2023
Moving toward standardization: physician reporting of sleep studies.
Lastra A, Ingram D, Park J, James E, Matthews C, Canapari C, Mansukhani M, Stahl S. Moving toward standardization: physician reporting of sleep studies. Journal Of Clinical Sleep Medicine 2023, 19: 595-603. PMID: 36546360, PMCID: PMC9978423, DOI: 10.5664/jcsm.10442.Peer-Reviewed Original ResearchConceptsSleep studiesPhysician reportingDurable medical equipment companiesEvidence-based clinical recommendationsSleep medicine specialistsSleep centerClinical recommendationsMedicine specialistsPatient careMedical equipment companiesPatientsCareCaregiversStructured reportingWindow of opportunityReportReportingWide variationClear reportStudyCliniciansSleepPhysiciansRecipientsClinical and Public Health Considerations for HPV Vaccination in Midadulthood: A Narrative Review
King L, Lewnard J, Niccolai L. Clinical and Public Health Considerations for HPV Vaccination in Midadulthood: A Narrative Review. Open Forum Infectious Diseases 2023, 10: ofad004. PMID: 36726535, PMCID: PMC9887268, DOI: 10.1093/ofid/ofad004.Peer-Reviewed Original ResearchHPV vaccinationHuman papillomavirusNarrative reviewHPV natural historyRecurrent respiratory papillomatosisPublic health considerationsRespiratory papillomatosisOropharyngeal cancerAnogenital wartsPrevious infectionCancer casesUS guidelinesVaccinationImportant causeNatural historyAvailable evidenceSexual behaviorPatientsHealth considerationsCancerCliniciansBroad implementationGreater awarenessWide variationPapillomatosis
2022
Health services access, utilization, and barriers for Arabic-speaking refugees resettled in Connecticut, USA
Elreichouni A, Aly S, Maciejewski K, Salem I, Ghossein N, Mankash M, Dziura J, Mowafi H. Health services access, utilization, and barriers for Arabic-speaking refugees resettled in Connecticut, USA. BMC Health Services Research 2022, 22: 1337. PMID: 36369007, PMCID: PMC9652044, DOI: 10.1186/s12913-022-08733-5.Peer-Reviewed Original ResearchConceptsPatient satisfactionHealth servicesCross-sectional observational studyMedian patient satisfactionPatient satisfaction questionnaireChronic medical conditionsHealth service accessHealth seeking behaviourDaily medicationInsurance statusPSQ-18Chronic conditionsObservational studyMedical conditionsMethodsThis studyHealthcare accessSatisfaction questionnaireSeeking behaviourWide variationMedicationsMedical assistanceHigh satisfactionDescriptive statisticsService accessNeed of improvementPostprocedural Pain Associated With 5 Versus 20 Intradetrusor Injections of OnabotulinumtoxinA for Treatment of Overactive Bladder: A Multicenter Randomized Clinical Trial
Chang E, Ringel N, Woodburn K, Tanner J, Bassaly R, Greene K, Wyman A, Iglesia C. Postprocedural Pain Associated With 5 Versus 20 Intradetrusor Injections of OnabotulinumtoxinA for Treatment of Overactive Bladder: A Multicenter Randomized Clinical Trial. Obstetrical & Gynecological Survey 2022, 77: 650-651. DOI: 10.1097/ogx.0000000000001102.Peer-Reviewed Original ResearchOveractive bladderNonneurogenic overactive bladderThird-line therapyΒ-agonist therapyAmerican Urological AssociationFemale pelvic medicineSociety of UrodynamicsIntradetrusor injectionsPain AssociatedTreatment episodesClinical trialsUrological AssociationPelvic medicineBladderTherapyBehavioral changesInjectionWide variationMulticenterOnabotulinumtoxinACholinergicUrodynamicsTrialsPan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination
Fourati S, Tomalin LE, Mulè MP, Chawla DG, Gerritsen B, Rychkov D, Henrich E, Miller HER, Hagan T, Diray-Arce J, Dunn P, Levy O, Gottardo R, Sarwal M, Tsang J, Suárez-Fariñas M, Pulendran B, Kleinstein S, Sékaly R. Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination. Nature Immunology 2022, 23: 1777-1787. PMID: 36316476, PMCID: PMC9747610, DOI: 10.1038/s41590-022-01329-5.Peer-Reviewed Original ResearchConceptsAntibody responsePro-inflammatory response genesToll-like receptor ligandsBlood transcriptional profilesHigher serum antibodyPro-inflammatory responseSerum antibodiesDifferent vaccinesImmune responseImmune stateMetabolism alterationsEndotypesImmune systemVaccinationReceptor ligandsCell proliferationGene expression characteristicsActivation stateDifferential expressionTranscriptional profilesResponse genesExpression characteristicsResponseWide variationAdjuvantUnderstanding the Factors Influencing Health Care Provider Recommendations about Adolescent Vaccines: A Proposed Framework
Ellingson MK, Bednarczyk RA, O’Leary S, Schwartz JL, Shapiro ED, Niccolai LM. Understanding the Factors Influencing Health Care Provider Recommendations about Adolescent Vaccines: A Proposed Framework. Journal Of Behavioral Medicine 2022, 46: 356-365. PMID: 35194726, PMCID: PMC8862696, DOI: 10.1007/s10865-022-00296-4.Peer-Reviewed Original Research
2021
Hospital capacities and shortages of healthcare resources among US hospitals during the coronavirus disease 2019 (COVID-19) pandemic, National Healthcare Safety Network (NHSN), March 27–July 14, 2020
Wu H, Soe M, Konnor R, Dantes R, Haass K, Dudeck M, Gross C, Leaptrot D, Sapiano M, Allen-Bridson K, Wattenmaker L, Peterson K, Lemoine K, Tejedor S, Edwards J, Pollock D, Benin A, Network F. Hospital capacities and shortages of healthcare resources among US hospitals during the coronavirus disease 2019 (COVID-19) pandemic, National Healthcare Safety Network (NHSN), March 27–July 14, 2020. Infection Control And Hospital Epidemiology 2021, 43: 1473-1476. PMID: 34167599, PMCID: PMC8280389, DOI: 10.1017/ice.2021.280.Peer-Reviewed Original ResearchConceptsNational Healthcare Safety NetworkPrevention's National Healthcare Safety NetworkHospital capacityCoronavirus disease 2019 (COVID-19) pandemicDisease 2019 pandemicVentilator usageCase burdenUS hospitalsHealthcare resourcesBed occupancyHealthcare personnelDisease controlSafety NetworkCOVID-19 pandemicHospitalWide variationPandemic
2020
Wide variation in use and interpretation of gene mutation profiling panels among health care providers of patients with myelodysplastic syndromes: results of a large web-based survey
Pine AB, Chokr N, Stahl M, Steensma DP, Sekeres MA, Litzow MR, Luger SM, Stone RM, Greenberg PL, Bejar R, Bewersdorf JP, Gore SD, Zeidan AM. Wide variation in use and interpretation of gene mutation profiling panels among health care providers of patients with myelodysplastic syndromes: results of a large web-based survey. Leukemia & Lymphoma 2020, 61: 1455-1464. PMID: 32026740, DOI: 10.1080/10428194.2020.1723013.Peer-Reviewed Original ResearchConceptsMyelodysplastic syndromeRisk stratificationMolecular profilingNext-generation sequencingWeb-based surveyRole of NGSManagement of patientsUtility of NGSEvidence-based guidelinesHealth care providersLarge web-based surveyMDS patientsPractice patternsTreatment decisionsCare providersResponse assessmentProviders' beliefsPatientsInstitutional guidelinesGene mutationsDiagnosisSyndromeTesting logisticsInterpretation of resultsWide variation
2019
The Evolving Landscape of Impella® Use in the United States Among Patients Undergoing Percutaneous Coronary Intervention with Mechanical Circulatory Support
Amin AP, Spertus JA, Curtis JP, Desai N, Masoudi FA, Bach RG, McNeely C, Al-Badarin F, House JA, Kulkarni H, Rao SV. The Evolving Landscape of Impella® Use in the United States Among Patients Undergoing Percutaneous Coronary Intervention with Mechanical Circulatory Support. Circulation 2019, 141: 273-284. PMID: 31735078, DOI: 10.1161/circulationaha.119.044007.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionMechanical circulatory supportAcute kidney injuryImpella useOdds ratioKidney injuryCoronary interventionClinical outcomesCirculatory supportAdverse outcomesPremier Healthcare DatabaseClustering of patientsHigh rateAdverse eventsPatient levelImpellaPropensity adjustmentHospital levelHealthcare databasesPatientsUS hospitalsHospitalPropensity scoreAssociated outcomesWide variationVariable management strategies for NEC totalis: a national survey
Pyle AK, Shabanova V, Cleary MA, Ozgediz D, Cummings CL, Kamin DS, Mercurio MR. Variable management strategies for NEC totalis: a national survey. Journal Of Perinatology 2019, 39: 1521-1527. PMID: 31371831, DOI: 10.1038/s41372-019-0448-0.Peer-Reviewed Original ResearchConceptsLife-sustaining interventionsNEC totalisSignificant practice variabilityChi-square testVariable management strategiesNeonatal-perinatal medicineSurgical managementAAP SectionTreatment optionsMethodsAn anonymous surveyPediatric surgeryPractice variabilityTotalisSpearman correlationAnonymous surveySerious diseaseNational surveyMost respondentsWide variationEnterocolitisPrematuritySurgeryOptionsCounseling practiceConclusionsManagement
2017
Standards for MRI reporting—the evolution to PI-RADS v 2.0
Spektor M, Mathur M, Weinreb JC. Standards for MRI reporting—the evolution to PI-RADS v 2.0. Translational Andrology And Urology 2017, 6: 355-367. PMID: 28725577, PMCID: PMC5503981, DOI: 10.21037/tau.2017.01.02.Peer-Reviewed Original ResearchPI-RADS v2Prostate-specific antigenProstate cancerTransrectal ultrasoundSerum prostate-specific antigenMultiparametric magnetic resonance imagingIndolent prostate cancerSignificant prostate cancerMagnetic resonance imagingConsensus guidelinesLeading causeMRI reportingResonance imagingLack of standardizationV 2.0Prostate imagingCauseVast majorityWide variationImagingProstateCancerData SystemAntigenDate informationInformation Needs of Older Women With Early-Stage Breast Cancer When Making Radiation Therapy Decisions
Wang SY, Kelly G, Gross C, Killelea BK, Mougalian S, Presley C, Fraenkel L, Evans SB. Information Needs of Older Women With Early-Stage Breast Cancer When Making Radiation Therapy Decisions. International Journal Of Radiation Oncology • Biology • Physics 2017, 98: 733-740. PMID: 28366581, PMCID: PMC5468466, DOI: 10.1016/j.ijrobp.2017.02.001.Peer-Reviewed Original ResearchConceptsRadiation therapy decisionsEarly-stage breast cancerTherapy decisionsOlder womenRadiation therapyBreast cancerSide effectsAdjuvant radiation therapyBreast cancer careBreast cancer survivorsCancer survivorsMean ageCancer careCancer needsResponse rateProfessional Advisory CommitteeTherapyWomenCancerAdvisory CommitteeParticipantsYearsWide variationLumpectomyMain decision makersFactors influencing plasma transfusion practices in paediatric intensive care units around the world
Karam O, Demaret P, Duhamel A, Shefler A, Spinella PC, Tucci M, Leteurtre S, Stanworth SJ, investigators T. Factors influencing plasma transfusion practices in paediatric intensive care units around the world. Vox Sanguinis 2017, 112: 140-149. PMID: 28176380, DOI: 10.1111/vox.12490.Peer-Reviewed Original ResearchConceptsPlasma transfusion practicesPlasma transfusionTransfusion practiceCoagulation testsPediatric intensive care unitInternational pediatric studiesLocal transfusion serviceAbnormal coagulation testsIntensive care unitEfficacy of transfusionSignificant relevant factorTransfusion policyTransfusion rateCare unitAppropriate indicationsPediatric studiesFrequent treatmentTransfusionResponse rateTransfusion servicesLocal investigatorsPatientsCenter characteristicsWide variationBleeding
2014
Increased mortality associated with EMS transport of gunshot wound victims when compared to private vehicle transport
Zafar S, Haider A, Stevens K, Ray-Mazumder N, Kisat M, Schneider E, Chi A, Galvagno S, Cornwell E, Efron D, Haut E. Increased mortality associated with EMS transport of gunshot wound victims when compared to private vehicle transport. Injury 2014, 45: 1320-1326. PMID: 24957424, DOI: 10.1016/j.injury.2014.05.032.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAmbulancesAutomobilesEmergency Medical ServicesFemaleFluid TherapyGravity SuitsHospital MortalityHumansImmobilizationInjury Severity ScoreIntubation, IntratrachealMaleMiddle AgedMonitoring, PhysiologicOutcome and Process Assessment, Health CareRetrospective StudiesTime FactorsTransportation of PatientsTrauma CentersUnited StatesWounds, GunshotConceptsEmergency medical servicesProportion of patientsGSW patientsTrauma centerGunshot woundsNational Trauma Data BankGunshot wound victimsTrauma Data BankIndividual trauma centersMultivariable regression analysisHospital mortalityPatient demographicsUnadjusted mortalityTrauma patientsMultivariable analysisTwofold oddsEMS transportMortality differencesPatientsInjury severityPrivate vehicle transportMortalityWide variationMedical servicesFurther studies
2013
Development of a new oncology quality metric: The rate of evidence-based adherence.
Adelson K, Holcombe R. Development of a new oncology quality metric: The rate of evidence-based adherence. Journal Of Clinical Oncology 2013, 31: 84-84. DOI: 10.1200/jco.2013.31.31_suppl.84.Peer-Reviewed Original ResearchEvidence-based adherenceClinical evidenceEvidence-based practiceEvidence-based clinical pathwayElectronic health recordsNCCN guidelinesBreast groupDose modificationCancer CenterDisease groupClinical trialsClinical pathwayPatient careProportion of protocolsHealth recordsProvider ratesAdherenceGroup rateElectronic protocolFirst cycleGroupWide variationChemotherapyNumber of timesIndividual protocolsDeterminants of fluoroscopy time for invasive coronary angiography and percutaneous coronary intervention: Insights from the NCDR®
Fazel R, Curtis J, Wang Y, Einstein AJ, Smith‐Bindman R, Tsai TT, Chen J, Shah ND, Krumholz HM, Nallamothu BK. Determinants of fluoroscopy time for invasive coronary angiography and percutaneous coronary intervention: Insights from the NCDR®. Catheterization And Cardiovascular Interventions 2013, 82: 1091-1105. PMID: 23703793, DOI: 10.1002/ccd.24996.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionInvasive coronary angiographyHospital-level factorsFluoroscopy timePrior CABGCoronary interventionPrior coronary artery bypassRadiation exposureCoronary artery bypassNumerous clinical scenariosArtery bypassCathPCI RegistryPatient characteristicsCoronary angiographyPCI proceduresModifiable determinantsPatientsClinical scenariosModifiable sourceProcedure complexityCABGMinutesInterventionExposureWide variationChapter 38 Pathophysiology of Sodium Retention and Wastage
Palmer B, Alpern R, Seldin D. Chapter 38 Pathophysiology of Sodium Retention and Wastage. 2013, 1283-1317. DOI: 10.1016/b978-0-12-381462-3.00038-0.Peer-Reviewed Original Research
2011
Genetic Modifiers of Liver Injury in Hereditary Liver Disease
Ala A, Schilsky M. Genetic Modifiers of Liver Injury in Hereditary Liver Disease. Seminars In Liver Disease 2011, 31: 208-214. PMID: 21538285, DOI: 10.1055/s-0031-1276648.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine Triphosphatasesalpha 1-Antitrypsinalpha 1-Antitrypsin DeficiencyAnimalsCation Transport ProteinsCopper-transporting ATPasesDisease ProgressionGenetic Predisposition to DiseaseHemochromatosisHemochromatosis ProteinHepatolenticular DegenerationHeredityHistocompatibility Antigens Class IHumansLiverMembrane ProteinsPhenotypeSeverity of Illness IndexConceptsLiver diseaseWilson's diseaseGenetic hemochromatosisHereditary liver diseasesHepatic injuryLiver injuryIron overloadATP7B genotypeA1-ATC282Y mutationClinical phenotypeDiseaseRegenerative capacityGenetic modifiersPatientsInjuryHemochromatosisHeterozygous genotypeModifier genesGenetic backgroundMutationsWide variationModifier effectSignificant variabilityLiver
2009
Hospital Variation in Time to Defibrillation After In-Hospital Cardiac Arrest
Chan PS, Nichol G, Krumholz HM, Spertus JA, Nallamothu BK. Hospital Variation in Time to Defibrillation After In-Hospital Cardiac Arrest. JAMA Internal Medicine 2009, 169: 1265-1273. PMID: 19636027, DOI: 10.1001/archinternmed.2009.196.Peer-Reviewed Original ResearchConceptsCardiac arrestHospital factorsHospital variationIn-hospital cardiac arrestHospital-level effectsHospital cardiac arrestWorse survivalImproved survivalPatient factorsAdult inpatientsHospital predictorsNational registryHospital ratesCardiopulmonary resuscitationGreater oddsIdentical covariatesDefibrillation delaysHospitalDefibrillationDefibrillation timeSurvivalArrestWide variationPatientsInpatients
2008
Evaluating the process of care in nonvariceal upper gastrointestinal haemorrhage: a survey of expert vs. non‐expert gastroenterologists
ESRAILIAN E, GRALNEK IM, JENSEN D, LAINE L, DULAI GS, EISEN G, SPIEGEL BM. Evaluating the process of care in nonvariceal upper gastrointestinal haemorrhage: a survey of expert vs. non‐expert gastroenterologists. Alimentary Pharmacology & Therapeutics 2008, 28: 1199-1208. PMID: 18729846, DOI: 10.1111/j.1365-2036.2008.03838.x.Peer-Reviewed Original ResearchConceptsHigh-risk bleedingProcess of careIntravenous proton pump inhibitorsNonvariceal upper gastrointestinal hemorrhageUpper gastrointestinal tract hemorrhageLarge-channel endoscopeUpper gastrointestinal hemorrhageUse of hemoclipsGastrointestinal tract hemorrhageProton pump inhibitorsChoice of endoscopeNasogastric lavageGastrointestinal hemorrhageTract hemorrhagePromotility agentsContinuous infusionPump inhibitorsGuideline complianceWide variationBleedingHemorrhageGastroenterologistsVignette surveyCareEndoscope
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