2023
Design and Rationale the SCAN‐MP (Screening for Cardiac Amyloidosis With Nuclear Imaging in Minority Populations) Study
Ruberg F, Blaner W, Chiuzan C, Connors L, Einstein A, Fine D, Helmke S, Kurian D, Pandey S, Raiszadeh F, Rodriguez C, Sabogal N, Teruya S, Winburn M, Chung W, Cohn E, Miller E, Kelly J, Maurer M. Design and Rationale the SCAN‐MP (Screening for Cardiac Amyloidosis With Nuclear Imaging in Minority Populations) Study. Journal Of The American Heart Association 2023, 12: e028534. PMID: 37066788, PMCID: PMC10227254, DOI: 10.1161/jaha.122.028534.Peer-Reviewed Original ResearchConceptsATTR-CMHeart failureHealth/National HeartOlder black patientsYears of ageCaribbean Hispanic patientsDeposition of transthyretinNoninvasive nuclear imagingBlack patientsHispanic patientsProspective studyBlood InstituteSelf-identified Black individualsNational HeartCardiac amyloidosisUS FoodImportant causeSecondary objectiveOlder individualsSubstitution of valineHispanic individualsNuclear imagingNational InstituteBlack individualsPatientsCell-matrix interactions control biliary organoid polarity, architecture, and differentiation
Fiorotto R, Mariotti V, Taleb S, Zehra S, Nguyen M, Amenduni M, Strazzabosco M. Cell-matrix interactions control biliary organoid polarity, architecture, and differentiation. Hepatology Communications 2023, 7: e0094. PMID: 36972396, PMCID: PMC10503667, DOI: 10.1097/hc9.0000000000000094.Peer-Reviewed Original ResearchConceptsBiliary organoidsNovel organoid modelImmune cell typesOrganotypic culture systemProinflammatory chemokinesStem cell featuresBiliary epitheliumExtracellular matrixEpithelial permeabilityImportant causeBile acidsBiliary differentiationBile transportHuman liverOrganoid modelsDisease modelsCholangiopathyCell featuresTight junctionsLiverCell typesInternal lumenOrganoidsSingle-cell transcriptomicsPathogenic bacteriaThe role of hepatokines in NAFLD
Stefan N, Schick F, Birkenfeld A, Häring H, White M. The role of hepatokines in NAFLD. Cell Metabolism 2023, 35: 236-252. PMID: 36754018, PMCID: PMC10157895, DOI: 10.1016/j.cmet.2023.01.006.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseaseNon-communicable diseasesInsulin resistanceVisceral obesityMajor non-communicable diseasesRole of hepatokinesFatty liver diseaseRole of fetuinVisceral adiposityFatty liverLiver diseaseCardiometabolic diseasesPathophysiological mechanismsOrgan crosstalkHepatokinesMain pathomechanismClinical practiceImportant causeDiseasePrecision medicineAdipokinesObesityMetabolismAdiposityPathomechanismClinical and Public Health Considerations for HPV Vaccination in Midadulthood: A Narrative Review
King L, Lewnard J, Niccolai L. Clinical and Public Health Considerations for HPV Vaccination in Midadulthood: A Narrative Review. Open Forum Infectious Diseases 2023, 10: ofad004. PMID: 36726535, PMCID: PMC9887268, DOI: 10.1093/ofid/ofad004.Peer-Reviewed Original ResearchHPV vaccinationHuman papillomavirusNarrative reviewHPV natural historyRecurrent respiratory papillomatosisPublic health considerationsRespiratory papillomatosisOropharyngeal cancerAnogenital wartsPrevious infectionCancer casesUS guidelinesVaccinationImportant causeNatural historyAvailable evidenceSexual behaviorPatientsHealth considerationsCancerCliniciansBroad implementationGreater awarenessWide variationPapillomatosis
2022
Firearm-Related Injuries and Deaths in Children and Youth: Injury Prevention and Harm Reduction.
Lee L, Fleegler E, Goyal M, Doh K, Laraque-Arena D, Hoffman B, Culyba A, Dodington J, Johnston B, Kendi S, Kiragu A, McFadden T, Osterhoudt K, Tenenbein M, Quinlan K, Dixon C, Beno S, Kozial B, Delgado A. Firearm-Related Injuries and Deaths in Children and Youth: Injury Prevention and Harm Reduction. 2022, 150 PMID: 36207776, DOI: 10.1542/peds.2022-060070.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsFirearm injuriesHarm reductionInjury preventionMotor vehicle-related injuriesFirearm injury preventionVehicle-related injuriesEffective prevention interventionsCause of deathPediatric firearm injuriesYears of ageCommunity-level interventionsFirearm violenceMental health consequencesPublic health crisisViolence intervention programsYouth 0Prevention interventionsAnticipatory guidancePublic health advocatesImportant causeInjuryHealth consequencesProtective factorsSafe firearm storageUS youthEpigenome-wide association study of biomarkers of liver function identifies albumin-associated DNA methylation sites among male veterans with HIV
Titanji BK, Lee M, Wang Z, Chen J, Hui Q, Re V, So-Armah K, Justice AC, Xu K, Freiberg M, Gwinn M, Marconi VC, Sun YV. Epigenome-wide association study of biomarkers of liver function identifies albumin-associated DNA methylation sites among male veterans with HIV. Frontiers In Genetics 2022, 13: 1020871. PMID: 36303554, PMCID: PMC9592923, DOI: 10.3389/fgene.2022.1020871.Peer-Reviewed Original ResearchLiver diseaseLiver biomarkersLiver functionDNAm age accelerationAge accelerationVeterans Aging Cohort StudyEpigenome-wide association studiesFIB-4 scoreAging Cohort StudyMale PWHAPRI scoreCohort studyPlatelet countTotal bilirubinAlanine transaminaseClinical dataBlood samplesIndependent cohortSerum albuminMale veteransHIVImportant causeSignificant associationPWHDNAm sitesAnemia in the pediatric patient
Gallagher PG. Anemia in the pediatric patient. Blood 2022, 140: 571-593. PMID: 35213686, PMCID: PMC9373018, DOI: 10.1182/blood.2020006479.Peer-Reviewed Original ResearchConceptsLow birth weightIron deficiency anemiaNovel pharmacologic agentsWorld Health OrganizationNeurologic complicationsHeart failurePediatric patientsPhysical examinationBirth weightDeficiency anemiaChronic diseasesNutritional anemiaPharmacologic agentsSyndromic causesUndiagnosed casesTreatment strategiesCommon causeFamily historyPopulation-based approachAnemiaImportant causePreschool-age childrenDiagnostic testingGenetic testingDysmorphic featuresIncidence, recurring admissions and mortality of severe bacterial infections and sepsis over a 22-year period in the population-based HUNT study
Liyanarachi KV, Solligård E, Mohus RM, Åsvold BO, Rogne T, Damås JK. Incidence, recurring admissions and mortality of severe bacterial infections and sepsis over a 22-year period in the population-based HUNT study. PLOS ONE 2022, 17: e0271263. PMID: 35819970, PMCID: PMC9275692, DOI: 10.1371/journal.pone.0271263.Peer-Reviewed Original ResearchConceptsSevere bacterial infectionsPositive blood culturesBacterial infectionsBlood culturesPopulation-based HUNT StudyPositive blood culture rateTrøndelag Health StudyUrinary tract infectionPopulation-based cohortBlood culture rateCommon infectious diseasesInfectious disease burdenRegistry linkageTract infectionsLoss of healthMedian timeHUNT StudyDisease burdenIncidence rateCulture rateGeneral populationHealth StudyHospitalizationImportant causeTotal burden
2021
Changes in Invasive Pneumococcal Disease Caused by Streptococcus pneumoniae Serotype 1 following Introduction of PCV10 and PCV13: Findings from the PSERENADE Project
Bennett JC, Hetrich MK, Quesada M, Sinkevitch JN, Knoll M, Feikin DR, Zeger SL, Kagucia EW, Cohen AL, Ampofo K, Brandileone MC, Bruden D, Camilli R, Castilla J, Chan G, Cook H, Cornick JE, Dagan R, Dalby T, Danis K, de Miguel S, De Wals P, Desmet S, Georgakopoulou T, Gilkison C, Grgic-Vitek M, Hammitt LL, Hilty M, Ho PL, Jayasinghe S, Kellner JD, Kleynhans J, Knol MJ, Kozakova J, Kristinsson KG, Ladhani SN, MacDonald L, Mackenzie GA, Mad’arová L, McGeer A, Mereckiene J, Morfeldt E, Mungun T, Muñoz-Almagro C, Nuorti JP, Paragi M, Pilishvili T, Puentes R, Saha SK, Khan A, Savrasova L, Scott JA, Skoczyńska A, Suga S, van der Linden M, Verani JR, von Gottberg A, Winje BA, Yildirim I, Zerouali K, Hayford K. Changes in Invasive Pneumococcal Disease Caused by Streptococcus pneumoniae Serotype 1 following Introduction of PCV10 and PCV13: Findings from the PSERENADE Project. Microorganisms 2021, 9: 696. PMID: 33801760, PMCID: PMC8066231, DOI: 10.3390/microorganisms9040696.Peer-Reviewed Original ResearchInvasive pneumococcal diseasePneumococcal conjugate vaccinePneumococcal diseaseIncidence rateSerotype 1Streptococcus pneumoniae serotype 1Mixed-effects Poisson regressionInfant immunization programIntroduction of PCV10Pneumococcal serotype replacementIncidence rate ratiosIPD surveillance dataYears of ageIPD incidenceSerotype replacementLinear mixed-effects regressionConjugate vaccineBurden countriesImmunization programsMixed-effects regressionImportant causePoisson regressionSurveillance dataRate ratioPCV10/13
2020
Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program
Klarin D, Verma S, Judy R, Dikilitas O, Wolford B, Paranjpe I, Levin M, Pan C, Tcheandjieu C, Spin J, Lynch J, Assimes T, Åldstedt Nyrønning L, Mattsson E, Edwards T, Denny J, Larson E, Lee M, Carrell D, Zhang Y, Jarvik G, Gharavi A, Harley J, Mentch F, Pacheco J, Hakonarson H, Skogholt A, Thomas L, Gabrielsen M, Hveem K, Nielsen J, Zhou W, Fritsche L, Huang J, Natarajan P, Sun Y, DuVall S, Rader D, Cho K, Chang K, Wilson P, O’Donnell C, Kathiresan S, Scali S, Berceli S, Willer C, Jones G, Bown M, Nadkarni G, Kullo I, Ritchie M, Damrauer S, Tsao P, Gaziano J, Ramoni R, Beckham J, Breeling J, Chang K, Huang G, Muralidhar S, O’Donnell C, Casas Romero J, Tsao P, Muralidhar S, Moser J, Whitbourne S, Brewer J, Concato J, Warren S, Argyres D, Tsao P, Gaziano J, Stephens B, Brophy M, Humphries D, Do N, Shayan S, Nguyen X, O’Donnell C, Pyarajan S, Tsao P, Cho K, Pyarajan S, Hauser E, Sun Y, Zhao H, Wilson P, McArdle R, Dellitalia L, Harley J, Zablocki C, Whittle J, Beckham J, Wells J, Gutierrez S, Gibson G, Kaminsky L, Villareal G, Kinlay S, Xu J, Hamner M, Haddock K, Bhushan S, Iruvanti P, Godschalk M, Ballas Z, Buford M, Mastorides S, Klein J, Ratcliffe N, Florez H, Swann A, Murdoch M, Sriram P, Yeh S, Washburn R, Jhala D, Aguayo S, Cohen D, Sharma S, Callaghan J, Oursler K, Whooley M, Ahuja S, Gutierrez A, Schifman R, Greco J, Rauchman M, Servatius R, Oehlert M, Wallbom A, Fernando R, Morgan T, Stapley T, Sherman S, Anderson G, Tsao P, Sonel E, Boyko E, Meyer L, Gupta S, Fayad J, Hung A, Lichy J, Hurley R, Robey B, Striker R. Genetic Architecture of Abdominal Aortic Aneurysm in the Million Veteran Program. Circulation 2020, 142: 1633-1646. PMID: 32981348, PMCID: PMC7580856, DOI: 10.1161/circulationaha.120.047544.Peer-Reviewed Original ResearchConceptsAbdominal aortic aneurysmBlood pressurePolygenic risk scoresAortic aneurysmFamily historyDiastolic blood pressureSystolic blood pressureGenome-wide polygenic risk scoreRisk variantsSmoking risk factorsMendelian randomization analysisAAA prevalenceCardiovascular mortalityRisk factorsAAA developmentArterial bedCurrent guidelinesVascular territoriesLower extremitiesMillion Veteran ProgramRisk scoreTherapeutic implicationsCurrent screeningImportant causeAAA riskGenome-Wide Linkage Analysis of the Risk of Contracting a Bloodstream Infection in 47 Pedigrees Followed for 23 Years Assembled From a Population-Based Cohort (the HUNT Study).
Rogne T, Damås JK, Solligård E, DeWan AT. Genome-Wide Linkage Analysis of the Risk of Contracting a Bloodstream Infection in 47 Pedigrees Followed for 23 Years Assembled From a Population-Based Cohort (the HUNT Study). Critical Care Medicine 2020, 48: 1580-1586. PMID: 32885941, DOI: 10.1097/ccm.0000000000004520.Peer-Reviewed Original ResearchGlioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions
Wen PY, Weller M, Lee EQ, Alexander BM, Barnholtz-Sloan JS, Barthel FP, Batchelor TT, Bindra RS, Chang SM, Chiocca EA, Cloughesy TF, DeGroot JF, Galanis E, Gilbert MR, Hegi ME, Horbinski C, Huang RY, Lassman AB, Le Rhun E, Lim M, Mehta MP, Mellinghoff IK, Minniti G, Nathanson D, Platten M, Preusser M, Roth P, Sanson M, Schiff D, Short SC, Taphoorn MJB, Tonn JC, Tsang J, Verhaak RGW, von Deimling A, Wick W, Zadeh G, Reardon DA, Aldape KD, van den Bent MJ. Glioblastoma in adults: a Society for Neuro-Oncology (SNO) and European Society of Neuro-Oncology (EANO) consensus review on current management and future directions. Neuro-Oncology 2020, 22: 1073-1113. PMID: 32328653, PMCID: PMC7594557, DOI: 10.1093/neuonc/noaa106.Peer-Reviewed Original ResearchConceptsNeuro-oncologyConsensus reviewCurrent managementMalignant primary brain tumorIsocitrate dehydrogenase-wildtype glioblastomaPrimary brain tumorsNovel therapiesViral therapyBrain tumorsImportant causeMolecular pathogenesisMolecular therapyEuropean AssociationTherapyEuropean SocietyCommon formGlioblastomaWildtype glioblastomaTumorsFuture directionsImportant advancesImmunotherapyMorbidityPatientsDNA damage responseComplete Genome Sequence of Leptospira interrogans Strains FMAS_KW1, FMAS_KW2 and FMAS_AW1 Isolated from Leptospirosis Patients from Karawanalla and Awissawella, Sri Lanka
Senevirathna I, Jayasundara D, Lefler JP, Chaiboonm KL, Warnasekara J, Agampodi S, Matthias MA, Vinetz JM. Complete Genome Sequence of Leptospira interrogans Strains FMAS_KW1, FMAS_KW2 and FMAS_AW1 Isolated from Leptospirosis Patients from Karawanalla and Awissawella, Sri Lanka. Journal Of Genomics 2020, 8: 49-52. PMID: 32494307, PMCID: PMC7256012, DOI: 10.7150/jgen.43953.Peer-Reviewed Original ResearchManagement of Patient Undergoing Carotid Stenting
Rao S. Management of Patient Undergoing Carotid Stenting. 2020, 391-401. DOI: 10.1007/978-981-15-0458-7_28.Peer-Reviewed Original ResearchHigh-risk patient populationLong-term morbidityCarotid artery atherosclerosisCarotid artery stentingPreoperative risk stratificationArtery atherosclerosisArtery stentingAnesthetic considerationsCarotid stentingRisk stratificationPatient populationIntraoperative neuromonitoringEarly recognitionSurgical techniqueCarotid arteryImportant causeStentingMorbidityStenosisAtherosclerosisNeuromonitoringArteryStrokeSymptomsOccupational lung diseases in the 21st century: the changing landscape and future challenges.
Fazen LE, Linde B, Redlich CA. Occupational lung diseases in the 21st century: the changing landscape and future challenges. Current Opinion In Pulmonary Medicine 2020, 26: 142-148. PMID: 31895883, DOI: 10.1097/mcp.0000000000000658.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsOccupational lung diseaseChronic obstructive pulmonary diseaseLung diseaseRespiratory diseaseWork-related lung diseaseWork-related asthmaObstructive pulmonary diseaseCareful occupational historyPulmonary diseasePreventable causeAdvanced silicosisOccupational exposureHigh-income countriesOccupational historyPulmonary cliniciansHigh indexImportant causeDiseaseWorkplace hazardsSilicosisCliniciansPresent reviewStone countertopsCauseDecades of progress
2019
Alpha-Tocotrienol Prevents Oxidative Stress-Mediated Post-Translational Cleavage of Bcl-xL in Primary Hippocampal Neurons
Park HA, Mnatsakanyan N, Broman K, Davis AU, May J, Licznerski P, Crowe-White KM, Lackey KH, Jonas EA. Alpha-Tocotrienol Prevents Oxidative Stress-Mediated Post-Translational Cleavage of Bcl-xL in Primary Hippocampal Neurons. International Journal Of Molecular Sciences 2019, 21: 220. PMID: 31905614, PMCID: PMC6982044, DOI: 10.3390/ijms21010220.Peer-Reviewed Original ResearchConceptsPrimary hippocampal neuronsHippocampal neuronsReactive oxygen speciesMitochondrial dysfunctionBcl-xLMitochondrial membrane potentialMitochondrial functionProduction of ROSExcitotoxic conditionsGlutamate challengeNeuroprotective propertiesMembrane potentialNeuronal deathExcitotoxic stimulationBcl-xL levelsNeuronal survivalIntracellular ATP depletionMitochondrial reactive oxygen speciesB cellsImportant causeDysfunctionNeuronsROS productionATP depletionNeurite outgrowthAssociation Between Diaphragmatic Paralysis and Ipsilateral Cervical Spondylosis on MRI
O’Beirne S, Chazen JL, Cornman-Homonoff J, Carey BT, Gelbman BD. Association Between Diaphragmatic Paralysis and Ipsilateral Cervical Spondylosis on MRI. Lung 2019, 197: 727-733. PMID: 31535202, DOI: 10.1007/s00408-019-00271-y.Peer-Reviewed Original ResearchConceptsCervical spine magnetic resonance imagingMagnetic resonance imagingSpine magnetic resonance imagingCervical spondylosisCervical spineUnderrecognized causeContralateral foraminal stenosisCervical spine levelsDiaphragmatic paralysisDiaphragmatic dysfunctionNeuroforaminal stenosisTotal cohortForaminal stenosisRetrospective studyUnderlying etiologySpine levelImportant causeOverall severityResonance imagingEtiologySeveritySpineSpondylosisStenosisC4-C5Update on Obstetric Hemorrhage
Reale S, Leffert L, Farber M. Update on Obstetric Hemorrhage. Current Anesthesiology Reports 2019, 9: 60-68. DOI: 10.1007/s40140-019-00311-6.Peer-Reviewed Original ResearchPostpartum hemorrhageObstetric hemorrhageRecent evidence-based advancesEarly fibrinogen replacementPreventable maternal morbidityTranexamic acid therapyMassive transfusion protocolRecent epidemiologic dataEvidence-based advancesPostpartum hemorrhage managementConsensus BundleMaternal morbidityTransfusion protocolTransfusion strategyBlood lossAcid therapyEpidemiologic dataFibrinogen replacementHemorrhageHemorrhage managementImportant causeProtocol useEnhanced risk assessmentMorbidityNational Partnership
2018
Direct and possible indirect effects of vaccination on rotavirus hospitalisations among children in Malawi four years after programmatic introduction
Bennett A, Pollock L, Jere K, Pitzer V, Parashar U, Tate J, Heyderman R, Mwansambo C, French N, Nakagomi O, Iturriza-Gomara M, Everett D, Cunliffe N, Bar-Zeev N, Consortium F. Direct and possible indirect effects of vaccination on rotavirus hospitalisations among children in Malawi four years after programmatic introduction. Vaccine 2018, 36: 7142-7148. PMID: 29887320, PMCID: PMC6238204, DOI: 10.1016/j.vaccine.2018.04.030.Peer-Reviewed Original ResearchConceptsPost-vaccine introductionPrevalence of rotavirusVaccine effectivenessRotavirus prevalenceAcute gastroenteritisVaccine introductionRotavirus hospitalisationsVaccine coverageEfficacy estimatesAdjusted vaccine effectivenessRotavirus vaccine introductionYears of ageUse of vaccinesUnvaccinated infantsRotavirus diarrheaRotavirus diseaseUnvaccinated childrenReferral hospitalRoutine immunisationMalawian childrenSevere diarrheaStool samplesImportant causePoisson regressionHospitalisationAsymptomatic Plasmodium vivax parasitaemia in the low-transmission setting: the role for a population-based transmission-blocking vaccine for malaria elimination
Martin TCS, Vinetz JM. Asymptomatic Plasmodium vivax parasitaemia in the low-transmission setting: the role for a population-based transmission-blocking vaccine for malaria elimination. Malaria Journal 2018, 17: 89. PMID: 29466991, PMCID: PMC5822557, DOI: 10.1186/s12936-018-2243-3.Peer-Reviewed Original ResearchConceptsTransmission-blocking vaccinesPlasmodium vivax parasitaemiaLow transmission settingsControl of transmissionVivax parasitaemiaChloroquine resistanceAsymptomatic carriageMalaria eliminationNew therapiesPlasmodium vivaxImportant causeCarrier stateImmunological interactionsVaccineOnward infectionInfectionParasite transmissionEradication effortsMosquitoesMorbidityParasitaemiaTherapyMortalityDiagnosisVivax
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