2024
Standardization and clinical applications of retinal imaging biomarkers for cardiovascular disease: a Roadmap from an NHLBI workshop
Chew E, Burns S, Abraham A, Bakhoum M, Beckman J, Chui T, Finger R, Frangi A, Gottesman R, Grant M, Hanssen H, Lee C, Meyer M, Rizzoni D, Rudnicka A, Schuman J, Seidelmann S, Tang W, Adhikari B, Danthi N, Hong Y, Reid D, Shen G, Oh Y. Standardization and clinical applications of retinal imaging biomarkers for cardiovascular disease: a Roadmap from an NHLBI workshop. Nature Reviews Cardiology 2024, 22: 47-63. PMID: 39039178, DOI: 10.1038/s41569-024-01060-8.Peer-Reviewed Original ResearchPrimary care dataMicrovascular diseaseDiverse at-risk populationsCardiovascular diseaseRetinal biomarkersOphthalmic imaging techniqueRisk of cardiovascular diseaseRetinal microvascular diseaseIndividual-level riskAt-risk populationsMacrovascular risk factorsSystemic vascular bedsDevelopment of microvascular diseaseCoronary artery diseaseHealth workersCare dataLifestyle factorsMonitoring of systemic diseasesRetinal imaging biomarkersNational HeartVascular dementiaBlood InstituteHeart failureMultidisciplinary networkSystemic diseaseTransforming Hypertension Diagnosis and Management in The Era of Artificial Intelligence: A 2023 National Heart, Lung, and Blood Institute (NHLBI) Workshop Report
Shimbo D, Shah R, Abdalla M, Agarwal R, Ahmad F, Anaya G, Attia Z, Bull S, Chang A, Commodore-Mensah Y, Ferdinand K, Kawamoto K, Khera R, Leopold J, Luo J, Makhni S, Mortazavi B, Oh Y, Savage L, Spatz E, Stergiou G, Turakhia M, Whelton P, Yancy C, Iturriaga E. Transforming Hypertension Diagnosis and Management in The Era of Artificial Intelligence: A 2023 National Heart, Lung, and Blood Institute (NHLBI) Workshop Report. Hypertension 2024, 82: 36-45. PMID: 39011653, PMCID: PMC11655265, DOI: 10.1161/hypertensionaha.124.22095.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMachine learning toolsManagement of hypertensionNational HeartArtificial intelligenceBlood InstitutePredictive of incident hypertensionHealth care systemImplementation challengesDiverse group of stakeholdersAI toolsPopulation healthMeasurement of blood pressureCare systemHealth careIncident hypertensionHypertension riskEra of artificial intelligenceHypertension diagnosisLearning toolsManaging hypertensionHypertension-related complicationsAntihypertensive medicationsHealthPublic healthGroups of stakeholdersTackling Brain and Muscle Dysfunction in Acute Respiratory Distress Syndrome Survivors: NHLBI Workshop Report.
Palakshappa J, Batt J, Bodine S, Connolly B, Doles J, Falvey J, Ferrante L, Files D, Harhay M, Harrell K, Hippensteel J, Iwashyna T, Jackson J, Lane-Fall M, Monje M, Moss M, Needham D, Semler M, Lahiri S, Larsson L, Sevin C, Sharshar T, Singer B, Stevens T, Taylor S, Gomez C, Zhou G, Girard T, Hough C. Tackling Brain and Muscle Dysfunction in Acute Respiratory Distress Syndrome Survivors: NHLBI Workshop Report. American Journal Of Respiratory And Critical Care Medicine 2024, 209: 1304-1313. PMID: 38477657, PMCID: PMC11146564, DOI: 10.1164/rccm.202311-2130ws.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsNational HeartAcute respiratory distress syndrome survivorsEvidence-based interventionsQuality of lifeAssociated with long-term impairmentNational Institutes of HealthInstitutes of HealthAcute respiratory distress syndromeBlood InstituteARDS survivorsMuscle functionAcute illnessMuscle dysfunctionLong-term impairmentNational InstituteHealthSurvivorsRespiratory distress syndromeNationalWorkshopMuscleImpairmentDistress syndromeNHLBIInterventionResearch opportunities and ethical considerations for heart and lung xenotransplantation research: A report from the National Heart, Lung, and Blood Institute workshop
Khush K, Bernat J, Pierson R, Silverman H, Parent B, Glazier A, Adams A, Fishman J, Gusmano M, Hawthorne W, Homan M, Hurst D, Latham S, Park C, Maschke K, Mohiuddin M, Montgomery R, Odim J, Pentz R, Reichart B, Savulescu J, Wolpe P, Wong R, Fenton K. Research opportunities and ethical considerations for heart and lung xenotransplantation research: A report from the National Heart, Lung, and Blood Institute workshop. American Journal Of Transplantation 2024, 24: 918-927. PMID: 38514013, PMCID: PMC11144553, DOI: 10.1016/j.ajt.2024.03.015.Peer-Reviewed Original ResearchConceptsMaintenance of immunosuppressionNational HeartEthical questionsBlood Institute WorkshopDonor organ supplyLung transplantationOrgan injuryImmune activationXenograft survivalXenotransplantation researchClinical trial participationAnimal rightsClinical xenotransplantationRegulatory oversightLungWelfare considerationsDonor organsBlood InstituteProtocol reviewXenotransplantationDeceased humansTrial participantsHeartEthical considerationsBloodClinical phenotypes among patients with normal cardiac perfusion using unsupervised learning: a retrospective observational study
Miller R, Bednarski B, Pieszko K, Kwiecinski J, Williams M, Shanbhag A, Liang J, Huang C, Sharir T, Hauser M, Dorbala S, Di Carli M, Fish M, Ruddy T, Bateman T, Einstein A, Kaufmann P, Miller E, Sinusas A, Acampa W, Han D, Dey D, Berman D, Slomka P. Clinical phenotypes among patients with normal cardiac perfusion using unsupervised learning: a retrospective observational study. EBioMedicine 2024, 99: 104930. PMID: 38168587, PMCID: PMC10794922, DOI: 10.1016/j.ebiom.2023.104930.Peer-Reviewed Original ResearchMyocardial infarctionMyocardial perfusion imagingBlood InstituteNational HeartPharmacologic stressExternal testing cohortNormal imaging resultsRetrospective observational studyCoronary artery diseasePrevious myocardial infarctionRisk of deathNormal perfusion scanBritish Heart FoundationNational InstituteCluster 4 patientsDistinct phenotypesCardiovascular riskArtery diseaseRisk stratificationPerfusion scanNormal perfusionImaging featuresNormal scansMPI patientsHeart Foundation
2023
Clinical trial data sharing: a cross-sectional study of outcomes associated with two U.S. National Institutes of Health models
Rowhani-Farid A, Grewal M, Solar S, Eghrari A, Zhang A, Gross C, Krumholz H, Ross J. Clinical trial data sharing: a cross-sectional study of outcomes associated with two U.S. National Institutes of Health models. Scientific Data 2023, 10: 529. PMID: 37553403, PMCID: PMC10409750, DOI: 10.1038/s41597-023-02436-0.Peer-Reviewed Original ResearchDesign and methods of a randomized trial testing "Advancing care for COPD in people living with HIV by implementing evidence-based management through proactive E-consults (ACHIEVE)"
Ives J, Bagchi S, Soo S, Barrow C, Akgün K, Erlandson K, Goetz M, Griffith M, Gross R, Hulgan T, Moanna A, Soo Hoo G, Weintrob A, Wongtrakool C, Adams S, Sayre G, Helfrich C, Au D, Crothers K. Design and methods of a randomized trial testing "Advancing care for COPD in people living with HIV by implementing evidence-based management through proactive E-consults (ACHIEVE)". Contemporary Clinical Trials 2023, 132: 107303. PMID: 37481201, PMCID: PMC10528346, DOI: 10.1016/j.cct.2023.107303.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseE-consultsEvidence-based managementElectronic health recordsCOPD managementVeterans Affairs Medical CenterCommon comorbid diseasesObstructive pulmonary diseaseChronic disease comorbiditiesEvidence-based careEvidence-based recommendationsComorbid diseasesPulmonary diseaseHIV populationInappropriate therapyBlood InstituteNational HeartACHIEVE trialMedical CenterClinical providersDisease comorbiditiesHIVPWHTrial testingCareDesign and Rationale the SCAN‐MP (Screening for Cardiac Amyloidosis With Nuclear Imaging in Minority Populations) Study
Ruberg F, Blaner W, Chiuzan C, Connors L, Einstein A, Fine D, Helmke S, Kurian D, Pandey S, Raiszadeh F, Rodriguez C, Sabogal N, Teruya S, Winburn M, Chung W, Cohn E, Miller E, Kelly J, Maurer M. Design and Rationale the SCAN‐MP (Screening for Cardiac Amyloidosis With Nuclear Imaging in Minority Populations) Study. Journal Of The American Heart Association 2023, 12: e028534. PMID: 37066788, PMCID: PMC10227254, DOI: 10.1161/jaha.122.028534.Peer-Reviewed Original ResearchConceptsATTR-CMHeart failureHealth/National HeartOlder black patientsYears of ageCaribbean Hispanic patientsDeposition of transthyretinNoninvasive nuclear imagingBlack patientsHispanic patientsProspective studyBlood InstituteSelf-identified Black individualsNational HeartCardiac amyloidosisUS FoodImportant causeSecondary objectiveOlder individualsSubstitution of valineHispanic individualsNuclear imagingNational InstituteBlack individualsPatients
2022
Interventions to mitigate vaping misinformation: protocol for a scoping review
Kumar N, Hampsher S, Walter N, Nyhan K, De Choudhury M. Interventions to mitigate vaping misinformation: protocol for a scoping review. Systematic Reviews 2022, 11: 214. PMID: 36210470, PMCID: PMC9548303, DOI: 10.1186/s13643-022-02094-0.Peer-Reviewed Original ResearchConceptsStudy Quality Assessment ToolsJoanna Briggs Institute ReviewersEgger's regression testJBI Scoping ReviewsScoping ReviewFull-text articlesQuality assessment toolEffect sizePublication bias testsBlood InstituteNational HeartSTUDY SELECTIONRegression testFunnel plotRelative harmNarrative summaryGoogle ScholarSociological AbstractsInterventionGlobal healthGrey literatureCorrelation testAssessment toolOriginal studyDisaster LitLongitudinal lung function and gas transfer in individuals with idiopathic pulmonary fibrosis: a genome-wide association study
Allen RJ, Oldham JM, Jenkins DA, Leavy OC, Guillen-Guio B, Melbourne CA, Ma SF, Jou J, Kim JS, Cooperative C, Fahy WA, Oballa E, Hubbard RB, Navaratnam V, Braybrooke R, Saini G, Roach KM, Tobin MD, Hirani N, Whyte MKB, Kaminski N, Zhang Y, Martinez FJ, Linderholm AL, Adegunsoye A, Strek ME, Maher TM, Molyneaux PL, Flores C, Noth I, Jenkins R, Wain LV. Longitudinal lung function and gas transfer in individuals with idiopathic pulmonary fibrosis: a genome-wide association study. The Lancet Respiratory Medicine 2022, 11: 65-73. PMID: 35985358, PMCID: PMC10077113, DOI: 10.1016/s2213-2600(22)00251-x.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisPulmonary fibrosisLung capacityAmerican Thoracic Society/European Respiratory Society guidelinesDiagnosis of IPFEuropean Respiratory Society guidelinesPotential novel therapeutic approachHealth-National HeartLongitudinal lung functionRespiratory Society guidelinesGenetic variantsNovel therapeutic approachesIncurable lung diseaseMedical Research CouncilProgressive scarringFVC declineLung functionVital capacityBlood InstituteSociety guidelinesLung diseaseNational HeartDisease progressionTherapeutic approachesSignificant associationProceedings From a National Heart, Lung, and Blood Institute and the Centers for Disease Control and Prevention Workshop to Control Hypertension
Commodore-Mensah Y, Loustalot F, Himmelfarb CD, Desvigne-Nickens P, Sachdev V, Bibbins-Domingo K, Clauser SB, Cohen DJ, Egan BM, Fendrick AM, Ferdinand KC, Goodman C, Graham GN, Jaffe MG, Krumholz HM, Levy PD, Mays GP, McNellis R, Muntner P, Ogedegbe G, Milani RV, Polgreen LA, Reisman L, Sanchez EJ, Sperling LS, Wall HK, Whitten L, Wright JT, Wright JS, Fine LJ. Proceedings From a National Heart, Lung, and Blood Institute and the Centers for Disease Control and Prevention Workshop to Control Hypertension. American Journal Of Hypertension 2022, 35: 232-243. PMID: 35259237, PMCID: PMC8903890, DOI: 10.1093/ajh/hpab182.Peer-Reviewed Original ResearchConceptsHypertension controlBlood pressureHypertension treatmentBlood InstituteNational HeartSelf-measured BP monitoringDisease controlCommunity-clinical linkagesModifiable risk factorsMore cardiovascular eventsAge-adjusted proportionSurgeon General's CallTeam-based careHigh-quality health carePublic health messagingCardiovascular eventsStroke preventionControl hypertensionBP monitoringHeart diseaseRisk factorsUS adultsClinical supportHealth messagingSocial determinantsCost-Effectiveness of Long-Acting Injectable HIV Preexposure Prophylaxis in the United States : A Cost-Effectiveness Analysis.
Neilan AM, Landovitz RJ, Le MH, Grinsztejn B, Freedberg KA, McCauley M, Wattananimitgul N, Cohen MS, Ciaranello AL, Clement ME, Reddy KP, Hyle EP, Paltiel AD, Walensky RP. Cost-Effectiveness of Long-Acting Injectable HIV Preexposure Prophylaxis in the United States : A Cost-Effectiveness Analysis. Annals Of Internal Medicine 2022, 175: 479-489. PMID: 35099992, PMCID: PMC9087297, DOI: 10.7326/m21-1548.Peer-Reviewed Original ResearchConceptsCAB-LAHIV preexposure prophylaxisCost-effectiveness analysisPreexposure prophylaxisHigh riskNational InstituteIncremental cost-effectiveness ratioCost-effectiveness ratioBase-case analysisHealth care systemEunice KennedyInjectable cabotegravirPrEP retentionOral PrEPHIV PrEPHIV incidenceBlood InstituteDisoproxil fumarateNational HeartChild healthSide effectsTransgender womenInfectious diseasesPrEPQALY
2021
Diagnosis and Treatment of Right Heart Failure in Pulmonary Vascular Diseases
Leopold JA, Kawut SM, Aldred MA, Archer SL, Benza RL, Bristow MR, Brittain EL, Chesler N, DeMan FS, Erzurum SC, Gladwin MT, Hassoun PM, Hemnes AR, Lahm T, Lima JAC, Loscalzo J, Maron BA, Mercer Rosa L, Newman JH, Redline S, Rich S, Rischard F, Sugeng L, Tang WHW, Tedford RJ, Tsai EJ, Ventetuolo CE, Zhao Y, Aggarwal NR, Xiao L, Cai H, Cai L, Chen X, Elinoff J, Freed B, Frump A, Goss K, Gray M, Huang W, Kolb T, Simon M, Solomon M, Spiekerkoetter E, Vanderpool R, Zou M, Chen Y, Bishow A, Shi S, Weinmann G, Wong R. Diagnosis and Treatment of Right Heart Failure in Pulmonary Vascular Diseases. Circulation Heart Failure 2021, 14: e007975. PMID: 34422205, PMCID: PMC8375628, DOI: 10.1161/circheartfailure.120.007975.Peer-Reviewed Original ResearchConceptsPulmonary vascular diseaseRight ventricleNational HeartVascular diseaseRight heart failureRight ventricular dysfunctionBlood Institute WorkshopClinical research programVentricular dysfunctionHeart failureLung parenchymalPulmonary vascularBlood InstituteRV structureRV tissueHeart diseaseDiseasePrecision medicineInvasive methodologyLungDiagnosisHeartSpecific recommendationsWorking GroupPatientsObesity and Corticosteroid Dosing Guideline Adherence in Children Hospitalized With Asthma
Kyler KE, Bettenhausen JL, Hall M, Glynn EF, Hoffman MA, Shakhnovich V, Smolderen K, Davis AM. Obesity and Corticosteroid Dosing Guideline Adherence in Children Hospitalized With Asthma. Hospital Pediatrics 2021, 11: 380-388. PMID: 33664119, DOI: 10.1542/hpeds.2020-001420.Peer-Reviewed Original ResearchConceptsWeight categoriesSystemic corticosteroidsGuideline adherenceRetrospective cross-sectional studyMultivariable logistic regression modelCerner Health FactsClass III obesityCross-sectional studyDrug dosing recommendationsLogistic regression modelsAsthma increasesGuideline adherentSevere obesityDosing recommendationsBlood InstituteCDC guidelinesHealthy weightNational HeartBMI percentileAsthma hospitalizationsClinical covariatesTotal bodyDrug dosesObesityRisk of harm
2020
Addressing Recruitment Challenges in the Engage-HU Trial in Young Children with Sickle Cell Disease
Hood A, Strong H, Nwankwo C, Johnson Y, Mara C, Shook L, Brinkman W, Real F, Klein M, King A, Calhoun C, Smith-Whitley K, Creary S, Britto M, Saving K, Piccone C, Raphael J, Volanakis E, Hildenbrand A, Reader S, Rana S, Neumayr L, Yates A, Badawy S, Thompson A, Sobota A, Meier E, Quinn C, Crosby L. Addressing Recruitment Challenges in the Engage-HU Trial in Young Children with Sickle Cell Disease. Blood 2020, 136: 26-27. DOI: 10.1182/blood-2020-141471.Peer-Reviewed Original ResearchSickle cell diseaseSite principal investigatorsNational HeartCell diseaseCaregivers' perceptionsBluebird BioAdvisory CommitteeYoung childrenPrincipal investigatorBlood Institute guidelinesPatient-centered outcomesChild health outcomesRandomized control trialStepped-wedge designMonths of ageCurrent equity holderMistrust of researchStudy's principal investigatorNeurologic morbidityPrimary endpointTreat principleBlood InstituteFuture trialsIntervention trialsSCD populationStem Cells, Cell Therapies, and Bioengineering in Lung Biology and Disease 2019
Wagner D, Ikonomou L, Gilpin S, Magin C, Cruz F, Greaney A, Magnusson M, Chen Y, Davis B, Vanuytsel K, Enes S, Krasnodembskaya A, Lehmann M, Westergren-Thorsson G, Stegmayr J, Alsafadi H, Hoffman E, Weiss D, Ryan A. Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Disease 2019. ERJ Open Research 2020, 6: 00123-2020. PMID: 33123557, PMCID: PMC7569162, DOI: 10.1183/23120541.00123-2020.Peer-Reviewed Original ResearchCell therapyProgenitor cellsLung stemLung biologyInduced pluripotent stem cell modelsInternational Society for CellTreatment of lung diseasesPluripotent stem cell modelsPulmonary Fibrosis FoundationCystic Fibrosis FoundationStem cell modelRegenerative medicine productsAlpha-1 FoundationUniversity of Vermont Larner College of MedicineGene therapyCystic fibrosisLung diseaseCollege of MedicineTherapyStem cellsAlpha 1LungBlood InstituteNational HeartExtracellular vesicles
2019
Predicting 6-Month Mortality for Older Adults Hospitalized With Acute Myocardial Infarction: A Cohort Study.
Dodson JA, Hajduk AM, Geda M, Krumholz HM, Murphy TE, Tsang S, Tinetti ME, Nanna MG, McNamara R, Gill TM, Chaudhry SI. Predicting 6-Month Mortality for Older Adults Hospitalized With Acute Myocardial Infarction: A Cohort Study. Annals Of Internal Medicine 2019, 172: 12-21. PMID: 31816630, PMCID: PMC7695040, DOI: 10.7326/m19-0974.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPost-AMI mortalityFunctional impairmentOlder adultsCohort studyMean ageMyocardial infarctionPatient-reported health statusNet reclassification improvement indexProspective cohort studyParticipants' mean ageFinal risk modelMobility impairmentsGood discriminatory abilityRisk modelChart reviewHospital dischargePrognostic utilityBlood InstituteClinical variablesNational HeartHigh prevalenceHealth statusMortalityYounger counterparts
2018
Implementation of the Asthma Control Test in Primary Care to Improve Patient Outcomes
Banasiak NC. Implementation of the Asthma Control Test in Primary Care to Improve Patient Outcomes. Journal Of Pediatric Health Care 2018, 32: 591-599. PMID: 30104128, DOI: 10.1016/j.pedhc.2018.05.004.Peer-Reviewed Original ResearchConceptsAsthma Control TestPrimary care practicesAsthma controlCare practicesChildhood Asthma Control TestManagement of patientsMajor chronic diseasesPediatric resident physiciansPost-implementation studyControl testsEvidence-based projectMedication therapyPediatric populationBlood InstituteNational HeartPrimary careChronic diseasesPatient outcomesAsthmaPatientsResident physiciansAdvanced practicePeriodic assessmentChildrenEducational programsRelationship between Baseline Phenotype and Measures of Insulin Sensitivity and Beta-Cell Responses in the GRADE Cohort
RASOULI N, COHEN R, DEFRONZO R, INZUCCHI S, ISMAIL-BEIGI F, KAHN S, UTZSCHNEIDER K, LACHIN J, YOUNES N. Relationship between Baseline Phenotype and Measures of Insulin Sensitivity and Beta-Cell Responses in the GRADE Cohort. Diabetes 2018, 67 DOI: 10.2337/db18-1822-p.Peer-Reviewed Original ResearchC-peptide responseBaseline phenotypic characteristicsDisposition indexInsulin sensitivityBoehringer Ingelheim PharmaceuticalsΒ-cell functionT2D durationJanssen PharmaceuticalsBristol-Myers Squibb CompanyNational Diabetes Education ProgramBoehringer Ingelheim GmbHBeta-cell responseType 2 diabetesΒ-cell responseDiabetes education programΒ-cell dysfunctionWaist circumferenceBlood InstituteKidney diseaseNational HeartAbbVie Inc.Grade cohortsCelgene CorporationDisease controlBaseline phenotype
2017
Perspectives from NHLBI Global Health Think Tank Meeting for Late Stage (T4) Translation Research
Engelgau MM, Peprah E, Sampson UKA, Mishoe H, Benjamin IJ, Douglas PS, Hochman JS, Ridker PM, Brandes N, Checkley W, El-Saharty S, Ezzati M, Hennis A, Jiang L, Krumholz HM, Lamourelle G, Makani J, Narayan KMV, Ohene-Frempong K, Straus SE, Stuckler D, Chambers DA, Belis D, Bennett GC, Boyington JE, Creazzo TL, de Jesus JM, Krishnamurti C, Lowden MR, Punturieri A, Shero ST, Young NS, Zou S, Mensah GA. Perspectives from NHLBI Global Health Think Tank Meeting for Late Stage (T4) Translation Research. Global Heart 2017, 12: 341-348. PMID: 27452772, DOI: 10.1016/j.gheart.2016.03.640.Peer-Reviewed Original ResearchConceptsNational HeartDisease burdenNoncommunicable disease burdenHealth delivery modelsGlobal health researchMiddle-income countriesBlood InstituteGlobal health disparitiesThink Tank meetingHealth disparitiesEffective interventionsCompelling scientific questionsLungTank meetingHealth researchSustainable interventionsHeartThree-quartersDelivery modelInterventionBurdenImplementation strategiesResearch capacityMajor themesLater stages
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