2025
Dysregulated responses to stress and alcohol cues in cortico-striatal-limbic regions in social drinkers with early trauma
Heilner E, Sinha R, Eringros N, Constable R, Seo D. Dysregulated responses to stress and alcohol cues in cortico-striatal-limbic regions in social drinkers with early trauma. Journal Of Neural Transmission 2025, 1-16. PMID: 40500419, DOI: 10.1007/s00702-025-02961-9.Peer-Reviewed Original ResearchFunctional magnetic resonance imagingAlcohol cuesEarly traumaSocial drinkersResponse to stressNeurobehavioral responses to stressDysregulated responses to stressNeutral cue exposureReward processing regionsReward-related disordersEmotional provocation taskPosterior cingulate cortexAlcohol-related disordersDecreased activityCraving ratingsDorsolateral PFCPrefrontal regulationAnterior PFCCue exposureReward processingEmotional reactivityPrefrontal regionsCingulate cortexNeural correlatesCue responses
2023
The effects of age on the severity of problem drinking: Mediating effects of positive alcohol expectancy and neural correlates
Chaudhary S, Chen Y, Zhornitsky S, Le T, Zhang S, Chao H, Dominguez J, Li C. The effects of age on the severity of problem drinking: Mediating effects of positive alcohol expectancy and neural correlates. Addiction Biology 2023, 28: e13278. PMID: 37252876, DOI: 10.1111/adb.13278.Peer-Reviewed Original ResearchConceptsPositive alcohol expectanciesAlcohol Use Disorders Identification TestAlcohol expectanciesAlcohol use disorderNeural correlatesCue responsesPath analysisProblem drinkingAlcohol misuseEffect of ageAUDIT scoresRostral anterior cingulate cortexWhole-brain regressionAlcohol cue exposureMiddle occipital cortexModerate alcohol use disorderAlcohol Expectancy QuestionnaireAnterior cingulate cortexAlcohol use severityBilateral rostral anterior cingulate cortexPsychological mechanismsBilateral parahippocampal gyrusCue exposureNeural processesSeverity of problemsAppetitive and aversive cue reactivities differentiate neural subtypes of alcohol drinkers
Chen Y, Li C. Appetitive and aversive cue reactivities differentiate neural subtypes of alcohol drinkers. Addiction Neuroscience 2023, 7: 100089. PMID: 37483686, PMCID: PMC10358306, DOI: 10.1016/j.addicn.2023.100089.Peer-Reviewed Original ResearchCue responsesMonetary incentive delay taskDistinct neural correlatesDistinct neural underpinningsIncentive delay taskNegative emotional statesMid-cingulate cortexMedial cortical regionsDrug cuesNeural underpinningsCue reactivityNeural correlatesSubjective urgeAlcohol expectanciesDelay taskEmotional statesLoss processingSensation seekingVentral striatumAlcohol drinkersAversive componentCortical regionsAversive responsesSubstance misusePotential subtypes
2020
A Laboratory‐Based Study of the Priming Effects of Food Cues and Stress on Hunger and Food Intake in Individuals with Obesity
Chao AM, Fogelman N, Hart R, Grilo CM, Sinha R. A Laboratory‐Based Study of the Priming Effects of Food Cues and Stress on Hunger and Food Intake in Individuals with Obesity. Obesity 2020, 28: 2090-2097. PMID: 32918391, PMCID: PMC7644599, DOI: 10.1002/oby.22952.Peer-Reviewed Original ResearchConceptsHigh-calorie foodsFood cuesWeight statusNormal weightStress cuesScript-driven imagery taskHigh-calorie snack foodsVisual analog scaleLow-calorie snacksNeutral cuesCue exposureAnalog scaleImagery tasksEffects of exposureCue responsesPriming effectTotal caloriesFood intakeObesitySeparate daysCuesAd libitumLaboratory-based experimental studyCaloriesParticipants
2019
Problem drinking alters gray matter volume and food cue responses of the lateral orbitofrontal cortex
Le TM, Zhornitsky S, Wang W, Zhang S, Li C. Problem drinking alters gray matter volume and food cue responses of the lateral orbitofrontal cortex. Addiction Biology 2019, 26: e12857. PMID: 31746092, PMCID: PMC8627684, DOI: 10.1111/adb.12857.Peer-Reviewed Original ResearchConceptsLateral orbitofrontal cortexAlcohol Use Disorders Identification TestGray matter volumeEffect of ProblemOrbitofrontal cortexWhole-brain multiple regressionLeft middle frontal gyrusAlcohol misuseFood cue responsesFunctional magnetic resonance imaging (fMRI) dataVisual food cuesAUDIT scoresMatter volumeMiddle frontal gyrusAffective processesNonfood cuesFood cuesNonfood imagesBrain substratesDisorders Identification TestFrontal gyrusNeural mechanismsFood stimuliCue responsesFood imagesWeaker Memory Performance Exacerbates Stress-Induced Cannabis Craving in Youths’ Daily Lives
Miranda R, Wemm SE, Padovano H, Carpenter RW, Emery NN, Gray JC, Mereish EH. Weaker Memory Performance Exacerbates Stress-Induced Cannabis Craving in Youths’ Daily Lives. Clinical Psychological Science 2019, 7: 1094-1108. PMID: 31737439, PMCID: PMC6857838, DOI: 10.1177/2167702619841976.Peer-Reviewed Original ResearchCue exposureWeaker memory performanceDrug cue responseEcological momentary assessmentMemory performanceAddiction positCue responsesStressful momentsHigher cravingMomentary assessmentMomentary stressSubstance misuseWMYouthControl capacityReal-world settingDrug useCravingCuesMemoryAdolescentsPositStimuliCannabisAssociation
2018
Alcohol Expectancy and Cerebral Responses to Cue-Elicited Craving in Adult Nondependent Drinkers
Zhornitsky S, Zhang S, Ide JS, Chao HH, Wang W, Le TM, Leeman RF, Bi J, Krystal JH, Li CR. Alcohol Expectancy and Cerebral Responses to Cue-Elicited Craving in Adult Nondependent Drinkers. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2018, 4: 493-504. PMID: 30711509, PMCID: PMC6500759, DOI: 10.1016/j.bpsc.2018.11.012.Peer-Reviewed Original ResearchConceptsAlcohol Use Disorders Identification Test (AUDIT) scoresFrontal cortical connectivityCerebral responsesCortical connectivityPositive scoreAlcohol cuesNondependent drinkersAlcohol Use Disorders Identification TestLeft caudate headCue activityCue responsesAlcohol expectanciesProblem drinkingDisorders Identification TestNeutral cuesMedial orbitofrontal cortexAlcohol Expectancy QuestionnaireFunctional magnetic resonanceBilateral thalamusThalamic processingCaudate headRisk drinkingThalamic responsesRed nucleusImaging studies
2015
Neurobiological features of binge eating disorder
Balodis IM, Grilo CM, Potenza MN. Neurobiological features of binge eating disorder. CNS Spectrums 2015, 20: 557-565. PMID: 26530404, PMCID: PMC4658223, DOI: 10.1017/s1092852915000814.Peer-Reviewed Original ResearchConceptsBinge-eating disorderOrbitofrontal cortexTreatment of BEDPalatable food cuesInhibitory control processesFrontostriatal areasMotivational processesFood cuesCue responsesPrefrontal areasNeurobiological featuresNeural featuresControl processTreatment effortsSpecific relationshipNeural functionDisordersBingeCuesSystematic reviewRewardHypofunctioningCortexMeasuresFindings
1995
Differences between responders and nonresponders to cocaine cues in the laboratory
Avants S, Margolin A, Kosten T, Cooney N. Differences between responders and nonresponders to cocaine cues in the laboratory. Addictive Behaviors 1995, 20: 215-224. PMID: 7484315, DOI: 10.1016/0306-4603(94)00066-2.Peer-Reviewed Original ResearchConceptsDrug cuesGroup differencesDrug-dependent subjectsCocaine-dependent methadone patientsGroups of subjectsMethadone patientsCocaine cravingCocaine dependenceCocaine expectanciesCocaine aversionNonrespondersOne-thirdRespondersCue responsesCravingDemographic variablesSubjectsCurrent studyPatientsDifferences
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