2025
Chemically Induced Hypertension: Antineoplastic Agents Associated with High Blood Pressure
Moss E, Shirali A. Chemically Induced Hypertension: Antineoplastic Agents Associated with High Blood Pressure. Updates In Hypertension And Cardiovascular Protection 2025, 79-91. DOI: 10.1007/978-3-031-81292-7_5.Peer-Reviewed Original ResearchVascular endothelial growth factor signal pathway inhibitorsAdverse effects of anticancer therapyEffects of anticancer therapySystemic adverse effectsTyrosine kinase inhibitorsExacerbation of hypertensionTreatment of malignanciesDevelopment of hypertensionAssociated with hypertensionDrug-drug interactionsBlood pressure monitoringSignaling pathway inhibitorsCalcineurin inhibitorsHigh blood pressureAdjuvant medicationsAntineoplastic therapyProteosome inhibitorKinase inhibitorsIncreased riskSubsequent treatmentAnticancer therapyPathway inhibitorBlood pressureAntineoplastic drugsHypertension
2023
3D-Shaped Binders of Unfolded Proteins Inducing Cancer Cell-Specific Endoplasmic Reticulum Stress In Vitro and In Vivo
Klemt I, Varzatskii O, Selin R, Vakarov S, Kovalska V, Bila G, Bilyy R, Voloshin Y, Cuartero I, Hidalgo A, Frey B, Becker I, Friedrich B, Tietze R, Friedrich R, Alexiou C, Ursu E, Rotaru A, Solymosi I, Pérez-Ojeda M, Mokhir A. 3D-Shaped Binders of Unfolded Proteins Inducing Cancer Cell-Specific Endoplasmic Reticulum Stress In Vitro and In Vivo. Journal Of The American Chemical Society 2023, 145: 22252-22264. PMID: 37773090, DOI: 10.1021/jacs.3c08827.Peer-Reviewed Original ResearchEndoplasmic reticulum stressCancer cellsDose-limiting side effectReticulum stressPrimary tumor growthSK-MES-1ER stressBone marrow cellsPromyelocytic leukemia HL-60Acute promyelocytic leukemia HL-60LLC1 cellsActive doseSide effectsER stress inducersTumor growthSuch drugsLeukemia HL-60Normal bloodProteosome inhibitorMarrow cellsT cell leukemia JurkatOvarian carcinoma A2780DrugsROS increaseNormal cells
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