2022
Age-related changes in Folliculogenesis and potential modifiers to improve fertility outcomes - A narrative review
Esencan E, Beroukhim G, Seifer D. Age-related changes in Folliculogenesis and potential modifiers to improve fertility outcomes - A narrative review. Reproductive Biology And Endocrinology 2022, 20: 156. PMID: 36397149, PMCID: PMC9670479, DOI: 10.1186/s12958-022-01033-x.Peer-Reviewed Original ResearchConceptsInsulin-like growth factor-1Vascular endothelial growth factorAge-related changesAntimullerian hormoneFertility outcomesIndividual studiesGrowth factor-1Endothelial growth factorObstetrical outcomesVitamin DOocyte quantityOvarian agingFollicular depletionFollicular fluidIntraovarian regulatorsRodent studiesHealthy oocytesNarrative reviewReproductive agingPotential modifiersCumulus cellsGrowth factorFactor 1Mitochondrial functionOutcomesFertility Counseling beyond 40
Mor A, Seifer D. Fertility Counseling beyond 40. 2022, 98-105. DOI: 10.1017/9781009025270.009.Peer-Reviewed Original ResearchTargeted Deletion of Mitofusin 1 and Mitofusin 2 Causes Female Infertility and Loss of Follicular Reserve
Cozzolino M, Ergun Y, Seli E. Targeted Deletion of Mitofusin 1 and Mitofusin 2 Causes Female Infertility and Loss of Follicular Reserve. Reproductive Sciences 2022, 30: 560-568. PMID: 35739352, DOI: 10.1007/s43032-022-01014-w.Peer-Reviewed Original ResearchConceptsMitofusin 1Mitofusin 2Double deletionFemale reproductive competencePotential functional redundancyDynamic organellesCellular homeostasisFunctional redundancyMitochondrial dynamicsEnvironmental stressMitochondrial functionMitochondrial dysfunctionMfn1Reproductive competenceTargeted deletionMfn2Oocyte maturationDeletionCritical roleReproductive agingFemale infertilityOocytesOocyte qualityFusion mechanismMitofusinsChapter 19 Ovarian Tissue Cryopreservation for Delaying Childbearing and Menopause
Oktay K, Marin L. Chapter 19 Ovarian Tissue Cryopreservation for Delaying Childbearing and Menopause. 2022, 193-201. DOI: 10.1016/b978-0-12-823344-3.00003-0.Peer-Reviewed Original ResearchOvarian tissue cryopreservationHealthy womenTissue cryopreservationOvarian tissue harvestingOvarian tissue freezingRisk-benefit assessmentOvarian cryopreservationClinical guidelinesReproductive yearsAmount of tissueMedical indicationsReproductive agingTransplantation techniquesTissue harvestingMenopauseTransplantationWomenTissue freezingCryopreservation
2021
DOES HARVESTING OVARIAN TISSUE TO DELAY REPRODUCTIVE AGING HAVE A NEGATIVE IMPACT ON THE NATURAL AGE OF MENOPAUSE IN HEALTHY WOMEN?
Petrikovsky B, Marin L, Oktay K. DOES HARVESTING OVARIAN TISSUE TO DELAY REPRODUCTIVE AGING HAVE A NEGATIVE IMPACT ON THE NATURAL AGE OF MENOPAUSE IN HEALTHY WOMEN? Fertility And Sterility 2021, 116: e9. DOI: 10.1016/j.fertnstert.2021.07.032.Peer-Reviewed Original ResearchEmerging follicular activation strategies to treat women with poor ovarian response and primary ovarian insufficiency
Reig A, Herraiz S, Pellicer A, Seli E. Emerging follicular activation strategies to treat women with poor ovarian response and primary ovarian insufficiency. Current Opinion In Obstetrics & Gynecology 2021, 33: 241-248. PMID: 33896920, DOI: 10.1097/gco.0000000000000703.Peer-Reviewed Original ResearchConceptsPoor ovarian responsePrimary ovarian insufficiencyLive birthsOngoing pregnancyOvarian responseOvarian insufficiencyAutologous platelet-rich plasmaBone marrow transplantFemale reproductive agingPlatelet-rich plasmaIntraovarian injectionOvarian transplantationMarrow transplantReproductive agingFertility treatmentReproductive medicineWomenPregnancyBirthInsufficiencyPrevious reportsPreliminary studyMechanical disruptionAkt stimulationCutting-edge strategiesDelaying Reproductive Aging by Ovarian Tissue Cryopreservation and Transplantation: Is it Prime Time?
Oktay K, Marin L, Petrikovsky B, Terrani M, Babayev S. Delaying Reproductive Aging by Ovarian Tissue Cryopreservation and Transplantation: Is it Prime Time? Trends In Molecular Medicine 2021, 27: 753-761. PMID: 33549473, PMCID: PMC8427891, DOI: 10.1016/j.molmed.2021.01.005.Peer-Reviewed Original ResearchConceptsOvarian tissue cryopreservationTissue cryopreservationHealthy womenFertility preservation proceduresOvarian endocrine functionRisk-benefit assessmentOvarian cryopreservationEndocrine functionMedical indicationsOvarian tissueReproductive agingReproductive medicinePreservation proceduresAmerican SocietyWomenPrime timeCryopreservationResearch guidelinesAutotransplantationMenopauseTransplantation
2020
Mitochondrial Dysfunction and Ovarian Aging
Kasapoğlu I, Seli E. Mitochondrial Dysfunction and Ovarian Aging. Endocrinology 2020, 161: bqaa001. PMID: 31927571, DOI: 10.1210/endocr/bqaa001.Peer-Reviewed Original ResearchSex effects across the lifespan in women with multiple sclerosis
Krysko KM, Graves JS, Dobson R, Altintas A, Amato MP, Bernard J, Bonavita S, Bove R, Cavalla P, Clerico M, Corona T, Doshi A, Fragoso Y, Jacobs D, Jokubaitis V, Landi D, Llamosa G, Longbrake EE, Maillart E, Marta M, Midaglia L, Shah S, Tintore M, van der Walt A, Voskuhl R, Wang Y, Zabad RK, Zeydan B, Houtchens M, Hellwig K. Sex effects across the lifespan in women with multiple sclerosis. Therapeutic Advances In Neurological Disorders 2020, 13: 1756286420936166. PMID: 32655689, PMCID: PMC7331774, DOI: 10.1177/1756286420936166.Peer-Reviewed Original ResearchMultiple sclerosisCentral nervous system disordersMS disease activityLong-term prognosisEffect of pregnancyNervous system disordersMS careMS relapsesDisability progressionDisease activityMS riskOvarian agingRelapse riskReproductive yearsSexual dysfunctionDMT useSex effectsMS susceptibilitySystem disordersPregnancyReproductive agingEffects of sexFamily planningWomenMale sex ratio
2019
Mitofusin 1 is required for female fertility and to maintain ovarian follicular reserve
Zhang M, Bener MB, Jiang Z, Wang T, Esencan E, Scott III R, Horvath T, Seli E. Mitofusin 1 is required for female fertility and to maintain ovarian follicular reserve. Cell Death & Disease 2019, 10: 560. PMID: 31332167, PMCID: PMC6646343, DOI: 10.1038/s41419-019-1799-3.Peer-Reviewed Original ResearchConceptsOocyte-granulosa cell communicationDynamic organellesAccumulation of ceramideFemale reproductive agingMitofusin 1Secondary follicle stageMitochondrial dynamicsCell communicationReproductive phenotypesCeramide synthesis inhibitor myriocinDevelopmental arrestApoptotic cell lossMitochondrial dysfunctionTargeted deletionOvarian follicular reserveOocyte maturationFemale fertilityFollicle stageDeletionPhenotypeReproductive agingOocytesCadherinFollicular reserveOrganellesMitofusin 2 plays a role in oocyte and follicle development, and is required to maintain ovarian follicular reserve during reproductive aging
Zhang M, Bener MB, Jiang Z, Wang T, Esencan E, Scott R, Horvath T, Seli E. Mitofusin 2 plays a role in oocyte and follicle development, and is required to maintain ovarian follicular reserve during reproductive aging. Aging 2019, 11: 3919-3938. PMID: 31204316, PMCID: PMC6628992, DOI: 10.18632/aging.102024.Peer-Reviewed Original ResearchConceptsMitofusin 2Key regulatory proteinsImpaired oocyte maturationFollicle developmentMitochondrial fusionRegulatory proteinsEndoplasmic reticulumMitochondrial dysfunctionTargeted deletionOocyte maturationOocytesReproductive agingFemale subfertilityOocyte qualityOvarian follicular reserveTelomeresMitochondriaMetabolic milieuProteinReticulumDeletionFusionPhenotypeApoptosisMaturationAnti-Müllerian Hormone and its Predictive Utility in Assisted Reproductive Technologies Outcomes
GRANGER E, TAL R. Anti-Müllerian Hormone and its Predictive Utility in Assisted Reproductive Technologies Outcomes. Clinical Obstetrics & Gynecology 2019, Publish Ahead of Print: &na;. DOI: 10.1097/grf.0000000000000436.Peer-Reviewed Original ResearchAnti-Müllerian hormoneART outcomesOvarian responseAssisted Reproductive Technology OutcomesControlled ovarian stimulationReproductive technology outcomesInformative biochemical markersHyperstimulation risksOvarian stimulationClinical utilitySensitive markerStimulation protocolBiochemical markersReproductive agingTechnology outcomesOutcomesHormonePredictive utilityBest predictorMarkersResponseMitochondrial unfolded protein response: a stress response with implications for fertility and reproductive aging
Seli E, Wang T, Horvath TL. Mitochondrial unfolded protein response: a stress response with implications for fertility and reproductive aging. Fertility And Sterility 2019, 111: 197-204. PMID: 30691623, DOI: 10.1016/j.fertnstert.2018.11.048.Peer-Reviewed Original ResearchConceptsMitochondrial unfolded protein responseTwo-cell embryo developmentUnfolded protein responseImpaired oocyte maturationMorphology of mitochondriaMitochondrial dysfunction resultsPremature reproductive agingNovel mechanistic insightsMitochondrial DNA contentReactive oxygen species productionPrevention of agingCLPP resultsProtein responseOxygen species productionReproductive agingPreimplantation embryosAge-related accumulationOxidative phosphorylationStress responseEmbryo developmentForm blastocystsMitochondrial functionMitochondriaMitochondrial dysfunctionEnergy metabolismChapter 25 The Role of Antimullerian Hormone in Assisted Reproduction
Tal R, Seifer D. Chapter 25 The Role of Antimullerian Hormone in Assisted Reproduction. 2019, 403-414. DOI: 10.1016/b978-0-12-813209-8.00025-x.ChaptersAntimullerian hormoneOvarian responseControlled ovarian stimulationOnset of menopausePrimordial follicle poolInformative biochemical markersOvarian stimulationOvarian reserveFertility preservationAbnormal folliculogenesisFollicle poolClinical utilityParacrine regulatorSensitive markerStimulation protocolChronologic ageOvarian folliclesGranulosa cellsBiochemical markersReproductive agingReproductive medicineInverse correlationAssisted reproductionReproductive technologiesClinical application
2018
DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation
Morin SJ, Tao X, Marin D, Zhan Y, Landis J, Bedard J, Scott RT, Seli E. DNA methylation-based age prediction and telomere length in white blood cells and cumulus cells of infertile women with normal or poor response to ovarian stimulation. Aging 2018, 10: 3761-3773. PMID: 30530921, PMCID: PMC6326671, DOI: 10.18632/aging.101670.Peer-Reviewed Original ResearchConceptsChronologic agePremature reproductive agingReproductive-age womenWhite blood cellsOvarian stimulationInfertile womenOvarian responsePatient ageInfertile patientsAge womenPoor responseFollicular somatic cellsReproductive agingFertility treatmentCumulus cellsBlood cellsTelomere lengthAgeWomenPatientsStimulationWBCFemale ageRiskReproductive senescence
2016
Reproductive aging is associated with changes in oocyte mitochondrial dynamics, function, and mtDNA quantity
Babayev E, Wang T, Szigeti-Buck K, Lowther K, Taylor HS, Horvath T, Seli E. Reproductive aging is associated with changes in oocyte mitochondrial dynamics, function, and mtDNA quantity. Maturitas 2016, 93: 121-130. PMID: 27523387, PMCID: PMC5064871, DOI: 10.1016/j.maturitas.2016.06.015.Peer-Reviewed Original ResearchConceptsReactive oxygen speciesUnfolded protein response genesProtein response genesMitochondrial DNAMitochondrial dynamicsMitochondrial stressResponse genesMammalian reproductionMitochondria morphologyStressful conditionsMitochondrial changesMitochondriaROS levelsMtDNA levelsElevated expressionMtDNA quantityOxygen speciesOocytesGenesMature oocytesNumerous aspectsExpressionReproductive agingMII oocytesFollicle-enclosed oocytes
2013
Potential Mechanisms for Racial and Ethnic Differences in Antimüllerian Hormone and Ovarian Reserve
Tal R, Seifer DB. Potential Mechanisms for Racial and Ethnic Differences in Antimüllerian Hormone and Ovarian Reserve. International Journal Of Endocrinology 2013, 2013: 818912. PMID: 24348557, PMCID: PMC3857838, DOI: 10.1155/2013/818912.Peer-Reviewed Original ResearchOvarian reserveAntimüllerian hormoneRacial differencesSerum antimüllerian hormoneSerum AMH levelsVitamin D deficiencyReproductive technology treatmentEthnic differencesImportant clinical implicationsSuch racial differencesAMH levelsD deficiencyInfertility treatmentTreatment outcomesReproductive endocrinologistsReproductive planningEthnic groupsTimely interventionClinical implicationsReproductive agingSensitive biomarkerTechnology treatmentEthnic variationGenetic factorsPotential mechanisms
2007
Biologic markers of ovarian reserve and reproductive aging: application in a cohort study of HIV infection in women
Seifer DB, Golub ET, Lambert-Messerlian G, Springer G, Holman S, Moxley M, Cejtin H, Nathwani N, Anastos K, Minkoff H, Greenblatt RM. Biologic markers of ovarian reserve and reproductive aging: application in a cohort study of HIV infection in women. Fertility And Sterility 2007, 88: 1645-1652. PMID: 17418155, PMCID: PMC2682326, DOI: 10.1016/j.fertnstert.2007.01.122.Peer-Reviewed Original ResearchConceptsWomen's Interagency HIV StudyEarly follicular phaseOvarian reserveInhibin BHIV infectionMIS levelsFollicular phaseHIV StudyLower inhibin B levelsReproductive agingSerum samplesHIV infection influencesInhibin B levelsMulticenter prospective studyCross-sectional studyMenstrual cycle phaseCycle phaseUninfected womenCohort studyFSH levelsMenstrual bleedingNegative womenHIV serostatusSerum markersProspective study
2003
Estrogen, synaptic plasticity and hypothalamic reproductive aging
Hung AJ, Stanbury MG, Shanabrough M, Horvath TL, Garcia-Segura LM, Naftolin F. Estrogen, synaptic plasticity and hypothalamic reproductive aging. Experimental Gerontology 2003, 38: 53-59. PMID: 12543261, DOI: 10.1016/s0531-5565(02)00183-3.Peer-Reviewed Original ResearchConceptsConstant estrusReproductive agingEstrogen exposureMale ratsAnti-oxidant vitamin EEarly estrogen exposureArcuate nucleus neuronsHypothalamic arcuate nucleus neuronsConstant vaginal estrusHypothalamic failureEstradiol exposureGonadotrophin surgeOvarian estrogenArcuate nucleusConstant diestrusNucleus neuronsOvarian failureElevated estradiolPerikaryal membraneFemale ratsPerinatal periodTesticular androgensRat brainSex steroidsHormonal factors
1994
Increasing Hypothalamic Arcuate Nucleus Glial Peroxidase Activity in Aging Female Rats Is Reduced by an Antiestrogen and a Gonadotropin-Releasing Hormone Agonist
Seifer D, Roa-Peña L, Keefe D, Zhang H, Goodman S, Jones E, Naftolin F. Increasing Hypothalamic Arcuate Nucleus Glial Peroxidase Activity in Aging Female Rats Is Reduced by an Antiestrogen and a Gonadotropin-Releasing Hormone Agonist. Menopause The Journal Of The North American Menopause Society 1994, 1: 83-90. DOI: 10.1097/00042192-199400120-00005.Peer-Reviewed Original ResearchMonths of ageFemale ratsGoserelin acetate depotPosterior periventricular areasComputerized image analyzerAge-related increaseDiaminobenzidine tetrahydrochloridePeriventricular areaArcuate nucleusGoserelin acetateEndogenous estrogensHypothalamic sectionsControl groupSuper agonistReproductive agingMonthsRatsPeroxidase activityDAB reactionAgeGroupImplantsAnimalsImage analyzerSerial sectioning
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