2023
Sensory Systems in the Peripheral and Central Nervous Systems Shape Host Response During Infections
Wyart C, Jim K, Prendergast A. Sensory Systems in the Peripheral and Central Nervous Systems Shape Host Response During Infections. Neuroscience 2023, 525: 47-50. PMID: 37419406, DOI: 10.1016/j.neuroscience.2023.07.008.Peer-Reviewed Original ResearchConceptsSensory cellsNervous systemInternal physiologyPresence of pathogensExternal cuesRelease of compoundsPathogenic bacteriaCentral nervous systemHomeostatic regulationInternal cuesHost defenseNeuronal activationCellsClassical functionsHost responseReceptor propertiesSensory systemsCuesInfectionBacteriaRegulationPhysiologyField of neurosciencePathogensInvasion146-OR: Causative Role of Hypothalamic Ventromedial Glucose-Inhibited Neurons in Impaired Counterregulatory Responses to Hypoglycemia
COPPERI F, SHEN X, DIANO S. 146-OR: Causative Role of Hypothalamic Ventromedial Glucose-Inhibited Neurons in Impaired Counterregulatory Responses to Hypoglycemia. Diabetes 2023, 72 DOI: 10.2337/db23-146-or.Peer-Reviewed Original ResearchImpaired counterregulatory responseCounterregulatory responsesGI neuronsRecurrent hypoglycemiaCausative roleGlucose-inhibited neuronsType 1 diabetesBlood glucose levelsScientific evidence pointsDiabetes CenterChemogenetic activationKidney diseaseVentromedial nucleusNeuronal activationGlucose levelsMouse modelCurrent evidenceConsecutive daysMiceNeuronsAdministrationSignificant decreaseCausal involvementNational InstituteHypoglycemia
2021
An increase in VGF expression through a rapid, transcription-independent, autofeedback mechanism improves cognitive function
Lin W, Zhao Y, Li Z, Zheng S, Zou J, Warren N, Bali P, Wu J, Xing M, Jiang C, Tang Y, Salton S, Ye X. An increase in VGF expression through a rapid, transcription-independent, autofeedback mechanism improves cognitive function. Translational Psychiatry 2021, 11: 383. PMID: 34238925, PMCID: PMC8266826, DOI: 10.1038/s41398-021-01489-2.Peer-Reviewed Original ResearchConceptsDense-core vesiclesTLQP-62VGF-derived peptide TLQP-62Cognitive functionGranin familyDepression-like behaviorRelease of neuropeptidesGranin proteinsHippocampus-dependent learningCultured primary neuronsLuciferase-based reporter assayGranin family proteinsTranscription-independent inductionNeuronal activationMood disordersAutofeedback mechanismNeuronal activityPrimary neuronsVGF expressionMice exhibitMood stabilityAlzheimer's diseaseBrain tissueMRNA expressionNeurodegenerative diseasesDrp1 is required for AgRP neuronal activity and feeding
Jin S, Yoon NA, Liu ZW, Song JE, Horvath TL, Kim JD, Diano S. Drp1 is required for AgRP neuronal activity and feeding. ELife 2021, 10: e64351. PMID: 33689681, PMCID: PMC7946429, DOI: 10.7554/elife.64351.Peer-Reviewed Original ResearchConceptsAgRP neuronal activityFatty acid oxidationAgRP neuronsNeuronal activityAgRP neuronal functionHypothalamic AgRP neuronsBody weight regulationMitochondrial fatty acid utilizationWhole-body energy homeostasisHypothalamic orexigenic agoutiFatty acid utilizationAcid oxidationFat massCKO miceNeuronal activationPeptide-1Body weightNeuronal functionOrexigenic agoutiEnergy homeostasisMitochondrial fissionSignificant decreaseEnergy expenditureNeuronsAcid utilization
2020
MC4R Signaling in Dorsal Raphe Nucleus Controls Feeding, Anxiety, and Depression
Bruschetta G, Jin S, Liu ZW, Kim JD, Diano S. MC4R Signaling in Dorsal Raphe Nucleus Controls Feeding, Anxiety, and Depression. Cell Reports 2020, 33: 108267. PMID: 33053350, DOI: 10.1016/j.celrep.2020.108267.Peer-Reviewed Original ResearchConceptsDorsal raphe nucleusNeuronal activationR neuronsDepressive-like behaviorMajor depressive disorderChemogenetic activationR miceChemogenetic inhibitionRaphe nucleusSerotonin levelsDepressive disorderMood behaviorΑ-MSHDRN infusionsControl feedingMiceWeight lossNeuronsSelective knockdownDepressionBehavioral phenotypesAnxietyActivationFeedingPRCP
2019
Variability in nicotine conditioned place preference and stress‐induced reinstatement in mice: Effects of sex, initial chamber preference, and guanfacine
Lee AM, Calarco CA, McKee SA, Mineur YS, Picciotto MR. Variability in nicotine conditioned place preference and stress‐induced reinstatement in mice: Effects of sex, initial chamber preference, and guanfacine. Genes Brain & Behavior 2019, 19: e12601. PMID: 31364813, PMCID: PMC8045136, DOI: 10.1111/gbb.12601.Peer-Reviewed Original ResearchConceptsStress-induced reinstatementEffects of guanfacinePlace preferenceFemale miceInfralimbic cortexArc immunoreactivityΑ2-adrenergic receptor agonistAnterior insulaNeurobiological mechanismsLateral central amygdalaNovel treatment optionsChamber preferencePlace preference acquisitionSex-dependent changesStress-induced relapseDose-response patternNucleus accumbens coreNicotine-dependent behaviorsSmoking occursTreatment optionsNicotine rewardReceptor agonistCentral amygdalaNeuronal activationPreclinical studies
2017
Cl− channel is required for CXCL10-induced neuronal activation and itch response in a murine model of allergic contact dermatitis
Qu L, Fu K, Shimada SG, LaMotte RH. Cl− channel is required for CXCL10-induced neuronal activation and itch response in a murine model of allergic contact dermatitis. Journal Of Neurophysiology 2017, 118: 619-624. PMID: 28446581, PMCID: PMC5511864, DOI: 10.1152/jn.00187.2017.Peer-Reviewed Original ResearchConceptsAllergic contact dermatitisSquaric acid dibutylesterAllergic itchNeuronal activationContact hypersensitivityContact dermatitisMurine modelItch-related scratching behaviorBehavioral effectsDorsal root ganglion neuronsItch-like behaviorsPrimary sensory neuronsWhole-cell recordingsPromising therapeutic targetPersistent itchItch responseIonic mechanismsGanglion neuronsScratching behaviorChannel blockersCXCL10Sensory neuronsTherapeutic targetChannel inhibitorsCell recordingsDRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons
Santoro A, Campolo M, Liu C, Sesaki H, Meli R, Liu ZW, Kim JD, Diano S. DRP1 Suppresses Leptin and Glucose Sensing of POMC Neurons. Cell Metabolism 2017, 25: 647-660. PMID: 28190775, PMCID: PMC5366041, DOI: 10.1016/j.cmet.2017.01.003.Peer-Reviewed Original ResearchConceptsPeroxisome proliferator-activated receptorPOMC neuronsLeptin sensitivityHypothalamic pro-opiomelanocortin (POMC) neuronsPro-opiomelanocortin (POMC) neuronsCounter-regulatory responseProliferator-activated receptorMitochondrial sizeFed miceGlucoprivic stimuliNeuronal activationFl/Glucose metabolismMetabolic environmentNeuronsFasted animalsIntracellular mechanismsReduced expressionGlucose responsivenessGreater activationInducible deletionROS productionMiceStrong inhibitionMitochondrial fission regulator
2016
Secretagogue-dependent and -independent transport of zinc hydration forms in rat parietal cells
Ferstl FS, Kitay AM, Trattnig RM, Alsaihati A, Geibel JP. Secretagogue-dependent and -independent transport of zinc hydration forms in rat parietal cells. Pflügers Archiv - European Journal Of Physiology 2016, 468: 1877-1883. PMID: 27757581, DOI: 10.1007/s00424-016-1889-3.Peer-Reviewed Original ResearchConceptsGastroesophageal reflux diseaseAcid secretionParietal cellsSecretagogue-stimulated acid secretionRecurrence of symptomsAlternative treatment optionNumber of patientsNon-fasted conditionsApplication of bumetanideEffects of secretagoguesRat parietal cellsReflux diseaseInhibitor therapyTreatment optionsNon-fasted animalsLeading causeNeuronal activationNKCC1 transporterNeuronal pathwaysGastric acidInhibitor bumetanideSecretagogue carbacholFasted animalsMechanism of entryHormonal activationProgressive neuronal activation accompanies epileptogenesis caused by hippocampal glutamine synthetase inhibition
Albright B, Dhaher R, Wang H, Harb R, Lee TW, Zaveri H, Eid T. Progressive neuronal activation accompanies epileptogenesis caused by hippocampal glutamine synthetase inhibition. Experimental Neurology 2016, 288: 122-133. PMID: 27769717, PMCID: PMC5547560, DOI: 10.1016/j.expneurol.2016.10.007.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyNeuronal activationHippocampal formationHuman mesial temporal lobe epilepsyAnterior olfactory areaEntorhinal-hippocampal areaProcess of epileptogenesisC-Fos immunohistochemistryTemporal lobe epilepsyTypes of seizuresGlutamine synthetase inhibitionSurgical resectionPiriform cortexSeizure severityLobe epilepsyHippocampal astrocytesEpilepsy developmentEpileptogenic processElectroencephalogram monitoringOlfactory areasPharmacological interventionsSeizure phenotypeBed nucleusMidline thalamusStria terminalisHypothalamic TLR2 triggers sickness behavior via a microglia-neuronal axis
Jin S, Kim JG, Park JW, Koch M, Horvath TL, Lee BJ. Hypothalamic TLR2 triggers sickness behavior via a microglia-neuronal axis. Scientific Reports 2016, 6: 29424. PMID: 27405276, PMCID: PMC4942617, DOI: 10.1038/srep29424.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnorexiaArcuate Nucleus of HypothalamusCyclooxygenase InhibitorsEnergy MetabolismFeverInflammationLipopeptidesMaleMiceMice, KnockoutMicrogliaMyeloid Differentiation Factor 88NF-kappa BPro-OpiomelanocortinRatsReceptor, Melanocortin, Type 3Receptor, Melanocortin, Type 4Toll-Like Receptor 2Weight LossConceptsSickness behaviorHypothalamic inflammationToll-like receptor 2 (TLR2) activationSickness behavior symptomsNuclear factor kappa BBody weight lossReceptor 2 activationFactor kappa BNeuronal circuit functionHypothalamic microgliaProopiomelanocortin neuronsInflammatory mechanismsIntracerebroventricular injectionPathophysiologic mechanismsTLR2 activationInflammatory processCyclooxygenase pathwayNeuronal activationKappa BBehavior symptomsWeight lossInput organizationMicrogliaTLR2Inflammation
2015
Clinically effective OCD treatment prevents 5-HT1B receptor-induced repetitive behavior and striatal activation
Ho EV, Thompson SL, Katzka WR, Sharifi MF, Knowles JA, Dulawa SC. Clinically effective OCD treatment prevents 5-HT1B receptor-induced repetitive behavior and striatal activation. Psychopharmacology 2015, 233: 57-70. PMID: 26423528, DOI: 10.1007/s00213-015-4086-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCorpus StriatumDesipramineExploratory BehaviorFemaleFluoxetineIndolesMiceMice, Inbred C57BLObsessive-Compulsive DisorderReceptor, Serotonin, 5-HT1BSerotonin 5-HT1 Receptor AgonistsSerotonin 5-HT1 Receptor AntagonistsSerotonin Receptor AgonistsStereotyped BehaviorTreatment OutcomeConceptsAcute treatmentFos expressionDorsal striatumOCD treatmentStriatal activationReceptor agonist treatmentEffective OCD treatmentOpen-field behaviorChronic fluoxetineAgonist treatmentObsessive-compulsive disorderChronic pretreatmentLocomotor stereotypySeparate miceNeuronal activationDrug treatmentTreatment preventsRepetitive behaviorsOCD pathophysiologyBrain regionsOrbitofrontal cortexBehavioral effectsRU24969Inhibition deficitsBrain activation
2014
Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice
Kim JD, Toda C, D’Agostino G, Zeiss CJ, DiLeone RJ, Elsworth JD, Kibbey RG, Chan O, Harvey BK, Richie CT, Savolainen M, Myöhänen T, Jeong JK, Diano S. Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 11876-11881. PMID: 25071172, PMCID: PMC4136568, DOI: 10.1073/pnas.1406000111.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood GlucoseGene ExpressionGene Knockdown TechniquesGlucagonGlucose Clamp TechniqueGlucose IntoleranceHypothalamusIndolesInsulinInsulin SecretionIon ChannelsMaleMiceMice, TransgenicMitochondrial ProteinsPancreasPhosphorylationProlyl OligopeptidasesReceptor, InsulinRecombinant ProteinsSerine EndopeptidasesSerine Proteinase InhibitorsThiazolidinesUncoupling Protein 1Ventromedial Hypothalamic NucleusConceptsWild-type miceGlucose intoleranceGlucagon secretionProlyl endopeptidaseHyperinsulinemic-euglycemic clamp studiesWild-type control miceGlucose-induced insulin releaseGlucose-induced insulin secretionEuglycemic clamp studiesAutonomic nervous systemVMH injectionsSympathetic outflowWild-type controlsNorepinephrine levelsGlucagon levelsGlucose toleranceControl miceInsulin levelsCentral infusionPancreatic functionVentromedial nucleusInsulin secretionNeuronal activationGlucose-intolerant phenotypeCentral regulation
2013
Metabolic Regulation of Brain Response to Food Cues
de Araujo IE, Lin T, Veldhuizen MG, Small DM. Metabolic Regulation of Brain Response to Food Cues. Current Biology 2013, 23: 878-883. PMID: 23643837, PMCID: PMC3767438, DOI: 10.1016/j.cub.2013.04.001.Peer-Reviewed Original Research
2012
Sleep restriction leads to increased activation of brain regions sensitive to food stimuli
St-Onge MP, McReynolds A, Trivedi ZB, Roberts AL, Sy M, Hirsch J. Sleep restriction leads to increased activation of brain regions sensitive to food stimuli. American Journal Of Clinical Nutrition 2012, 95: 818-824. PMID: 22357722, PMCID: PMC3302360, DOI: 10.3945/ajcn.111.027383.Peer-Reviewed Original ResearchConceptsFood stimuliNeuronal activityHabitual sleepSleep restrictionNormal-weight menOverall neuronal activityAverage sleep durationFunctional magnetic resonance imagingMagnetic resonance imagingPartial sleep restrictionCrossover studyEpidemiologic evidenceClinical studiesNeuronal activationNucleus accumbensSleep durationFasted stateResonance imagingBrain regionsDay 6Prefrontal cortexSleepBrain activityRelative increaseStimuli
2010
Changes in Memory Function and Neuronal Activation Associated with Atorvastatin Therapy
Parker B, Polk D, Rabdiya V, Meda S, Anderson K, Hawkins K, Pearlson G, Thompson P. Changes in Memory Function and Neuronal Activation Associated with Atorvastatin Therapy. Pharmacotherapy The Journal Of Human Pharmacology And Drug Therapy 2010, 30: 625-625. DOI: 10.1592/phco.30.6.625.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingCognitive complaintsCognitive test performanceMemory taskCognitive testsFMRI findingsFMRI patternsCognitive testingCognitive functionMemory functionCognitive symptomsMemory impairmentTest performanceNeuronal activationBrain functionPreliminary evidenceObjective measuresMemory lossPsychiatric problemsAtorvastatin therapyMajor head traumaFirst case reportDays of cessationCentral nervous systemAlcohol consumption
2007
Prenatal exposure to cocaine is associated with increased number of spine synapses in rat prelimbic cortex
Morrow BA, Hajszan T, Leranth C, Elsworth JD, Roth RH. Prenatal exposure to cocaine is associated with increased number of spine synapses in rat prelimbic cortex. Synapse 2007, 61: 862-865. PMID: 17630673, DOI: 10.1002/syn.20430.Peer-Reviewed Original ResearchConceptsPrenatal exposureFemale ratsSpine synapsesPrelimbic cortexDendritic spinesCognitive deficitsLayers II/IIIPrenatal saline controlsExcitatory synaptic inputsAsymmetric spine synapsesPrenatal cocaine exposureRat prelimbic cortexYoung adult malesPhysical disector methodPyramidal neuronsSaline controlsNeuronal activationCocaine exposureExcitatory synapsesFrontal cortexSynaptic inputsAnimal modelsExcess activationPrefrontal cortexCortex
2004
Novel analogs of ghrelin: physiological and clinical implications
Halem H, Taylor J, Dong J, Shen Y, Datta R, Abizaid A, Diano S, Horvath T, Zizzari P, Bluet-Pajot M, Epelbaum J, Culler M. Novel analogs of ghrelin: physiological and clinical implications. European Journal Of Endocrinology 2004, 151: s71-s75. PMID: 15339248, DOI: 10.1530/eje.0.151s071.Peer-Reviewed Original ResearchConceptsBIM-28163GH secretionGHS receptorWeight gainNeuronal activationGrowth hormone secretagogue receptorAntagonist of ghrelinAction of ghrelinNormal GH secretionRole of ghrelinStimulation of feedingActivity of ghrelinPotential therapeutic benefitAnalogues of ghrelinNative ghrelinEndogenous ghrelinGhrelin actionGH levelsHypothalamic GHHypothalamic sitesSecretagogue receptorGhrelin receptorFood intakeNormal ratsGhrelin analogs
1997
Noninvasive assessment of language dominance in children and adolescents with functional MRI: a preliminary study.
Hertz-Pannier L, Gaillard W, Mott S, Cuenod C, Bookheimer S, Weinstein S, Conry J, Papero P, Schiff S, Bihan D, Theodore W. Noninvasive assessment of language dominance in children and adolescents with functional MRI: a preliminary study. Neurology 1997, 48: 1003-12. PMID: 9109891, DOI: 10.1212/wnl.48.4.1003.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingElectrostimulation mappingLeft dominanceFunctional mapping techniquesMagnetic resonance imagingNoninvasive functional mappingRight-handed childrenLanguage dominanceBilateral languageHemodynamic changesEpilepsy surgeryPartial epilepsySurgery outcomesTemporal epilepsyAmobarbital testNeuronal activationWord generation taskFrontal lobeLanguage lateralizationRight dominanceNoninvasive assessmentResonance imagingFunctional MRISignal time courseBrain development
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