2025
N-acetylcysteine reduces prefrontal reactivity to cocaine cues in individuals with cocaine use disorder
Engeli E, Preller K, Rieser N, Klar J, Staempfli P, Hulka L, Kirschner M, Seifritz E, Herdener M. N-acetylcysteine reduces prefrontal reactivity to cocaine cues in individuals with cocaine use disorder. Frontiers In Psychiatry 2025, 15: 1489194. PMID: 40083914, PMCID: PMC11903417, DOI: 10.3389/fpsyt.2024.1489194.Peer-Reviewed Original ResearchCocaine use disorderSuperior frontal gyrusCue reactivityCocaine cuesUse disorderFrontal gyrusPrefrontal regionsResponse to cocaine cuesTreating cocaine use disorderDuration of cocaine useModulation of glutamatergic signalingCue reactivity paradigmCue-induced activationDrug cue reactivityIncreased cue reactivityNeural cue reactivityCue-induced cravingMedial prefrontal regionsRisk of substance usePlacebo-controlled cross-over trialAlleviate cravingCocaine cravingCocaine picturesNucleus accumbensRelapse behaviorPreliminary effects of oral ANS-6637, an ALDH2 inhibitor, on cue-induced craving, safety and alcohol consumption among adults with alcohol use disorder: a proof-of-concept, randomized, human laboratory trial
O’Malley S, Miranda R, Book S, Chun T, Liss T, Malcolm R, Muvvala S, Padovano H, Schacht J, Blackburn B, Diamond I, Ransom J, Ryan M, Falk D, Litten R. Preliminary effects of oral ANS-6637, an ALDH2 inhibitor, on cue-induced craving, safety and alcohol consumption among adults with alcohol use disorder: a proof-of-concept, randomized, human laboratory trial. Alcohol And Alcoholism 2025, 60: agaf001. PMID: 39829301, PMCID: PMC11744046, DOI: 10.1093/alcalc/agaf001.Peer-Reviewed Original ResearchAlcohol use disorderAldehyde dehydrogenase 2 inhibitorUse disorderTreat alcohol use disorderCue reactivity sessionsCue-elicited cravingCue-induced cravingHuman laboratory studiesTreatment-seeking adultsAlcohol use disorder pharmacotherapiesAldehyde dehydrogenase 2Multisite clinical trialDose to placeboWeeks of medicationEffect size estimatesReactivation sessionDrinking outcomesGroup differencesCravingMeasured 1 weekEffect sizeCohen's dDouble-blindPreliminary effectivenessAlcohol consumption
2024
Neural responses to stress and alcohol cues in individuals with pain with and without alcohol use disorder
Radoman M, McGowan C, Heilner E, Lacadie C, Sinha R. Neural responses to stress and alcohol cues in individuals with pain with and without alcohol use disorder. Addiction Biology 2024, 29: e70010. PMID: 39660770, PMCID: PMC11632857, DOI: 10.1111/adb.70010.Peer-Reviewed Original ResearchConceptsAnterior insular cortexAlcohol use disorderRight anterior insular cortexOrbitofrontal cortexUse disorderAlcohol cue-induced cravingStages of alcohol use disorderDorsal anterior cingulate cortexLeft anterior insular cortexNeural responses to stressAlcohol cue-reactivityCue-elicited cravingOFC responsesRight dorsal caudateCue-induced cravingAnterior cingulate cortexVoxel-based analysisResponse to stressPreoccupation/anticipation stageAlcohol cuesCraving assessmentCue-reactivityAmygdala hyperactivationAlcohol cravingCue exposureNeural Correlates of Stress and Alcohol Cue-Induced Alcohol Craving and of Future Heavy Drinking: Evidence of Sex Differences
Radoman M, Fogelman N, Lacadie C, Seo D, Sinha R. Neural Correlates of Stress and Alcohol Cue-Induced Alcohol Craving and of Future Heavy Drinking: Evidence of Sex Differences. American Journal Of Psychiatry 2024, 181: 412-422. PMID: 38706332, PMCID: PMC11117176, DOI: 10.1176/appi.ajp.20230849.Peer-Reviewed Original ResearchConceptsAlcohol use disorderPercentage of heavy drinking daysNeural correlates of stressCue-induced cravingHeavy drinking daysAlcohol cravingSex differencesCorrelates of stressDrinking daysAlcohol cue-induced cravingCue-induced alcohol cravingBed nucleus of the stria terminalisSubgenual anterior cingulate cortexAssessment of alcohol cravingHeavy drinkingAlcohol cue reactivityAssociated with poor treatment outcomesCue-induced responsesNeutral cue exposureAssociated with hypoactivationTreatment-seeking adultsHeavy drinking outcomesEvidence of sex differencesVoxel-based regression analysisAnterior cingulate cortex
2023
Randomized Trial of Mindfulness- and Reappraisal-Based Regulation of Craving Training Among Daily Cigarette Smokers
Roos C, Harp N, Vafaie N, Gueorguieva R, Frankforter T, Carroll K, Kober H. Randomized Trial of Mindfulness- and Reappraisal-Based Regulation of Craving Training Among Daily Cigarette Smokers. Psychology Of Addictive Behaviors 2023, 37: 829-840. PMID: 37535555, PMCID: PMC10834831, DOI: 10.1037/adb0000940.Peer-Reviewed Original ResearchCue-induced cravingDaily cigarette smokersGreater reductionSmoking-related imagesRandomized trialsCigarette smokersDaily smokersQuit ratesSmokingLarge effect sizesIntervention phaseIntervention controlCravingSmokersComputerized interventionSignificant increaseCBTEffect sizeEntire studyInterventionControlPostinterventionROCRegulationTrials
2022
Pregnenolone effects on provoked alcohol craving, anxiety, HPA axis, and autonomic arousal in individuals with alcohol use disorder
Milivojevic V, Sullivan L, Tiber J, Fogelman N, Simpson C, Hermes G, Sinha R. Pregnenolone effects on provoked alcohol craving, anxiety, HPA axis, and autonomic arousal in individuals with alcohol use disorder. Psychopharmacology 2022, 240: 101-114. PMID: 36445398, PMCID: PMC10630889, DOI: 10.1007/s00213-022-06278-3.Peer-Reviewed Original ResearchConceptsAlcohol use disorderDiastolic blood pressureHeart rateGABAergic transmissionNeuroactive steroidsHPA axisRelapse riskUse disordersAlcohol cravingTreatment of AUDAlcohol cue-induced cravingPilot clinical trialStress-induced anxietyCue-induced cravingAutonomic arousalNeurosteroid systemPreg groupStudy drugDBP responseBlood pressureDay groupClinical trialsPregnenolone levelsWeek 2Cue-provoked cravingPregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder
Milivojevic V, Charron L, Fogelman N, Hermes G, Sinha R. Pregnenolone Reduces Stress-Induced Craving, Anxiety, and Autonomic Arousal in Individuals with Cocaine Use Disorder. Biomolecules 2022, 12: 1593. PMID: 36358943, PMCID: PMC9687893, DOI: 10.3390/biom12111593.Peer-Reviewed Original ResearchConceptsDiastolic blood pressureCocaine use disorderHeart ratePrecursor pregnenoloneUse disordersCocaine cravingCue-induced cocaine cravingCue-induced anxietyWeeks of treatmentCue-induced cravingAutonomic arousalChronic cocaine usePreg groupBlood pressureDay groupRelapse riskHigher cocainePregnenolone levelsCue-provoked cravingSeparate daysAutonomic responsesCocaine useTreatment-seeking individualsCravingSteroid systemsAssociation of Drug Cues and Craving With Drug Use and Relapse
Vafaie N, Kober H. Association of Drug Cues and Craving With Drug Use and Relapse. JAMA Psychiatry 2022, 79: 641-650. PMID: 35648415, PMCID: PMC9161117, DOI: 10.1001/jamapsychiatry.2022.1240.Peer-Reviewed Original Research
2020
Biological Underpinning of Behavioral Addictions and Management Implications
Yau Y, Leeman R, Potenza M. Biological Underpinning of Behavioral Addictions and Management Implications. 2020, 889-910. DOI: 10.1007/978-3-030-36391-8_63.ChaptersCommon and gender‐specific associations with cocaine use on gray matter volume: Data from the ENIGMA addiction working group
Rabin RA, Mackey S, Parvaz MA, Cousijn J, Li C, Pearlson G, Schmaal L, Sinha R, Stein E, Veltman D, Thompson PM, Conrod P, Garavan H, Alia‐Klein N, Goldstein RZ. Common and gender‐specific associations with cocaine use on gray matter volume: Data from the ENIGMA addiction working group. Human Brain Mapping 2020, 43: 543-554. PMID: 32857473, PMCID: PMC8675419, DOI: 10.1002/hbm.25141.Peer-Reviewed Original ResearchConceptsGray matter volumeCocaine useCocaine-dependent individualsMatter volumeCD individualsWhole-brain linear regressionAnterior insulaHippocampal gray matter volumeSelect brain areasT1-weighted MRI scansGender-specific associationsTotal intracranial volumeENIGMA Addiction Working GroupCue-induced cravingLeft anterior insulaGender-specific mechanismsAge-matched participantsCD menCD womenVoxel-based morphometry dataControl menLimbic regionsClinical dataMRI scansBrain areasThe effects of repetitive transcranial magnetic stimulation on cue-induced craving in male patients with heroin use disorder
Liu X, Zhao X, Liu T, Liu Q, Tang L, Zhang H, Luo W, Daskalakis ZJ, Yuan TF. The effects of repetitive transcranial magnetic stimulation on cue-induced craving in male patients with heroin use disorder. EBioMedicine 2020, 56: 102809. PMID: 32512513, PMCID: PMC7276507, DOI: 10.1016/j.ebiom.2020.102809.Peer-Reviewed Original ResearchConceptsOpioid use disorderRepetitive transcranial magnetic stimulationDorsolateral prefrontal cortexTranscranial magnetic stimulationTreatment cessationHz rTMSMagnetic stimulationUse disordersHeroin use disorder patientsDaily consecutive sessionsHeroin use disorderLeft dorsolateral prefrontal cortexTreatment effectsWait-list groupCue-induced cravingHeroin patientsMale patientsDisorder patientsHeroin usersPatientsList groupRehabilitation centerSuch treatment effectsPrefrontal cortexRTMSEffects of Alcohol Cue Reactivity on Subsequent Treatment Outcomes Among Treatment‐Seeking Individuals with Alcohol Use Disorder: A Multisite Randomized, Double‐Blind, Placebo‐Controlled Clinical Trial of Varenicline
Miranda R, O’Malley S, Padovano H, Wu R, Falk DE, Ryan ML, Fertig JB, Chun TH, Muvvala SB, Litten RZ. Effects of Alcohol Cue Reactivity on Subsequent Treatment Outcomes Among Treatment‐Seeking Individuals with Alcohol Use Disorder: A Multisite Randomized, Double‐Blind, Placebo‐Controlled Clinical Trial of Varenicline. Alcohol Clinical And Experimental Research 2020, 44: 1431-1443. PMID: 32363592, PMCID: PMC7572549, DOI: 10.1111/acer.14352.Peer-Reviewed Original ResearchConceptsAlcohol use disorderEffects of vareniclineAlcohol cue reactivityClinical trialsCue-reactivity paradigmAlcohol useCue reactivityUse disordersHuman laboratoryAlcohol cue-induced cravingSubsequent treatment outcomesΑ4β2 nicotinic acetylcholine receptorsCue-induced alcoholAlcohol cue reactivity paradigmCue-induced cravingNicotinic acetylcholine receptorsHeavy alcohol useCue-elicited cravingHuman laboratory paradigmTreatment outcomesVareniclinePlaceboProspective associationsAlcohol cravingAcetylcholine receptorsRegulating food craving: From mechanisms to interventions
Sun W, Kober H. Regulating food craving: From mechanisms to interventions. Physiology & Behavior 2020, 222: 112878. PMID: 32298667, PMCID: PMC7321886, DOI: 10.1016/j.physbeh.2020.112878.Peer-Reviewed Original ResearchConceptsCognitive strategiesCue reactivityNeural mechanismsCue-induced cravingUnderlying neural mechanismsToxic food environmentSubsequent food choiceFood cravingsCommon experienceCravingFood choicesStrong desireWeight outcomesFuture directionsCausal effectClinical perspectiveImportant lineInterventionTaskFood environmentCaloric consumptionPromising effectsObesity epidemicIndividualsExperience
2018
Hypothalamic response to cocaine cues and cocaine addiction severity
Zhang S, Zhornitsky S, Angarita GA, Li C. Hypothalamic response to cocaine cues and cocaine addiction severity. Addiction Biology 2018, 25: e12682. PMID: 30295396, PMCID: PMC6453736, DOI: 10.1111/adb.12682.Peer-Reviewed Original ResearchConceptsCocaine Craving QuestionnaireCocaine Selective Severity AssessmentFunctional magnetic resonance imagingCocaine-dependent individualsAddiction severityOrbitofrontal cortexHypothalamic responseVentral striatumCocaine addictionCocaine cuesAngular gyrusBilateral orbitofrontal cortexBilateral visual cortexCue-induced cravingMagnetic resonance imagingMiddle frontal gyrusClinical featuresNeutral cuesDopaminergic circuitsHypothalamusVisual cortexResonance imagingDopaminergic midbrainFrontal gyrusAg response
2015
Food cue reactivity and craving predict eating and weight gain: a meta‐analytic review
Boswell RG, Kober H. Food cue reactivity and craving predict eating and weight gain: a meta‐analytic review. Obesity Reviews 2015, 17: 159-177. PMID: 26644270, PMCID: PMC6042864, DOI: 10.1111/obr.12354.Peer-Reviewed Original ResearchConceptsFood cue reactivityCue-induced cravingCue reactivityWeight gainEffect sizeBody mass indexWeight-related outcomesSubsequent weight gainVisual food cuesMass indexTonic cravingFood exposureOverall medium effectClinical implicationsSimilar effect sizesCue exposureMedium effect sizeDietary restraintMeta-analytic reviewFood-related outcomesFood cuesStrong effect sizesCravingSignificant differencesPresent findingsNeural Mechanisms Associated with Stress‐Induced Drug Craving
Milivojevic V, Fox H, Sinha R. Neural Mechanisms Associated with Stress‐Induced Drug Craving. 2015, 240-265. DOI: 10.1002/9781118472415.ch11.ChaptersStress-induced drug cravingDrug cravingBrain circuitryMedial prefrontal activityStress-induced cravingCue-induced cravingHigh arousal statesPathophysiology of addictionRole of stressAvoidance motivationBiology of stressNeural correlatesPrefrontal activityIncentive motivationNeural mechanismsAddicted individualsNegative reinforcementDrug useRelapse outcomesCravingArousal stateSubstance abuseAnxietyMotivationConditions of stressNeural Mechanisms Underlying Craving and the Regulation of Craving
Kober H, Mell M. Neural Mechanisms Underlying Craving and the Regulation of Craving. 2015, 195-218. DOI: 10.1002/9781118472415.ch9.ChaptersFunctional magnetic resonance imagingVentral striatumNeural activityRegulation of cravingVentrolateral prefrontal cortexCue-induced cravingMindfulness-based treatmentsAnterior cingulate cortexCentral causal roleWealth of researchCognitive strategiesRegulation strategiesPrefrontal cortexCingulate cortexBrain regionsCravingPositron emission tomography studyCausal roleEmission tomography studiesDrug useAddictionCortexMagnetic resonance imagingResonance imagingAmygdalaN‐Methyl‐d‐Aspartate Receptor Antagonism has Differential Effects on Alcohol Craving and Drinking in Heavy Drinkers
Krishnan‐Sarin S, O'Malley SS, Franco N, Cavallo DA, Morean M, Shi J, Pittman B, Krystal JH. N‐Methyl‐d‐Aspartate Receptor Antagonism has Differential Effects on Alcohol Craving and Drinking in Heavy Drinkers. Alcohol Clinical And Experimental Research 2015, 39: 300-307. PMID: 25664775, PMCID: PMC4331214, DOI: 10.1111/acer.12619.Peer-Reviewed Original ResearchConceptsAlcohol drinkingFamily historyHeavy drinkersAlcohol cravingN-methyl-D-aspartate receptor antagonistN-methyl-D-aspartate receptor antagonismAlcohol cue-induced cravingEffects of FHHigher baseline levelsPresence of impulsivityAlcohol use disorderCue-induced cravingAlcohol-induced stimulationReceptor antagonismReceptor antagonistPriming doseNMDA receptorsUse disordersMemantineBaseline levelsModulatory influencePotential efficacyAlcohol accessDrinkersEighth day
2014
Biological Underpinning of Behavioural Addictions and Management Implications
Yau Y, Leeman R, Potenza M. Biological Underpinning of Behavioural Addictions and Management Implications. 2014, 1411-1442. DOI: 10.1007/978-88-470-5322-9_71.ChaptersBehavioral addictionsCue-induced cravingNon-substance addictionVideo game playPresent chapter reviewsMaladaptive engagementNeurocircuitry levelImpaired inhibitionFrontal areasBrain regionsMultiple domainsNeurochemical levelsBiological underpinningsMesolimbic dopaminergic pathwayAddictionGenetic overlapArea of researchChapter reviewsHistory evidenceInternet useDopaminergic pathwaysPsychopathologyCravingGamblingEating
2013
The effects of exogenous progesterone on drug craving and stress arousal in cocaine dependence: Impact of gender and cue type
Fox HC, Sofuoglu M, Morgan PT, Tuit KL, Sinha R. The effects of exogenous progesterone on drug craving and stress arousal in cocaine dependence: Impact of gender and cue type. Psychoneuroendocrinology 2013, 38: 1532-1544. PMID: 23374328, PMCID: PMC3772967, DOI: 10.1016/j.psyneuen.2012.12.022.Peer-Reviewed Original ResearchMeSH KeywordsAdrenocorticotropic HormoneAdultAffectAlcohol DrinkingAnxietyArousalBlood PressureCocaine-Related DisordersComorbidityCuesDepressionDouble-Blind MethodEmotionsEstradiolFemaleHeart RateHumansHydrocortisoneHypothalamo-Hypophyseal SystemImagery, PsychotherapyMaleMiddle AgedPituitary-Adrenal SystemProgesteroneRelaxation TherapySex CharacteristicsSmokingStress, PsychologicalStroop TestConceptsDrug cravingCocaine-dependent menCognitive performanceStress arousalTreatment-seeking cocaine dependent individualsCue-induced cravingCocaine-dependent individualsCue typesStroop performanceSubjective cravingCognitive measuresImagery conditionNegative emotionsCue exposureInhibitory controlRelaxed moodDependent individualsDependent menArousal stateCravingArousalCounterbalanced orderStress exposureRewarding effectsCocaine dependence
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