2025
Age-invariant benefits of spatiotemporal predictions amidst distraction during dynamic visual search
Shalev N, Boettcher S, Nobre A. Age-invariant benefits of spatiotemporal predictions amidst distraction during dynamic visual search. Scientific Reports 2025, 15: 17078. PMID: 40379870, PMCID: PMC12084335, DOI: 10.1038/s41598-025-01796-4.Peer-Reviewed Original ResearchConceptsSensitivity to distractionGoal-driven attentionGuidance of attentionVisual search taskOlder adultsAge-related differencesEffects of predictabilityDynamic visual searchAttentional controlHigh distractionAttentional guidanceGoal-directedVisual searchSearch taskDistractorsStudy attentionDistractionPoor performanceSpatiotemporal regularityDistracting elementsAdultsAttentionDeficits
2024
Using mobile eye-tracking to evaluate gaze behavior during a speech in pediatric anxiety disorders
Kitt E, Abend R, Amelio P, Galbraith J, Poe A, Gee D, Pine D, Harrewijn A. Using mobile eye-tracking to evaluate gaze behavior during a speech in pediatric anxiety disorders. Journal Of Affective Disorders 2024, 369: 462-466. PMID: 39389116, DOI: 10.1016/j.jad.2024.10.024.Peer-Reviewed Original ResearchSocial anxiety symptom severityAnxiety symptom severityAnxiety-related differencesAnxiety disordersState anxietyTask conditionsPediatric anxietySocial anxietyGaze behaviorSymptom severityNon-anxious controlsPediatric anxiety disordersSocial stress taskEye trackingAnxiety-provoking contextsPassive viewing conditionsAge-related differencesNaturalistic stressorElevated anxietyStress taskMobile eye-trackerDevelopmental sampleDiagnostic groupsEye-tracking technologyLonger gazeGyrification across psychotic disorders: A bipolar-schizophrenia network of intermediate phenotypes study
Rychagov N, Del Re E, Zeng V, Oykhman E, Lizano P, McDowell J, Yassin W, Clementz B, Gershon E, Pearlson G, Sweeney J, Tamminga C, Keshavan M. Gyrification across psychotic disorders: A bipolar-schizophrenia network of intermediate phenotypes study. Schizophrenia Research 2024, 271: 169-178. PMID: 39032429, PMCID: PMC11384321, DOI: 10.1016/j.schres.2024.07.009.Peer-Reviewed Original ResearchBipolar-Schizophrenia NetworkPsychotic disordersDSM-IVIntermediate Phenotypes studyGyrification changesSchizophrenia compared to controlsBipolar I disorderRight cingulate cortexSchizoaffective disorder probandsBipolar disorder probandsDisorders compared to controlsAge-related differencesSchizoaffective disorderCingulate cortexVerbal memoryBipolar disorderAge-related changesFalse discovery rate correctionSchizophreniaCortical gyrificationHypogyriaFrontal lobeGyrificationDisordersHealthy controlsAge-related reduction in anxiety and neural encoding of negative emotional memory
Chaudhary S, Zhang S, Chen Y, Dominguez J, Chao H, Li C. Age-related reduction in anxiety and neural encoding of negative emotional memory. Frontiers In Aging Neuroscience 2024, 16: 1375435. PMID: 39021704, PMCID: PMC11252031, DOI: 10.3389/fnagi.2024.1375435.Peer-Reviewed Original ResearchNegative emotional memoriesSpielberger State-Trait Anxiety InventoryEmotional memoryAge-related reductionSpielberger State-Trait Anxiety Inventory scoresWhole-brain regressionNegative emotional imagesState-Trait Anxiety InventoryTrait Anxiety InventoryAge-related differencesSignal detection theoryMemory taskNeutral imagesAge-related changesEmotional imagesAnxiety InventoryMediation analysisAnxietyPost-scanCortical activityNeural encodingState scoresMemoryOlder adultsDetection theoryThe Youth Sheehan Disability Scale: A Psychometric Evaluation
DiFonte M, Sain K, Tolin D. The Youth Sheehan Disability Scale: A Psychometric Evaluation. Journal Of Psychopathology And Behavioral Assessment 2024, 46: 655-667. DOI: 10.1007/s10862-024-10137-0.Peer-Reviewed Original ResearchChild reportsFunctional impairmentSessions of cognitive behavioral therapyMeasures of functional impairmentSheehan Disability ScalePotential age-related differencesCognitive behavioral therapyChild functional impairmentMeasures of youthParent-child dyadsAge-related differencesSpecialty outpatient clinicMild to moderate impairmentDepression severityBehavioral therapyParent reportChild impairmentChildren's symptomsPsychometric propertiesDisability ScaleModerate impairmentImpairmentImprove severityCronbach's aYouth
2023
Association of Maternal Age and Blood Markers for Metabolic Disease in Newborns
Xie Y, Peng G, Zhao H, Scharfe C. Association of Maternal Age and Blood Markers for Metabolic Disease in Newborns. Metabolites 2023, 14: 5. PMID: 38276295, PMCID: PMC10821442, DOI: 10.3390/metabo14010005.Peer-Reviewed Original ResearchMaternal ageAdvanced maternal ageBlood metabolic markersMaternal age groupsInborn metabolic disordersNeonatal outcomesSingleton infantsGestational ageClinical variablesMarker levelsBirth weightBlood levelsBlood markersRisk factorsAge-related differencesInfant sexMetabolic disordersMetabolic markersPotential confoundingMetabolic diseasesScreening markerAge groupsBlood collectionScreening panelHigh false positive rateAre hair cortisol levels dependent on hair growth rate? A pilot study in rhesus macaques
Dettmer A, Novak M, Meyer J. Are hair cortisol levels dependent on hair growth rate? A pilot study in rhesus macaques. General And Comparative Endocrinology 2023, 340: 114308. PMID: 37244411, PMCID: PMC10330586, DOI: 10.1016/j.ygcen.2023.114308.Peer-Reviewed Original ResearchConceptsHair cortisol concentrationsHair growth rateHair growthMacaque monkeysCortisol accumulationPilot studyAccumulation of cortisolHPA axis regulationLower hair cortisol concentrationsHigher hair cortisol concentrationsGlucocorticoid-mediated inhibitionPresent pilot studyRhesus macaque monkeysAdult female macaquesHair cortisol levelsAge-related differencesAxis regulationHair samplesInfants 3Rodent studiesCortisol levelsCortisol concentrationsAge groupsCortisol studiesNonhuman primate speciesMultimodal study of the neural sources of error monitoring in adolescents and adults
Conte S, Richards J, Fox N, Valadez E, McSweeney M, Tan E, Pine D, Winkler A, Liuzzi L, Cardinale E, White L, Buzzell G. Multimodal study of the neural sources of error monitoring in adolescents and adults. Psychophysiology 2023, 60: e14336. PMID: 37212619, PMCID: PMC10524909, DOI: 10.1111/psyp.14336.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexEvent-related potentialsError monitoringGoal-directed behaviorUnderlying neural mechanismsAnterior cingulate cortexAge-related differencesPerformance monitoringTemperamental riskERN componentIndividual differencesN2 componentNeural mechanismsNeural responsesAge differencesNeural generatorsCingulate cortexNeural sourcesFunctional MRIAdult participantsMultimodal studyPatterns of activityDevelopmental changesROI analysisAdult group
2022
Metabolomic and transcriptomic signatures of influenza vaccine response in healthy young and older adults
Chou C, Mohanty S, Kang HA, Kong L, Avila‐Pacheco J, Joshi SR, Ueda I, Devine L, Raddassi K, Pierce K, Jeanfavre S, Bullock K, Meng H, Clish C, Santori FR, Shaw AC, Xavier RJ. Metabolomic and transcriptomic signatures of influenza vaccine response in healthy young and older adults. Aging Cell 2022, 21: e13682. PMID: 35996998, PMCID: PMC9470889, DOI: 10.1111/acel.13682.Peer-Reviewed Original ResearchConceptsInfluenza vaccine responsesInfluenza vaccinationVaccine responsesHigh respondersAntibody responseImmune responseMore effective influenza vaccinesOlder adultsEffective influenza vaccinesSevere respiratory infectionsRobust immune responseLow antibody responseInfluenza vaccineRespiratory infectionsSignificant morbiditySeasonal influenzaInflammatory responseAge-related differencesDay 28Flu seasonOlder subjectsVaccinationHR subjectsMetabolomic signaturePlasma metabolites
2021
Older immigrants perceived health after migration to the United States: Influence of age and level of acculturation
Kang G, Hajduk A, Marottoli R, Nunez‐Smith M. Older immigrants perceived health after migration to the United States: Influence of age and level of acculturation. Journal Of The American Geriatrics Society 2021, 69: 2625-2637. PMID: 34252200, PMCID: PMC8440395, DOI: 10.1111/jgs.17363.Peer-Reviewed Original ResearchConceptsHealth statusAge groupsWorse healthWorse health statusCross-sectional studyLevel of acculturationSpecific health needsYears of ageInfluence of ageAge-related differencesRepresentative cohortFunctional comorbiditiesHealth needsAcculturation levelDemographic characteristicsMain predictorsAgeHealthLate-life immigrantsSecondary variablesUnited StatesStatusAssociationGroupYearsLeveraging big data to map neurodevelopmental trajectories in pediatric anxiety
Zacharek SJ, Kribakaran S, Kitt ER, Gee DG. Leveraging big data to map neurodevelopmental trajectories in pediatric anxiety. Developmental Cognitive Neuroscience 2021, 50: 100974. PMID: 34147988, PMCID: PMC8225701, DOI: 10.1016/j.dcn.2021.100974.Peer-Reviewed Original ResearchConceptsPediatric anxietyNeurodevelopmental trajectoriesAnxiety disordersNormative brain developmentPrevalent psychiatric conditionAge-related differencesAnxious youthSafety learningUnderstanding of neurodevelopmentAnxietyInconsistent findingsBrain structuresLongitudinal studyNeural structuresPsychiatric conditionsNovel treatment targetsMarker of riskBrain developmentTreatment targetsEarly risk identificationYouthFuture directionsDisordersAdolescenceNeurobiologyEthnicity/Race and Age-Specific Variations of Serum AMH in Women—A Review
Kotlyar AM, Seifer DB. Ethnicity/Race and Age-Specific Variations of Serum AMH in Women—A Review. Frontiers In Endocrinology 2021, 11: 593216. PMID: 33633682, PMCID: PMC7900163, DOI: 10.3389/fendo.2020.593216.Peer-Reviewed Original Research
2020
Physiologically Based Pharmacokinetic Modeling in Risk Assessment: Case Study With Pyrethroids
Mallick P, Song G, Efremenko A, Pendse S, Creek M, Osimitz T, Hines R, Hinderliter P, Clewell H, Lake B, Yoon M, Moreau M. Physiologically Based Pharmacokinetic Modeling in Risk Assessment: Case Study With Pyrethroids. Toxicological Sciences 2020, 176: 460-469. PMID: 32421774, PMCID: PMC7416317, DOI: 10.1093/toxsci/kfaa070.Peer-Reviewed Original ResearchConceptsAge-related pharmacokinetic differencesPharmacokinetic differencesPBPK modelTarget tissue exposureAge-related sensitivityHuman PBPK modelAge-dependent changesAge-related differencesRat modelTissue exposureVivo rat dataPharmacokinetic modellingPharmacokinetic modelingInternal exposureRat dataRisk assessmentVivo extrapolationRisk assessment purposesExposureAdultsExternal exposureSensitive populationsChildrenMetabolic capacityAssessment
2019
Measuring Treatment Response in Pediatric Trichotillomania: A Meta-Analysis of Clinical Trials
Farhat LC, Olfson E, Levine JLS, Li F, Franklin ME, Lee HJ, Lewin AB, McGuire JF, Rahman O, Storch EA, Tolin DF, Zickgraf HF, Bloch MH. Measuring Treatment Response in Pediatric Trichotillomania: A Meta-Analysis of Clinical Trials. Journal Of Child And Adolescent Psychopharmacology 2019, 30: 306-315. PMID: 31794677, PMCID: PMC7476376, DOI: 10.1089/cap.2019.0103.Peer-Reviewed Original ResearchConceptsClinical trialsTreatment responseOptimal cut pointCut pointsMassachusetts General Hospital Hair Pulling ScalePediatric trichotillomaniaClinical Global Impressions-Improvement scoreMeta-DiSc softwareClinical responsePediatric populationAge-related differencesSeverity ScaleImprovement scoresMeta-analysisYouden indexStandardized definitionsTTM severityOlder childrenTrichotillomaniaTrialsParent versionNational InstituteYoung childrenMGH-HPSDiscriminative abilityThe effects of age on reward magnitude processing in the monetary incentive delay task
Dhingra I, Zhang S, Zhornitsky S, Le T, Wang W, Chao HH, Levy I, Li CR. The effects of age on reward magnitude processing in the monetary incentive delay task. NeuroImage 2019, 207: 116368. PMID: 31743790, PMCID: PMC7463276, DOI: 10.1016/j.neuroimage.2019.116368.Peer-Reviewed Original ResearchConceptsMonetary incentive delay taskIncentive delay taskSupplementary motor areaMagnitude of rewardAge-related differencesDelay taskRT differencesRegional activationAge effectsEffect of ageReaction time differencesRight anterior insulaMiddle frontal gyrusReward-directed behaviorExplicit cuesMagnitude processingBrain activationRight caudate headAnterior insulaFrontal gyrusReward magnitudeLarge rewardPrimary motor cortexCerebral processesParahippocampal gyrusLB19. Patterns of Influenza A Hospitalizations by Subtype and Age in the United States, FluSurv-NET, 2018–2019
Garg S, O’Halloran A, O’Halloran A, Cummings C, Cummings C, Holstein R, Kniss K, Anderson E, Anderson E, Bennett N, Bennett N, Billing L, Billing L, Herlihy R, Hill M, Irizarry L, Irizarry L, Kim S, Kim S, Kirley P, Lynfield R, Lynfield R, Monroe M, Monroe M, Spina N, Talbot K, Talbot K, Thomas A, Thomas A, Yousey-Hindes K, Budd A, Brammer L, Reed C, Reed C. LB19. Patterns of Influenza A Hospitalizations by Subtype and Age in the United States, FluSurv-NET, 2018–2019. Open Forum Infectious Diseases 2019, 6: s1001-s1002. PMCID: PMC6810298, DOI: 10.1093/ofid/ofz415.2502.Peer-Reviewed Original ResearchProportion of casesAge groupsFluSurv-NETHospitalization ratesVirologic surveillanceInfluenza Hospitalization Surveillance NetworkUS Public Health LaboratoriesCumulative hospitalization rateDistribution of influenzaInfluenza hospitalization ratesLaboratory-confirmed influenzaYears of agePublic health laboratoriesInfluenza resultsH1N1pdm09 virusInfluenza vaccinationHospital admissionInfluenza seasonAge-related differencesInfluenza ASubtype distributionHospitalizationSanofi PasteurUnknown subtypeH1 virusesDevelopment and Application of a Life-Stage Physiologically Based Pharmacokinetic (PBPK) Model to the Assessment of Internal Dose of Pyrethroids in Humans
Mallick P, Moreau M, Song G, Efremenko A, Pendse S, Creek M, Osimitz T, Hines R, Hinderliter P, Clewell H, Lake B, Yoon M. Development and Application of a Life-Stage Physiologically Based Pharmacokinetic (PBPK) Model to the Assessment of Internal Dose of Pyrethroids in Humans. Toxicological Sciences 2019, 173: 86-99. PMID: 31593217, PMCID: PMC6944222, DOI: 10.1093/toxsci/kfz211.Peer-Reviewed Original ResearchConceptsTarget tissue exposureTissue exposurePharmacokinetic modelLiver blood flowLow internal exposureAge-related sensitivityAge-dependent changesEfficient metabolic clearanceIndividual cytochrome P450Human hepatic metabolismAge-related differencesCis-permethrinHepatic metabolismBlood flowMetabolic clearanceCES enzymesHepatic CLintInternal doseIntrinsic clearanceTarget tissuesInternal exposureClearanceCarboxylesterase enzymesCytochrome P450Vivo extrapolationAge-Related Differences in Hospitalization Rates, Clinical Presentation, and Outcomes Among Older Adults Hospitalized With Influenza—U.S. Influenza Hospitalization Surveillance Network (FluSurv-NET)
Czaja CA, Miller L, Alden N, Wald HL, Cummings CN, Rolfes MA, Anderson EJ, Bennett NM, Billing LM, Chai SJ, Eckel S, Mansmann R, McMahon M, Monroe ML, Muse A, Risk I, Schaffner W, Thomas AR, Yousey-Hindes K, Garg S, Herlihy RK. Age-Related Differences in Hospitalization Rates, Clinical Presentation, and Outcomes Among Older Adults Hospitalized With Influenza—U.S. Influenza Hospitalization Surveillance Network (FluSurv-NET). Open Forum Infectious Diseases 2019, 6: ofz225. PMID: 31363771, PMCID: PMC6602897, DOI: 10.1093/ofid/ofz225.Peer-Reviewed Original ResearchLaboratory-confirmed influenzaInfluenza hospitalizationsAge-related differencesHospitalization ratesInfluenza seasonClinical presentationInfluenza Hospitalization Surveillance NetworkInfluenza-associated hospitalization ratesOlder adultsHospital deathHospitalized patientsMedical historyHigher oddsAge strataPatientsAge groupsHospitalizationTreatment effortsAdultsPopulation ratesSurveillance networkInfluenzaPresentationStepwise increaseAge1141-P: Detailed Phenotype of Randomized Participants by Age in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE)
ARODA V, KRAUSE-STEINRAUF H, BUSE J, GULANSKI B, FLOREZ H, AHMANN A, LOVELAND A, KUHN A, LONIER J, MATHER K, WEXLER D. 1141-P: Detailed Phenotype of Randomized Participants by Age in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE). Diabetes 2019, 68 DOI: 10.2337/db19-1141-p.Peer-Reviewed Original ResearchNovo Nordisk A/SMannKind CorporationBaseline characteristicsKidney diseaseSpouse/partnerInclusion criteriaClinical phenotypeAge groupsGlycemia Reduction ApproachesComparative effectiveness studiesDistinct clinical phenotypesNational InstituteEli LillyAdvisory PanelEisai Inc.More CVDProminent hyperglycemiaSecond medicationAdvancing Translational SciencesDiabetic dyslipidemiaMore medicationsPrevalent comorbiditiesRandomized participantsAge-related differencesRandomized treatmentNeuroendocrine Mechanisms of Psychological Stress: Age and Sex Differences in Adults
Gaffey A, Martinez B. Neuroendocrine Mechanisms of Psychological Stress: Age and Sex Differences in Adults. 2019 DOI: 10.1093/acrefore/9780190264086.013.280.Peer-Reviewed Original ResearchHPA axisPsychological stressHypersecretion of cortisolLater lifeNegative physical health outcomesAutonomic nervous systemHPA axis functioningDiurnal cortisol rhythmCortisol awakening responseDiurnal cortisol outputPhysical health outcomesAge-related changesAdrenal axisHuman stress responseAge-related differencesNormative aging processesCortisol rhythmAxis functioningCortisol productionNervous systemHealth outcomesHealth problemsHormone cascadeAwakening responseCortisol output
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