2022
Nucleic Acid Delivery to the Vascular Endothelium
Reschke M, Piotrowski-Daspit AS, Pober JS, Saltzman WM. Nucleic Acid Delivery to the Vascular Endothelium. Molecular Pharmaceutics 2022, 19: 4466-4486. PMID: 36251765, PMCID: PMC10673694, DOI: 10.1021/acs.molpharmaceut.2c00653.Peer-Reviewed Original Research
2019
Update on Obstetric Hemorrhage
Reale S, Leffert L, Farber M. Update on Obstetric Hemorrhage. Current Anesthesiology Reports 2019, 9: 60-68. DOI: 10.1007/s40140-019-00311-6.Peer-Reviewed Original ResearchPostpartum hemorrhageObstetric hemorrhageRecent evidence-based advancesEarly fibrinogen replacementPreventable maternal morbidityTranexamic acid therapyMassive transfusion protocolRecent epidemiologic dataEvidence-based advancesPostpartum hemorrhage managementConsensus BundleMaternal morbidityTransfusion protocolTransfusion strategyBlood lossAcid therapyEpidemiologic dataFibrinogen replacementHemorrhageHemorrhage managementImportant causeProtocol useEnhanced risk assessmentMorbidityNational Partnership
2015
In vivo systemic chlorogenic acid therapy under diabetic conditions: Wound healing effects and cytotoxicity/genotoxicity profile
Bagdas D, Etoz B, Gul Z, Ziyanok S, Inan S, Turacozen O, Gul N, Topal A, Cinkilic N, Tas S, Ozyigit M, Gurun M. In vivo systemic chlorogenic acid therapy under diabetic conditions: Wound healing effects and cytotoxicity/genotoxicity profile. Food And Chemical Toxicology 2015, 81: 54-61. PMID: 25846499, DOI: 10.1016/j.fct.2015.04.001.Peer-Reviewed Original ResearchConceptsSide effectsOxidative stressStreptozotocin-induced diabetic ratsChronic antioxidant treatmentEndogenous antioxidant defense systemNitric oxide levelsWound healingBlood glucose levelsSystemic antioxidant therapyDays of treatmentPossible side effectsDiabetic wound repairLipid peroxidation levelsChlorogenic acidAcid therapyDiabetic ratsHistopathological examinationPossible pro-oxidative effectsPro-oxidative effectsAntioxidant intakePivotal organAntioxidant therapyDiabetic conditionsAntioxidant balanceGlucose levels
2014
Pharmacologic overview of systemic chlorogenic acid therapy on experimental wound healing
Bagdas D, Gul N, Topal A, Tas S, Ozyigit M, Cinkilic N, Gul Z, Etoz B, Ziyanok S, Inan S, Turacozen O, Gurun M. Pharmacologic overview of systemic chlorogenic acid therapy on experimental wound healing. Naunyn-Schmiedeberg's Archives Of Pharmacology 2014, 387: 1101-1116. PMID: 25129377, DOI: 10.1007/s00210-014-1034-9.Peer-Reviewed Original ResearchConceptsSide effectsWound healingHigh doseBone marrowEffects of CGAAnti-inflammatory effectsDietary chlorogenic acidNitric oxide levelsMatrix metalloproteinase-9Oxidative stress markersPossible side effectsDose-dependent mannerChlorogenic acidCGA supplementationPharmacologic overviewFree radical scavengerAcid therapyCGA treatmentLeukocyte infiltrationPivotal organImmunohistochemical examinationRat bone marrowMetalloproteinase-9Oxide levelsStress markersBioreactor technologies to support liver function in vitro
Ebrahimkhani MR, Neiman JA, Raredon MS, Hughes DJ, Griffith LG. Bioreactor technologies to support liver function in vitro. Advanced Drug Delivery Reviews 2014, 69: 132-157. PMID: 24607703, PMCID: PMC4144187, DOI: 10.1016/j.addr.2014.02.011.Peer-Reviewed Original ResearchConceptsSmall molecule drugsNucleic acid therapyNew experimental modelPrediction of metabolismImmunologic homeostasisAcid therapyLiver functionDrug discoveryMolecule drugsLiver physiologyExperimental modelLong-term liver-specific functionDisease modelsDrug developmentMolecular therapeuticsTarget effectsTherapeuticsWide spectrumIndirect targetsPathophysiologyTherapyLiver-specific functions
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