2025
Chemically Induced Hypertension: Antineoplastic Agents Associated with High Blood Pressure
Moss E, Shirali A. Chemically Induced Hypertension: Antineoplastic Agents Associated with High Blood Pressure. Updates In Hypertension And Cardiovascular Protection 2025, 79-91. DOI: 10.1007/978-3-031-81292-7_5.Peer-Reviewed Original ResearchVascular endothelial growth factor signal pathway inhibitorsAdverse effects of anticancer therapyEffects of anticancer therapySystemic adverse effectsTyrosine kinase inhibitorsExacerbation of hypertensionTreatment of malignanciesDevelopment of hypertensionAssociated with hypertensionDrug-drug interactionsBlood pressure monitoringSignaling pathway inhibitorsCalcineurin inhibitorsHigh blood pressureAdjuvant medicationsAntineoplastic therapyProteosome inhibitorKinase inhibitorsIncreased riskSubsequent treatmentAnticancer therapyPathway inhibitorBlood pressureAntineoplastic drugsHypertensionThe Molecular Basis of Polycystic Ovary Syndrome and Its Cardiometabolic Correlates: Exploring the Intersection and Its Clinical Implications—A Narrative Review
Mahabamunuge J, Sekula N, Lepore C, Kudrimoti M, Upadhyay A, Alshowaikh K, Li H, Seifer D, AlAshqar A. The Molecular Basis of Polycystic Ovary Syndrome and Its Cardiometabolic Correlates: Exploring the Intersection and Its Clinical Implications—A Narrative Review. Biomedicines 2025, 13: 709. PMID: 40149685, PMCID: PMC11940587, DOI: 10.3390/biomedicines13030709.Peer-Reviewed Original ResearchPolycystic ovary syndromeType 2 diabetes mellitusCardiometabolic morbidityIncreased cardiovascular riskDevelopment of hypertensionCardiovascular risk factorsNarrative reviewPotential clinical implicationsAndrogen excessEndothelial dysfunctionCardiovascular riskClinical conditionsPredisposed individualsTherapeutic strategiesAdipokine secretionRisk factorsInsulin resistanceCardiometabolic diseasesCardiovascular diseaseClinical implicationsMorbidityMellitusSyndromeMolecular mechanismsDisease
2023
Associations of SGLT2 genetic polymorphisms with salt sensitivity, blood pressure changes and hypertension incidence in Chinese adults
Jia H, Bao P, Yao S, Zhang X, Mu J, Hu G, Du M, Chu C, Zhang X, Wang L, Liao Y, Wang D, Ma Q, Yan Y, Niu Z, Gao W, Li H, Wu G, Chang J, Wang Y. Associations of SGLT2 genetic polymorphisms with salt sensitivity, blood pressure changes and hypertension incidence in Chinese adults. Hypertension Research 2023, 46: 1795-1803. PMID: 37160967, DOI: 10.1038/s41440-023-01301-2.Peer-Reviewed Original ResearchConceptsLongitudinal BP changesLow-salt dietDevelopment of hypertensionBlood pressureHypertension incidenceBP changesSodium-glucose cotransporter 2 inhibitorsSalt sensitivityCotransporter 2 inhibitorsIncidence of hypertensionHigh-salt dietSystolic blood pressureBlood pressure changesGenetic polymorphismsIncident hypertensionSystolic BPDietary interventionSBP changeUsual dietHypertensionChinese adultsSalutary effectsIncidenceDietSGLT2A systems biology approach identifies the role of dysregulated PRDM6 in the development of hypertension
Gunawardhana K, Hong L, Rugira T, Uebbing S, Kucharczak J, Mehta S, Karunamuni D, Cabera-Mendoza B, Gandotra N, Scharfe C, Polimanti R, Noonan J, Mani A. A systems biology approach identifies the role of dysregulated PRDM6 in the development of hypertension. Journal Of Clinical Investigation 2023, 133: e160036. PMID: 36602864, PMCID: PMC9927944, DOI: 10.1172/jci160036.Peer-Reviewed Original ResearchConceptsDevelopment of hypertensionParallel reporter assaysRenin inhibitor aliskirenNeural crest-derived cellsRenin-producing cellsSystems biology approachRNA-seq analysisCell-specific disruptionCrest-derived cellsSmooth muscle cellsMuscle cell proteinsSystemic hypertensionBlood pressureWT miceAntihypertensive drugsBiology approachSuper enhancersFine mappingWT littermatesThird intronMultiple GWASCollagen depositionMouse aortaReporter assaysFate mapping
2022
Central Gαi2 Protein Mediated Neuro-Hormonal Control of Blood Pressure and Salt Sensitivity
Amraei R, Moreira J, Wainford R. Central Gαi2 Protein Mediated Neuro-Hormonal Control of Blood Pressure and Salt Sensitivity. Frontiers In Endocrinology 2022, 13: 895466. PMID: 35837296, PMCID: PMC9275552, DOI: 10.3389/fendo.2022.895466.Peer-Reviewed Original ResearchConceptsDietary sodium intakeG protein-coupled receptorsParaventricular nucleusBlood pressureSodium intakeElectrolyte homeostasisCentral angiotensin II type 1 receptorsAcute isotonic volume expansionAngiotensin II type 1 receptorII type 1 receptorSalt sensitivityMajor public health issueAcute pharmacological activationAfferent renal nervesNeuro-hormonal responseSalt-sensitive animalsDevelopment of hypertensionSalt-resistant ratsIsotonic volume expansionHypothalamic paraventricular nucleusMultiple G protein-coupled receptorsType 1 receptorNeuro-hormonal controlGαi/oPublic health issueAssociations of Renalase With Blood Pressure and Hypertension in Chinese Adults
Wang Y, Chen C, Hu GL, Chu C, Zhang XY, Du MF, Zou T, Zhou Q, Liao YY, Ma Q, Wang KK, Sun Y, Wang D, Yan Y, Li Y, Jia H, Niu ZJ, Zhang X, Wang L, Man ZY, Gao WH, Li CH, Zhang J, Gao K, Li HX, Chang J, Desir GV, Lu WH, Mu JJ. Associations of Renalase With Blood Pressure and Hypertension in Chinese Adults. Frontiers In Cardiovascular Medicine 2022, 9: 800427. PMID: 35282385, PMCID: PMC8907541, DOI: 10.3389/fcvm.2022.800427.Peer-Reviewed Original ResearchSerum renalase levelsRisk of hypertensionRenalase levelsRenal biopsy specimensHypertension incidenceRenalase expressionStudy cohortBiopsy specimensMean arterial pressure changesLongitudinal BP changesNon-hypertensive patientsDevelopment of hypertensionArterial pressure changesBlood pressure regulationExpression of renalaseHuman renal biopsy specimensBP progressionHypertensive patientsHypertensive subjectsNormotensive subjectsBlood pressureDiastolic BPSystolic BPRenal expressionSerum renalase
2015
Increased phosphorylation of the renal Na+-Cl− cotransporter in male kidney transplant recipient patients with hypertension: a prospective cohort
Rojas-Vega L, Jiménez-Vega A, Bazúa-Valenti S, Arroyo-Garza I, Jiménez J, Gómez-Ocádiz R, Carrillo-Pérez D, Moreno E, Morales-Buenrostro L, Alberú J, Gamba G. Increased phosphorylation of the renal Na+-Cl− cotransporter in male kidney transplant recipient patients with hypertension: a prospective cohort. American Journal Of Physiology. Renal Physiology 2015, 309: f836-f842. PMID: 26336164, DOI: 10.1152/ajprenal.00326.2015.Peer-Reviewed Original ResearchConceptsHypertensive patientsUrinary exosomesPosttransplant hypertensionHistory of acute rejectionKidney transplant recipient patientsTacrolimus trough blood levelsPatients treated with tacrolimusAmbulatory 24-h blood pressure monitoringAdult kidney transplant recipientsTacrolimus-induced hypertensionTacrolimus trough levelsTrough blood levelsNa+-Cl- cotransporterTransplant recipient patientsKidney transplant recipientsDevelopment of hypertensionProspective cohort studyBlood pressure monitoringImmunosuppressive therapyNCC expressionHigh blood pressureTrough levelsAcute rejectionKidney allograftsTransplant recipientsBlood pressure is associated with the presence and severity of nonalcoholic fatty liver disease across the spectrum of cardiometabolic risk
Aneni EC, Oni ET, Martin SS, Blaha MJ, Agatston AS, Feldman T, Veledar E, Conçeicao RD, Carvalho JA, Santos RD, Nasir K. Blood pressure is associated with the presence and severity of nonalcoholic fatty liver disease across the spectrum of cardiometabolic risk. Journal Of Hypertension 2015, 33: 1207-1214. PMID: 25693058, DOI: 10.1097/hjh.0000000000000532.Peer-Reviewed Original ResearchConceptsNonobese hypertensive patientsPrevalence of NAFLDMetabolic risk factorsHypertensive patientsNormal BPRisk factorsHigh Blood Pressure classificationNonalcoholic fatty liver diseaseHealthy middle-aged menBlood pressure groupJoint National CommitteeDevelopment of hypertensionFatty liver diseaseYearly physical examinationMiddle-aged menBlood pressure classificationBP controlPrehypertensive patientsCardiometabolic riskCross-sectional relationshipBlood pressureNAFLD severityLiver diseaseNormotensive individualsPhysical examination
2013
Hypertension and endothelial dysfunction in obstructive sleep apnea (OSA) – Is it related to hypoxia?
Mohsenin V, Jafari B. Hypertension and endothelial dysfunction in obstructive sleep apnea (OSA) – Is it related to hypoxia? Sleep Medicine 2013, 14: e210. DOI: 10.1016/j.sleep.2013.11.503.Peer-Reviewed Original ResearchObstructive sleep apneaEndothelial dysfunctionSFlt-1Fms-like tyrosine kinase-1Endothelial-dependent vasodilatory capacitySevere obstructive sleep apneaAngiogenic inhibitorsN-OSACardiovascular adverse outcomesNon-OSA patientsNormotensive OSAS patientsTarget organ damageApnea-hypopnea indexDevelopment of hypertensionArterial oxygen saturationTyrosine kinase-1Significant inverse correlationImpaired FMDIntermittent hypoxemiaSEng concentrationsVasodilatory capacityOSA patientsSympathetic toneIntermittent hypoxiaOrgan damage
2010
The glucocorticoid receptor in the distal nephron is not necessary for the development or maintenance of dexamethasone-induced hypertension
Goodwin JE, Zhang J, Velazquez H, Geller DS. The glucocorticoid receptor in the distal nephron is not necessary for the development or maintenance of dexamethasone-induced hypertension. Biochemical And Biophysical Research Communications 2010, 394: 266-271. PMID: 20188070, PMCID: PMC2946623, DOI: 10.1016/j.bbrc.2010.02.123.Peer-Reviewed Original ResearchConceptsGlucocorticoid-Induced HypertensionGlucocorticoid receptorDistal nephronKnockout miceSimilar hypertensive responsesBaseline blood pressureDevelopment of hypertensionReceptor knockout miceAdministration of glucocorticoidsSimilar body weightGlucocorticoid receptor actionHypertensive responseRenal histologyBlood pressureUrinary excretionTissue-specific knockoutMineralocorticoid receptorHypertensionMouse modelLittermate controlsNephron numberSide effectsBody weightReceptor actionImportant mediator
2008
Rare independent mutations in renal salt handling genes contribute to blood pressure variation
Ji W, Foo JN, O'Roak BJ, Zhao H, Larson MG, Simon DB, Newton-Cheh C, State MW, Levy D, Lifton RP. Rare independent mutations in renal salt handling genes contribute to blood pressure variation. Nature Genetics 2008, 40: 592-599. PMID: 18391953, PMCID: PMC3766631, DOI: 10.1038/ng.118.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmino Acid SequenceAmino Acid SubstitutionBlood PressureCohort StudiesFemaleHeterozygoteHumansHypertensionKidneyMaleMiddle AgedMolecular Sequence DataMutationPotassium Channels, Inwardly RectifyingPrevalenceReceptors, DrugSodium ChlorideSodium-Potassium-Chloride SymportersSolute Carrier Family 12, Member 1Solute Carrier Family 12, Member 3SymportersConceptsIndependent mutationsCommon complex traitsCommon complex diseasesRare recessive diseaseBlood pressure variationComparative genomicsGenetic architectureComplex traitsFramingham Heart StudyTrait lociEffects of allelesRare allelesSignificant blood pressure reductionComplex diseasesBlood pressure reductionCommon variantsDevelopment of hypertensionMutationsAllelesGenesBlood pressureRisk allelesRenal saltRecessive diseaseGeneral populationRenalase deficiency in chronic kidney disease, and its contribution to hypertension and cardiovascular disease
Desir GV. Renalase deficiency in chronic kidney disease, and its contribution to hypertension and cardiovascular disease. Current Opinion In Nephrology & Hypertension 2008, 17: 181-185. PMID: 18277152, DOI: 10.1097/mnh.0b013e3282f521ba.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseKidney diseaseBlood pressureAnimal modelsCardiac functionEnd-stage renal diseaseRegulation of renalaseSalt-dependent hypertensionDevelopment of hypertensionSystolic blood pressurePlasma renalaseRenalase deficiencyCatecholamine administrationSympathetic toneRenal diseaseKidney functionSubtotal nephrectomyPlasma catecholaminesCardiovascular diseaseHypertensionLower plasmaRenalaseCatecholaminesDiseaseAbnormalities
2007
Ala92 Type 2 Deiodinase Allele Increases Risk for the Development of Hypertension
Gumieniak O, Perlstein TS, Williams JS, Hopkins PN, Brown NJ, Raby BA, Williams GH. Ala92 Type 2 Deiodinase Allele Increases Risk for the Development of Hypertension. Hypertension 2007, 49: 461-466. PMID: 17224473, DOI: 10.1161/01.hyp.0000256295.72185.fd.Peer-Reviewed Original ResearchConceptsDevelopment of hypertensionType 2 iodothyronine deiodinaseNormotensive subjectsIodothyronine deiodinaseConversion of thyroxineSequenom MassARRAY platformEuthyroid adultsThr92Ala polymorphismEuthyroid subjectsOdds ratioHypertensionPeripheral tissuesAllele carriersIncrease riskMassARRAY platformInfluence susceptibilityHypertension susceptibilityThyroid pathwaysIntermediate phenotypesPresent studyNonsynonymous polymorphismsSubjectsDeiodinaseRiskAllele frequencies
2003
Morbidity and mortality in obstructive sleep apnea syndrome 1: Effect of treatment on cardiovascular morbidity
Shepertycky M, AL‐BARRAK M, KRYGER M. Morbidity and mortality in obstructive sleep apnea syndrome 1: Effect of treatment on cardiovascular morbidity. Sleep And Biological Rhythms 2003, 1: 15-28. DOI: 10.1046/j.1446-9235.2003.00003.x.Peer-Reviewed Original ResearchObstructive sleep apnea syndromeSevere cardiovascular outcomesCongestive heart failureIschemic heart diseaseCardiovascular morbidityHeart failureCardiovascular outcomesPulmonary hypertensionSystemic hypertensionHeart diseaseCardiac arrhythmiasContinuous positive airway pressure (CPAP) treatmentPositive airway pressure treatmentOngoing population-based studyLarge ongoing trialsUntreated OSAS patientsIndependent risk factorDevelopment of hypertensionEpisodes of apneaSleep apnea syndromePopulation-based studyEffect of treatmentNocturnal hypoxemiaOSA patientsOSAS patients
2002
Obstructive Sleep Apnea Syndrome: Its Relationship with Hypertension
Krieger AC, Redeker NS. Obstructive Sleep Apnea Syndrome: Its Relationship with Hypertension. The Journal Of Cardiovascular Nursing 2002, 17: 1-11. PMID: 12358089, DOI: 10.1097/00005082-200210000-00002.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep apneaExcessive cardiovascular morbidityArterial blood pressureDevelopment of hypertensionCardiovascular morbidityBlood pressureClinical evidenceRespiratory disturbancesPrevalent conditionGeneral populationClinical importanceTherapeutic interventionsHypertensionApneaCommon formPossible linkPossible mechanismMorbidityPatientsMortalitySleep
1997
Cardiovascular Abnormalities in Patients with X-Linked Hypophosphatemia
Nehgme R, Fahey J, Smith C, Carpenter T. Cardiovascular Abnormalities in Patients with X-Linked Hypophosphatemia. The Journal Of Clinical Endocrinology & Metabolism 1997, 82: 2450-2454. PMID: 9253316, DOI: 10.1210/jcem.82.8.4181.Peer-Reviewed Original ResearchConceptsBaseline blood pressureDiastolic baseline blood pressureVentricular hypertrophyCardiovascular abnormalitiesSystolic baseline blood pressureComplications of treatmentDevelopment of hypertensionExercise stress testingSex-matched controlsCardiovascular physical examinationMaximal systolic pressureModerate nephrocalcinosisCreatinine clearanceAbnormal findingsBlood pressureHealthy ageSystolic pressureHolter studiesSerum calciumCardiovascular statusTherapeutic guidelinesPhysical examinationXLH patientsPatientsSuch abnormalities
1996
Birth weight and adult hypertension and obesity in women.
Curhan G, Chertow G, Willett W, Spiegelman D, Colditz G, Manson J, Speizer F, Stampfer M. Birth weight and adult hypertension and obesity in women. Circulation 1996, 94: 1310-5. PMID: 8822985, DOI: 10.1161/01.cir.94.6.1310.Peer-Reviewed Original ResearchConceptsAge-adjusted odds ratioHealth Study IIBody mass indexBirth weightYears of ageOdds ratioNHS IMass indexNurses' Health Study INurses' Health Study IIAdult body mass indexHealth Study INHS II cohortDevelopment of hypertensionLow birth weightPhysician-diagnosed hypertensionRisk of hypertensionHigh birth weightEarly life exposureAdult hypertensionNHS IIBlood pressureLowest quintileRisk factorsLife exposure
1982
Oral contraception as a risk factor for preeclampsia
Bracken M, Srisuphan W. Oral contraception as a risk factor for preeclampsia. American Journal Of Obstetrics And Gynecology 1982, 142: 191-196. PMID: 7055184, DOI: 10.1016/s0002-9378(16)32335-3.Peer-Reviewed Original ResearchConceptsOral contraceptivesOral contraceptionRisk factorsIncidence of preeclampsiaDevelopment of hypertensionMajor medical centersOverall incidenceEarly pregnancyMedical CenterPreeclampsiaMaternal factorsHypertensionContraceptivesMonthsMonth periodWomenPregnancyContraceptionIncidencePossible relationshipRecent useFactors
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