2024
Delusional Unreality and Predictive Processing
Castiello S, Rossi-Goldthorpe R, Fan S, Kenney J, Waltz J, Erickson M, Bansal S, Gold J, Corlett P. Delusional Unreality and Predictive Processing. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024 PMID: 39710316, PMCID: PMC12179324, DOI: 10.1016/j.bpsc.2024.12.006.Peer-Reviewed Original ResearchHealthy control participantsSense of unrealityPeters Delusions InventoryAssociated with delusionsDelusion-like beliefsPrediction error processingImpact of psychosisUnreal experiencesPrediction processDelusions InventoryExtinction learningKamin blockingEsoteric beliefsDelusional ideationClinical delusionsPhenomenological psychopathologistsControl participantsDelusionsSchizophreniaLearning tasksError processHealthy participantsAssess symptomsParticipant groupsKaminResting-state functional MRI of the nose as a novel investigational window into the nervous system
Ponticorvo S, Paasonen J, Stenroos P, Salo R, Tanila H, Filip P, Rothman D, Eberly L, Garwood M, Metzger G, Gröhn O, Michaeli S, Mangia S. Resting-state functional MRI of the nose as a novel investigational window into the nervous system. Scientific Reports 2024, 14: 26352. PMID: 39487180, PMCID: PMC11530622, DOI: 10.1038/s41598-024-77615-z.Peer-Reviewed Original ResearchConceptsFunctional MRICentral nervous system integrityAutonomic nervous system innervationNervous system innervationAir-tissue interfaceNervous system integrityNervous system activityAutonomic nervous system activityAwake miceResting-state functional MRIAir intakeAbundant vasculatureCSF spacesNervous systemHeart rateSystem activityMRIBrain vesselsClearance sitesResting-stateSystem integrationHealthy participantsNoseSignal lossBreathing rateCommon and unique brain aging patterns between females and males quantified by large‐scale deep learning
Du Y, Yuan Z, Sui J, Calhoun V. Common and unique brain aging patterns between females and males quantified by large‐scale deep learning. Human Brain Mapping 2024, 45: e70005. PMID: 39225381, PMCID: PMC11369911, DOI: 10.1002/hbm.70005.Peer-Reviewed Original ResearchConceptsBrain functional changesFunctional connectivityCognitive controlBrain agingBrain functionPatterns of brain agingResting-state brain functional connectivityBrain functional interactionsBrain functional connectivityHuman brain functionBrain aging patternsGender commonalitiesAge-related changesDeep learningHealthy participantsNormal agingNegative connectionFunctional changesBrainPositive connectionDeep learning modelsFunctional domainsAge effectsFunctional interactionsCross-validation schemeNoninvasive quantification of [18F]SynVesT-1 binding using simplified reference tissue model 2
Naganawa M, Gallezot J, Li S, Nabulsi N, Henry S, Cai Z, Matuskey D, Huang Y, Carson R. Noninvasive quantification of [18F]SynVesT-1 binding using simplified reference tissue model 2. European Journal Of Nuclear Medicine And Molecular Imaging 2024, 52: 113-121. PMID: 39155309, DOI: 10.1007/s00259-024-06885-6.Peer-Reviewed Original ResearchPositron emission tomographyCentrum semiovaleReference regionPositron emission tomography scanTest-retest variabilityTest-retest reproducibilitySynaptic vesicle glycoprotein 2AOne-tissue compartmentArterial blood samplesRetest scansGold standardBrain uptakeEmission tomographyBlood samplesCerebellumNoninvasive quantificationSRTM2ConclusionOur findingsPopulation averageHealthy participantsMetabolite analysisScan timeBPNDSemiovaleIndividual differences in spatial working memory strategies differentially reflected in the engagement of control and default brain networks
Suljič N, Kraljič A, Rahmati M, Cho Y, Ozimič A, Murray J, Anticevic A, Repovš G. Individual differences in spatial working memory strategies differentially reflected in the engagement of control and default brain networks. Cerebral Cortex 2024, 34: bhae350. PMID: 39214852, PMCID: PMC11364466, DOI: 10.1093/cercor/bhae350.Peer-Reviewed Original ResearchConceptsCategorical representationsWorking memoryBrain activityFunctional magnetic resonance imaging studySpatial working memory strategySpatial Working Memory taskFrontoparietal network activitySpatial working memoryWorking Memory TaskEngagement of controlAssociated with distinct patternsWorking memory strategiesMagnetic resonance imaging studiesNetwork activityMemory taskBrain systemsAttentional resourcesTask trialsBrain networksMemory strategiesStimulus informationStronger deactivationTiming of stimuliHealthy participantsSpatial representationRobust Brain Correlates of Cognitive Performance in Psychosis and Its Prodrome
Ward H, Beermann A, Xie J, Yildiz G, Felix K, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Seidman L, Stone W, Tsuang M, Walker E, Woods S, Coleman M, Bouix S, Holt D, Öngür D, Breier A, Shenton M, Heckers S, Halko M, Lewandowski K, Brady R. Robust Brain Correlates of Cognitive Performance in Psychosis and Its Prodrome. Biological Psychiatry 2024, 97: 139-147. PMID: 39032726, PMCID: PMC11634655, DOI: 10.1016/j.biopsych.2024.07.012.Peer-Reviewed Original ResearchAuditory continuous performance taskConnectome-wide association studiesEarly psychosisCognitive performanceNorth American Prodrome Longitudinal Study 2At-risk individualsCorrelates of cognitive performanceBrain-cognition relationshipsBrain-phenotype relationshipsBrain-behavior associationsContinuous performance taskEarly-course psychosisLongitudinal Study 2Resting-state fMRIProspective study of individualsHuman Connectome ProjectPsychosis onsetStudy of individualsPsychosisStudy 2Performance tasksNeurocognitive impairmentCognitive instrumentsHealthy participantsRobust associationsTesting the structural disconnection hypothesis: Myelin content correlates with memory in healthy aging
Mendez Colmenares A, Thomas M, Anderson C, Arciniegas D, Calhoun V, Choi I, Kramer A, Li K, Lee J, Lee P, Burzynska A. Testing the structural disconnection hypothesis: Myelin content correlates with memory in healthy aging. Neurobiology Of Aging 2024, 141: 21-33. PMID: 38810596, PMCID: PMC11290458, DOI: 10.1016/j.neurobiolaging.2024.05.013.Peer-Reviewed Original ResearchDisconnection hypothesisVirginia Cognitive Aging ProjectHypothesis of cognitive agingFractional anisotropyAssociated with reduced memory performanceDeterioration of white matterAge-related memory lossPrefrontal white matterGenu of the corpus callosumMyelin water fractionVoxel-wise analysisWhite matterCorpus callosumExecutive functionCognitive agingDiffusion tensor imagingMemory performancePrefrontal WMStructural equation modelingWM microstructureAge differencesProcessing speedStructural disconnectionCognitive declineHealthy participantsKetamine induces multiple individually distinct whole-brain functional connectivity signatures
Moujaes F, Ji J, Rahmati M, Burt J, Schleifer C, Adkinson B, Savic A, Santamauro N, Tamayo Z, Diehl C, Kolobaric A, Flynn M, Rieser N, Fonteneau C, Camarro T, Xu J, Cho Y, Repovs G, Fineberg S, Morgan P, Seifritz E, Vollenweider F, Krystal J, Murray J, Preller K, Anticevic A. Ketamine induces multiple individually distinct whole-brain functional connectivity signatures. ELife 2024, 13: e84173. PMID: 38629811, PMCID: PMC11023699, DOI: 10.7554/elife.84173.Peer-Reviewed Original ResearchConceptsResponse to ketamineAcute ketamineBehavioral effectsQuantified resting-state functional connectivityEffects of acute ketamineSymptom variationResting-state functional connectivityTreatment-resistant depressionFunctional connectivity signaturesGlobal brain connectivitySingle-subject levelInter-individual variabilityPlacebo-controlled studyFunctional connectivityConnectivity signaturesBrain connectivityHealthy participantsSingle-blind placebo-controlled studyNeural variationsTreatment conditionsKetamineGene expression targetsPharmacological biomarkersPilot awardParvalbuminEvaluation of automated airway morphological quantification for assessing fibrosing lung disease
Pakzad A, Cheung W, Van Moorsel C, Quan K, Mogulkoc N, Bartholmai B, Van Es H, Ezircan A, Van Beek F, Veltkamp M, Karwoski R, Peikert T, Clay R, Foley F, Braun C, Savas R, Sudre C, Doel T, Alexander D, Wijeratne P, Hawkes D, Hu Y, Hurst J, Jacob J. Evaluation of automated airway morphological quantification for assessing fibrosing lung disease. Computer Methods In Biomechanics And Biomedical Engineering Imaging & Visualization 2024, 12: 2325361. DOI: 10.1080/21681163.2024.2325361.Peer-Reviewed Original ResearchIdiopathic pulmonary fibrosisIdiopathic pulmonary fibrosis patientsDisease extentAbnormal airway dilatationCompared to healthy controlsFibrosing lung diseaseAirway segmentsVolumetric computed tomographyChest CTTraction bronchiectasisAirway dilationAirway measurementsLower lobePulmonary fibrosisAirway abnormalitiesLung diseaseHealthy controlsAirwayCT imagesImaging biomarkersClinical interpretationAirway branchingAutomated quantificationPatientsHealthy participantsApplication of glutamate weighted CEST in brain imaging of nicotine dependent participants in vivo at 7T
Jacobs P, Jee J, Fang L, Devlin E, Iannelli C, Thakuri D, Loughead J, Epperson C, Wilson N, Roalf D, Reddy R, Nanga R. Application of glutamate weighted CEST in brain imaging of nicotine dependent participants in vivo at 7T. PLOS ONE 2024, 19: e0297310. PMID: 38363747, PMCID: PMC10871471, DOI: 10.1371/journal.pone.0297310.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexNon-smokersCingulate gyrusAnterior cingulate cortexContext of addictionTreating nicotine addictionApplication of glutamatePopulation of smokersWilcoxon rank sum testGluCEST imagingTraumatic brain injuryT1-weighted imagesInvestigated glutamateSignificant healthcare issueCingulate cortexGray matter regionsRank sum testNicotine useNicotine addictionNicotine dependenceBrain regionsChemical exchange saturation transferNegative age dependenceHealthy participantsUltra-high field MRI
2023
Safety, pharmacokinetics and pharmacodynamics of HRS‐7535, a novel oral small molecule glucagon‐like peptide‐1 receptor agonist, in healthy participants: A phase 1, randomized, double‐blind, placebo‐controlled, single‐ and multiple‐ascending dose, and food effect trial
Wu J, Zhou R, Zhang Q, Zhang Q, Qin H, Ye Z, Xu Y, Feng S, Shu C, Shen Y, Fan Y, Wang Q, Du Y, Hu W. Safety, pharmacokinetics and pharmacodynamics of HRS‐7535, a novel oral small molecule glucagon‐like peptide‐1 receptor agonist, in healthy participants: A phase 1, randomized, double‐blind, placebo‐controlled, single‐ and multiple‐ascending dose, and food effect trial. Diabetes Obesity And Metabolism 2023, 26: 901-910. PMID: 38100147, DOI: 10.1111/dom.15383.Peer-Reviewed Original ResearchGlucagon-like peptide-1 receptor agonistsPeptide-1 receptor agonistsSingle ascending doseMAD partsReceptor agonistGeometric mean tNovel glucagon-like peptide-1 receptor agonistFood effectHealthy participantsMultiple ascending dosePhase 1 trialType 2 diabetesGLP-1RAsPrimary endpointSingle doseDay 29Day 28Mean reductionClinical developmentMean TBody weightPharmacokineticsPlaceboTolerabilityEffect trialEffects of the HIV‐1 maturation inhibitor GSK3640254 on QT interval in healthy participants
Zhang Y, Bush M, Yazdani P, Zhan J, Wen B, Bainbridge V, Wynne B, Joshi S, Lataillade M. Effects of the HIV‐1 maturation inhibitor GSK3640254 on QT interval in healthy participants. Pharmacology Research & Perspectives 2023, 11: e01151. PMID: 37961928, PMCID: PMC10644204, DOI: 10.1002/prp2.1151.Peer-Reviewed Original ResearchConceptsConcentration-QTc analysisHealthy participantsQT intervalNovel HIV-1 maturation inhibitorsPlacebo-adjusted changeHIV-1 treatmentHIV-1 maturation inhibitorsMoxifloxacin doseSupratherapeutic dosePlasma concentrationsRelevant effectsFridericia's formulaTreatment periodCardiac repolarizationHeart rateMaturation inhibitorsCardiac conductionCardiac parametersDay 7QT studyDoseTime pointsGSK3640254ΔΔQTcFPharmacokineticsmiR-122 and miR-21 are Stable Components of miRNA Signatures of Early Lung Cancer after Validation in Three Independent Cohorts
Zyla J, Dziadziuszko R, Marczyk M, Sitkiewicz M, Szczepanowska M, Bottoni E, Veronesi G, Rzyman W, Polanska J, Widlak P. miR-122 and miR-21 are Stable Components of miRNA Signatures of Early Lung Cancer after Validation in Three Independent Cohorts. Journal Of Molecular Diagnostics 2023, 26: 37-48. PMID: 37865291, DOI: 10.1016/j.jmoldx.2023.09.010.Peer-Reviewed Original ResearchConceptsEarly lung cancerLung cancerLung cancer screening studyMiR-122MiR-21MiRNA signatureCancer screening studyLung cancer developmentPlasma miRNA signatureScreening studyIndependent cohortDiagnostic biomarkersPotential biomarkersCancer typesCohortCancer developmentCancerHealthy participantsMiR-144MiRNA panelDiagnostic potentialBiomarkersAdenocarcinomaDifferent cohortsMiRNAsBrain activation during fear extinction recall in unmedicated patients with obsessive-compulsive disorder
Diniz J, Bazán P, Pereira C, Saraiva E, Ramos P, de Oliveira A, Reimer A, Hoexter M, Miguel E, Shavitt R, Batistuzzo M. Brain activation during fear extinction recall in unmedicated patients with obsessive-compulsive disorder. Psychiatry Research Neuroimaging 2023, 336: 111733. PMID: 37913655, DOI: 10.1016/j.pscychresns.2023.111733.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderExtinction recallNeutral stimuliFear conditioningFear extinction recallBlood oxygenation level-dependent (BOLD) responseFear conditioning experimentSkin conductance reactivitySpecific brain activation patternsBrain activation patternsSkin conductance responsesLevel-dependent responsesEntire sampleDACC activationUnmedicated adult patientsFear responsesBrain activationAversive stimuliLingual gyrusUnmedicated samplesActivation patternsHealthy participantsRecallOpercular cortexInsular cortexDouble dissociation between P300 components and task switch error type in healthy but not psychosis participants
Huang L, Parker D, Ethridge L, Hamm J, Keedy S, Tamminga C, Pearlson G, Keshavan M, Hill S, Sweeney J, McDowell J, Clementz B. Double dissociation between P300 components and task switch error type in healthy but not psychosis participants. Schizophrenia Research 2023, 261: 161-169. PMID: 37776647, PMCID: PMC11015813, DOI: 10.1016/j.schres.2023.09.025.Peer-Reviewed Original ResearchConceptsEvent-related potentialsDouble dissociationParietal P300Oddball taskCognitive functionPsychosis participantsInductive reasoningP300 event-related potentialFrontal P300 amplitudePossible neural correlatesMental flexibilityCognitive demandsMemory maintenanceNeural correlatesPerseverative errorsRegressive errorsBehavioral performanceOddball targetsP300 componentP300 amplitudeError typesSubjects' abilityNeural activityP300 reductionHealthy participantsRelationships of in vivo brain norepinephrine transporter and age, BMI, and gender
Koohsari S, Sadabad F, Pittman B, Gallezot J, Carson R, van Dyck C, Li C, Potenza M, Matuskey D. Relationships of in vivo brain norepinephrine transporter and age, BMI, and gender. Synapse 2023, 77: e22279. PMID: 37382240, PMCID: PMC10416616, DOI: 10.1002/syn.22279.Peer-Reviewed Original ResearchConceptsBody mass indexMultilinear reference tissue model 2Gender-related differencesBrain norepinephrine transportersNorepinephrine transporterAge-related declineStructural MR scansBrain regionsReference tissue model 2Mass indexRaphe nucleusLocus coeruleusOccipital cortexBMI relationshipHealthy adultsHigh-resolution research tomographAvailable radiotracersHealthy participantsMR scansAgeAnatomic templateReference regionNegative associationNet availabilityPotential ageInterrater reproducibility of the Myoton and durometer devices to quantify sclerotic chronic graft-versus-host disease
Ghosh S, Baker L, Chen F, Khera Z, Vain A, Zhang K, Hood A, Smith H, Chen H, Jagasia M, Tkaczyk E. Interrater reproducibility of the Myoton and durometer devices to quantify sclerotic chronic graft-versus-host disease. Archives Of Dermatological Research 2023, 315: 2545-2554. PMID: 37227518, PMCID: PMC11755669, DOI: 10.1007/s00403-023-02626-1.Peer-Reviewed Original ResearchConceptsSkin sclerosisChronic graftHost diseaseAnatomic sitesAllogeneic hematopoietic stem cell transplantationHematopoietic stem cell transplantationSclerotic chronic graftLong-term survivorsStem cell transplantationConfidence intervalsCGVHD treatmentSclerotic cGvHDSevere complicationsSkin scoreCurrent gold standardCell transplantationTherapeutic responseClinical reproducibilityCGVHDDorsal forearmMyotonSclerosisVolar forearmHealthy participantsMean pairwise differenceReproducibility of 13C labeling of glutamate and glutamine in human brain using selPOCE MRS at 7T upon [U-13C]-labeled glucose infusion
Ahmadian N, Jacobs S, Gosselink M, van der Kemp W, Hoogduin H, Coppoli A, Mason G, de Graaf R, Norouzizadeh H, Mahon C, van Marle S, van Eijsden P, Cerneus D, Miller C, De Lepeleire I, Basile A, Klomp D, Prompers J, Wiegers E. Reproducibility of 13C labeling of glutamate and glutamine in human brain using selPOCE MRS at 7T upon [U-13C]-labeled glucose infusion. Proceedings Of The International Society For Magnetic Resonance In Medicine ... Scientific Meeting And Exhibition. 2023 DOI: 10.58530/2023/5332.Peer-Reviewed Original ResearchLabeling of glutamateHealthy participantsHuman brainNeurotransmitter cyclingTest-retest measurementsClinical Phenotypes of Patients With Systemic Sclerosis With Distinct Molecular Signatures in Skin
Yang M, Goh V, Lee J, Espinoza M, Yuan Y, Carns M, Aren K, Chung L, Khanna D, McMahan ZH, Agrawal R, Nelson L, Shah SJ, Whitfield ML, Hinchcliff M. Clinical Phenotypes of Patients With Systemic Sclerosis With Distinct Molecular Signatures in Skin. Arthritis Care & Research 2023, 75: 1469-1480. PMID: 35997480, PMCID: PMC9947190, DOI: 10.1002/acr.24998.Peer-Reviewed Original ResearchConceptsRadiographic interstitial lung diseaseInterstitial lung diseaseHigher mRSSSSc patientsSerum autoantibodiesClinical phenotypeHealthy participantsScl-70 antibodyPresent multicenter studySimilar disease durationSystemic sclerosis patientsDistinct clinical phenotypesSkin gene expressionValuable clinical informationDcSSc patientsDisease durationIdentifies patientsSystemic sclerosisSclerosis patientsMulticenter studyLung diseaseSkin fibrosisSimilar prevalenceClinical dataMultivariable modelingTwo different brain networks underlying picture naming with familiar pre-existing native words and new vocabulary
Palomar-García M, Villar-Rodríguez E, Pérez-Lozano C, Sanjuán A, Bueichekú E, Miró-Padilla A, Costumero V, Adrián-Ventura J, Parcet M, Ávila C. Two different brain networks underlying picture naming with familiar pre-existing native words and new vocabulary. Brain And Language 2023, 237: 105231. PMID: 36716643, DOI: 10.1016/j.bandl.2023.105231.Peer-Reviewed Original ResearchConceptsLanguage control networkPicture naming taskOld wordsNaming TaskMeasured BOLD signal changesControl networkBOLD signal changesNative wordsPicture namingBrain networksSpanish wordsParietal regionsCortical networksCortical/subcortical networksHealthy participantsActivity patternsFunctional circuitsWordsSignal changesVocabularyTaskCognitive purposesFMRILanguageHippocampus
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