized crossover trialPIPP scoresPain ProfileHeel warmingMother-infant dyadsCrossover trialKC effectsPretermSalivary cortisolInfantsSerumTime pointsCortisol
2008
Molecular basis for pancreatitis
Thrower E, Husain S, Gorelick F. Molecular basis for pancreatitis. Current Opinion In Gastroenterology 2008, 24: 580-585. PMID: 19122498, PMCID: PMC3030809, DOI: 10.1097/mog.0b013e32830b10e6.Peer-Reviewed Original ResearchConceptsChronic pancreatitisAcute pancreatitisPain responseAnimal modelsToll-like receptor 4Transient receptor potential vanilloid subtype 1Specific neural receptorsSevere acute pancreatitisBasic science studiesChymotrypsin CShock protein 70Neural receptorsReceptor 4Chronic diseasesPancreatitisAlcohol abuseReceptor 2Subtype 1Potential treatmentPilot studyProtective mechanismAcinar cellsProtein 70Genetic factorsYear findings
2007
Organ cross talk modulates pelvic pain
Rudick CN, Chen MC, Mongiu AK, Klumpp DJ. Organ cross talk modulates pelvic pain. AJP Regulatory Integrative And Comparative Physiology 2007, 293: r1191-r1198. PMID: 17626130, DOI: 10.1152/ajpregu.00411.2007.Peer-Reviewed Original ResearchConceptsPelvic painInterstitial cystitisLidocaine instillationNeurogenic cystitisCystitis modelPseudorabies virusVascular permeabilityChronic bladder inflammatory diseaseMurine neurogenic cystitis modelVon Frey filament stimulationOrgan cross talkPelvic pain behaviorPelvic pain symptomsProgressive pelvic painMarkers of inflammationIC symptomsPain symptomsVisceral inputsPain behaviorPain responseUnknown etiologySubthreshold doseColon histologyInflammatory diseasesUrothelial lesions
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