2025
1761-P: Sex Differences in Emotion Regulation, Leptin, and Eating Behavior in Response to Stress and Food Cues
HORVATH-DIANO C, DAUGINIKAS E, HEILNER E, SAKMAR E, SINHA R, HARVANEK Z. 1761-P: Sex Differences in Emotion Regulation, Leptin, and Eating Behavior in Response to Stress and Food Cues. Diabetes 2025, 74 DOI: 10.2337/db25-1761-p.Peer-Reviewed Original ResearchEmotion regulationResponse to stressEating behaviorsSex differencesLaboratory sessionsFunding National Institutes of HealthSex-specific effectsStress-related eating behaviorFood cuesBehavioral therapyCue conditionEffect of genderEmotionsPersonal stressHormone samplingSnack testAssociated with lower leptinMultiple pre-CuesSignificant interactionAd libAssociated with lower totalSessionsHigher leptinAcute Physiology1771-P: Influence of Stressful and Traumatic Life Events and Chronic Stress on Ad-lib Sweet Food Intake and Its Relationship to Obesity
DOYLE E, FOGELMAN N, JOSEPH K, HU P, JASTREBOFF A, SINHA R. 1771-P: Influence of Stressful and Traumatic Life Events and Chronic Stress on Ad-lib Sweet Food Intake and Its Relationship to Obesity. Diabetes 2025, 74 DOI: 10.2337/db25-1771-p.Peer-Reviewed Original ResearchTraumatic life eventsCumulative Adversity InterviewLife eventsChronic stressSweet food intakeCue contextLife traumaAcute stressCumulative stressful life eventsScript-driven imageryFood ad libitumRecent life eventsStressful life eventsTotal life eventsSnack foods ad libitumSweet food consumptionFood intakeEffects of stressChronic stress scoresStress scoresFood cuesCommunity adultsNeutral contextsCue conditionTraumatic events
2024
Neural Responses to Auditory Food Stimuli Following Cognitive Behavioral Therapy for Binge‐Eating Disorder
Chao A, Agarwal K, Zhou Y, Grilo C, Gur R, Joseph P, Shinohara R, Richmond T, Wadden T. Neural Responses to Auditory Food Stimuli Following Cognitive Behavioral Therapy for Binge‐Eating Disorder. International Journal Of Eating Disorders 2024, 57: 1911-1923. PMID: 38953334, PMCID: PMC11483217, DOI: 10.1002/eat.24244.Peer-Reviewed Original ResearchCognitive behavioral therapyFunctional magnetic resonance imagingBlood oxygen level-dependentWait-list controlBinge-eating disorderBehavioral therapyFunctional magnetic resonance imaging sessionNeutral-relaxing cuesReward-based eating driveReward-related regionsReducing binge eatingMeasured BOLD responsesReward regionsBinge eatingBinge-eating episodesFood cuesEating drivePersonalized scriptsBOLD responseRandomized Controlled TrialsNeural responsesFood-stimuliBinge-eatingCuesMagnetic resonance imaging
2022
A neuromarker for drug and food craving distinguishes drug users from non-users
Koban L, Wager T, Kober H. A neuromarker for drug and food craving distinguishes drug users from non-users. Nature Neuroscience 2022, 26: 316-325. PMID: 36536243, DOI: 10.1038/s41593-022-01228-w.Peer-Reviewed Original ResearchConceptsFood cravingsFunctional magnetic resonance imaging studySelf-regulation strategiesCue-induced drugMagnetic resonance imaging studySelf-reported intensityResonance imaging studyFood cuesVentromedial prefrontalSubstance use disordersIntrospective accessMaladaptive behaviorsNeurobiological markersNeurobiological mechanismsParietal association areasCingulate cortexVentral striatumConvergent validityCore featuresCravingAssociation areasSubstance useNeuromarkersUse disordersClinical interventionsFood cue reactivity in successful laparoscopic gastric banding: A sham-deflation-controlled pilot study
Koenis MMG, Ng J, Anderson B, Stevens MC, Tishler DS, Papasavas PK, Stone A, McLaughlin T, Verhaak A, Domakonda MJ, Pearlson GD. Food cue reactivity in successful laparoscopic gastric banding: A sham-deflation-controlled pilot study. Frontiers In Human Neuroscience 2022, 16: 902192. PMID: 36092648, PMCID: PMC9454014, DOI: 10.3389/fnhum.2022.902192.Peer-Reviewed Original ResearchLaparoscopic adjustable gastric bandingLateral occipital cortexGastric bandingOccipital cortexPilot studyWeight lossExcess weight lossAdjustable gastric bandingLaparoscopic gastric bandingSham-controlled designFood cue reactivityInferior temporal gyrusUnderlying neuronal mechanismsLAGB surgeryUnderwent removalNeuronal changesFrontal cortexLingual gyrusNeuronal mechanismsSurgery changesTemporal gyrusFood cravingsCue reactivityGyrusFood cues
2020
A Laboratory‐Based Study of the Priming Effects of Food Cues and Stress on Hunger and Food Intake in Individuals with Obesity
Chao AM, Fogelman N, Hart R, Grilo CM, Sinha R. A Laboratory‐Based Study of the Priming Effects of Food Cues and Stress on Hunger and Food Intake in Individuals with Obesity. Obesity 2020, 28: 2090-2097. PMID: 32918391, PMCID: PMC7644599, DOI: 10.1002/oby.22952.Peer-Reviewed Original ResearchConceptsHigh-calorie foodsFood cuesWeight statusNormal weightStress cuesScript-driven imagery taskHigh-calorie snack foodsVisual analog scaleLow-calorie snacksNeutral cuesCue exposureAnalog scaleImagery tasksEffects of exposureCue responsesPriming effectTotal caloriesFood intakeObesitySeparate daysCuesAd libitumLaboratory-based experimental studyCaloriesParticipantsCentral nervous pathways of insulin action in the control of metabolism and food intake
Kullmann S, Kleinridders A, Small DM, Fritsche A, Häring HU, Preissl H, Heni M. Central nervous pathways of insulin action in the control of metabolism and food intake. The Lancet Diabetes & Endocrinology 2020, 8: 524-534. PMID: 32445739, DOI: 10.1016/s2213-8587(20)30113-3.Peer-Reviewed Original ResearchConceptsPalatable food cuesCentral insulin actionCurrent findingsInsulin actionCognitive controlFood cuesCognitive healthPeripheral metabolismFood intakeMesocorticolimbic circuitryBrain insulin actionWhole-body insulin sensitivityCentral nervous pathwaysType 2 diabetesHuman researchCognitive diseasesEndogenous glucose productionDopamine systemNervous pathwaysTherapeutic optionsInsulin sensitivitySystemic metabolismAnimal modelsGlucose productionControl of metabolismCirculating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons
Berland C, Montalban E, Perrin E, Di Miceli M, Nakamura Y, Martinat M, Sullivan M, Davis XS, Shenasa MA, Martin C, Tolu S, Marti F, Caille S, Castel J, Perez S, Salinas CG, Morel C, Hecksher-Sørensen J, Cador M, Fioramonti X, Tschöp MH, Layé S, Venance L, Faure P, Hnasko TS, Small DM, Gangarossa G, Luquet SH. Circulating Triglycerides Gate Dopamine-Associated Behaviors through DRD2-Expressing Neurons. Cell Metabolism 2020, 31: 773-790.e11. PMID: 32142669, PMCID: PMC7250662, DOI: 10.1016/j.cmet.2020.02.010.Peer-Reviewed Original ResearchConceptsDopamine receptor subtype 2Lipoprotein lipaseReceptor subtype 2Energy-rich dietDopaminergic transmissionMesocorticolimbic systemDietary triglyceridesSubtype 2Reward deficitsReward circuitMetabolic signaturesWeight gainCompulsive feedingFood cuesTriglyceridesGenetic riskBrain responsesNew mechanistic basisCompulsive behaviorsNeuronsNovel mechanismMechanistic basisDysfunction
2019
Problem drinking alters gray matter volume and food cue responses of the lateral orbitofrontal cortex
Le TM, Zhornitsky S, Wang W, Zhang S, Li C. Problem drinking alters gray matter volume and food cue responses of the lateral orbitofrontal cortex. Addiction Biology 2019, 26: e12857. PMID: 31746092, PMCID: PMC8627684, DOI: 10.1111/adb.12857.Peer-Reviewed Original ResearchConceptsLateral orbitofrontal cortexAlcohol Use Disorders Identification TestGray matter volumeEffect of ProblemOrbitofrontal cortexWhole-brain multiple regressionLeft middle frontal gyrusAlcohol misuseFood cue responsesFunctional magnetic resonance imaging (fMRI) dataVisual food cuesAUDIT scoresMatter volumeMiddle frontal gyrusAffective processesNonfood cuesFood cuesNonfood imagesBrain substratesDisorders Identification TestFrontal gyrusNeural mechanismsFood stimuliCue responsesFood imagesHypothalamic Responses to Cocaine and Food Cues in Individuals with Cocaine Dependence
Zhang S, Zhornitsky S, Le TM, Li CR. Hypothalamic Responses to Cocaine and Food Cues in Individuals with Cocaine Dependence. The International Journal Of Neuropsychopharmacology 2019, 22: 754-764. PMID: 31420667, PMCID: PMC6929672, DOI: 10.1093/ijnp/pyz044.Peer-Reviewed Original ResearchConceptsHealthy control participantsHypothalamic activationCocaine useCocaine-dependent participantsFood cuesCocaine addictionHypothalamic responseControl participantsCocaine Craving QuestionnaireRecent cocaine useFunctional magnetic resonance imagingMagnetic resonance imagingCue-related activationsInferior parietal cortexHypothalamic dysfunctionClinical variablesDopaminergic pathwaysTonic cravingFood intakeQuestionnaire scoresRodent studiesVisual cortexParietal cortexResonance imagingHypothalamusFood craving, cortisol and ghrelin responses in modeling highly palatable snack intake in the laboratory
Sinha R, Gu P, Hart R, Guarnaccia JB. Food craving, cortisol and ghrelin responses in modeling highly palatable snack intake in the laboratory. Physiology & Behavior 2019, 208: 112563. PMID: 31145919, PMCID: PMC6620125, DOI: 10.1016/j.physbeh.2019.112563.Peer-Reviewed Original ResearchConceptsFood cuesHP foodsCue exposureFood cravingsFood motivationFood cue exposureOverweight/obese rangeImagery exposureImagery conditionCue environmentSnack testBiobehavioral processesBody mass indexPalatable foodNeutral conditionsCuesNeuroendocrine responsesSnack intakeGroup effectsOB conditionsCravingTest dayAnxietyWeight gainCortisol response
2018
Food Cues and Obesity: Overpowering Hormones and Energy Balance Regulation
Belfort-DeAguiar R, Seo D. Food Cues and Obesity: Overpowering Hormones and Energy Balance Regulation. Current Obesity Reports 2018, 7: 122-129. PMID: 29619632, PMCID: PMC5959777, DOI: 10.1007/s13679-018-0303-1.BooksConceptsEnergy balance regulationFood cuesObesity epidemicBalance regulationTreatment of obesityDevelopment of obesityPoor treatment outcomesFood cue exposureFood cue reactivityPurpose of ReviewInModern obesogenic environmentFood cue responsesObese individualsWeight managementTreatment outcomesFood intakeCue-elicited responsesPsychosocial interventionsObesityConventional treatmentObesogenic environmentCue exposurePhysiology of feedingCue reactivityHormone
2017
Emotional eating and instructed food-cue processing in adolescents: An ERP study
Wu J, Willner CJ, Hill C, Fearon P, Mayes LC, Crowley MJ. Emotional eating and instructed food-cue processing in adolescents: An ERP study. Biological Psychology 2017, 132: 27-36. PMID: 29097149, PMCID: PMC5801158, DOI: 10.1016/j.biopsycho.2017.10.012.Peer-Reviewed Original ResearchConceptsEvent-related potentialsNonfood cuesFood cuesLate positive potential (LPP) event-related potentialsAutomatic emotional responsesEmotional eating behaviorFood cue processingFronto-central regionsHigh-density EEG recordingsSelf-reported dataLPP amplitudesCognitive resourcesAttention systemMood inductionERP studyEmotional eatingEmotional responsesEating behaviorsNetwork activationCuesAdolescentsGreater EELow eeExploratory analysisEEG recordings
2015
Food cue reactivity and craving predict eating and weight gain: a meta‐analytic review
Boswell RG, Kober H. Food cue reactivity and craving predict eating and weight gain: a meta‐analytic review. Obesity Reviews 2015, 17: 159-177. PMID: 26644270, PMCID: PMC6042864, DOI: 10.1111/obr.12354.Peer-Reviewed Original ResearchConceptsFood cue reactivityCue-induced cravingCue reactivityWeight gainEffect sizeBody mass indexWeight-related outcomesSubsequent weight gainVisual food cuesMass indexTonic cravingFood exposureOverall medium effectClinical implicationsSimilar effect sizesCue exposureMedium effect sizeDietary restraintMeta-analytic reviewFood-related outcomesFood cuesStrong effect sizesCravingSignificant differencesPresent findingsNeurobiological features of binge eating disorder
Balodis IM, Grilo CM, Potenza MN. Neurobiological features of binge eating disorder. CNS Spectrums 2015, 20: 557-565. PMID: 26530404, PMCID: PMC4658223, DOI: 10.1017/s1092852915000814.Peer-Reviewed Original ResearchConceptsBinge-eating disorderOrbitofrontal cortexTreatment of BEDPalatable food cuesInhibitory control processesFrontostriatal areasMotivational processesFood cuesCue responsesPrefrontal areasNeurobiological featuresNeural featuresControl processTreatment effortsSpecific relationshipNeural functionDisordersBingeCuesSystematic reviewRewardHypofunctioningCortexMeasuresFindingsGreater anterior cingulate activation and connectivity in response to visual and auditory high-calorie food cues in binge eating: Preliminary findings
Geliebter A, Benson L, Pantazatos SP, Hirsch J, Carnell S. Greater anterior cingulate activation and connectivity in response to visual and auditory high-calorie food cues in binge eating: Preliminary findings. Appetite 2015, 96: 195-202. PMID: 26275334, PMCID: PMC4684801, DOI: 10.1016/j.appet.2015.08.009.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexHigh-calorie food cuesNon-BE groupFood cuesNeural responsesPsychophysiologic interactionsOrbitofrontal cortexFunctional connectivityGreater functional connectivityRegional brain activationAnterior cingulate activationHigh energy density foodsAnterior cingulate cortexLow-ED foodsAuditory cuesFMRI scanningActivation differencesBrain activationCingulate activationMore activationSupramarginal gyrusNeuroimaging studiesBE groupObese individualsCingulate cortex
2014
Amodal brain activation and functional connectivity in response to high‐energy‐density food cues in obesity
Carnell S, Benson L, Pantazatos SP, Hirsch J, Geliebter A. Amodal brain activation and functional connectivity in response to high‐energy‐density food cues in obesity. Obesity 2014, 22: 2370-2378. PMID: 25098957, PMCID: PMC4224976, DOI: 10.1002/oby.20859.Peer-Reviewed Original ResearchConceptsFunctional connectivityObese individualsFood cuesEffect of obesityLow-ED foodsWhole-brain activationGreater functional connectivityLean womenDifferential neural responsesObesogenic environmentMidbrainExcessive foodVTABrain activationNeural responsesObeseFMRI scanningObesityPutamenCerebellumActivationResponseCue modalityIndividualsWomenHeightened vagal activity during high-calorie food presentation in obese compared with non-obese individuals—Results of a pilot study
Udo T, Weinberger AH, Grilo CM, Brownell KD, DiLeone RJ, Lampert R, Matlin SL, Yanagisawa K, McKee SA. Heightened vagal activity during high-calorie food presentation in obese compared with non-obese individuals—Results of a pilot study. Obesity Research & Clinical Practice 2014, 8: e258-e265. PMID: 24847667, PMCID: PMC4031442, DOI: 10.1016/j.orcp.2013.05.006.Peer-Reviewed Original ResearchConceptsNon-obese individualsHigh-calorie food itemsVagal activityObese individualsHF-HRVHigh-frequency heart rate variabilityHeart rate variabilityConsumption of foodPalatable foodFood itemsAppetitive behaviorCue reactivityPilot studyFood presentationRate variabilityFood cuesFood deprivationObesePotential roleMood statesHRVFurther investigationPresentationInductionMood induction
2013
Metabolic Regulation of Brain Response to Food Cues
de Araujo IE, Lin T, Veldhuizen MG, Small DM. Metabolic Regulation of Brain Response to Food Cues. Current Biology 2013, 23: 878-883. PMID: 23643837, PMCID: PMC3767438, DOI: 10.1016/j.cub.2013.04.001.Peer-Reviewed Original ResearchEffects of Reduced Weight Maintenance and Leptin Repletion on Functional Connectivity of the Hypothalamus in Obese Humans
Hinkle W, Cordell M, Leibel R, Rosenbaum M, Hirsch J. Effects of Reduced Weight Maintenance and Leptin Repletion on Functional Connectivity of the Hypothalamus in Obese Humans. PLOS ONE 2013, 8: e59114. PMID: 23555620, PMCID: PMC3605420, DOI: 10.1371/journal.pone.0059114.Peer-Reviewed Original ResearchConceptsLeptin repletionRight hypothalamusFunctional connectivityFood cuesWeight lossGreater weight lossOrbital frontal cortexDorsal anterior cingulatePsychophysiological interaction analysisPlacebo injectionsObese subjectsObese populationLeptin injectionObese humansWeight maintenanceFrontal cortexAnterior cingulateHypothalamusFrontal poleInteroceptive systemPatient subjectsVisual areasDorsal ACCFood stimuliRepletion
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