2024
Reproducibility of Semi-automated Quantitative Analyses of Tc-99m Pyrophosphate Uptake from Myocardial Perfusion Planar and SPECT Images
Goyal D, Sandoval V, Weyman C, Miller E, Liu Y. Reproducibility of Semi-automated Quantitative Analyses of Tc-99m Pyrophosphate Uptake from Myocardial Perfusion Planar and SPECT Images. Journal Of Medical And Biological Engineering 2024, 45: 84-91. DOI: 10.1007/s40846-024-00924-1.Peer-Reviewed Original ResearchStandardized uptake valueTc-99SPECT imagesStandard uptake value quantificationTransthyretin cardiac amyloidosisH/CL ratioTc-99m PYP uptakeMethodsOur study cohortInter-observer reproducibilityPlanar imagingTechnetium-99mCardiac amyloidosisClinical suspicionSPECT/CT imagingTc-99m PYP imagingTc-99m PYPConsecutive subjectsUptake valueObserver reproducibilityStudy cohortInter-observerPurposeThe aimResultsIntra-observerMyocardial uptakeSPECTThe Impact of Active Ascertainment on Sex-Specific Differences in the Prevalence and Phenotype of Transthyretin Cardiac Amyloidosis: The Screening for Cardiac Amyloidosis With Nuclear Imaging in Minority Populations Study
Chan N, Einstein A, Teruya S, Rodriguez C, Helmke S, Cuomo M, Santana D, Castillo M, Smiley D, Sabogal N, Lamour S, Winburn M, Fine D, de Freitas C, Kattan C, Miller E, Maurer M, Ruberg F. The Impact of Active Ascertainment on Sex-Specific Differences in the Prevalence and Phenotype of Transthyretin Cardiac Amyloidosis: The Screening for Cardiac Amyloidosis With Nuclear Imaging in Minority Populations Study. The American Journal Of Cardiology 2024, 237: 60-64. PMID: 39581521, PMCID: PMC11761373, DOI: 10.1016/j.amjcard.2024.11.019.Peer-Reviewed Original ResearchATTR-CATransthyretin cardiac amyloidosisProportion of womenCardiac amyloidosisReferral cohortLower left ventricular mass indexHigher left ventricular ejection fractionPrevalence of ATTR-CAATTR-CA patientsWild-type diseaseVentricular ejection fractionVentricular mass indexPosterior wall thicknessAscertainment cohortLeft ventricular hypertrophyReduce sex disparitiesHigher proportion of womenATTRwt-CAEjection fractionEchocardiographic evidenceHeart failureMass indexSex-specific differencesSevere phenotypeSex distributionFrom transthyretin cardiac amyloidosis diagnosis to tafamidis treatment: Association of drop-off with patient sociodemographic characteristics
Walenczyk K, Singh A, Tong K, Burg M, Miller E. From transthyretin cardiac amyloidosis diagnosis to tafamidis treatment: Association of drop-off with patient sociodemographic characteristics. American Journal Of Health-System Pharmacy 2024, 81: 1245-1251. PMID: 38963826, DOI: 10.1093/ajhp/zxae183.Peer-Reviewed Original ResearchPatient sociodemographic characteristicsATTR-CASociodemographic characteristicsSpecialty pharmacyPyrophosphate scintigraphyPopulation prevalence ratesEconomically disadvantaged areasTransthyretin cardiac amyloidosisBlack/African American raceReduce disparitiesPotential patient subgroupsPharmacy processesProportion of daysClinical pathwayCompare sociodemographicsDisadvantaged areasEquitable provisionTafamidis therapyCardiac amyloidosisTafamidis treatmentPrevalence ratesClinical programsAmerican racePatient subgroupsPosting manuscriptsReproducibility for quantification of myocardial Tc-99m PYP amyloid uptake in grade 1 patients
Sandoval V, Goyal D, Miller E, Liu Y. Reproducibility for quantification of myocardial Tc-99m PYP amyloid uptake in grade 1 patients. European Heart Journal - Cardiovascular Imaging 2024, 25: jeae142.047. DOI: 10.1093/ehjci/jeae142.047.Peer-Reviewed Original ResearchStandardized uptake valueTc-99m PYP uptakeTc-99Cardiac amyloidosisHeart failureStandard uptake value quantificationStandardized uptake value calculationSPECT imagesIntractable heart failureSystolic heart failureIntroduction of therapyPlanar imagingTc-99m pyrophosphateAmyloid patientsSPECT/CT imagingInter-reproducibilityUptake valueContralateral ratioCoefficient of variationDisease progressionH/M ratioGrade 1Blood poolPatientsH/CL ratioContemporary American and European Guidelines for Heart Failure Management JACC: Heart Failure Guideline Comparison
Ostrominski J, DeFilippis E, Bansal K, Riello R, Bozkurt B, Heidenreich P, Vaduganathan M. Contemporary American and European Guidelines for Heart Failure Management JACC: Heart Failure Guideline Comparison. JACC Heart Failure 2024, 12: 810-825. PMID: 38583167, DOI: 10.1016/j.jchf.2024.02.020.Peer-Reviewed Original ResearchConceptsEuropean Society of CardiologySocial determinants of healthDeterminants of healthHealth care disparitiesHeart failureClinical practice recommendationsManagement of heart failureCare disparitiesDevice-based therapiesSocial determinantsEvidence-based pharmacotherapyGroup of patientsHF careSociety of CardiologyClinical careHF preventionPotential downstream implicationsCardiac amyloidosisAmerican CollegeHF risk predictionPractice recommendationsManagement pathwayNoncardiac comorbiditiesRisk predictionHF stages
2023
Prevalence and significance of extracardiac uptake on pyrophosphate imaging in the SCAN-MP study: the first 379 cases.
Chan N, Einstein A, Griffin J, Rosenblum H, Teruya S, Cuomo M, De Los Santos J, DeLuca A, Johnson L, Kinkhabwala M, Leb J, Mintz A, Fine D, Helmke S, Muralidhar V, Pandey S, Sabogal N, Saith S, Winburn M, Smiley D, Miller E, Ruberg F, Maurer M. Prevalence and significance of extracardiac uptake on pyrophosphate imaging in the SCAN-MP study: the first 379 cases. Journal Of Nuclear Cardiology 2023, 30: 2531-2539. PMID: 38245059, DOI: 10.1007/s12350-023-03310-7.Peer-Reviewed Original ResearchConceptsTc-99m PYP uptakeExtracardiac uptakeATTR-CACardiac amyloidosisClinically actionable findingsDiagnose transthyretin cardiac amyloidosisTc-99Transthyretin cardiac amyloidosisBone uptakeTime of scanningBreast uptakeTc-99m PYP imagingThyroid uptakeHeart failureBlack raceRenal uptakeNuclear imagingPyrophosphate imagingTechnetium pyrophosphateHispanic ethnicityHispanic participantsNuclear scintigraphyMinority populationsClinicSelf-identifyUneven burden of cardiac amyloidosis in people of African descent — global imbalance in resources and access
Madu E, Mezue K. Uneven burden of cardiac amyloidosis in people of African descent — global imbalance in resources and access. BMC Global And Public Health 2023, 1: 15. PMID: 39681929, PMCID: PMC11622854, DOI: 10.1186/s44263-023-00016-3.Peer-Reviewed Original ResearchTTR-CABlack populationHealthcare financing mechanismsPublic health budgetsCardiac amyloidosisGlobal health equityAt-risk populationsHeart failureHealth literacyHealth equityHealth workersTransthyretin cardiac amyloidosisHealth budgetDiastolic heart failureImprove accessPoor awarenessWest African ancestryDisease RegistryCenters of excellenceInternational Center of ExcellenceUneven burdenFinancial remunerationCaribbean populationGenetic basisAfrican ancestryPrevalence and significance of extracardiac uptake on pyrophosphate imaging in the SCAN-MP study: the first 379 cases
Chan N, Einstein A, Griffin J, Rosenblum H, Teruya S, Cuomo M, De Los Santos J, DeLuca A, Johnson L, Kinkhabwala M, Leb J, Mintz A, Fine D, Helmke S, Muralidhar V, Pandey S, Sabogal N, Saith S, Winburn M, Smiley D, Miller E, Ruberg F, Maurer M. Prevalence and significance of extracardiac uptake on pyrophosphate imaging in the SCAN-MP study: the first 379 cases. Journal Of Nuclear Cardiology 2023, 30: 2531-2539. PMID: 37311914, DOI: 10.1007/s12350-023-03310-7.Peer-Reviewed Original ResearchConceptsExtracardiac uptakePYP uptakeCardiac amyloidosisBone uptakeActionable findingsTiming of scansTransthyretin cardiac amyloidosisHeart failureBreast uptakeMean ageBlack raceRenal uptakeHispanic ethnicityThyroid uptakeATTR-CANuclear scintigraphyHispanic participantsTechnetium pyrophosphateNuclear imagingPYP scanPopulation studiesSelf-identified BlackAdditional testingAmyloidosisSubjectsDesign and Rationale the SCAN‐MP (Screening for Cardiac Amyloidosis With Nuclear Imaging in Minority Populations) Study
Ruberg F, Blaner W, Chiuzan C, Connors L, Einstein A, Fine D, Helmke S, Kurian D, Pandey S, Raiszadeh F, Rodriguez C, Sabogal N, Teruya S, Winburn M, Chung W, Cohn E, Miller E, Kelly J, Maurer M. Design and Rationale the SCAN‐MP (Screening for Cardiac Amyloidosis With Nuclear Imaging in Minority Populations) Study. Journal Of The American Heart Association 2023, 12: e028534. PMID: 37066788, PMCID: PMC10227254, DOI: 10.1161/jaha.122.028534.Peer-Reviewed Original ResearchConceptsATTR-CMHeart failureHealth/National HeartOlder black patientsYears of ageCaribbean Hispanic patientsDeposition of transthyretinNoninvasive nuclear imagingBlack patientsHispanic patientsProspective studyBlood InstituteSelf-identified Black individualsNational HeartCardiac amyloidosisUS FoodImportant causeSecondary objectiveOlder individualsSubstitution of valineHispanic individualsNuclear imagingNational InstituteBlack individualsPatientsThe Association Between Body Mass Index And Functional Status In Minority Patients With Heart Failure With Preserved Ejection Fraction: The SCAN-MP Study
Driggin E, Rosenblum H, Teruya S, Rodriguez C, Kurian D, Raiszadeh F, Fine D, Sabogal N, Edmiston J, Massillon D, Winburn M, Miller E, Ruberg F, Maurer M. The Association Between Body Mass Index And Functional Status In Minority Patients With Heart Failure With Preserved Ejection Fraction: The SCAN-MP Study. Journal Of Cardiac Failure 2023, 29: 668-669. DOI: 10.1016/j.cardfail.2022.10.299.Peer-Reviewed Original ResearchBody mass indexKCCQ overall summary scoreExcess fat massFunctional statusOverall summary scoreObesity statusQuality of lifeMinority patientsFunctional capacityObese patientsEjection fractionHeart failureIndependent predictorsMass indexSPPB scoreFat massCardiac amyloidosisSummary scoresMuscle massShort Physical Performance Battery scoreFirst heart failure hospitalizationMedian body mass indexPhysical Performance Battery scoreHigher Body Mass IndexWorse SPPB scoreAtrial Fibrillation And Conduction Disease Are Associated With Cardiac Amyloidosis Subtypes
Patolia H, Chandramouli S, Cavalier J, Sen S, Arps K, Pokorney S, Karra R, Khouri M. Atrial Fibrillation And Conduction Disease Are Associated With Cardiac Amyloidosis Subtypes. Journal Of Cardiac Failure 2023, 29: 550-551. DOI: 10.1016/j.cardfail.2022.10.014.Peer-Reviewed Original ResearchAtrial fibrillationConduction diseaseVentricular tachycardiaCardiac amyloidosisHigh prevalencePresence of AFCross-sectional observational studyRight bundle branch blockHeart failure symptomsResults Patient characteristicsStandardized chart reviewSubtypes/genotypesPrevalence of arrhythmiasBundle branch blockLonger QRS intervalGenotype-related differencesATTR-CA patientsCardiac amyloidosis subtypesATTR-CMBaseline characteristicsChart reviewPatient characteristicsVentricular arrhythmiasAtrial arrhythmiasInfiltrative diseaseTEMPORALITY OF ISCHEMIC STROKE AND NEW-ONSET ATRIAL FIBRILLATION AND THE UTILITY OF LEFT ATRIAL STRAIN IN PATIENTS WITH CARDIAC AMYLOIDOSIS
Akintoye E, Majid M, Hanna M, Klein A. TEMPORALITY OF ISCHEMIC STROKE AND NEW-ONSET ATRIAL FIBRILLATION AND THE UTILITY OF LEFT ATRIAL STRAIN IN PATIENTS WITH CARDIAC AMYLOIDOSIS. Journal Of The American College Of Cardiology 2023, 81: 340. DOI: 10.1016/s0735-1097(23)00784-2.Peer-Reviewed Original ResearchDiagnostic performance characteristics of planar quantitative and semi-quantitative parameters of Tc99m pyrophosphate (PYP) imaging for diagnosis of transthyretin (ATTR) cardiac amyloidosis: the SCAN-MP study
Pandey S, Teruya S, Rodriguez C, Deluca A, Kinkhabwala M, Johnson L, Fine D, Sabogal N, Winburn M, Castillo M, Bhatia K, Malkovskaya R, Raiszadeh F, Kurian D, Miller E, Einstein A, Maurer M, Ruberg F. Diagnostic performance characteristics of planar quantitative and semi-quantitative parameters of Tc99m pyrophosphate (PYP) imaging for diagnosis of transthyretin (ATTR) cardiac amyloidosis: the SCAN-MP study. Journal Of Nuclear Cardiology 2023, 30: 1414-1419. PMID: 36823486, PMCID: PMC11268194, DOI: 10.1007/s12350-023-03203-9.Peer-Reviewed Original ResearchConceptsTransthyretin cardiac amyloidosisATTR-CACardiac amyloidosisLow pretest probabilityLow pretest likelihoodLV wall thicknessDiagnostic performance characteristicsPositive predictive valueNon-invasive diagnosisConclusionAmong patientsMinority older adultsHeart failurePretest likelihoodPretest probabilitySemi-quantitative parametersPYP uptakeImportant misclassificationPredictive valueImaging thresholdsOptimal heartOlder adultsDiagnostic performancePatientsReference standardScans
2022
The role of cardiac magnetic resonance-based feature-tracking strain analysis in the differential diagnosis and prognostic assessment of patients with left ventricular hypertrophy
Dohy Z, Szabo L, Pozsonyi Z, Csecs I, Toth A, Suhai F, Czimbalmos C, Szucs A, Kiss A, Becker D, Merkely B, Vago H. The role of cardiac magnetic resonance-based feature-tracking strain analysis in the differential diagnosis and prognostic assessment of patients with left ventricular hypertrophy. European Heart Journal 2022, 43: ehac544.272. DOI: 10.1093/eurheartj/ehac544.272.Peer-Reviewed Original ResearchFeature-tracking strain analysisCardiac magnetic resonanceLeft ventricular hypertrophyLV hypertrophyMyocardial diseaseHypertrophic cardiomyopathyEndomyocardial fibrosisBasal LSCardiac amyloidosisCA patientsVentricular hypertrophyGlobal dyssynchronyDifferential diagnosisLeft ventricular (LV) hypertrophyPatient populationCardiac magnetic resonance examinationLV stroke volume indexFabry diseasePrognostic assessment of patientsSignificant independent predictors of mortalityIndependent predictor of mortalityEndomyocardial fibrosis patientsLV strain parametersLV) hypertrophyLV strain analysisRadiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 1: Technical Considerations and Perfusion and Neuronal Imaging.
Stendahl JC, Kwan JM, Pucar D, Sadeghi MM. Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 1: Technical Considerations and Perfusion and Neuronal Imaging. Journal Of Nuclear Medicine 2022, 63: 649-658. PMID: 35487563, PMCID: PMC12079752, DOI: 10.2967/jnumed.121.263506.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsUnmet diagnostic needsCardiovascular medicineNeuronal imagingImaging of inflammationHeart failureValvular diseaseTechnical considerationsDiagnostic needsCardiac amyloidosisUnmet ClinicalNew radiotracersCardiovascular imagingPersonalized therapyPerfusion tracerPET perfusion tracerThrombosisRadiotracer developmentRadiotracerPerfusionF-FlurpiridazImagingReviewMedicineKey technical considerationsMolecular characterization
2021
A Case Report on Papillary Muscle Rupture Following Mitral Valve Replacement in the Setting of Previously Undiagnosed Amyloidosis.
Choudhury N, Munoz Acuna R, Chaudhary O, Chu L, VanderLaan P, Mahmood F, Sharkey A. A Case Report on Papillary Muscle Rupture Following Mitral Valve Replacement in the Setting of Previously Undiagnosed Amyloidosis. A&A Practice 2021, 15: e01415. PMID: 33684090, DOI: 10.1213/xaa.0000000000001415.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseAbsence of CADMitral valve replacement surgeryMitral valve replacementValve replacement surgeryLight chain subtypesCardiac involvementValve replacementArtery diseaseCardiopulmonary bypassAmyloid depositionCase reportReplacement surgeryCardiac amyloidosisSubvalvular apparatusPapillary musclesSubsequent pathologyAmyloidosisPatientsIschemiaSurgeryBypassTherapyMortalitySubtypes
2020
Survival Following Implantable Cardioverter‐Defibrillator Implantation in Patients With Amyloid Cardiomyopathy
Higgins AY, Annapureddy AR, Wang Y, Minges KE, Lampert R, Rosenfeld LE, Jacoby DL, Curtis JP, Miller EJ, Freeman JV. Survival Following Implantable Cardioverter‐Defibrillator Implantation in Patients With Amyloid Cardiomyopathy. Journal Of The American Heart Association 2020, 9: e016038. PMID: 32867553, PMCID: PMC7726970, DOI: 10.1161/jaha.120.016038.Peer-Reviewed Original ResearchConceptsImplantable cardioverter defibrillator implantationCardioverter-defibrillator implantationNonischemic cardiomyopathyCardiac amyloidosisDiabetes mellitusCerebrovascular diseaseVentricular tachycardiaMultivariable Cox proportional hazards regression modelsCox proportional hazards regression modelProportional hazards regression modelsKaplan-Meier survival curvesCox proportional hazards modelPropensity-matched cohortOutcomes of patientsHazards regression modelsProportional hazards modelCause mortalityICD implantationRenal functionMultivariable analysisConclusions MortalityRisk factorsRegistry dataAmyloid cardiomyopathyHigh riskAdvances in PET-Based Cardiac Amyloid Radiotracers
Gallegos C, Miller EJ. Advances in PET-Based Cardiac Amyloid Radiotracers. Current Cardiology Reports 2020, 22: 40. PMID: 32430600, DOI: 10.1007/s11886-020-01284-3.Peer-Reviewed Original ResearchConceptsPositron emission tomographyCardiac amyloidosisAmyloid depositionAmyloid radiotracersCardiac amyloid depositionCare of patientsTransthyretin cardiac amyloidosisCardiac imaging techniquesCongo red stainingPurpose of ReviewWeNovel positron emission tomographyEndomyocardial biopsyImaging featuresAmyloid depositsUnmet needInvasive methodEmission tomographyAmyloidosisGold standardAdditive valueRed stainingBiopsyFurther dataDiagnosisRecent studies
2019
SURVIVAL FOLLOWING IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR IMPLANTATION IN PATIENTS WITH CARDIAC AMYLOIDOSIS
Higgins A, Annapureddy A, Wang Y, Minges K, Lampert R, Rosenfeld L, Jacoby D, Curtis J, Miller E, Freeman J. SURVIVAL FOLLOWING IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR IMPLANTATION IN PATIENTS WITH CARDIAC AMYLOIDOSIS. Journal Of The American College Of Cardiology 2019, 73: 694. DOI: 10.1016/s0735-1097(19)31302-6.Peer-Reviewed Original Research
2018
Time Course of Common Clinical Manifestations in Patients with Transthyretin Cardiac Amyloidosis: Delay From Symptom Onset to Diagnosis
Papoutsidakis N, Miller EJ, Rodonski A, Jacoby D. Time Course of Common Clinical Manifestations in Patients with Transthyretin Cardiac Amyloidosis: Delay From Symptom Onset to Diagnosis. Journal Of Cardiac Failure 2018, 24: 131-133. PMID: 29305186, DOI: 10.1016/j.cardfail.2017.12.005.Peer-Reviewed Original Research
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