2024
Translating Prefrontal Cortex Insights to the Clinic and Society
Rowe J, Datta D, Fiebach C, Jaeggi S, Liston C, Luna B, Rasmussen S, Roberts A, Sinha R, Haber S. Translating Prefrontal Cortex Insights to the Clinic and Society. 2024, 319-360. DOI: 10.7551/mitpress/15679.003.0019.Peer-Reviewed Original ResearchHippocampal Engrams and Contextual Memory
Vasudevan K, Hassell J, Maren S. Hippocampal Engrams and Contextual Memory. Advances In Neurobiology 2024, 38: 45-66. PMID: 39008010, PMCID: PMC12006847, DOI: 10.1007/978-3-031-62983-9_4.Peer-Reviewed Original ResearchConceptsContextual fear conditioningFear conditioningFear memoryRetrieval of contextual fear memoryRetrieval of aversive memoriesNeural substrates of memoryPost-traumatic stress disorderContextual fear memorySubstrate of memoryActivity-dependent taggingRetrieval of eventsAversive memoryEncoding contextStress disorderContextual stimuliNeural substratesMemory ensemblesHippocampal ensemblesNeuronal mechanismsContextual learningHippocampusMemoryFearRetrievalEncodingDynamic effects of ventral hippocampal NRG3/ERBB4 signaling on nicotine withdrawal-induced responses
Fisher M, Prantzalos E, O'Donovan B, Anderson T, Sahoo P, Twiss J, Ortinski P, Turner J. Dynamic effects of ventral hippocampal NRG3/ERBB4 signaling on nicotine withdrawal-induced responses. Neuropharmacology 2024, 247: 109846. PMID: 38211698, PMCID: PMC10923109, DOI: 10.1016/j.neuropharm.2024.109846.Peer-Reviewed Original ResearchConceptsAnxiety-like behaviorNeuregulin 3Ventral hippocampusAnxiety-related behaviorDrugs of abuseSmoking cessation therapySingle nucleotide polymorphismsNicotine withdrawalAnxiety-relatedErbB-4Nicotine addictionKnock-down miceGABAergic transmissionNeuronal mechanismsCA1 areaCessation therapyNicotineSynaptic expressionWithdrawalRelapse rateFemale miceNetwork activityGenetic factorsNucleotide polymorphismsGenetic disruption
2023
Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures
McCafferty C, Gruenbaum B, Tung R, Li J, Zheng X, Salvino P, Vincent P, Kratochvil Z, Ryu J, Khalaf A, Swift K, Akbari R, Islam W, Antwi P, Johnson E, Vitkovskiy P, Sampognaro J, Freedman I, Kundishora A, Depaulis A, David F, Crunelli V, Sanganahalli B, Herman P, Hyder F, Blumenfeld H. Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures. Nature Communications 2023, 14: 117. PMID: 36627270, PMCID: PMC9832004, DOI: 10.1038/s41467-022-35535-4.Peer-Reviewed Original ResearchConceptsThalamic neuronsAbsence seizuresSeizure onsetNeuronal firingConsciousness-impairing seizuresFemale rat modelLow-frequency electroencephalographic activityFunctional magnetic resonanceBehavioral arrestRat modelRhythmic firingTransient initial peakFiring increasesSeizuresNeuronal mechanismsElectroencephalographic activityNeuronsBrain state changesBrief episodesFiring decreasesInitial peakFiringMagnetic resonanceDistinct patternsOnset
2022
Food cue reactivity in successful laparoscopic gastric banding: A sham-deflation-controlled pilot study
Koenis MMG, Ng J, Anderson B, Stevens MC, Tishler DS, Papasavas PK, Stone A, McLaughlin T, Verhaak A, Domakonda MJ, Pearlson GD. Food cue reactivity in successful laparoscopic gastric banding: A sham-deflation-controlled pilot study. Frontiers In Human Neuroscience 2022, 16: 902192. PMID: 36092648, PMCID: PMC9454014, DOI: 10.3389/fnhum.2022.902192.Peer-Reviewed Original ResearchLaparoscopic adjustable gastric bandingLateral occipital cortexGastric bandingOccipital cortexPilot studyWeight lossExcess weight lossAdjustable gastric bandingLaparoscopic gastric bandingSham-controlled designFood cue reactivityInferior temporal gyrusUnderlying neuronal mechanismsLAGB surgeryUnderwent removalNeuronal changesFrontal cortexLingual gyrusNeuronal mechanismsSurgery changesTemporal gyrusFood cravingsCue reactivityGyrusFood cuesSexual dimorphism in a neuronal mechanism of spinal hyperexcitability across rodent and human models of pathological pain
Dedek A, Xu J, Lorenzo LÉ, Godin AG, Kandegedara CM, Glavina G, Landrigan JA, Lombroso PJ, De Koninck Y, Tsai EC, Hildebrand ME. Sexual dimorphism in a neuronal mechanism of spinal hyperexcitability across rodent and human models of pathological pain. Brain 2022, 145: 1124-1138. PMID: 35323848, PMCID: PMC9050559, DOI: 10.1093/brain/awab408.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factorSuperficial dorsal horn neuronsDorsal horn neuronsFemale ratsNeurotrophic factorNeuronal mechanismsCentral neuronal mechanismsSpinal nociceptive circuitsSpinal pain processingSuperficial dorsal hornChronic pain syndromeLamina I neuronsPreclinical pain modelsHuman organ donorsSynaptic NMDAR responsesNMDAR potentiationSpinal hyperexcitabilityInflammatory painNociceptive circuitsPain syndromeTactile allodyniaDorsal hornPain modelPathological painLaminae I
2021
Frequency modulation of entorhinal cortex neuronal activity drives distinct frequency-dependent states of brain-wide dynamics
Salvan P, Lazari A, Vidaurre D, Mandino F, Johansen-Berg H, Grandjean J. Frequency modulation of entorhinal cortex neuronal activity drives distinct frequency-dependent states of brain-wide dynamics. Cell Reports 2021, 37: 109954. PMID: 34731612, PMCID: PMC8609366, DOI: 10.1016/j.celrep.2021.109954.Peer-Reviewed Original ResearchConceptsBrain-wide dynamicsFrequency-dependent fashionEntorhinal cortex dysfunctionHuman neuroimaging studiesBasic neuronal mechanismsEntorhinal cortex activityExcitatory neuronsTransgenic modelStimulation frequencyCortex activityFMRI fluctuationsNeuronal mechanismsAnatomical circuitsNeuroimaging studiesNeural activityNeuronal spikingCognitive diseasesFMRI analysisDysfunctionModulationDiseaseMiceNeuronsActivityBrain
2019
Neuronal Mechanisms that Drive Organismal Aging Through the Lens of Perception
Gendron CM, Chakraborty TS, Chung BY, Harvanek ZM, Holme KJ, Johnson JC, Lyu Y, Munneke AS, Pletcher SD. Neuronal Mechanisms that Drive Organismal Aging Through the Lens of Perception. Annual Review Of Physiology 2019, 82: 1-23. PMID: 31635526, PMCID: PMC7012701, DOI: 10.1146/annurev-physiol-021119-034440.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSensory perceptionDecision-making behaviorTime perceptionLine of researchSocial perceptionNeural mechanismsSensory cuesFood perceptionThreat perceptionPerceptive experienceNeuronal mechanismsAge-related diseasesPerceptionNovel therapeutic targetAge-related physiologyTherapeutic targetGroups of neuronsInput influencesCuesPhysiologySensory neuronsAgingOrganismalGeneral thoughtsHuman healthRegulation of substrate utilization and adiposity by Agrp neurons
Cavalcanti-de-Albuquerque JP, Bober J, Zimmer MR, Dietrich MO. Regulation of substrate utilization and adiposity by Agrp neurons. Nature Communications 2019, 10: 311. PMID: 30659173, PMCID: PMC6338802, DOI: 10.1038/s41467-018-08239-x.Peer-Reviewed Original ResearchConceptsFat mass accumulationAgRP neuronsPositive energy balanceWhole-body substrate utilizationAgRP neuron activationHypothalamic AgRP neuronsPair-feeding conditionsSubstrate utilizationFatty acid synthaseCaloric ingestionFat utilizationNeuronal mechanismsWeight gainNeuronsMetabolic changesMass accumulationKey enzymeAdiposityAcid synthaseEnergy metabolismNeuron activationLipogenesisActivationCarbohydrate utilizationMetabolic efficiencyStrategy-dependent modulation of cortical pain circuits for the attenuation of pain
Schulz E, Stankewitz A, Witkovský V, Winkler A, Tracey I. Strategy-dependent modulation of cortical pain circuits for the attenuation of pain. Cortex 2019, 113: 255-266. PMID: 30711854, DOI: 10.1016/j.cortex.2018.12.014.Peer-Reviewed Original ResearchConceptsCognitive strategiesBrain activityDifferent cognitive strategiesPain attenuationUnderlying neuronal mechanismsPain-related brain activityVariability of performanceNeuroscientific techniquesNeurofeedback techniquesT fMRIPerception of painBehavioral dataBehavioral studiesTrial levelBrain regionsCortical regionsNeuronal mechanismsCortical feedbackInsular cortexDistractionTaskPain perceptionPotential predispositionAttenuation of painPerception
2014
Neuronal mechanism for acute mechanosensitivity in tactile-foraging waterfowl
Schneider ER, Mastrotto M, Laursen WJ, Schulz VP, Goodman JB, Funk OH, Gallagher PG, Gracheva EO, Bagriantsev SN. Neuronal mechanism for acute mechanosensitivity in tactile-foraging waterfowl. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 14941-14946. PMID: 25246547, PMCID: PMC4205607, DOI: 10.1073/pnas.1413656111.Peer-Reviewed Original ResearchConceptsTrigeminal ganglionIon channel Piezo2Light mechanical stimuliMechanoreceptive neuronsTG neuronsPrimary afferentsMechanical stimuliTrigeminal afferentsNeuronal excitationEnd organsNeuronal mechanismsDirect mechanical stimulationCellular mechanismsMechanical stimulationAfferentsNeuronsLow thresholdNumerical expansionGangliaStimuli
2012
Neuroendocrine Regulation of Energy Metabolism
Dietrich M, Horvath T. Neuroendocrine Regulation of Energy Metabolism. Endocrinology And Metabolism 2012, 27: 268-273. DOI: 10.3803/enm.2012.27.4.268.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPeripheral metabolic signalsEnergy expenditureBrain homeostatic systemsMechanism of actionBrain involvementChronic regulationPharmacological techniquesNeuronal controlNeuroendocrine regulationNeuronal mechanismsEnergy homeostasisComplex feeding behaviorHomeostatic systemMetabolic signalsReview articleFeeding behaviorInvolvementCurrent understandingBrain
2010
Attachment style, affective loss and gray matter volume: A voxel‐based morphometry study
Benetti S, McCrory E, Arulanantham S, De Sanctis T, McGuire P, Mechelli A. Attachment style, affective loss and gray matter volume: A voxel‐based morphometry study. Human Brain Mapping 2010, 31: 1482-1489. PMID: 20127871, PMCID: PMC6870872, DOI: 10.1002/hbm.20954.Peer-Reviewed Original ResearchConceptsAttachment styleGray matter volumeAffective lossesVoxel-based morphometryHigher attachment-related anxietyMatter volumeAttachment-related anxietyAttachment-related avoidanceEarly attachment experiencesNeural structuresAnterior temporal poleLateral orbital gyrusStructural brain differencesInfluences brain developmentAdult social behaviorEmotion regulationAttachment experiencesIndividual differencesInfant attachmentVoxel-based morphometry studyBrain differencesTemporal poleSocial behaviorNeuronal mechanismsBrain structures
2009
EEG–fMRI in Animal Models
Ellens D, Blumenfeld H. EEG–fMRI in Animal Models. 2009, 485-509. DOI: 10.1007/978-3-540-87919-0_24.Peer-Reviewed Original ResearchCerebral blood flowBrain functionBlood flowCerebral haemodynamic responseElectrical activityBlood flow increasesFundamental neuronal processesCortical electrical activityBrain activityIndividual brain regionsHaemodynamic responseCerebral cortexFunctional imaging technologyCortical neuronsBrain electrical activitySubcortical areasNeuronal activityAnimal modelsNeuronal functionBrain regionsElectrical brain activityNeuronal mechanismsElectrophysiological techniquesEntire brainNeuronal processes
2007
Neurobiology of Feeding and Energy Expenditure
Gao Q, Horvath TL. Neurobiology of Feeding and Energy Expenditure. Annual Review Of Neuroscience 2007, 30: 367-398. PMID: 17506645, DOI: 10.1146/annurev.neuro.30.051606.094324.Peer-Reviewed Original ResearchConceptsEnergy expenditureNeurobiology of feedingPeripheral metabolic signalsBrain homeostatic systemsMechanism of actionBrain involvementChronic regulationPharmacological techniquesNeuronal controlNeuronal mechanismsEnergy homeostasisComplex feeding behaviorHomeostatic systemMetabolic signalsFeeding behaviorInvolvementCurrent understandingBrain
2000
Membrane Mechanisms Underlying Contrast Adaptation in Cat Area 17In Vivo
Sanchez-Vives M, Nowak L, McCormick D. Membrane Mechanisms Underlying Contrast Adaptation in Cat Area 17In Vivo. Journal Of Neuroscience 2000, 20: 4267-4285. PMID: 10818163, PMCID: PMC6772627, DOI: 10.1523/jneurosci.20-11-04267.2000.Peer-Reviewed Original ResearchConceptsPrimary visual cortexContrast adaptationDorsal lateral geniculate nucleus (dLGN) neuronsVisual cortexLateral geniculate nucleus neuronsCat primary visual cortexAction potential activityHigh-contrast visual stimulusIntrinsic neuronal mechanismsMembrane potentialApparent membrane conductanceVisual cortex cellsVisual stimuliLow-contrast stimuliNeuronal responsivenessDLGN cellsNucleus neuronsCortical neuronsIntracellular recordingsIntracellular injectionNeuronal activityReduced responsivenessSynaptic barragesNeuronal mechanismsFiring rate
1996
Potential neuronal mechanisms of estrogen actions in synaptogenesis and synaptic plasticity
Naftolin F, Leranth C, Horvath TL, Garcia-Segura LM. Potential neuronal mechanisms of estrogen actions in synaptogenesis and synaptic plasticity. Cellular And Molecular Neurobiology 1996, 16: 213-223. PMID: 8743970, PMCID: PMC11563122, DOI: 10.1007/bf02088177.Peer-Reviewed Original ResearchConceptsSynaptic plasticityArcuate nucleusRole of GABAergicControl of LHMechanism of estrogenRat arcuate nucleusPotential neuronal mechanismsNeural cell adhesion moleculePOMC projectionsSynaptic retractionFSH secretionGnRH cellsGonadotropin levelsConstant estrusDevelopmental synaptogenesisEstrogen actionCell adhesion moleculeSynaptic inputsSynaptic patternsNeuronal mechanismsNeuronal membranesDevelopmental sex differencesAdhesion moleculesEstrogenAdult life
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply