2018
Glial Fatty Acid-Binding Protein 7 (FABP7) Regulates Neuronal Leptin Sensitivity in the Hypothalamic Arcuate Nucleus
Yasumoto Y, Miyazaki H, Ogata M, Kagawa Y, Yamamoto Y, Islam A, Yamada T, Katagiri H, Owada Y. Glial Fatty Acid-Binding Protein 7 (FABP7) Regulates Neuronal Leptin Sensitivity in the Hypothalamic Arcuate Nucleus. Molecular Neurobiology 2018, 55: 9016-9028. PMID: 29623545, DOI: 10.1007/s12035-018-1033-9.Peer-Reviewed Original ResearchConceptsFabp7 KO miceFatty Acid Binding Protein 7Arcuate nucleusHypothalamic arcuate nucleusKO miceFood intakeMedian eminenceFatty acid-binding protein 7Energy homeostasisWeight gainSingle leptin injectionHigh-fat dietNon-neuronal cell typesWild-type miceProtein 7Systemic energy homeostasisLeptin-induced activationPrimary astrocyte culturesNeuronal leptinHypothalamic astrocytesWT miceLeptin injectionObese miceHypothalamic sitesLeptin treatment
2013
Effects of Reduced Weight Maintenance and Leptin Repletion on Functional Connectivity of the Hypothalamus in Obese Humans
Hinkle W, Cordell M, Leibel R, Rosenbaum M, Hirsch J. Effects of Reduced Weight Maintenance and Leptin Repletion on Functional Connectivity of the Hypothalamus in Obese Humans. PLOS ONE 2013, 8: e59114. PMID: 23555620, PMCID: PMC3605420, DOI: 10.1371/journal.pone.0059114.Peer-Reviewed Original ResearchConceptsLeptin repletionRight hypothalamusFunctional connectivityFood cuesWeight lossGreater weight lossOrbital frontal cortexDorsal anterior cingulatePsychophysiological interaction analysisPlacebo injectionsObese subjectsObese populationLeptin injectionObese humansWeight maintenanceFrontal cortexAnterior cingulateHypothalamusFrontal poleInteroceptive systemPatient subjectsVisual areasDorsal ACCFood stimuliRepletion
2009
Human IL6 enhances leptin action in mice
Sadagurski M, Norquay L, Farhang J, D’Aquino K, Copps K, White M. Human IL6 enhances leptin action in mice. Diabetologia 2009, 53: 525-535. PMID: 19902173, PMCID: PMC2815798, DOI: 10.1007/s00125-009-1580-8.Peer-Reviewed Original ResearchConceptsOb/ob miceWild-type miceOb miceHuman IL6Leptin actionDiet-induced obesityHigh-fat dietLower leptin concentrationsHypothalamic signal transducerCentral leptin actionSystemic inflammationTranscription 3 (STAT3) phosphorylationLeptin injectionInflammatory cytokinesInsulin resistanceLeptin concentrationsFood intakePhysical activityGlucose homeostasisAims/Body weightIL6MiceEnergy expenditureObesity
2008
Bsx, a Novel Hypothalamic Factor Linking Feeding with Locomotor Activity, Is Regulated by Energy Availability
Nogueiras R, López M, Lage R, Perez-Tilve D, Pfluger P, Mendieta-Zerón H, Sakkou M, Wiedmer P, Benoit SC, Datta R, Dong JZ, Culler M, Sleeman M, Vidal-Puig A, Horvath T, Treier M, Diéguez C, Tschöp M. Bsx, a Novel Hypothalamic Factor Linking Feeding with Locomotor Activity, Is Regulated by Energy Availability. Endocrinology 2008, 149: 3009-3015. PMID: 18308842, PMCID: PMC2408820, DOI: 10.1210/en.2007-1684.Peer-Reviewed Original ResearchConceptsHigh-fat dietArcuate nucleusLeptin resistanceMelanocortin-4 receptor knockout miceObese leptin-deficient miceAgouti gene-related proteinCentral nervous system controlNovel hypothalamic factorPeripheral energy balanceOrexigenic neuropeptide YReceptor knockout miceSpontaneous physical activityGhrelin receptor antagonistLeptin-deficient miceNervous system controlEnergy balance signalsFasting-induced increaseGene-related proteinGhrelin administrationLeptin injectionPharmacological modificationNeuropeptide YGhrelin signalingHypothalamic factorsReceptor antagonist
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply