2025
Spermidine is a key polyamine required by intracellular parasites for survival within host erythrocytes
Singh P, Choi J, Cornillot E, Mamoun C. Spermidine is a key polyamine required by intracellular parasites for survival within host erythrocytes. Science Advances 2025, 11: eadv2397. PMID: 40531988, PMCID: PMC12175890, DOI: 10.1126/sciadv.adv2397.Peer-Reviewed Original ResearchConceptsSpermidine biosynthesisIntracellular parasitesRegulate protein translationOxidative stress defenseDe novo synthesisProduction of reactive oxygen speciesTranslational regulationIncreased production of reactive oxygen speciesMolecular functionsProtein translationStress defensePlasmodium falciparum</i>Evolutionary adaptationReactive oxygen speciesAgent of human babesiosisIntraerythrocytic developmentBiosynthesisOxygen speciesHost erythrocytesTherapeutic targetUremic toxin receptor NR1H3 contributes to hyperlipidemia- and chronic kidney disease-accelerated vascular inflammation, which is partially suppressed by novel YBX2 anti-ROS pathway
Lu Y, Sun Y, Saaoud F, Xu K, Shao Y, Han B, Jiang X, Martinez L, Vazquez-Padron R, Mohsin S, Zhao H, Wang H, Yang X. Uremic toxin receptor NR1H3 contributes to hyperlipidemia- and chronic kidney disease-accelerated vascular inflammation, which is partially suppressed by novel YBX2 anti-ROS pathway. Redox Biology 2025, 85: 103724. PMID: 40505347, PMCID: PMC12182350, DOI: 10.1016/j.redox.2025.103724.Peer-Reviewed Original ResearchChronic kidney diseaseReactive oxygen speciesROS regulationNephrectomy-induced chronic kidney diseaseVascular inflammationRNA-binding proteinsReactive oxygen species regulationPromote vascular inflammationPromotion of inflammationCellular ROS levelsTrained immunityDisease progressionKidney diseaseMouse modelCytokine genesMouse aortaProinflammatory genesTranscription factorsRisk factorsRegulating inflammationHyperlipidemiaCardiovascular diseaseInflammationNegative feedback mechanismYBX2ENaC contributes to macrophage dysfunction in cystic fibrosis
Moran J, Pugh C, Brown N, Thomas A, Zhang S, McCauley E, Cephas A, Shrestha C, Partida-Sanchez S, Bai S, Bruscia E, Kopp B. ENaC contributes to macrophage dysfunction in cystic fibrosis. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2025, 329: l61-l69. PMID: 40454714, PMCID: PMC12181047, DOI: 10.1152/ajplung.00009.2025.Peer-Reviewed Original ResearchConceptsCystic fibrosis transmembrane conductance regulatorCystic fibrosis transmembrane conductance regulator modulatorsMonocyte-derived macrophagesEpithelial sodium channelTransmembrane conductance regulatorCystic fibrosisImmune cellsProinflammatory cytokine productionENaC modulationENaC expressionConductance regulatorCystic fibrosis transmembrane conductance regulator inhibitionCytokine productionSodium channelsCF airway epithelial cellsReduced proinflammatory cytokine productionDecreased proinflammatory cytokine productionSodium channel expressionInfection controlTherapeutic targetAirway epithelial cellsIon channel dysfunctionReactive oxygen speciesIon channelsCFTR expressionOxidative Stress in People Living With HIV: Are Diverse Supplement Sources the Solution?
Amegashie E, Sikeola R, Tagoe E, Paintsil E, Torpey K, Quaye O. Oxidative Stress in People Living With HIV: Are Diverse Supplement Sources the Solution? Health Science Reports 2025, 8: e70824. PMID: 40330761, PMCID: PMC12054717, DOI: 10.1002/hsr2.70824.Peer-Reviewed Original ResearchHuman immunodeficiency virusAntiretroviral therapyMemory CD4 T cell responsesCD4 T cell responsesReducing human immunodeficiency virusOxidative stressAnimal modelsAntiretroviral therapy controlsLatent HIV infectionHIV-positive smokersT cell responsesReactive oxygen speciesCell linesT cell agingOxidation protein productsLow levels of antioxidantsIncreased oxidative stressWell-being of PLWHAntioxidant levelsHIV infectionImmunodeficiency virusOxidative stress levelsImmune overactivationOxygen speciesOverproduction of reactive oxygen speciesA compilation of reported alterations in the cerebrospinal fluid proteome in Alzheimer's disease
de Geus M, Nairn A, Arnold S, Carlyle B. A compilation of reported alterations in the cerebrospinal fluid proteome in Alzheimer's disease. Brain Communications 2025, 7: fcaf202. PMID: 40491829, PMCID: PMC12146149, DOI: 10.1093/braincomms/fcaf202.Peer-Reviewed Original ResearchDifferentially expressed proteinsExpressed proteinsAlzheimer's diseaseReactive oxygen speciesFunctional enrichment analysisHeterogeneity of Alzheimer's diseaseAmyloid-bAlzheimer's disease cerebrospinal fluidAlzheimer's disease pathologyAlzheimer's disease datasetProteomic dataProteomic landscapeTau accumulationEnrichment analysisMetabolic regulationOmics studiesCerebrospinal fluid proteomeProtein changesProteinNeurodegenerative disordersDiverse mechanismsSynaptic signal processingDisease pathologyGlutathione metabolismOxygen speciesThe molecular determinants regulating redox signaling in diabetic endothelial cells
Srivastava S, Kopasz-Gemmen O, Thurman A, Rajendran B, Selvam M, Kumar S, Srivastava R, Suresh M, Kumari R, Goodwin J, Inoki K. The molecular determinants regulating redox signaling in diabetic endothelial cells. Frontiers In Pharmacology 2025, 16: 1563047. PMID: 40290438, PMCID: PMC12023289, DOI: 10.3389/fphar.2025.1563047.Peer-Reviewed Original ResearchReactive oxygen speciesProcess of oxidative phosphorylationAberrant activation of mTOR signalingNutrient-sensing kinaseCellular signaling pathwaysCellular ROS levelsLoss of AMPKOxygen speciesActivation of mTOR signalingReactive oxygen species productionIncreased ROSTranscription of pro-inflammatory cytokinesActivation of MAPKCell powerhouseGenerate ATPCell oxidative statusRenal endothelial cellsOxidative phosphorylationRedox signalingDamaged DNASignaling pathwayMolecular determinantsMTOR signalingPI3KAberrant activationHSA Adductomics in the Shanghai Women’s Health Study Links Lung Cancer in Never-Smokers with Air Pollution, Redox Biology, and One-Carbon Metabolism
Imani P, Grigoryan H, Dudoit S, Shu X, Wong J, Zhang L, Zhang J, Hu W, Cai Q, Gao Y, Blechter B, Rahman M, Zheng W, Rothman N, Lan Q, Rappaport S. HSA Adductomics in the Shanghai Women’s Health Study Links Lung Cancer in Never-Smokers with Air Pollution, Redox Biology, and One-Carbon Metabolism. Antioxidants 2025, 14: 335. PMID: 40227422, PMCID: PMC11939640, DOI: 10.3390/antiox14030335.Peer-Reviewed Original ResearchPolycyclic aromatic hydrocarbonsNever-smokersAir pollutionLung cancerOne-carbon metabolismAirborne fine particulate matterLung adenocarcinomaUrinary polycyclic aromatic hydrocarbonsFine particulate matterShanghai Women's Health StudyWomen's Health StudySmoking-related cancersReactive oxygen speciesIncidence of lung adenocarcinomaAromatic hydrocarbonsLung cancer casesParticulate matterEast Asian womenHealth StudyCancer casesAsian womenDietary factorsPollutionHuman serum albuminHigher incidenceModulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology
Stem A, Michel C, Harris P, Rogers K, Gibb M, Roncal-Jimenez C, Reisdorph R, Johnson R, Roede J, Fritz K, Brown J. Modulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology. Particle And Fibre Toxicology 2025, 22: 3. PMID: 39910563, PMCID: PMC11800628, DOI: 10.1186/s12989-025-00619-8.Peer-Reviewed Original ResearchMeSH KeywordsBasic Helix-Loop-Helix Transcription FactorsCell LineChronic Kidney Diseases of Uncertain EtiologyHumansKidney Tubules, ProximalNanoparticlesOccupational ExposureOxidation-ReductionOxidative StressProteomeProteomicsReactive Oxygen SpeciesReceptors, Aryl HydrocarbonRenal Insufficiency, ChronicSaccharumSilicon DioxideSulfhydryl CompoundsConceptsProximal convoluted tubulesActivation of aryl hydrocarbon receptorExposure to silica nanoparticlesDisease of unknown etiologyReactive oxygen speciesKidney proximal convoluted tubuleIncreased reactive oxygen species generationChronic kidney diseaseSignaling pathwayIntroductionChronic kidney diseaseHK-2 cellsReactive oxygen species generationProfile in vitroPotential mechanisms of toxicityMembrane hyperpolarizationCKD progressionUnknown etiologyGeneration of reactive oxygen speciesMitochondrial membrane hyperpolarizationOxygen species generationAryl hydrocarbon receptorEnergy metabolismKidney diseaseConvoluted tubulesMechanisms of toxicityP-551. The Effects of Antiretroviral Therapy on Immune Activation, Inflammation, Cellular Changes and Clinical Outcomes in Elite Controllers
Chan E, Zhou L, Emu B, Paintsil E, Barakat L. P-551. The Effects of Antiretroviral Therapy on Immune Activation, Inflammation, Cellular Changes and Clinical Outcomes in Elite Controllers. Open Forum Infectious Diseases 2025, 12: ofae631.750. PMCID: PMC11777457, DOI: 10.1093/ofid/ofae631.750.Peer-Reviewed Original ResearchEffects of antiretroviral therapyAntiretroviral therapyElite controllersViral loadIL-6Inflammatory markersImmune activationReactive oxygen speciesReactive oxygen species productionAdverse effects of ARTMitochondrial membrane potentialBenefits of antiretroviral therapyAntiretroviral Therapy ToxicitiesInflammatory markers IL-6Antiretroviral therapy groupHIV viral loadMembrane potentialCurrent published dataUtilization of antiretroviral therapyCellular inflammatory markersCompared to baselineViremic controllersClinical outcomesCRP decreaseLevels of mtDNA deletionsOlanzapine Induces Adipogenesis and Glucose Uptake by Activating Glycolysis and Synergizing with the PI3K-AKT Pathway
Li S, Fu Y, Wang W, Qiu J, Huang Y, Li X, Yang K, Yu X, Ma Y, Zhang Y, Zhang M, Li J, Li W. Olanzapine Induces Adipogenesis and Glucose Uptake by Activating Glycolysis and Synergizing with the PI3K-AKT Pathway. Current Neuropharmacology 2025, 23: 412-425. PMID: 39150031, PMCID: PMC12105311, DOI: 10.2174/1570159x22666240815120547.Peer-Reviewed Original ResearchAdministration of olanzapineTreated with olanzapineReactive oxygen speciesDownstream PI3K-Akt signal pathwayAssociated with obesityActive glycolysisAssessed body weightWeight gainDifferentiated 3T3-L1 preadipocytesLiver fat levelsPI3K-Akt pathwayOlanzapineDrug doseFemale miceDietary patternsMetabolic markersPI3K-AktFood intakeGlucose uptakeMouse modelGlycolipid abnormalitiesRodent modelsBody weightGAPDH expressionSignaling pathway
2024
Development of a small molecule-based two-photon photosensitizer for targeting cancer cells
Lee D, Cao Y, Juvekar V, Sauraj, Noh C, Shin S, Liu Z, Kim H. Development of a small molecule-based two-photon photosensitizer for targeting cancer cells. Journal Of Materials Chemistry B 2024, 12: 12232-12238. PMID: 39469993, DOI: 10.1039/d4tb01706d.Peer-Reviewed Original ResearchConceptsTarget cancer cellsReactive oxygen speciesPhotodynamic therapyCancer cellsDiverse cell linesInduced ROS productionColon cancer tissuesTwo-photon (TPCell deathLow dark toxicityCancer modelsTwo-photon photosensitizerROS productionCancer selectivityInduce cell damageThree-dimensional spheroidsCell linesTP excitationImaging-guided photodynamic therapyCancer tissuesOxygen speciesTP-PDTProteolethargy is a pathogenic mechanism in chronic disease
Dall'Agnese A, Zheng M, Moreno S, Platt J, Hoang A, Kannan D, Dall'Agnese G, Overholt K, Sagi I, Hannett N, Erb H, Corradin O, Chakraborty A, Lee T, Young R. Proteolethargy is a pathogenic mechanism in chronic disease. Cell 2024, 188: 207-221.e30. PMID: 39610243, PMCID: PMC11724756, DOI: 10.1016/j.cell.2024.10.051.Peer-Reviewed Original ResearchPathogenic signalsExcessive reactive oxygen speciesMobility phenotypeCellular functionsAffected proteinsPathogenic mechanismsReactive oxygen speciesCysteine residuesSpectra of proteinsProtein mobilityPathogenic stimuliPathogenic featuresOxygen speciesMolecular levelCellular mechanismsDiverse chronic diseasesProteinChronic diseasesBalanced regulation of ROS production and inflammasome activation in preventing early development of colorectal cancer
Li L, Xu T, Qi X. Balanced regulation of ROS production and inflammasome activation in preventing early development of colorectal cancer. Immunological Reviews 2024, 329: e13417. PMID: 39523732, DOI: 10.1111/imr.13417.Peer-Reviewed Original ResearchRegulation of ROS productionBalanced ROS productionReactive oxygen speciesROS productionColitis-associated colorectal cancerInflammasome activationColorectal cancerInnate immune response to microbial infectionResponse to microbial infectionImmune response to microbial infectionReactive oxygen species sensorSource of ROS productionCell-cell contactNADPH oxidase complexInflammasome activation studiesReactive oxygen species generationASC speck formationBalance regulationCrohn's diseaseSignaling networksROS signalingSusceptibility genesNADPH complexPerinuclear regionSterile insultsTMED4 facilitates Treg suppressive function via ROS homeostasis in tumor and autoimmune mouse models
Jiang Z, Wang H, Wang X, Duo H, Tao Y, Li J, Li X, Liu J, Ni J, Wu E, Xiang H, Guan C, Wang X, Zhang K, Zhang P, Hou Z, Liu Y, Wang Z, Su B, Li B, Hao Y, Li B, Wu X. TMED4 facilitates Treg suppressive function via ROS homeostasis in tumor and autoimmune mouse models. Journal Of Clinical Investigation 2024, 135: e179874. PMID: 39480507, PMCID: PMC11684806, DOI: 10.1172/jci179874.Peer-Reviewed Original ResearchEndoplasmic reticulum stressER-associated degradationSuppressive functionTreg cellsFoxp3 stabilityReactive oxygen speciesSuppressive function of Treg cellsFunction of Treg cellsExacerbated inflammatory phenotypeAnti-tumor immunityTreg suppressive functionRegulatory T cellsTreg cell stabilityT cell hyperactivationAutoimmune mouse modelReactive oxygen species homeostasisTreg signatureT cellsTregsInflammatory phenotypeReactive oxygen species scavengingMouse modelTMED4Excessive reactive oxygen speciesProtein 4Understanding the significance of oxygen tension on the biology of Plasmodium falciparum blood stages: From the human body to the laboratory
Nahid D, Coffey K, Bei A, Cordy R. Understanding the significance of oxygen tension on the biology of Plasmodium falciparum blood stages: From the human body to the laboratory. PLOS Pathogens 2024, 20: e1012514. PMID: 39298535, PMCID: PMC11412506, DOI: 10.1371/journal.ppat.1012514.Peer-Reviewed Original ResearchConceptsRed blood cellsIntraerythrocytic developmentReactive oxygen speciesPlasmodium falciparum blood stagesMultiple organ systemsP. falciparum mitochondrionStatus of hemoglobinBlood stagesPlasmodium falciparumReactive oxygen species productionO2-sensing mechanismIn vitro experimentsPlasmodiumBlood cellsOxygenation statusOrgan systemsFunctional changesParasite growthOxidative stressOxygen tensionMosquito hostCulture systemDeep tissuesOxygen speciesBeyond glucose: The crucial role of redox signaling in β-cell metabolic adaptation
Holendová B, Šalovská B, Benáková Š, Plecitá-Hlavatá L. Beyond glucose: The crucial role of redox signaling in β-cell metabolic adaptation. Metabolism 2024, 161: 156027. PMID: 39260557, DOI: 10.1016/j.metabol.2024.156027.Peer-Reviewed Original ResearchPost-translational modificationsReactive oxygen speciesEndoplasmic reticulumTricarboxylic acidRedox signalingPancreatic B-cellsGlucose stimulationModification of proteinsB-cell metabolismRedox signaling pathwaysReversible cysteine oxidationIncreased ROS levelsProduction of reactive oxygen speciesB cell functionInsulin secretionB cellsProtein functionProtein processingCysteine thiol modificationsGlucose-induced increaseOxidative phosphorylationPyruvate metabolismProtein activityRegulatory mechanismsMetabolic pathwaysDeterminants of immune responses predictive of protection against shigellosis in an endemic zone: a systems analysis of antibody profiles and function
Bernshtein B, Kelly M, Cizmeci D, Zhiteneva J, Macvicar R, Kamruzzaman M, Bhuiyan T, Chowdhury F, Khan A, Qadri F, Charles R, Xu P, Kováč P, Clarkson K, Kaminski R, Alter G, Ryan E. Determinants of immune responses predictive of protection against shigellosis in an endemic zone: a systems analysis of antibody profiles and function. The Lancet Microbe 2024, 5: 100889. PMID: 39116906, PMCID: PMC11488819, DOI: 10.1016/s2666-5247(24)00112-5.Peer-Reviewed Original ResearchFlexneri 2aShigella infectionO-specific polysaccharideS sonneiShigella flexneri 2aEndemic settingsAntibody responseInnate immune cell activationProduction of reactive oxygen speciesShigella sonneiFunctional antibody responsesNon-endemic populationCorrelates of protectionShigellaImmune cell activationShigella vaccineNon-endemic settingsReceptor binding profileReactive oxygen speciesSerum samplesAntibody-mediated activationHigh-burden settingsSonneiPredictive of protectionAntibody-mediated complement depositionOvercoming melanin interference in melanocyte photodynamic therapy with a pyrene-derived two-photon photosensitizer
Juvekar V, Cao Y, Koh C, Lee D, Kwak S, Kim S, Park T, Park S, Liu Z, Kim H. Overcoming melanin interference in melanocyte photodynamic therapy with a pyrene-derived two-photon photosensitizer. Chemical Engineering Journal 2024, 493: 152796. DOI: 10.1016/j.cej.2024.152796.Peer-Reviewed Original ResearchPhotodynamic therapyPhotodynamic therapy efficacyPlasma membrane of melanoma cellsMelanoma cellsInhibition of tumor growthReactive oxygen speciesConventional photodynamic therapyTails of miceTreatment of skin diseasesTumor modelTreat melanomaTumor growthMelanin contentMulticellular tumor spheroidsSkin cancerMelanomaVisible light irradiationPDT efficacySkin diseasesMelanin interferenceVisible light excitationBroad absorption spectraChlorin e6ROS generation efficiencyTP-PDTMitochondrial network remodeling of the diabetic heart: implications to ischemia related cardiac dysfunction
Rudokas M, McKay M, Toksoy Z, Eisen J, Bögner M, Young L, Akar F. Mitochondrial network remodeling of the diabetic heart: implications to ischemia related cardiac dysfunction. Cardiovascular Diabetology 2024, 23: 261. PMID: 39026280, PMCID: PMC11264840, DOI: 10.1186/s12933-024-02357-1.Peer-Reviewed Original ResearchConceptsReactive oxygen speciesMitochondrial network remodelingDamaged mitochondrial DNAEfficiency of oxidative phosphorylationImpaired ATP productionMitochondrial ultrastructural alterationsCardiac functionDiabetic heartCellular energy metabolismProduction of reactive oxygen speciesMitochondrial DNAMitochondrial networkMitochondrial fissionExcessive production of reactive oxygen speciesOxidative phosphorylationATP productionResponse to ischemic insultGlobal cardiac functionCell deathOverall cardiac functionCardiac ischemic injuryResponse to injuryCardiac mitochondriaIrreversible cell deathMitochondriaA Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation
Bonetti L, Horkova V, Grusdat M, Longworth J, Guerra L, Kurniawan H, Franchina D, Soriano-Baguet L, Binsfeld C, Verschueren C, Spath S, Ewen A, Koncina E, Gérardy J, Kobayashi T, Dostert C, Farinelle S, Härm J, Fan Y, Chen Y, Harris I, Lang P, Vasiliou V, Waisman A, Letellier E, Becher B, Mittelbronn M, Brenner D. A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation. Cell Metabolism 2024, 36: 1726-1744.e10. PMID: 38986617, DOI: 10.1016/j.cmet.2024.06.010.Peer-Reviewed Original ResearchReactive oxygen speciesMitochondrial functionCatalytic subunit of glutamate cysteine ligaseMitochondrial gene expressionDecreased cellular ATPPhosphorylation of 4E-BP1Disrupt mitochondrial functionReduced phosphorylation of 4E-BP1T cell-specific ablationCell's antioxidant mechanismsCell-specific ablationCatalytic subunitIL-22Cellular signalingIntestinal homeostasisIL-22 productionSignificant reactive oxygen speciesSubunit of glutamate cysteine ligaseGene expressionReduced IL-22 productionReduced phosphorylationCellular ATPGut protectionProtein synthesisGlutamate cysteine ligase
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