2024
12241 Association Between Brain Glucose And Circulating Glucagon Levels In Response To Acute Hyperglycemia
Matson B, Gunawan F, Coppoli A, Jiang L, Rangel E, De Aguiar R, Rothman D, Mason G, Hwang J. 12241 Association Between Brain Glucose And Circulating Glucagon Levels In Response To Acute Hyperglycemia. Journal Of The Endocrine Society 2024, 8: bvae163.674. PMCID: PMC11454728, DOI: 10.1210/jendso/bvae163.674.Peer-Reviewed Original ResearchCentral nervous systemBrain glucose levelsPlasma glucagon levelsHyperglycemic clampType 2 diabetesGlucagon levelsGlucagon secretionGlucose levelsResponse to hyperglycemiaAcute hyperglycemiaOral glucose tolerance testBrain glucose metabolismResponse to central nervous systemPathophysiology of type 2 diabetesResponse to hypoglycemiaBrain glucoseIndices of insulin sensitivityEffect of obesityRegulation of glucagon secretionGlucose tolerance testConsequences of obesityModulating glucagon secretionOvert metabolic abnormalitiesBrain glucose uptakeCirculating glucagon levelsGLP-1, GIP, and Glucagon Agonists for Obesity Treatment: A Hunger Perspective
D’Ávila M, Hall S, Horvath T. GLP-1, GIP, and Glucagon Agonists for Obesity Treatment: A Hunger Perspective. Endocrinology 2024, 165: bqae128. PMID: 39301751, DOI: 10.1210/endocr/bqae128.Peer-Reviewed Original ResearchKeep It Moving: Physical Activity in the Prevention of Obesity-Driven Pancreatic Cancer.
Sogunro A, Muzumdar M. Keep It Moving: Physical Activity in the Prevention of Obesity-Driven Pancreatic Cancer. Cancer Research 2024, 84: 2935-2937. PMID: 39279380, DOI: 10.1158/0008-5472.can-24-1474.Peer-Reviewed Original ResearchConceptsPancreatic ductal adenocarcinomaTumor microenvironmentAntitumor effectPancreatic cancerObese micePhysical activityAdvanced tumor growthSystemic cytokine productionMyeloid cell infiltrationPancreatic ductal adenocarcinoma developmentEffect of obesityHigh-fat diet-induced obesityDiet-induced obesitySyngeneic allograftsAdvanced tumorsProtumorigenic effectsLean miceWhite adipose tissueCell infiltrationDuctal adenocarcinomaObesity-associatedTumor growthCytokine productionImpact of physical activityInflammatory cytokinesEffects of Obesity on Urogynecologic Prolapse Surgery Outcomes: A Systematic Review and Meta-Analysis
Ringel N, Lenger S, High R, Alas A, Houlihan S, Chang O, Pennycuff J, Singh R, White A, Lipitskaia L, Behbehani S, Sheyn D, Kudish B, Nihira M, Sleemi A, Grimes C, Gupta A, Balk E, Antosh D. Effects of Obesity on Urogynecologic Prolapse Surgery Outcomes: A Systematic Review and Meta-Analysis. Obstetrical & Gynecological Survey 2024, 79: 409-411. DOI: 10.1097/ogx.0000000000001302.Peer-Reviewed Original ResearchMetabolic obesity phenotypes and all-cause mortality among the Chinese oldest-old population: a prospective cohort study
Song W, Zhong W, Gao J, Li Z, Ren J, Shen D, Wang X, Shen Q, You F, Fu Q, Li C, Chen H, Lv Y, Shi X, Mao C. Metabolic obesity phenotypes and all-cause mortality among the Chinese oldest-old population: a prospective cohort study. International Journal Of Obesity 2024, 48: 1438-1446. PMID: 38926462, DOI: 10.1038/s41366-024-01571-x.Peer-Reviewed Original ResearchMetabolically unhealthy non-obeseMetabolically healthy non-obeseMetabolically Healthy ObesityMetabolic obesity phenotypesOldest-old populationMetabolically unhealthy obesityProspective cohort studyMortality riskCohort studyHazard ratioObese phenotypeManagement of metabolic healthUnhealthy non-obeseOldest-old adultsHealthy non-obeseMethodsThis prospective cohort studyDecreased mortality riskIncreased mortality riskHigher mortality riskYears of follow-upAll-Cause MortalityNon-obeseEffect of obesityHealthy obesityCentral obesityDeficits in brain glucose transport among younger adults with obesity
Gunawan F, Matson B, Coppoli A, Jiang L, Ding Y, Perry R, Sanchez‐Rangel E, DeAguiar R, Behar K, Rothman D, Mason G, Hwang J. Deficits in brain glucose transport among younger adults with obesity. Obesity 2024, 32: 1329-1338. PMID: 38764181, PMCID: PMC11966602, DOI: 10.1002/oby.24034.Peer-Reviewed Original ResearchBrain glucose transportLean participantsMarkers of insulin resistanceMagnetic resonance spectroscopy scansEffect of obesityAssociated with alterationsLong-term brain functionCerebral glucose metabolic rateGlucose transportGlucose metabolic rateCardiometabolic comorbiditiesBrain energy utilizationPeripheral markersHyperglycemic clampInsulin resistanceObesityBrain glucose uptakeHuman findingsEating behaviorsYounger ageYoung healthy participantsNeurocognitive functionGlucose transport capacityBrain functionNonesterified fatty acidsAdiposity, immunity, and inflammation: interrelationships in health and disease: a report from 24th Annual Harvard Nutrition Obesity Symposium, June 2023
Burak M, Stanley T, Lawson E, Campbell S, Lynch L, Hasty A, Domingos A, Dixit V, Hotamışlıgil G, Sheedy F, Dixon A, Brinkley T, Hill J, Donath M, Grinspoon S. Adiposity, immunity, and inflammation: interrelationships in health and disease: a report from 24th Annual Harvard Nutrition Obesity Symposium, June 2023. American Journal Of Clinical Nutrition 2024, 120: 257-268. PMID: 38705359, PMCID: PMC11347817, DOI: 10.1016/j.ajcnut.2024.04.029.Peer-Reviewed Original ResearchLow-grade systemic inflammationChronic low-grade inflammationLocal immune environmentAdipose tissueLow-grade inflammationEffect of obesityObesity Research CenterPro-inflammatory pathwaysOutcome of metabolic diseasesImmune environmentSystemic inflammationHealth and DiseaseTreatment therapiesInflammationMultifaceted effectsDisease severityMetabolic diseasesImmunometabolic diseasesImmunityAdiposeDiseaseReduced disease severityObesityTissueDisrupting cellular homeostasisEffect of obesity on sleep apnea pathogenesis differs in women versus men: multiple mediation analyses in the retrospective SNOOzzzE cohort
Nokes B, Orr J, White S, Luu S, Chen Z, Alex R, Sands S, Wojeck B, Owens R, Malhotra A, Schmickl C. Effect of obesity on sleep apnea pathogenesis differs in women versus men: multiple mediation analyses in the retrospective SNOOzzzE cohort. Journal Of Applied Physiology 2024, 136: 1516-1525. PMID: 38660729, PMCID: PMC11368527, DOI: 10.1152/japplphysiol.00925.2023.Peer-Reviewed Original ResearchApnea-hypopnea indexObstructive sleep apneaBody mass indexEffect of body mass indexCirculatory delayArousal thresholdAssociated with apnea-hypopnea indexObstructive sleep apnea risk factorsObstructive Sleep Apnea EndotypesIn-laboratory polysomnographyUpper airway collapseEvents per hourHigh arousal thresholdsEffect of obesityHypopnea indexOSA pathogenesisSleep apneaConsecutive adultsSleep clinicEndotypic traitsAirway collapseMass indexPathogenesis differencesRisk factorsPolysomnography signalsEffects of Obesity on Urogynecologic Prolapse Surgery Outcomes
Ringel N, Lenger S, High R, Alas A, Houlihan S, Chang O, Pennycuff J, Singh R, White A, Lipitskaia L, Behbehani S, Sheyn D, Kudish B, Nihira M, Sleemi A, Grimes C, Gupta A, Balk E, Antosh D. Effects of Obesity on Urogynecologic Prolapse Surgery Outcomes. Obstetrics And Gynecology 2024, 143: 539-549. PMID: 38330397, DOI: 10.1097/aog.0000000000005525.Peer-Reviewed Original ResearchBody mass indexPelvic organ prolapseProlapse recurrenceProlapse repairSurgical outcomesSurgical approachSurgery outcomesOutcomes of pelvic organ prolapseMeta-analysisCategories of body mass indexPelvic organ prolapse repairVaginal prolapse repairAssociated with increased likelihoodFull-text screeningEffect of obesityPOP repairOrgan prolapseMesh exposureObese categoryMesh complicationsMass indexNonrandomized studiesIncreased oddsSubjective outcomesCochrane DatabaseThiazolidinedione enhances the efficacy of anti-PD-1 monoclonal antibody in murine melanoma
Zhang X, Gao Y, Tang K, Li Z, Halberstam A, Zhou L, Perry R. Thiazolidinedione enhances the efficacy of anti-PD-1 monoclonal antibody in murine melanoma. AJP Endocrinology And Metabolism 2024, 326: e341-e350. PMID: 38294697, PMCID: PMC11901343, DOI: 10.1152/ajpendo.00346.2023.Peer-Reviewed Original ResearchPD-1 expressionCD8+ T cellsT cell exhaustionPD-1T cellsImmunotherapy efficacyAnti-programmed cell death protein 1Tumor-infiltrating CD8+ T cellsAnti-PD-1 monoclonal antibodyAnti-PD-1 responseAnti-PD-1 treatmentCell death protein 1Enhance immunotherapy efficacyEnhance immunotherapy responseImprove immunotherapy efficacyEfficacy of immunotherapyMurine melanoma modelTumor-bearing miceExpression of peroxisome proliferator-activated receptor gammaOverall survival timePeroxisome proliferator-activated receptor gammaEffect of obesityProliferator-activated receptor gammaHuman T cellsTreated in vitro
2023
xCT-mediated glutamate excretion in white adipocytes stimulates interferon-γ production by natural killer cells in obesity
Kim H, Shim Y, Kim H, Yang K, Ryu T, Kim K, Choi S, Kim M, Woo C, Chung K, Hong S, Shin H, Suh J, Jung Y, Hwang G, Kim W, Kim S, Eun H, Seong J, Jeong W. xCT-mediated glutamate excretion in white adipocytes stimulates interferon-γ production by natural killer cells in obesity. Cell Reports 2023, 42: 112636. PMID: 37310859, DOI: 10.1016/j.celrep.2023.112636.Peer-Reviewed Original ResearchConceptsIFN-g productionObesity-related metabolic disordersNK cellsIFN-gNatural killer (NK) cellsMetabolic disordersMetabotropic glutamate receptor 5NK cell recruitmentNatural killer cellsInterferon-g productionC-X-C motif chemokine ligandGlutamate receptor 5Effect of obesityC-X-CMotif chemokine ligandKiller cellsGlutamate excretionBidirectional pathwaysCXCL12/CXCR4 axisWhite adipose tissueCXCL12 expressionReceptor 5Cell recruitmentInflammatory activityChemokine ligand
2022
Risk of Postoperative Stiffness Following Multiligamentous Knee Injury Surgery Is Not Affected by Obesity: A Multicenter Study
Bi AS, Mojica ES, Markus DH, Blaeser AM, Kahan J, Moran J, Jazrawi LM, Medvecky MJ, Alaia MJ. Risk of Postoperative Stiffness Following Multiligamentous Knee Injury Surgery Is Not Affected by Obesity: A Multicenter Study. Arthroscopy The Journal Of Arthroscopic And Related Surgery 2022, 38: 3175-3181. PMID: 35777677, DOI: 10.1016/j.arthro.2022.06.017.Peer-Reviewed Original ResearchConceptsMultiligamentous knee injuriesBody mass indexPostoperative stiffnessVascular injuryIndex surgerySurgical managementExact testLevel 1 academic trauma centerBMI of patientsMulticenter retrospective cohort studyMean body mass indexLogistic regressionRate of MUATwo-center cohortRetrospective cohort studyEffect of obesityAcademic trauma centerGrade of obesityMultivariate logistic regressionExternal fixator useFisher's exact testSignificant differencesCovariates of ageMUA proceduresSchenck classificationEffect of Obesity on Risk of Hospitalization, Surgery, and Serious Infection in Biologic-Treated Patients With Inflammatory Bowel Diseases: A CA-IBD Cohort Study
Gu P, Luo J, Kim J, Paul P, Limketkai B, Sauk J, Park S, Parekh N, Zheng K, Rudrapatna V, Syal G, Ha C, McGovern D, Melmed G, Fleshner P, Eisenstein S, Ramamoorthy S, Dulai P, Boland B, Grunvald E, Mahadevan U, Ohno-Machado L, Sandborn W, Singh S. Effect of Obesity on Risk of Hospitalization, Surgery, and Serious Infection in Biologic-Treated Patients With Inflammatory Bowel Diseases: A CA-IBD Cohort Study. The American Journal Of Gastroenterology 2022, 117: 1639-1647. PMID: 35973139, DOI: 10.14309/ajg.0000000000001855.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseBiologic-treated patientsRisk of hospitalizationBody mass indexNormal body mass indexSerious infectionsBiologic agentsBowel diseaseCox proportional hazards analysisWorld Health Organization classificationEffect of obesityProportional hazards analysisElectronic health recordsCause hospitalizationVisceral obesityAdult patientsBaseline demographicsBiologic initiationBiologic therapyCohort studyEndoscopic outcomesMass indexOrganization classificationTreatment characteristicsStratified analysis978-P: Rare Variants in Melanocortin 4 Receptor Gene (MC4R) Are Associated with Increased Visceral Fat and Altered Glucose Metabolism Independent of the Effect of Obesity in Children
GALUPPO B, MANNAM P, TRICO D, BALE A, CAPRIO S, SANTORO N. 978-P: Rare Variants in Melanocortin 4 Receptor Gene (MC4R) Are Associated with Increased Visceral Fat and Altered Glucose Metabolism Independent of the Effect of Obesity in Children. Diabetes 2022, 71 DOI: 10.2337/db22-978-p.Peer-Reviewed Original ResearchOral glucose tolerance testEffect of obesityIntrahepatic fatInsulin resistanceVisceral fatMelanocortin-4 receptor gene mutationsVariant groupsSimilar BMI z-scoresOverweight/obese youthRare variantsAbdominal fat distributionGlucose tolerance testLower insulin clearanceBMI z-scoreEarly-onset obesityBody fat percentageΒ-cell functionGreater visceral fatMelanocortin-4 receptor geneHigher plasma glucoseRegion of MC4RReceptor gene mutationsMetabolic sequelaeInsulin clearanceTolerance testImpact of Obesity on Clinical and Financial Outcomes of Minimally Invasive Hysterectomy for Benign Conditions
Le Neveu M, AlAshqar A, Kohn J, Tambovtseva A, Wang K, Borahay M. Impact of Obesity on Clinical and Financial Outcomes of Minimally Invasive Hysterectomy for Benign Conditions. Journal Of Obstetrics And Gynaecology Canada 2022, 44: 953-959. PMID: 35598864, PMCID: PMC9481667, DOI: 10.1016/j.jogc.2022.04.018.Peer-Reviewed Original ResearchConceptsLength of stayClass III obesityAdverse perioperative eventsEffect of obesityInvasive hysterectomyPerioperative eventsClass IRetrospective cohort studyImpact of obesityOperating room timeCohort studyMean BMIBlood lossBenign hysterectomyClinical outcomesHysterectomy methodsHospital chargesRobotic hysterectomyObesityHysterectomyRoom timePatientsBenign conditionsClass IIIClass IIEffects of diet-induced obesity in the development of lymphedema in the animal model: A literature review
Khan N, Huayllani MT, Lu X, Boczar D, Cinotto G, Avila FR, Guliyeva G, Forte AJ. Effects of diet-induced obesity in the development of lymphedema in the animal model: A literature review. Obesity Research & Clinical Practice 2022, 16: 197-205. PMID: 35659463, DOI: 10.1016/j.orcp.2022.05.003.Peer-Reviewed Original ResearchConceptsAerobic exerciseT cellsAnimal modelsLymphatic dysfunctionEffect of obesityLipid metabolism disordersDiet-induced obesityHigh-fat dietDevelopment of lymphedemaAdipose tissue depositionVEGFR-3 expressionImpaired lymphatic drainageInhibition of lymphangiogenesisUnderlying cellular mechanismsInflammatory cascadeOvid EmbaseDiet/Metabolism disordersPharmacological interventionsEligibility criteriaLymphatic drainageContractile propertiesLong-term exposureObesityLymphatic endothelial cellsEffect of obesity on vedolizumab response in inflammatory bowel disease
Levine LJ, Gaidos JKJ, Proctor DD, Viana AV, Al-Bawardy B. Effect of obesity on vedolizumab response in inflammatory bowel disease. Annals Of Gastroenterology 2022, 35: 275-280. PMID: 35599926, PMCID: PMC9062841, DOI: 10.20524/aog.2022.0699.Peer-Reviewed Original ResearchBody mass indexInflammatory bowel diseaseSteroid-free clinical remissionNon-obese groupC-reactive proteinObese groupCRP normalizationEndoscopic remissionIBD patientsBowel diseaseDose escalationNormal serum C-reactive proteinMedian body mass indexSerum C-reactive proteinHigher Body Mass IndexEndoscopic remission ratesEffect of obesityVedolizumab discontinuationVedolizumab levelsClinical remissionMedian followRemission rateSecondary outcomesMedian agePrimary outcome
2021
FeV1 and BMI influence King’s Sarcoidosis Questionnaire score in sarcoidosis patients
Frye B, Potasso L, Farin-Glattacker E, Birring S, Müller-Quernheim J, Schupp J. FeV1 and BMI influence King’s Sarcoidosis Questionnaire score in sarcoidosis patients. BMC Pulmonary Medicine 2021, 21: 395. PMID: 34861850, PMCID: PMC8643005, DOI: 10.1186/s12890-021-01761-7.Peer-Reviewed Original ResearchConceptsKing's Sarcoidosis QuestionnaireBody mass indexSarcoidosis patientsQuality of lifeSerological parametersHigher Body Mass IndexGerman Clinical Trials RegisterLife style modificationClinical Trials RegisterEffect of obesitySteroid-sparing therapiesLung functional parametersGeneral health statusOrgan-specific domainsConclusionThis observationKSQ scoresTrials RegisterClinical chartsMethodsClinical dataOrgan manifestationsLung functionMass indexClinical parametersStyle modificationTRIAL REGISTRATIONAssociation between adiposity and cardiovascular outcomes: an umbrella review and meta-analysis of observational and Mendelian randomization studies
Kim M, Kim W, Khera A, Kim J, Yon D, Lee S, Shin J, Won H. Association between adiposity and cardiovascular outcomes: an umbrella review and meta-analysis of observational and Mendelian randomization studies. European Heart Journal 2021, 42: 3388-3403. PMID: 34333589, PMCID: PMC8423481, DOI: 10.1093/eurheartj/ehab454.Peer-Reviewed Original ResearchConceptsBody mass indexMendelian randomizationCardiovascular diseaseCVD-specific mortality risksRisk of incident cardiovascular diseaseSystematic reviewMeta-analysesHaemorrhagic strokeMendelian randomization studiesCVD risk increasesIncident cardiovascular diseaseAssociated with increased CVD riskMR studiesCausal risk factorCardiovascular disease riskObesity-related indicesAssociated with higher riskMeta-analyses resultsCoronary heart diseaseEffect of obesityUmbrella reviewAll-CauseCVD riskHigher adiposityMortality risk
2020
Effects of Obesity on Axillary Lymph Node Structure: Association of Hilar Fat Deposition and Alterations in Cortex Width.
Keshavarz E, Ahangaran A, Pouya E, Maheronnaghsh R, Chavoshi M, Rouzrokh P. Effects of Obesity on Axillary Lymph Node Structure: Association of Hilar Fat Deposition and Alterations in Cortex Width. MAEDICA – A Journal Of Clinical Medicine 2020, 15: 99-104. PMID: 32419869, PMCID: PMC7221265, DOI: 10.26574/maedica.2020.15.1.99.Peer-Reviewed Original ResearchAxillary lymph nodesBody mass indexPrognosis of breast cancerLymph nodesEffect of obesityMass indexBreast cancerParticipants' body mass indexCortex widthIncreased Body Mass IndexInter-rater reliabilityLymph node cortexLymph node structureIndependent sample t-testScreening mammographyObese patientsImmune dysfunctionObese womenSample t-testProspective studyMultiple regression analysisImmune functionObesityNormal populationT-test
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