2022
Epigenome-wide association study of biomarkers of liver function identifies albumin-associated DNA methylation sites among male veterans with HIV
Titanji BK, Lee M, Wang Z, Chen J, Hui Q, Re V, So-Armah K, Justice AC, Xu K, Freiberg M, Gwinn M, Marconi VC, Sun YV. Epigenome-wide association study of biomarkers of liver function identifies albumin-associated DNA methylation sites among male veterans with HIV. Frontiers In Genetics 2022, 13: 1020871. PMID: 36303554, PMCID: PMC9592923, DOI: 10.3389/fgene.2022.1020871.Peer-Reviewed Original ResearchLiver diseaseLiver biomarkersLiver functionDNAm age accelerationAge accelerationVeterans Aging Cohort StudyEpigenome-wide association studiesFIB-4 scoreAging Cohort StudyMale PWHAPRI scoreCohort studyPlatelet countTotal bilirubinAlanine transaminaseClinical dataBlood samplesIndependent cohortSerum albuminMale veteransHIVImportant causeSignificant associationPWHDNAm sites
2019
Predicting morbidity and mortality in laparoscopic cholecystectomy: Preoperative serum albumin still matters
Rudasill S, Morales R, Sanaiha Y, Sareh S, Antonios J, Khoury H, Mardock A, Benharash P. Predicting morbidity and mortality in laparoscopic cholecystectomy: Preoperative serum albumin still matters. The American Journal Of Surgery 2019, 220: 432-437. PMID: 31831157, DOI: 10.1016/j.amjsurg.2019.12.005.Peer-Reviewed Original ResearchConceptsPreoperative serum albuminLaparoscopic cholecystectomyNormal nutritionMild malnutritionAmerican College of Surgeons National Surgical Quality Improvement ProgramSurgeons National Surgical Quality Improvement ProgramNational Surgical Quality Improvement ProgramAssociated with increased morbiditySurgical Quality Improvement ProgramPostoperative septic shockAssociated with increased riskMultivariate regressionQuality Improvement ProgramModerate malnutritionAdult patientsSeptic shockSevere malnutritionPredicting MorbidityCholecystectomyAmerican CollegeSerum albuminMalnutritionPatientsMortality riskMortalitySerum and Urine Albumin and Response to Loop Diuretics in Heart Failure
Charokopos A, Griffin M, Rao VS, Inker L, Sury K, Asher J, Turner J, Mahoney D, Cox ZL, Wilson FP, Testani JM. Serum and Urine Albumin and Response to Loop Diuretics in Heart Failure. Clinical Journal Of The American Society Of Nephrology 2019, 14: cjn.11600918. PMID: 31010938, PMCID: PMC6500945, DOI: 10.2215/cjn.11600918.Peer-Reviewed Original ResearchConceptsDiuretic efficiencyHeart failureAlbumin levelsDiuretic excretionDiuretic doseInpatient cohortUrine albuminOutpatient cohortLoop diureticsIL-6Higher urine albuminLoop diuretic doseUrinary albumin levelsLow serum albuminPlasma IL-6Heart failure cohortHuman heart failureDiuretic resistanceSuccessful decongestionDiuretic treatmentSystemic inflammationKidney functionSite of actionSerum albuminSodium output
2011
Chapter 59 The Hypocalcemic Disorders Differential Diagnosis and Therapeutic Use of Vitamin D
Carpenter T, Insogna K. Chapter 59 The Hypocalcemic Disorders Differential Diagnosis and Therapeutic Use of Vitamin D. 2011, 1091-1106. DOI: 10.1016/b978-0-12-381978-9.10059-9.ChaptersTotal serum calcium concentrationCalcium concentrationSerum calcium concentrationTotal serum calciumDL declineSecondary hyperparathyroidismSerum calciumSkeletal consequencesVitamin DCalcium measuresClinical guidelinesDifferential diagnosisMineralization defectNormal individualsTherapeutic useHypocalcemiaSerum albuminExtracellular fluidCalcium deficiencyDlCalciumAlbuminHyperparathyroidismHypokalemiaHypoparathyroidism
2009
Ligand-modified gene carriers increased uptake in target cells but reduced DNA release and transfection efficiency
Cu Y, LeMoëllic C, Caplan MJ, Saltzman WM. Ligand-modified gene carriers increased uptake in target cells but reduced DNA release and transfection efficiency. Nanomedicine Nanotechnology Biology And Medicine 2009, 6: 334-343. PMID: 19800989, PMCID: PMC2847641, DOI: 10.1016/j.nano.2009.09.001.Peer-Reviewed Original ResearchConceptsTransfection efficiencyDNA deliveryDNA release rateParticle carriersUnmodified particlesCLINICAL EDITORDrug carriersGene carriersPayload releaseBovine serum albuminCell uptakeParticle surfaceDNA releasePolymer drug carriersPLGASpecific cellsBiodegradable polymersCarriersSerum albuminRelease rateBSAParticlesHigh densityHigh uptakeDelivery
2003
Electrochemically Derived Gradients of the Extracellular Matrix Protein Fibronectin on Gold
Plummer S, Wang Q, Bohn P, Stockton R, Schwartz M. Electrochemically Derived Gradients of the Extracellular Matrix Protein Fibronectin on Gold. Langmuir 2003, 19: 7528-7536. DOI: 10.1021/la030075r.Peer-Reviewed Original ResearchSurface coverageTwo-component gradientsExternal reflection spectroscopyTerminal functional groupsPhysisorbed proteinsAmine groupsBovine serum albuminProtein adsorptionSurface composition gradientFunctional groupsCarboxylic acidsReflection spectroscopyLinear potential profileChemistryGold filmFluorescence microscopyCoverage gradientCarbodiimideSerum albuminFN gradientsGreat promiseComposition gradientPotential profileMicroscopyCellular adhesion
2001
Development of immunoassays for biomonitoring of hexamethylene diisocyanate exposure.
Lemus R, Lukinskeine L, Bier ME, Wisnewski AV, Redlich CA, Karol MH. Development of immunoassays for biomonitoring of hexamethylene diisocyanate exposure. Environmental Health Perspectives 2001, 109: 1103-1108. PMID: 11712993, PMCID: PMC1240469, DOI: 10.1289/ehp.011091103.Peer-Reviewed Original ResearchConceptsHexamethylene diisocyanateHuman serum albuminLaser desorption timeMatrix-assisted laser desorption timeFlight mass spectrometryWorkplace air monitoringMass spectrometryDesorption timeDiisocyanateAdductsDevelopment of immunoassaysHSA antigenSerum albuminMicrotiter platesReactionAir monitoringHexamethylene diisocyanate exposurePpbAbsence of reactionSensitive bioassayNumerous samplesSpectrometryDiphenylPolyurethaneCoatings
2000
Immunological Evidence that Non-carboxymethyllysine Advanced Glycation End-products Are Produced from Short Chain Sugars and Dicarbonyl Compounds in vivo
Takeuchi M, Makita Z, Bucala R, Suzuki T, Koike T, Kameda Y. Immunological Evidence that Non-carboxymethyllysine Advanced Glycation End-products Are Produced from Short Chain Sugars and Dicarbonyl Compounds in vivo. Molecular Medicine 2000, 6: 114-125. PMID: 10859028, PMCID: PMC1949938, DOI: 10.1007/bf03401779.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodiesCattleChromatography, AffinityCross ReactionsDiabetes Mellitus, Type 2Enzyme-Linked Immunosorbent AssayGlycation End Products, AdvancedGlyceraldehydeGlyoxalHumansImmunoblottingKidney Failure, ChronicLysineMaillard ReactionOxidation-ReductionPyruvaldehydeRabbitsRenal DialysisConceptsAGE antibodyCML-AGEDiabetic patientsAGE-bovine serum albuminShort Chain SugarsAdvanced glycation end productsAnti-AGE antibodyGlycation end productsAutoxidation of sugarsImmunization of rabbitsCML-BSADiabetic serumSerum albuminAdvanced glycationAGE contentSugar autoxidationRabbit serum albuminAGE modificationAntibodiesImmunological evidenceApparent molecular weightPatientsAge 3AgeImmunoblot analysis
1999
Potent, Low-Molecular-Weight Non-Peptide Inhibitors of Malarial Aspartyl Protease Plasmepsin II
Haque T, Skillman A, Lee C, Habashita H, Gluzman I, Ewing T, Goldberg D, Kuntz I, Ellman J. Potent, Low-Molecular-Weight Non-Peptide Inhibitors of Malarial Aspartyl Protease Plasmepsin II. Journal Of Medicinal Chemistry 1999, 42: 1428-1440. PMID: 10212129, DOI: 10.1021/jm980641t.Peer-Reviewed Original ResearchConceptsPlasmepsin IIStructure-based designNon-peptide inhibitorsCalculated log P valuesCombinatorial chemistryLog P valuesParallel synthesisHuman serum albuminFocused libraryMolecular weightBest inhibitorApparent bindingEnzyme specificityLow-MolecularSerum albuminAspartyl protease inhibitorsCompoundsSmall molecule inhibitorsHuman proteasesChemistrySelectivitySynthesisSerum proteinsMinimal bindingBinding
1995
Expression of sodium-independent organic anion uptake systems of skate liver in Xenopus laevis oocytes
Jacquemin E, Hagenbuch B, Wolkoff A, Meier P, Boyer J. Expression of sodium-independent organic anion uptake systems of skate liver in Xenopus laevis oocytes. American Journal Of Physiology 1995, 268: g18-g23. PMID: 7840202, DOI: 10.1152/ajpgi.1995.268.1.g18.Peer-Reviewed Original ResearchConceptsBSP uptakeSkate liverTaurocholate uptakeXenopus laevis oocytesOrganic anion transport systemInjection of oocytesLaevis oocytesLiverAnion transport systemRat liverSulfobromophthalein uptakeUptake systemOocytesMRNADisulfonic acidUptake activityFunctional expressionLiver mRNAUptakeExpressionSerum albuminLower vertebrates
1993
Protein-losing enteropathy and hypoalbuminemia in AIDS
Laine L, Garcia F, McGilligan K, Malinko A, Sinatra F, Thomas D. Protein-losing enteropathy and hypoalbuminemia in AIDS. AIDS 1993, 7: 837-840. PMID: 8363760, DOI: 10.1097/00002030-199306000-00012.Peer-Reviewed Original ResearchConceptsNormal bowel habitsProtein-losing enteropathyFecal alphaBowel habitsNormal serum albuminNormal albuminFecal alpha 1Normal albumin groupUrban county hospitalGroup of patientsDevelopment of hypoalbuminemiaUpper endoscopyFlexible sigmoidoscopyAlbumin groupMucosal diseaseCounty HospitalHypoalbuminemiaMAIN OUTCOMEProspective assessmentSerum albuminPatientsLinear regression analysisDiarrheaSignificant negative correlationGross abnormalities
1988
Identification of Factors Associated with the Diagnosis of Delirium in Elderly Hospitalized Patients
Levkoff S, Safran C, Cleary P, Gallop J, Phillips R. Identification of Factors Associated with the Diagnosis of Delirium in Elderly Hospitalized Patients. Journal Of The American Geriatrics Society 1988, 36: 1099-1104. PMID: 3192888, DOI: 10.1111/j.1532-5415.1988.tb04396.x.Peer-Reviewed Original ResearchConceptsUrinary tract infectionLow serum albuminTract infectionsHospital stayRisk factorsElevated white blood cell countWhite blood cell countRisk of deliriumDiagnosis of deliriumBlood cell countCases of deliriumMajor teaching hospitalHospital mortalityDischarge diagnosisHospital chargesSame hospitalTeaching hospitalDeliriumFactors AssociatedPatientsCell countAdmissionInfectionSerum albuminStay
1986
Phorbol Ester Serves As a Coepibolin in the Spreading of Primary Guinea Pig Epidermal Cells
Stenn K, Core N, Halaban R. Phorbol Ester Serves As a Coepibolin in the Spreading of Primary Guinea Pig Epidermal Cells. Journal Of Investigative Dermatology 1986, 87: 754-757. PMID: 2431072, DOI: 10.1111/1523-1747.ep12456946.Peer-Reviewed Original Research
1983
Assay of Na,K-ATPase in plasma membrane preparations: Increasing the permeability of membrane vesicles using sodium dodecyl sulfate buffered with bovine serum albumin
Forbush B. Assay of Na,K-ATPase in plasma membrane preparations: Increasing the permeability of membrane vesicles using sodium dodecyl sulfate buffered with bovine serum albumin. Analytical Biochemistry 1983, 128: 159-163. PMID: 6303151, DOI: 10.1016/0003-2697(83)90356-1.Peer-Reviewed Original ResearchConceptsMaximal Na,K-ATPase activityAmount of membrane proteinNa,K-ATPase activityElectric organ of eelIsolated plasma membranesNa,K-ATPaseSodium dodecyl sulfate bufferK-ATPase activityPlasma membrane preparationsTransmembrane proteinsMembrane proteinsDetergent bufferPlasma membraneOptimal activityActivity of membranesBovine serum albuminMembrane vesiclesK-ATPasePermeability of membrane vesiclesDetergentDetergent activitySulfate bufferProteinVesicular natureSerum albumin
1978
Pyrogen Reactions Associated with the Infusion of Normal Serum Albumin (Human)
Steere A, Rifaat M, Seligmann E, Hochstein H, Friedland G, Dasse P, Wustrack K, Axnick K, Barker L. Pyrogen Reactions Associated with the Infusion of Normal Serum Albumin (Human). Transfusion 1978, 18: 102-107. PMID: 625774, DOI: 10.1046/j.1537-2995.1978.18178118551.x.Peer-Reviewed Original ResearchConceptsNormal serum albuminEndotoxin concentrationsPyrogen reactionsLimulus testAlbumin infusionHospital surveillanceProspective studySame physicianRecurrent reactionsSingle patientPositive testPatientsLimulus amebocyte lysate testInfusionLimulus assaySerum albuminRabbit pyrogen testLysate testMedian concentrationsAlbuminPyrogen testSuspect reactions
1972
Metabolic and Ultrastructural Studies in a Patient With Pustular Psoriasis (von Zumbusch)
Braverman I, Cohen I, O'Keefe E. Metabolic and Ultrastructural Studies in a Patient With Pustular Psoriasis (von Zumbusch). JAMA Dermatology 1972, 105: 189-196. PMID: 4334267, DOI: 10.1001/archderm.1972.01620050003001.Peer-Reviewed Original ResearchConceptsChronic hypoalbuminemiaPustular psoriasisClinical Research CenterPersistent hypocalcemiaUninvolved skinAbnormal vesselsElectron microscopic examinationSkin lesionsWhite womenPatientsEndothelial cellsEndothelial wallMicroscopic examinationHypoalbuminemiaUltrastructural studyPsoriasisCapillary segmentsSerum albuminVesselsHypocalcemiaLesionsMicrocirculationAbnormalitiesMonthsWomen
1968
CYTOTOXICITY MEDIATED BY SOLUBLE ANTIGEN AND LYMPHOCYTES IN DELAYED HYPERSENSITIVITY
Ruddle N, Waksman B. CYTOTOXICITY MEDIATED BY SOLUBLE ANTIGEN AND LYMPHOCYTES IN DELAYED HYPERSENSITIVITY. Journal Of Experimental Medicine 1968, 128: 1255-1265. PMID: 4235040, PMCID: PMC2138586, DOI: 10.1084/jem.128.6.1255.Peer-Reviewed Original ResearchConceptsLymph node cellsNode cellsSensitized lymph node cellsArthus reactivityLewis ratsBN ratsSkin reactivityAllogeneic fibroblastsDelayed hypersensitivitySoluble antigenSpecific antigenHomologous conjugateCytotoxic effectsRatsAntigenHypersensitivityProtein carrierHuman serum albuminCellsAnimalsRat embryo fibroblastsSpecific damageSerum albuminFibroblastsConjugates
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