2025
Blood-based protein biomarkers of sickle cell disease pain: a systematic review and meta-analysis.
Mirbeyk M, Misra S, Koneru G, Funaro M, Rangaraju S, Bakshi N. Blood-based protein biomarkers of sickle cell disease pain: a systematic review and meta-analysis. Pain 2025 PMID: 40981515, DOI: 10.1097/j.pain.0000000000003773.Peer-Reviewed Original ResearchVaso-occlusive pain episodesSickle cell diseaseSickle Cell Disease PainChronic painBlood-based protein biomarkersMeta-analysisComplication of sickle cell diseaseChronic SCD painAcute vaso-occlusive pain episodesAssociated with frequencySystematic reviewNO biomarkersAcute painPain biologyPain episodesImmune activationPainCell diseaseObservational studyTissue damageBiomarker researchBiomarkersElectronic databasesBiomarker discoveryClinical contextImpact of age-related changes in buccal epithelial cells on pediatric epigenetic biomarker research
Merrill S, Konwar C, Fatima F, Dever K, MacIsaac J, Letourneau N, Giesbrecht G, Dewey D, England-Mason G, Lewis C, Wang D, Teh A, Meaney M, Gonzalez A, Noll J, De Weerth C, Bush N, O’Donnell K, Stewart S, Kobor M. Impact of age-related changes in buccal epithelial cells on pediatric epigenetic biomarker research. Nature Communications 2025, 16: 609. PMID: 39800776, PMCID: PMC11725590, DOI: 10.1038/s41467-025-55909-8.Peer-Reviewed Original ResearchConceptsBuccal epithelial cellsAge-related changesObsessive-compulsive disorderEpithelial cellsDiurnal cortisol slopeCheek swabsImpact of age-related changesCortisol slopeAssociated with ageOral cellsDevelopmental rangeAge accelerationDNA methylation studiesHeterogeneous sampleNeutrophil proportionBiomarker researchMethylation studiesAgeSwabsWeak associationEpigenetic age
2022
The neurobiology of apathy in depression and neurocognitive impairment in older adults: a review of epidemiological, clinical, neuropsychological and biological research
Steffens D, Fahed M, Manning K, Wang L. The neurobiology of apathy in depression and neurocognitive impairment in older adults: a review of epidemiological, clinical, neuropsychological and biological research. Translational Psychiatry 2022, 12: 525. PMID: 36572691, PMCID: PMC9792580, DOI: 10.1038/s41398-022-02292-3.Peer-Reviewed Original ResearchConceptsPrefrontal cortex circuitCortex circuitPeripheral biomarkersPresence of apathyNeurobiology of apathyPoor health outcomesDefinitive treatmentFuture studiesApathy symptomsClinical managementNeuropsychiatric comorbiditiesFunctional declineCommon conditionNeurocognitive impairmentCognitive disordersNeuropsychological featuresHealth outcomesCognitive impairmentBrain circuitryNeuropsychiatric disordersPrefrontal cortexOlder adultsClinical realityBiomarker researchImpairment
2015
Biomarkers in multiple sclerosis
Housley WJ, Pitt D, Hafler DA. Biomarkers in multiple sclerosis. Clinical Immunology 2015, 161: 51-58. PMID: 26143623, DOI: 10.1016/j.clim.2015.06.015.Peer-Reviewed Original ResearchConceptsMultiple sclerosisB cell chemoattractant CXCL13Myelin-reactive T cellsMacrophage marker CD163Reactive T cellsMarkers of neurodegenerationKIR4.1 antibodiesMS seraClinical outcomesOligoclonal bandsYKL-40Disease progressionT cellsMS susceptibilityCerebrospinal fluidPotential biomarkersViral titersClinical useBiomarkersBiomarker researchSclerosisProgressionDisease diagnosisCD163CXCL13
2014
Neuroimaging and Biomarkers in Addiction Treatment
Garrison KA, Potenza MN. Neuroimaging and Biomarkers in Addiction Treatment. Current Psychiatry Reports 2014, 16: 513. PMID: 25308385, PMCID: PMC4427893, DOI: 10.1007/s11920-014-0513-5.Peer-Reviewed Original ResearchConceptsCognitive controlNeural correlatesAddiction treatmentAddiction treatment outcomesDimensions of functioningNeural circuitsPossible mediatorsImpulsivityTreatment responseAddictionCorrelatesPromising indexRelated disordersTreatment outcomesModeratorFunctioningNeuroimagingTreatment subgroupsDimensionsMeasurable indicesReliable biomarkersPotential biomarkersBiomarkersDisordersBiomarker research
1995
Significance of individual sensitivity to chemicals: elucidation of host susceptibility by use of biomarkers in environmental health research.
Cullen M, Redlich C. Significance of individual sensitivity to chemicals: elucidation of host susceptibility by use of biomarkers in environmental health research. Clinical Chemistry 1995, 41: 1809-1813. PMID: 7497637, DOI: 10.1093/clinchem/41.12.1809.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHost susceptibilityBiomarker researchMultiple chemical sensitivityUse of biomarkersRisk modifiersCarcinogen metabolismNutritional statusPractical biomarkersEnvironmental health researchImmunological variabilityEnvironmental chemicalsInadequate knowledgeHealth researchIndividual sensitivityBiomarkersCarcinogenic riskBiomarker methodsMarkersChemical sensitivityResponse relationHost variability
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